2-acetyl-4(5)-tetrahydroxybutylimidazole and fingolimod

2-acetyl-4(5)-tetrahydroxybutylimidazole has been researched along with fingolimod in 2 studies

Compound Research Comparison

Studies (2-acetyl-4(5)-tetrahydroxybutylimidazole)	Trials (2-acetyl-4(5)-tetrahydroxybutylimidazole)	Recent Studies (post-2010) (2-acetyl-4(5)-tetrahydroxybutylimidazole)	Studies (fingolimod)	Trials (fingolimod)	Recent Studies (post-2010) (fingolimod)
43	0	11	65	0	51

Protein Interaction Comparison

Protein	Taxonomy	2-acetyl-4(5)-tetrahydroxybutylimidazole (IC50)	fingolimod (IC50)
Sphingosine 1-phosphate receptor 1	Homo sapiens (human)		0.7219
Sphingosine 1-phosphate receptor 5	Homo sapiens (human)		2.1

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (50.00)	29.6817
2010's	1 (50.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Augeri, DJ; Bagdanoff, JT; Barbosa, J; Baugh, SD; Bednarz, M; Bruce, D; Carlsen, M; Carson, KG; Courtney, LF; Digeorge-Foushee, AM; Donoviel, MS; Fu, Q; Gardyan, M; Gopinathan, S; Hazelwood, J; Jessop, TC; Kimball, SD; Kramer, J; Lai, Z; Layek, S; Liu, Q; Main, A; Moran, L; Nguyen, H; Nouraldeen, A; O'Neill, E; Oravecz, T; Smith, T; Sun, W; Swaffield, J; Tarver, J; Taylor, J; Terranova, KM; Wilson, A; Yan, J; Yu, S; Zhang, H	1
Beerli, C; Bergsdorf, C; Billich, A; Braendlin, N; Oberhauser, B; Schubart, A; Srinivas, H; Weiler, S	1

Studies

Augeri, DJ; Bagdanoff, JT; Barbosa, J; Baugh, SD; Bednarz, M; Bruce, D; Carlsen, M; Carson, KG; Courtney, LF; Digeorge-Foushee, AM; Donoviel, MS; Fu, Q; Gardyan, M; Gopinathan, S; Hazelwood, J; Jessop, TC; Kimball, SD; Kramer, J; Lai, Z; Layek, S; Liu, Q; Main, A; Moran, L; Nguyen, H; Nouraldeen, A; O'Neill, E; Oravecz, T; Smith, T; Sun, W; Swaffield, J; Tarver, J; Taylor, J; Terranova, KM; Wilson, A; Yan, J; Yu, S; Zhang, H

Beerli, C; Bergsdorf, C; Billich, A; Braendlin, N; Oberhauser, B; Schubart, A; Srinivas, H; Weiler, S

Other Studies

2 other study(ies) available for 2-acetyl-4(5)-tetrahydroxybutylimidazole and fingolimod

Article	Year
Inhibition of sphingosine-1-phosphate lyase for the treatment of autoimmune disorders. Journal of medicinal chemistry, 2009, Jul-09, Volume: 52, Issue:13 Topics: Administration, Oral; Aldehyde-Lyases; Animals; Autoimmune Diseases; Enzyme Inhibitors; Imidazoles; Lymphocyte Count; Mice; Structure-Activity Relationship	2009
Orally active 7-substituted (4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as active-site inhibitors of sphingosine 1-phosphate lyase for the treatment of multiple sclerosis. Journal of medicinal chemistry, 2014, Jun-26, Volume: 57, Issue:12 Topics: Administration, Oral; Aldehyde-Lyases; Animals; Catalytic Domain; Cells, Cultured; Crystallography, X-Ray; Encephalomyelitis, Autoimmune, Experimental; Female; Humans; Male; Models, Molecular; Multiple Sclerosis; Mutation; Phthalazines; Protein Conformation; Pyridines; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship	2014

Article

Year

Inhibition of sphingosine-1-phosphate lyase for the treatment of autoimmune disorders.

Journal of medicinal chemistry, 2009, Jul-09, Volume: 52, Issue:13

Topics: Administration, Oral; Aldehyde-Lyases; Animals; Autoimmune Diseases; Enzyme Inhibitors; Imidazoles; Lymphocyte Count; Mice; Structure-Activity Relationship

2009

Orally active 7-substituted (4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as active-site inhibitors of sphingosine 1-phosphate lyase for the treatment of multiple sclerosis.

Journal of medicinal chemistry, 2014, Jun-26, Volume: 57, Issue:12

Topics: Administration, Oral; Aldehyde-Lyases; Animals; Catalytic Domain; Cells, Cultured; Crystallography, X-Ray; Encephalomyelitis, Autoimmune, Experimental; Female; Humans; Male; Models, Molecular; Multiple Sclerosis; Mutation; Phthalazines; Protein Conformation; Pyridines; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship

2014