2,6-diaminopurine has been researched along with 2-aminopurine in 183 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 55 (30.05) | 18.7374 |
| 1990's | 44 (24.04) | 18.2507 |
| 2000's | 38 (20.77) | 29.6817 |
| 2010's | 33 (18.03) | 24.3611 |
| 2020's | 13 (7.10) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, ST; Choong, KF; Hsieh, JF; Wu, SH; Yang, YL | 1 |
| Chaudhary, D; Chauhan, V; Dhaked, RK; Pathak, U; Saxena, N | 1 |
| Carlson, EE; Goswami, M; Wilke, KE | 1 |
| Chukanova, TI; Kocharian, ShM; Sukhodolets, VV | 1 |
| Duncan, ME | 1 |
| Rudakov, VF | 1 |
| Amundson, SA; Fortunato, JE; Liber, HL | 1 |
| Bishop, PL; Cooper, GE; DiMartino, DL; Khattar, NH; Turker, MS | 1 |
| De Clercq, E; Koga, M; Patil, SD; Schneller, SW; Snoeck, R | 1 |
| Berman, HM; Gaffney, B; Ginell, SL; Jones, R; Schneider, B | 1 |
| Hakoda, M; Kamatani, N; Kashiwazaki, S; Ohtsuka, S | 1 |
| Chazin, WJ; Chollet, A; Leupin, W; Rance, M | 1 |
| Hakoda, M; Kamatani, N; Yamanaka, H | 1 |
| Chovnick, A; Dutton, FL | 1 |
| Akiyama, Y; Hashimoto, H; Kitoh, T; Kubota, M; Mikawa, H; Shimizu, T; Takimoto, T | 1 |
| Hakoda, M; Kamatani, N; Nishioka, K | 1 |
| Simili, M; Tartaglia, P; Turchi, G | 1 |
| Martin, GM; Ogburn, CE; Turker, MS | 1 |
| McKenna, PG; Wilkinson, YA | 1 |
| Matveyev, AV; Szekeres, M | 1 |
| Chollet, A; Kawashima, E | 1 |
| Colella, CM; Della Valle, G; Mariani, T; Peverali, AF; Piras, A; Rainaldi, G; Simi, S; Simili, M; Talarico, D; van Boxel, T | 1 |
| Carrozza, ML; Colella, CM; Della Valle, G; Fratta, D; Mariani, T; Piras, A; Simi, S; Simili, M; Talarico, D; Van Boxel, T | 1 |
| Coll, M; Rich, A; van Boom, JH; van der Marel, GA; Wang, AH | 1 |
| Cheong, C; Chollet, A; Tinoco, I | 1 |
| Cory, JG; Weckbecker, G | 1 |
| Martin, GM; Turker, MS | 1 |
| Paeratakul, U; Taylor, MW | 1 |
| Clifford, AJ; Clifford, CK; Ho, YK; Koehn, DJ; Sobieski, RJ | 1 |
| Plagemann, PG; Wohlhueter, RM | 1 |
| Simon, AE; Taylor, MW | 1 |
| Howard, FB; Miles, HT | 1 |
| Bradley, WE; Simon, AE; Taylor, MW | 1 |
| Chen, CW; Cohen, JS; Howard, FB; Miles, HT | 1 |
| Garber, BB; Gots, JS | 1 |
| Warren, RA | 1 |
| DeMars, R; Steglich, C | 1 |
| Bradley, WE; Letovanec, D | 1 |
| Bailly, C; Travers, AA; Waring, MJ | 1 |
| Cano, A; DuBois, S; Eritja, R; Guschlbauer, W; Marzabal, S; Thielking, V | 1 |
| Andis, SL; Bewley, JR; Boder, GB; Burke, T; Dudley, DE; Eichelberger, LE; Grindey, GB; Grossman, CS; Hertel, LW; Jordan, CL | 1 |
| Beigelman, L; Cech, TR; Strobel, SA; Usman, N | 1 |
| Bailly, C; Waring, MJ | 3 |
| Cosstick, R; Gardner, JF; Gumport, RI; Wang, S | 1 |
| Jennings, CD; Khattar, NH; Turker, MS; Walker, KA | 1 |
| Day, RS; Xu, YZ | 1 |
| Moretti, A; Piras, A; Rainaldi, G; Vatteroni, L | 1 |
| Efremova, EJ; Limborska, SA; Myasnikov, VA; Potapov, VK; Prosnyak, MI; Sverdlov, ED; Veselovskaya, SI | 1 |
| Alvarez-Builla, J; Burgos, C; Gago, F; Gallego, J; Luque, FJ; Orozco, M; Rodrigo, MM | 1 |
| Efremova, EIu; Limborskaia, SA; Miasnikov, VA; Potapov, VK; Prosniak, MI; Sverdlov, ED; Veselovskaia, SI | 1 |
| Gamper, HB; Gorn, VV; Kutyavin, IV; Lukhtanov, EA; Meyer, RB; Rhinehart, RL | 1 |
| Akopyants, N; Azhikina, T; Berg, D; Lebedev, Y; Potapov, V; Shevchenko, Y; Stecenko, D; Sverdlov, E | 1 |
| Kypr, J; Sági, J; Szakonyi, E; Vorlícková, M | 1 |
| Bailly, C; Payet, D; Travers, AA; Waring, MJ | 1 |
| Angello, JC; Margolis, RL; Palmer, DK | 1 |
| Albertini, RJ; Boyadjiev, SA; Bye, S; Gupta, PK; Hunter, TC; O'Neill, JP; Sahota, A; Shao, C; Stambrook, PJ; Tischfield, JA | 1 |
| Jennewein, S; Waring, MJ | 1 |
| Dubois, S; Eritja, R; Guschlbauer, W; Thielking, V | 1 |
| Bailly, C; Mollegaard, NE; Nielsen, PE; Waring, MJ | 1 |
