Compounds > 2,7-diaminomitosene

2,7-diaminomitosene and mitomycin

2,7-diaminomitosene has been researched along with mitomycin in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (54.55)18.2507
2000's4 (36.36)29.6817
2010's1 (9.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Arai, H; Beall, H; Gibson, NW; Kasai, M; Ross, D; Senekowitsch, C; Siegel, D1
Beall, HD; Fisher, J; Peterson, DM; Ross, D1
Chirrey, L; Cummings, J; Halbert, GW; Smyth, JF1
Allan, L; Cummings, J; Smyth, JF1
Chirrey, L; Cummings, J; Halbert, GW; Smyth, JF; Willmott, N1
Arai, H; Belcourt, MF; Kasai, M; Kumar, GS; Palom, Y; Rockwell, S; Sartorelli, AC; Tomasz, M1
Belcourt, MF; Mehta, SS; Palom, Y; Pritsos, CA; Pritsos, KL; Rockwell, S; Sartorelli, AC; Tang, LQ; Tomasz, M1
Abbas, T; Bargonetti, J; Houser, S; Kumar, GS; Lopez, J; Olivier, M; Tomasz, M; Xiao, G1
Musser, SM; Palom, Y; Paz, MM; Rockwell, S; Suresh Kumar, G; Tang, LQ; Tomasz, M1
Basu, AK; Clement, CC; Das, A; Ramos, LA; Tomasz, M; Utzat, CD1
Basu, AK; Bose, A; Champeil, E; Pande, P; Surugihalli, C1

Other Studies

11 other study(ies) available for 2,7-diaminomitosene and mitomycin

ArticleYear
Bioreductive activation of mitomycin C by DT-diaphorase.
    Biochemistry, 1992, Sep-01, Volume: 31, Issue:34

    Topics: Animals; Chromatography, High Pressure Liquid; DNA; Glutathione; Hydrogen-Ion Concentration; Liver; Magnetic Resonance Spectroscopy; Mitomycin; Mitomycins; NAD; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Rats; Rats, Inbred Strains

1992
Noncovalent binding of a mitomycin C metabolite, 2,7-diaminomitosene, to duplex DNA.
    Cancer letters, 1995, Apr-14, Volume: 90, Issue:2

    Topics: Alkylation; Animals; Biotransformation; Cattle; Cross-Linking Reagents; DNA; DNA Adducts; DNA Damage; Electrophoresis, Polyacrylamide Gel; Hydrogen-Ion Concentration; Indolequinones; Indoles; Intercalating Agents; Mitomycin; Mitomycins; NAD(P)H Dehydrogenase (Quinone); Nucleic Acid Conformation; Nucleic Acid Denaturation; Oxidation-Reduction; Quinones

1995
Conversion of mitomycin C to 2,7-diaminomitosene and 10-decarbamoyl 2,7-diaminomitosene in tumour tissue in vivo.
    Cancer chemotherapy and pharmacology, 1995, Volume: 35, Issue:4

    Topics: Animals; Biotransformation; Chromatography, High Pressure Liquid; Half-Life; Mammary Neoplasms, Experimental; Mitomycin; Mitomycins; Rats; Rats, Inbred Strains

1995
Encapsulation of mitomycin C in albumin microspheres markedly alters pharmacokinetics, drug quinone reduction in tumour tissue and antitumour activity. Implications for the drugs' in vivo mechanism of action.
    Biochemical pharmacology, 1994, Apr-20, Volume: 47, Issue:8

    Topics: Adenocarcinoma; Albumins; Animals; Antineoplastic Agents; Biotransformation; Colonic Neoplasms; Drug Carriers; Drug Compounding; Mice; Mice, Inbred Strains; Microspheres; Mitomycin; Mitomycins; Oxidation-Reduction

1994
Determination of mitomycin C, 2,7-diaminomitosene, 1,2-cis- and 1,2-trans-1-hydroxy-2,7-diaminomitosene in tumour tissue by high-performance liquid chromatography.
    Journal of chromatography, 1993, Jan-29, Volume: 612, Issue:1

    Topics: Animals; Chromatography, High Pressure Liquid; Female; Hydrogen-Ion Concentration; Mammary Neoplasms, Experimental; Mitomycin; Mitomycins; Rats; Spectrophotometry, Ultraviolet

1993
Formation of a major DNA adduct of the mitomycin metabolite 2,7-diaminomitosene in EMT6 mouse mammary tumor cells treated with mitomycin C.
    Oncology research, 1998, Volume: 10, Issue:10

    Topics: Animals; Chromatography, High Pressure Liquid; DNA Adducts; DNA Damage; Dose-Response Relationship, Drug; Mammary Neoplasms, Animal; Mice; Mitomycin; Mitomycins; Nucleic Acid Synthesis Inhibitors; Time Factors; Tumor Cells, Cultured

1998
Bioreductive metabolism of mitomycin C in EMT6 mouse mammary tumor cells: cytotoxic and non-cytotoxic pathways, leading to different types of DNA adducts. The effect of dicumarol.
    Biochemical pharmacology, 2001, Jun-15, Volume: 61, Issue:12

    Topics: Animals; Biological Transport; Cell Division; Cell-Free System; Dicumarol; DNA Adducts; Drug Interactions; Enzyme Inhibitors; Mammary Neoplasms, Animal; Mice; Mitomycin; Mitomycins; NADH Dehydrogenase; Radiopharmaceuticals; Tritium; Tumor Cells, Cultured; Xanthine Dehydrogenase

2001
Differential activation of p53 by the various adducts of mitomycin C.
    The Journal of biological chemistry, 2002, Oct-25, Volume: 277, Issue:43

    Topics: Apoptosis; Base Sequence; Cell Nucleus; DNA; DNA Primers; Humans; K562 Cells; Mitomycin; Mitomycins; Protein Binding; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2002
Relative toxicities of DNA cross-links and monoadducts: new insights from studies of decarbamoyl mitomycin C and mitomycin C.
    Chemical research in toxicology, 2002, Volume: 15, Issue:11

    Topics: Alkylation; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Breast Neoplasms; Cattle; Cell Survival; Cross-Linking Reagents; DNA Adducts; DNA Damage; Hypoxia; Mice; Mitomycin; Mitomycins; Structure-Activity Relationship; Thymus Gland; Tumor Cells, Cultured

2002
DNA adduct of the mitomycin C metabolite 2,7-diaminomitosene is a nontoxic and nonmutagenic DNA lesion in vitro and in vivo.
    Chemical research in toxicology, 2005, Volume: 18, Issue:2

    Topics: Animals; COS Cells; DNA; DNA Adducts; DNA Damage; Escherichia coli; Mitomycin; Mitomycins; Molecular Structure; Mutagenicity Tests; Oligonucleotides

2005
Comparative Error-Free and Error-Prone Translesion Synthesis of N(2)-2'-Deoxyguanosine Adducts Formed by Mitomycin C and Its Metabolite, 2,7-Diaminomitosene, in Human Cells.
    Chemical research in toxicology, 2016, 05-16, Volume: 29, Issue:5

    Topics: Deoxyguanosine; HEK293 Cells; Humans; Mitomycin; Mitomycins

2016