2,6-dimethylphenylphthalimide has been researched along with phenytoin in 2 studies
*Phenytoin: An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs. [MeSH]
*Phenytoin: An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lambert, D; Masereel, B; Poupaert, JH; Stables, JP; Vamecq, J | 1 |
| Bac, P; Delcourt, P; Herrenknecht, C; Maurois, P; Stables, JP; Vamecq, J | 1 |
2 other study(ies) available for 2,6-dimethylphenylphthalimide and phenytoin
| Article | Year |
|---|---|
Anticonvulsant activity and interactions with neuronal voltage-dependent sodium channel of analogues of ameltolide.
Topics: Administration, Oral; Animals; Anticonvulsants; Batrachotoxins; Benzamides; Binding, Competitive; Brain; Electroshock; Injections, Intraperitoneal; Ion Channel Gating; Mice; Rats; Seizures; Sodium Channels; Structure-Activity Relationship; Synaptosomes | 1998 |
Synthesis and anticonvulsant and neurotoxic properties of substituted N-phenyl derivatives of the phthalimide pharmacophore.
Topics: Administration, Oral; Animals; Anticonvulsants; Batrachotoxins; Cerebral Cortex; Convulsants; Electroshock; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Channel Gating; Kainic Acid; Magnesium Deficiency; Mice; N-Methylaspartate; Patch-Clamp Techniques; Pentylenetetrazole; Phenytoin; Phthalimides; Rats; Seizures; Sodium Channel Blockers; Structure-Activity Relationship; Synaptosomes; Tumor Cells, Cultured | 2000 |