| Ealick, SE; Erion, MD; Parks, RE; Poirot, AF; Smith, RM; Stoeckler, JD; Takabayashi, K | 1 |
| Allemann, RK; Meierhans, D; Sieber, M | 1 |
| Christensen, L; Dahl, O; Haaima, G; Hansen, HF; Nielsen, PE | 1 |
| Blacker, M; Gaillard, C; Laloue, M; Moffatt, BA | 1 |
| Eastmond, DA; Grosovsky, AJ; Hasegawa, LS; Parks, KK; Smith, LE | 1 |
| Buc, H; Lavigne, M | 1 |
| Boudou, V; Busson, R; De Bouvere, B; Herdewijn, P; Kerremans, L; Lescrinier, E; Schepers, G; Van Aerschot, A | 1 |
| Bowlin, TL; de Muys, JM; Gu, Z; L'Heureux, L; Nguyen-Ba, N; Rando, RF; Wainberg, MA | 1 |
| Green, R; Kim, DF | 1 |
| Giege, R; Petyuk, V; Potapov, V; Serikov, R; Tolstikov, V; Vlassov, V; Zenkova, M | 1 |
| Bailly, C; Crow, S; Minnock, A; Waring, MJ | 1 |
| Fidanza, JA; McGall, GH | 1 |
| Donovan, PJ; Riggs, CW; Smith, GT | 1 |
| Alarcon, K; Carrez, D; Croisy, A; Demeunynck, M; Lhomme, J | 1 |
| Kozlov, IA; Orgel, LE | 1 |
| Delgado, G; Eschenmoser, A; Krishnamurthy, R; Wu, X | 1 |
| Chaput, JC; Sinha, S; Switzer, C | 1 |
| Cairns, MJ; King, A; Sun, LQ | 1 |
| Eschenmoser, A; Han, B; Huynh, HK; Krishnamurthy, R; Wang, Z | 1 |
| Eschenmoser, A; Han, B; Jaun, B; Krishnamurthy, R; Wang, Z | 1 |
| Holý, A; Kmoníèková, E; Potmesil, P; Zídek, Z | 1 |
| MILLER, C | 1 |
| SKIPPER, HE; WHEELER, GP | 1 |
| JACOBSON, WE; STOCK, CC; WILLIAMSON, M | 1 |
| DUNCAN, RE; SETTERFIELD, G | 1 |
| DEYSSON, G; DEYSSON, M; TRUHAUT, R | 1 |
| THIERSCH, JB | 1 |
| REMY, CN | 1 |
| HARRIS, M | 1 |
| GOTS, JS; KALLE, GP | 2 |
| BALDUZZI, PC; MORGAN, HR | 1 |
| BERENBLUM, I; KAYE, AM; TRAININ, N | 1 |
| CUTTS, JH | 1 |
| ALDERSON, T | 1 |
| GUTHRIE, R; LU, WC | 1 |
| SUBAK-SHARPE, H | 1 |
| Doláková, P; Holý, A; Masojídková, M | 1 |
| DUSTIN, P | 1 |
| BERGER, RE; BIESELE, JJ; ELION, GB; HITCHINGS, GH; WILSON, AY | 1 |
| ELION, GB; HITCHINGS, GH | 1 |
| BENNETT, LL; EIDSON, M; MITCHELL, JH; NEWTON, MA; SIMPSON, L; SKIPPER, HE | 1 |
| BIEDLER, JL; BURCHENAL, JH; MEIGS, GM; WEBBER, LF | 1 |
| BURCHENAL, JH; CRAVER, LF; DARGEON, HW; ESCHER, GC; KARNOFSKY, DA; KINGSLEY-PILLERS, EM; MYERS, WP; RHOADS, CP; SOUTHAM, CM | 1 |
| FRIEND, C | 1 |
| FRIEND, C; MOORE, AE | 1 |
| JACOBSON, W; STOCK, CC; WILLIAMSON, M | 1 |
| MORGAN, HR | 1 |
| Arent, S; Frieden, M; Jensen, FR; Koch, T; Larsen, S; Pedersen, DS; Rosenbohm, C | 1 |
| Koshkin, AA | 1 |
| Andrei, G; De Clercq, E; Snoeck, R | 1 |
| Hays, FA; Ho, PS; Jones, ZJ | 1 |
| Edwards, J; Gamper, HB; Gewirtz, A; Hou, YM | 1 |
| PHILIPS, FS; THIERSCH, JB | 1 |
| CARTWRIGHT, GE; ELION, GB; GUNN, FD; HITCHINGS, GH; PALMER, JG; WINTROBE, MM | 1 |
| BENDICH, A; BROWN, GB; FURST, SS | 1 |
| Edwardson, JM; Fitzgerald, WJ; Ge, H; Henderson, RM; Tseng, YD; Wang, X; Waring, MJ | 1 |
| Hwang, H; Taylor, JS | 1 |
| Arar, K; Gamper, HB; Gewirtz, A; Hou, YM | 1 |
| Kleinpeter, E; Klika, KD; Koch, A; Kronberg, L; Mattjus, P; Roslund, MU; Sjöholm, R; Virta, P | 1 |
| Breaker, RR; Cheah, MT; Crothers, DM; Wickiser, JK | 1 |
| Holý, A; Kmonícková, E; Potmesil, P; Zídek, Z | 1 |
| Al-Zoughool, M; Caruso, JA; Fischer, JM; Kannamkumarath, SS; Robbins, SB; Stambrook, PJ; Stringer, JR; Stringer, SL; Talaska, G | 1 |
| Arndt-Jovin, DJ; Jovin, TM; Kaluzhny, DN; Shchyolkina, AK; Zhurkin, VB | 1 |
| Corradini, R; Komiyama, M; Sforza, S; Tedeschi, T; Yamamoto, Y; Yoshida, J | 1 |
| Krishnakumar, V; Ramasamy, R | 1 |
| BONDICH, A; BROWN, GB | 1 |
| BENDICH, A; BURCHENAL, JH | 1 |
| Corradini, R; Ishizuka, T; Komiyama, M; Sforza, S; Sumaoka, J; Tedeschi, T; Yamamoto, Y; Yoshida, J | 1 |
| Chang, Y; Chen, T; He, XX; Lin, JS; Ye, BX | 1 |
| Aiba, Y; Ishizuka, T; Komiyama, M; Sumaoka, J | 1 |
| Billecocq, A; Bouloy, M; Guétard, D; Henry, M; Puyraimond-Zemmour, D; Renard, M; Suspène, R; Tangy, F; Vartanian, JP; Wain-Hobson, S | 1 |
| Lindemose, S; Møllegaard, NE; Nielsen, PE | 1 |
| Haynes, C; Hughesman, CB; Turner, RF | 1 |
| Arar, K; Gamper, H; Hou, YM; Lahoud, G | 1 |
| Matsika, S; Mburu, E | 1 |
| Batey, RT; Gilbert, SD | 1 |
| Amantia, D; Clegg, W; Galindo, MA; Harrington, RW; Houlton, A; Martinez-Martinez, A; Moreno Martinez, V | 1 |
| Kawai, K; Kodera, H; Majima, T | 1 |
| Arico, JW; Calhoun, AK; McLaughlin, LW | 1 |
| Barbatti, M; Callahan, MP; de Vries, MS; Gengeliczki, Z; Hobza, P; Lischka, H; Meerts, L; Nachtigallová, D; Pongor, CI; Svadlenak, N; Sztáray, B | 1 |
| Kierzek, E; Kierzek, R; Liang, R; Turner, DH | 1 |
| Balzarini, J; Baszczyňski, O; de Clercq, E; Dračínský, M; Holý, A; Janeba, Z; Jansa, P; Klepetářová, B; Votruba, I | 1 |
| Atria, AM; Baggio, R; Corsini, G; Garland, MT; Herrera, N | 1 |
| Hudson, RH; St Amant, AH | 1 |
| Fu, Q; Fuhrmann, A; Getfert, S; Lindsay, S; Reimann, P; Ros, R | 1 |
| Banáš, P; Beššeová, I; Košinová, P; Kührová, P; Otyepka, M; Šponer, J | 1 |
| Balaz, M; Kubelka, J; Sargsyan, G; Schatz, AA | 1 |
| Burrows, CJ; Ding, Y; Fleming, AM; Jin, Q; White, HS | 1 |
| Diblíková, D; Hrabálek, A; Kopečná, M; Krečmerová, M; Roh, J; Školová, B; Vávrová, K | 1 |
| Fukabori, K; Kikukawa, Y; Koga, Y; Sasaki, S; Taniguchi, Y | 1 |
| Maher, LJ; McCauley, MJ; Mogil, LS; Peters, JP; Williams, MC | 1 |
| Nakano, S; Sugimoto, N | 1 |
| Amblard, F; Amiralaei, S; Bassit, L; Bobeck, D; Cho, JH; Coats, SJ; Detorio, M; Ehteshami, M; McBrayer, TR; Pradere, U; Schinazi, RF; Tao, S; Whitaker, T; Zhang, HW; Zhou, L | 1 |
| Castiñeiras, A; Choquesillo-Lazarte, D; Domínguez-Martín, A; El Bakkali, H; García-Rubiño, ME; González-Pérez, JM; Niclós-Gutiérrez, J; Nurchi, VM; Pérez-Toro, I; Vílchez-Rodríguez, E | 1 |
| Bartheldyova, E; Celechovska, H; Eyer, L; Fojtikova, M; Hubatka, F; Janeba, Z; Koudelka, S; Kovarcik, K; Kulich, P; Lipenska, I; Masek, J; Miller, AD; Neca, J; Plockova, J; Prochazka, L; Raska, M; Ruzek, D; Slany, M; Turanek, J; Turanek-Knotigova, P; Zouharova, D | 1 |
| Anderson, BA; Hrdlicka, PJ | 1 |
| Froeyen, M; Kaptein, S; Neyts, J; Rozenski, J; Saudi, M; Van Aerschot, A; Venkatesham, A | 1 |
| Cameron, SA; Ducati, RG; Firestone, RS; Schramm, VL; Spitz, AZ; Tyler, PC | 1 |
| Jeong, LS; Kim, G; Naik, SD; Qu, S; Sahu, PK; Umme, T; Yu, J | 1 |
| Ariyoshi, J; Asanuma, H; Donoshita, Y; Kamimoto, H; Kamiya, Y; Murayama, K | 1 |
| Cepeda-Plaza, M; Lu, Y; McGhee, CE | 1 |
| Kamble, NR; Sigurdsson, ST | 1 |
| Costantino, G; Crespan, E; Kaptein, SJF; Maga, G; Neyts, J; Radi, M; Rivera, JIA; Vincetti, P | 1 |
| Li, X; Liu, G; Ren, P; Song, Y; Wang, J; Yang, F; Yu, Z | 1 |
| Erlacher, MD; Faserl, K; Fuchs, E; Gasser, C; Höbartner, C; Hoernes, TP; Hüttenhofer, A; Joseph, S; Juen, MA; Kremser, J; Kreutz, C; Lindner, H; Micura, R; Shi, X; Siewert, A; Westhof, E | 1 |
| Cassina, V; Corti, R; Cristofalo, M; Dunlap, D; Kovari, D; Mantegazza, F; Salerno, D | 1 |
| Hornum, M; Kumar, P; Nielsen, P; Nielsen, RB; Petersen, M; Sharma, PK; Stendevad, J | 1 |
| Chen, J; Pang, L; Wang, X; Zhang, JZH; Zhu, T | 1 |
| Chatterjee, S; Daher, M; Lund, PE; Walter, NG | 1 |
| Asanuma, H; Kamiya, Y; Kodama, A; Murayama, K; Sato, F; Uchiyama, S | 1 |
| Adriaenssens, E; Amand, S; Bailly, C; Benhabiles, H; Chassat, T; Copin, MC; Duvernois-Berthet, E; Guilbert, R; Hannebique, D; Kulozik, A; Lejeune, F; Leroy, C; Marchand, V; Moreau, PA; Motorin, Y; Mouray, A; Rebuffat, S; Saliou, JM; Trzaska, C; Tulasne, D; Werkmeister, E; Westhof, E | 1 |
| Bichenkova, E; Chiglintseva, D; Gaponova, S; Mironova, N; Patutina, O; Vlassov, V; Zenkova, M | 1 |
| Czernecki, D; Delarue, M; Kaminski, PA; Legrand, P; Rosario, S; Tekpinar, M | 1 |
| Garcia, PS; Gribaldo, S; Haouz, A; Kaminski, PA; Lagune, M; Loc'h, J; Marlière, P; Röthlisberger, P; Sleiman, D; Taib, N | 1 |
| Bourguignon, PY; Hatfull, GF; Herdewijn, P; Jacobs-Sera, D; Jaziri, F; Kaminski, PA; Louis, D; Marliere, P; Pezo, V; Pochet, S; Rozenski, J | 1 |
| Green, NJ; Kruse, H; Rak, J; Spisz, P; Šponer, J; Stadlbauer, P; Szabla, R; Zdrowowicz, M | 1 |
| Bonhomme, F; Czernecki, D; Delarue, M; Kaminski, PA | 1 |
| Czernecki, D; Delarue, M; Hu, H; Romoli, F | 1 |
| Caldero-Rodríguez, NE; Crespo-Hernández, CE; Gonzalez, AA; Ortiz-Rodríguez, LA | 1 |
| Guo, S; Kim, HS; Park, J; Schärer, OD; Tan, Y; Wang, Y; You, C | 1 |
| Datta, D; Egli, M; Madaoui, M; Manoharan, M; Ross, BS; Wassarman, K; Zlatev, I | 1 |
2 review(s) available for 2,6-diaminopurine and 2-aminopurine
| Article | Year |
|---|---|
Modified bases in bacteriophage DNAs.
Topics: 2-Aminopurine; 5-Methylcytosine; Adenine; Bacteriophages; Base Composition; Chemical Phenomena; Chemistry; Chemistry, Physical; Cytosine; Deoxyribonucleases; DNA Replication; DNA, Viral; Nucleic Acid Conformation; Pentoxyl; Substrate Specificity; Templates, Genetic; Thymine; Transcription, Genetic; Uracil | 1980 |
The use of diaminopurine to investigate structural properties of nucleic acids and molecular recognition between ligands and DNA.
Topics: 2-Aminopurine; Animals; Base Sequence; Binding Sites; DNA; Humans; Ligands; Molecular Sequence Data; Nucleic Acid Conformation; Sequence Analysis, DNA | 1998 |
181 other study(ies) available for 2,6-diaminopurine and 2-aminopurine
| Article | Year |
|---|---|
The screening and characterization of 6-aminopurine-based xanthine oxidase inhibitors.
Topics: Allopurinol; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; Enzyme Inhibitors; Kinetics; Magnetic Resonance Spectroscopy; Mass Spectrometry; Plant Leaves; Purines; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Triticum; Xanthine Oxidase | 2007 |
In Silico Discovery and Validation of Amide Based Small Molecule Targeting the Enzymatic Site of Shiga Toxin.
Topics: Amides; Animals; Cells, Cultured; Chlorocebus aethiops; Dose-Response Relationship, Drug; Drug Discovery; Male; Mice; Mice, Inbred BALB C; Models, Molecular; Molecular Structure; Shiga Toxin; Small Molecule Libraries; Structure-Activity Relationship; Vero Cells | 2016 |
Rational Design of Selective Adenine-Based Scaffolds for Inactivation of Bacterial Histidine Kinases.
Topics: Adenine; Adenosine Triphosphate; Anti-Bacterial Agents; Aspartic Acid; Bacteria; Drug Design; Histidine Kinase; HSP90 Heat-Shock Proteins; Models, Molecular; Molecular Docking Simulation; Structure-Activity Relationship | 2017 |
[Mutations of resistance to 2,6-diaminopurine and 6-methylpurine that affect adenine phosphoribosyltransferase in Escherichia coli K-12].
Topics: 2-Aminopurine; Adenine; Adenine Phosphoribosyltransferase; Chromosome Mapping; Drug Resistance, Microbial; Escherichia coli; Mutation; Pentosyltransferases; Phenotype; Purines; Recombination, Genetic; Transduction, Genetic | 1977 |
Isolation and preliminary characterization of drug resistant mutants of human lymphoblastoid cells.
Topics: 2-Aminopurine; Adenine; Adenine Phosphoribosyltransferase; Cell Line; Cell Membrane; Drug Resistance; Humans; Hypoxanthine Phosphoribosyltransferase; Karyotyping; Mutation; Nucleotidases; Ouabain; Thioguanine | 1977 |
[The antifolic activity of several derivatives of 2,4,6-triaminopyrimidine and 2,6-diaminopurine in a microbiologic test system].
Topics: 2-Aminopurine; Adenine; Biological Assay; Enterococcus faecalis; Folic Acid Antagonists; Pyrimidines | 1975 |
Heritable alterations at the adenine phosphoribosyltransferase (APRT) locus in human lymphoblastoid cell lines.
Topics: 2-Aminopurine; Adenine Phosphoribosyltransferase; Aminacrine; Azacitidine; Blotting, Southern; Cell Line; DNA; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Resistance; Ethyl Methanesulfonate; Gene Frequency; Humans; Mutagens; Mutation; Nitrogen Mustard Compounds; X-Rays | 1992 |
Molecular and biochemical elucidation of a cellular phenotype characterized by adenine analogue resistance in the presence of high levels of adenine phosphoribosyltransferase activity.
Topics: 2-Aminopurine; Adenine; Adenine Phosphoribosyltransferase; Adenosine Monophosphate; Amino Acid Sequence; Animals; Azaserine; Base Sequence; DNA Mutational Analysis; Drug Resistance; Exons; Genes; Mice; Molecular Sequence Data; Neoplasm Proteins; Phenotype; Polymerase Chain Reaction; Transfection; Tumor Cells, Cultured | 1992 |
(+-)-carbocyclic 5'-nor-2'-deoxyguanosine and related purine derivatives: synthesis and antiviral properties.
Topics: 2-Aminopurine; Antiviral Agents; Cytomegalovirus; Deoxyadenosines; Deoxyguanosine; Herpesvirus 3, Human; HIV-1; HIV-2; Molecular Structure; Simplexvirus; Structure-Activity Relationship; Vaccinia virus; Vesicular stomatitis Indiana virus | 1992 |
Crystal and molecular structure of a DNA fragment containing a 2-aminoadenine modification: the relationship between conformation, packing, and hydration in Z-DNA hexamers.
Topics: 2-Aminopurine; Crystallography; DNA; Models, Molecular; Nucleic Acid Conformation; Water | 1992 |
Germline and somatic mutations leading to adenine phosphoribosyltransferase (APRT) deficiency.
Topics: 2-Aminopurine; Adenine Phosphoribosyltransferase; Alleles; Genotype; Germ Cells; Heterozygote; Homozygote; Humans; Mutation; T-Lymphocytes | 1991 |
Comparative NMR analysis of the decadeoxynucleotide d-(GCATTAATGC)2 and an analogue containing 2-aminoadenine.
Topics: 2-Aminopurine; Base Sequence; DNA; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Nucleic Acid Conformation; Polydeoxyribonucleotides; Temperature | 1991 |
Diagnosis of heterozygous states for adenine phosphoribosyltransferase deficiency based on detection of in vivo somatic mutants in blood T cells: application to screening of heterozygotes.
Topics: 2-Aminopurine; Adenine Phosphoribosyltransferase; Alleles; Base Sequence; Cells, Cultured; Cloning, Molecular; Cytotoxins; DNA; Drug Resistance; Gene Frequency; Genetic Carrier Screening; Humans; Molecular Sequence Data; Mutation; Pedigree; T-Lymphocytes; Urinary Calculi | 1991 |
The PurR mutation of Drosophila melanogaster confers resistance to purine and 2,6-diaminopurine by elevating adenosine deaminase activity.
Topics: 2-Aminopurine; Adenine; Adenosine Deaminase; Animals; Chromosome Mapping; Crosses, Genetic; Drosophila melanogaster; Female; Gene Expression Regulation, Enzymologic; Genetic Linkage; Genotype; Hot Temperature; Male; Mutation; Nucleoside Deaminases; Purines; Recombination, Genetic; Repressor Proteins | 1990 |
Biochemical basis of the prevention of 6-thiopurine toxicity by the nucleobases, hypoxanthine and adenine.
Topics: 2-Aminopurine; Adenine; Adenine Phosphoribosyltransferase; Antineoplastic Agents; Biological Transport; Humans; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Inosine Monophosphate; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Promyelocytic, Acute; Mercaptopurine; Thioguanine; Thionucleotides; Tumor Cells, Cultured | 1990 |
Homozygous deficiency at autosomal locus aprt in human somatic cells in vivo induced by two different mechanisms.
Topics: 2-Aminopurine; Adenine Phosphoribosyltransferase; Cells, Cultured; Clone Cells; Drug Resistance; Genetic Carrier Screening; Homozygote; Humans; Mutation; Pentosyltransferases; Reference Values; T-Lymphocytes | 1990 |
High sensitivity of Chinese hamster epithelial liver cells to toxic analogues of purines.
Topics: 2-Aminopurine; Adenine; Adenine Phosphoribosyltransferase; Animals; Azaguanine; Cells, Cultured; Cricetinae; Epithelial Cells; Epithelium; Hypoxanthine Phosphoribosyltransferase; Liver; Mutagenicity Tests; Pentosyltransferases; Thioguanine; Thymine Nucleotides | 1990 |
Subpopulations of fibroblasts from mouse skeletal muscle defined by clonal variation for 5' nucleotidase expression.
Topics: 2-Aminopurine; 5'-Nucleotidase; Animals; Biomechanical Phenomena; Cell Survival; Clone Cells; Drug Resistance; Fibroblasts; Histocytochemistry; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Muscles; Nucleotidases; Phenotype; Staining and Labeling | 1985 |
The effects of thymidine on deoxyribonucleotide pool levels, cytotoxicity and mutation induction in Friend mouse erythroleukaemia cells.
Topics: 2-Aminopurine; Animals; Cell Cycle; Cell Line; Cell Survival; Clone Cells; Deoxyribonucleotides; Drug Resistance; Friend murine leukemia virus; Leukemia, Erythroblastic, Acute; Mice; Mutagens; Mutation; Thioguanine; Thymidine | 1989 |
Cleavage and sequence recognition of 2,6-diaminopurine-containing DNA by site-specific endonucleases.
Topics: 2-Aminopurine; Adenine; Base Sequence; DNA Restriction Enzymes; DNA, Viral; Kinetics; Substrate Specificity | 1987 |
DNA containing the base analogue 2-aminoadenine: preparation, use as hybridization probes and cleavage by restriction endonucleases.
Topics: 2-Aminopurine; Adenine; Base Sequence; DNA; DNA Restriction Enzymes; Indicators and Reagents; Molecular Sequence Data; Nucleic Acid Hybridization; Oligodeoxyribonucleotides; Templates, Genetic | 1988 |
Gene dosage mutants at adenine phosphoribosyltransferase locus induced by colcemid in Chinese hamster V79-AP4 cells.
Topics: 2-Aminopurine; Adenine Phosphoribosyltransferase; Aneuploidy; Animals; Chromosome Mapping; Cricetinae; Cricetulus; Demecolcine; Genes; Mutation; Pentosyltransferases; Ploidies | 1988 |
A genetic analysis of the adenine phosphoribosyl transferase locus in Chinese hamster V79-AP4 cells: relevance to mutagenesis studies.
Topics: 2-Aminopurine; Adenine Phosphoribosyltransferase; Animals; Blotting, Southern; Cell Line; Chromosome Banding; Chromosome Mapping; Cricetinae; Cricetulus; DNA Probes; Isoenzymes; L-Lactate Dehydrogenase; Mutagenicity Tests; Pentosyltransferases | 1988 |
Crystal structure of a Z-DNA fragment containing thymine/2-aminoadenine base pairs.
Topics: 2-Aminopurine; Adenine; Base Composition; Circular Dichroism; Crystallization; DNA; Nucleic Acid Conformation; Thymine | 1986 |
Thermodynamic studies of base pairing involving 2,6-diaminopurine.
Topics: 2-Aminopurine; Adenine; Base Composition; Oligodeoxyribonucleotides; Thermodynamics | 1988 |
2,6-Diaminopurinedeoxyriboside as a prodrug of deoxyguanosine in L1210 cells.
Topics: 2-Aminopurine; Adenosine Deaminase Inhibitors; Animals; Cell Division; Chromatography, High Pressure Liquid; Deoxyadenosines; Deoxycytidine; Deoxyguanosine; DNA Replication; Dose-Response Relationship, Drug; Leukemia L1210; Ribonucleotide Reductases | 1987 |
Induction of adenine salvage in mouse cell lines deficient in adenine phosphoribosyltransferase.
Topics: 2-Aminopurine; Adenine; Adenine Phosphoribosyltransferase; Alanine; Animals; Azaserine; Cell Line; Cross Reactions; Drug Resistance; Gene Expression Regulation; Karyotyping; Mice; Mycoplasma; Pentosyltransferases | 1985 |
Isolation and characterization of mutants at the APRT locus in the L-5178Y TK+/TK- mouse lymphoma cell line.
Topics: 2-Aminopurine; Adenine Phosphoribosyltransferase; Animals; Cell Line; Drug Resistance; Genes; Heterozygote; Immunoassay; Leukemia L5178; Leukemia, Experimental; Mice; Mutagens; Mutation; Nucleic Acid Hybridization; Pentosyltransferases; Thymidine Kinase | 1986 |
Effects of purine amino groups on the development of Drosophila.
Topics: 2-Aminopurine; Adenine; Animals; Charcoal; Drosophila melanogaster; Guanine; Larva; Purines | 1984 |
Adenosine metabolism in wild-type and enzyme-deficient variants of Chinese hamster ovary and Novikoff rat hepatoma cells.
Topics: 2-Aminopurine; Adenine Nucleotides; Adenosine; Adenosine Kinase; Animals; Cell Division; Cell Line; Cell-Free System; Coformycin; Cricetinae; Female; Kinetics; Liver Neoplasms, Experimental; Ovary; Pentostatin; Phosphorylation; Phosphotransferases; Purine-Nucleoside Phosphorylase; Rats; Tubercidin | 1983 |
Correlation between a mutant APRT protein and altered DNA in CHO cells.
Topics: 2-Aminopurine; Adenine Phosphoribosyltransferase; Animals; Base Sequence; Cell Line; Cricetinae; Cricetulus; DNA; DNA Restriction Enzymes; Drug Resistance; Female; Mutation; Nucleic Acid Hybridization; Ovary; Pentosyltransferases | 1984 |
2NH2A X T helices in the ribo- and deoxypolynucleotide series. Structural and energetic consequences of 2NH2A substitution.
Topics: 2-Aminopurine; Adenine; Base Composition; Nucleic Acid Conformation; Polydeoxyribonucleotides; Polyribonucleotides; Thermodynamics | 1984 |
Mechanism of mutation at the aprt locus in Chinese hamster ovary cells: analysis of heterozygotes and hemizygotes.
Topics: 2-Aminopurine; Adenine; Adenine Phosphoribosyltransferase; Animals; Cell Line; Chromosome Deletion; Cricetinae; Cricetulus; Drug Resistance; Female; Fibroblasts; Heterozygote; Models, Genetic; Mutation; Ovary; Pentosyltransferases | 1983 |
Poly(d2NH2A-dT): effect of 2-amino substituent on the B to Z transition.
Topics: 2-Aminopurine; Adenine; Circular Dichroism; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation; Poly dA-dT; Polydeoxyribonucleotides; Spectrophotometry, Infrared; Structure-Activity Relationship | 1984 |
Utilization of 2,6-diaminopurine by Salmonella typhimurium.
Topics: 2-Aminopurine; Adenine; Adenosine Deaminase; Guanine; Mutation; Purine-Nucleoside Phosphorylase; Purines; Salmonella typhimurium | 1980 |
Mutations causing deficiency of APRT in fibroblasts cultured from human heterozygous for mutant APRT alleles.
Topics: 2-Aminopurine; Adenine Phosphoribosyltransferase; Drug Resistance; Humans; Methylnitronitrosoguanidine; Mutation; Pentosyltransferases | 1982 |
High-frequency nonrandom mutational event at the adenine phosphoribosyltransferase (aprt) locus of sib-selected CHO variants heterozygous for aprt.
Topics: 2-Aminopurine; Adenine Phosphoribosyltransferase; Animals; Cell Line; Cricetinae; Cricetulus; Drug Resistance; Female; Heterozygote; Karyotyping; Mutation; Phenotype | 1982 |
Effects of base substitutions on the binding of a DNA-bending protein.
Topics: 2-Aminopurine; Base Sequence; Carrier Proteins; DNA Footprinting; DNA-Binding Proteins; DNA, Bacterial; Factor For Inversion Stimulation Protein; Guanine; Inosine; Integration Host Factors; Molecular Sequence Data; Nucleic Acid Conformation; Promoter Regions, Genetic; RNA, Transfer, Tyr | 1995 |
Dam methylase from Escherichia coli: kinetic studies using modified DNA oligomers: hemimethylated substrates.
Topics: 2-Aminopurine; Base Sequence; DNA; Escherichia coli; Escherichia coli Proteins; Hypoxanthine; Hypoxanthines; Kinetics; Methylation; Molecular Sequence Data; Nucleic Acid Denaturation; Polydeoxyribonucleotides; Site-Specific DNA-Methyltransferase (Adenine-Specific); Thermodynamics; Uracil | 1995 |
Medicinal chemistry of difluoropurines.
Topics: 2-Aminopurine; Animals; Antineoplastic Agents; Blood Cell Count; Blood Pressure; Deoxyadenosines; Deoxyguanosine; Dogs; Drug Screening Assays, Antitumor; Female; Guanosine; Heart; Humans; In Vitro Techniques; Infusions, Intravenous; Injections, Intraperitoneal; Liver; Lymphoid Tissue; Male; Mice; Neoplasms, Experimental; Ovarian Neoplasms; Structure-Activity Relationship; Testis | 1995 |
The 2,6-diaminopurine riboside.5-methylisocytidine wobble base pair: an isoenergetic substitution for the study of G.U pairs in RNA.
Topics: 2-Aminopurine; Amides; Base Composition; Base Sequence; Cytidine; Guanine; Molecular Sequence Data; Phosphoric Acids; RNA; Thermodynamics; Uridine | 1994 |
The purine 2-amino group as a critical recognition element for binding of small molecules to DNA.
Topics: 2-Aminopurine; Adenine; Anti-Bacterial Agents; Autoradiography; Base Sequence; Dactinomycin; Deoxyribonuclease I; DNA; Echinomycin; Guanine; Inosine; Molecular Sequence Data; Netropsin; Nucleic Acid Conformation; RNA, Transfer, Tyr | 1994 |
The specific binding of Escherichia coli integration host factor involves both major and minor grooves of DNA.
Topics: 2-Aminopurine; Bacterial Proteins; Base Sequence; DNA-Binding Proteins; DNA, Bacterial; Escherichia coli; Integration Host Factors; Molecular Sequence Data; Nucleic Acid Conformation; Structure-Activity Relationship | 1995 |
Isolation and characterization of mutations in the mouse APRT gene that encode functional enzymes with resistance to toxic adenine analogs.
Topics: 2-Aminopurine; Adenine; Adenine Phosphoribosyltransferase; Animals; Carcinoma, Embryonal; Cell Division; Cell Line; Ethyl Methanesulfonate; Kinetics; Mice; Mutagenesis; Tumor Cells, Cultured; Ultraviolet Rays | 1994 |
Transferring the purine 2-amino group from guanines to adenines in DNA changes the sequence-specific binding of antibiotics.
Topics: 2-Aminopurine; Adenine; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Base Sequence; Binding Sites; Dinucleoside Phosphates; DNA; Guanine; Inosine; Intercalating Agents; Ligands; Molecular Sequence Data; Peptides; RNA, Transfer, Tyr | 1995 |
Incision at diaminopurine: thymine base pairs but not at guanine:O4-methylthymine base pairs in DNA by extracts of human cells.
Topics: 2-Aminopurine; Base Composition; Base Sequence; Cell Line; Cell-Free System; DNA; Glioma; Guanine; Humans; Hydrogen Bonding; Molecular Sequence Data; Oligodeoxyribonucleotides; Thymine; Tumor Cells, Cultured | 1995 |
Gene amplification and gene deletion are induced at different rates in V79/AP4 Chinese hamster cells.
Topics: 2-Aminopurine; Animals; Aspartate Carbamoyltransferase; Aspartic Acid; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Cell Division; Cell Line; Cricetinae; Cricetulus; Dihydroorotase; DNA; DNA Replication; Drug Resistance; Gene Amplification; Gene Deletion; Mitomycin; Multienzyme Complexes; Mutagenesis; Mutagens; Phosphonoacetic Acid | 1993 |
Substitution of 2-aminoadenine and 5-methylcytosine for adenine and cytosine in hybridization probes increases the sensitivity of DNA fingerprinting.
Topics: 2-Aminopurine; 5-Methylcytosine; Adenine; Base Sequence; Blotting, Southern; Cytosine; DNA; DNA Fingerprinting; DNA Primers; Humans; Molecular Sequence Data; Oligonucleotide Probes; Sensitivity and Specificity | 1994 |
DNA sequence-specific reading by echinomycin: role of hydrogen bonding and stacking interactions.
Topics: 2-Aminopurine; Base Composition; Base Sequence; Binding Sites; Chemical Phenomena; Chemistry, Physical; Deoxyribonuclease I; DNA; Echinomycin; Electrochemistry; Hydrogen Bonding; Hypoxanthine; Hypoxanthines; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Quinoxalines; Thermodynamics | 1994 |
[Intensification of genomic dactyloscopy by means of hybridization with modified oligonucleotides, forming duplexes with increased stability].
Topics: 2-Aminopurine; 5-Methylcytosine; Cytosine; DNA Fingerprinting; Nucleic Acid Hybridization; Oligonucleotides | 1993 |
Oligonucleotides containing 2-aminoadenine and 2-thiothymine act as selectively binding complementary agents.
Topics: 2-Aminopurine; Base Sequence; Electrophoresis, Polyacrylamide Gel; Hydrogen Bonding; Molecular Sequence Data; Molecular Structure; Nucleic Acid Conformation; Nucleic Acid Denaturation; Nucleic Acid Hybridization; Oligodeoxyribonucleotides; Thermodynamics; Thymine | 1996 |
Oligonucleotides containing 2-aminoadenine and 5-methylcytosine are more effective as primers for PCR amplification than their nonmodified counterparts.
Topics: 2-Aminopurine; 5-Methylcytosine; Base Sequence; Cytosine; DNA Primers; Molecular Sequence Data; Polymerase Chain Reaction | 1996 |
Unusual contribution of 2-aminoadenine to the thermostability of DNA.
Topics: 2-Aminopurine; Absorption; Bacteriophages; Base Composition; Circular Dichroism; Deoxyribonucleotides; DNA; Molecular Structure; Nucleic Acid Conformation; Nucleic Acid Heteroduplexes; Purines; Pyrimidines; Structure-Activity Relationship; Ultraviolet Rays | 1996 |
PCR-based development of DNA substrates containing modified bases: an efficient system for investigating the role of the exocyclic groups in chemical and structural recognition by minor groove binding drugs and proteins.
Topics: 2-Aminopurine; Base Composition; Base Sequence; Binding Sites; Deoxyribonuclease I; Distamycins; DNA; DNA Footprinting; DNA Primers; Guanosine; High Mobility Group Proteins; Hydrogen Bonding; Inosine; Molecular Sequence Data; Nucleic Acid Conformation; Plasmids; Plicamycin; Polymerase Chain Reaction | 1996 |
2-Aminopurine induces spindle cell morphology in MM14 myoblasts in the absence of differentiation signals.
Topics: 2-Aminopurine; Actins; Animals; Cell Differentiation; Cell Line; Cyclin-Dependent Kinases; GTP Phosphohydrolases; HL-60 Cells; Humans; Kinetin; Mice; Microtubules; Muscles; PC12 Cells; Protein Synthesis Inhibitors; Purines; Rats; Signal Transduction; Spindle Apparatus | 1997 |
High frequency in vivo loss of heterozygosity is primarily a consequence of mitotic recombination.
Topics: 2-Aminopurine; Adenine Phosphoribosyltransferase; Chromosome Mapping; Clone Cells; Drug Resistance; Female; Gene Deletion; Gene Rearrangement, T-Lymphocyte; Heterozygote; Humans; Hypoxanthine Phosphoribosyltransferase; Male; Microsatellite Repeats; Mitosis; Point Mutation; Recombination, Genetic; T-Lymphocytes; Thioguanine | 1997 |
Footprinting of echinomycin and actinomycin D on DNA molecules asymmetrically substituted with inosine and/or 2,6-diaminopurine.
Topics: 2-Aminopurine; Base Composition; Binding Sites; Cytosine; Dactinomycin; DNA; DNA Footprinting; DNA Primers; Echinomycin; Hydrogen Bonding; Hypoxanthine; Inosine; Molecular Sequence Data; Nucleic Acid Heteroduplexes; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Thymine | 1997 |
Dam methyltransferase from Escherichia coli: kinetic studies using modified DNA oligomers: nonmethylated substrates.
Topics: 2-Aminopurine; Adenine; Base Sequence; DNA Methylation; DNA Probes; DNA, Bacterial; Enzyme Inhibitors; Escherichia coli; Escherichia coli Proteins; Guanine; Hypoxanthine; Kinetics; Molecular Sequence Data; Nucleic Acid Heteroduplexes; Oligonucleotide Probes; Site-Specific DNA-Methyltransferase (Adenine-Specific); Software; Substrate Specificity; Temperature; Thermodynamics; Thymine; Uracil | 1997 |
Effects of diaminopurine and inosine substitutions on A-tract induced DNA curvature. Importance of the 3'-A-tract junction.
Topics: 2-Aminopurine; Adenine; Base Sequence; Deoxyribonuclease EcoRI; Deoxyribonucleases, Type II Site-Specific; DNA; Electrophoresis, Polyacrylamide Gel; Inosine; Nucleic Acid Conformation; Photochemistry; Polymerase Chain Reaction; Repetitive Sequences, Nucleic Acid; Structure-Activity Relationship; Uranyl Nitrate | 1997 |
Purine nucleoside phosphorylase. 3. Reversal of purine base specificity by site-directed mutagenesis.
Topics: 2-Aminopurine; Catalysis; Computer Simulation; Crystallography, X-Ray; Humans; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Mutagenesis, Site-Directed; Nucleosides; Protein Conformation; Purine-Nucleoside Phosphorylase; Purinones; Structure-Activity Relationship; Substrate Specificity | 1997 |
High affinity binding of MEF-2C correlates with DNA bending.
Topics: 2-Aminopurine; Adenine; Amino Acid Sequence; Binding Sites; DNA; DNA-Binding Proteins; Escherichia coli; MEF2 Transcription Factors; Molecular Sequence Data; Myogenic Regulatory Factors; Nucleic Acid Conformation; Protein Binding; Purines; Recombinant Fusion Proteins; Transcription Factors | 1997 |
Increased DNA binding and sequence discrimination of PNA oligomers containing 2,6-diaminopurine.
Topics: 2-Aminopurine; Adenine; DNA; Molecular Mimicry; Nucleic Acids; Nylons; Peptides | 1997 |
Male sterility associated with APRT deficiency in Arabidopsis thaliana results from a mutation in the gene APT1.
Topics: 2-Aminopurine; Adenine Phosphoribosyltransferase; Alleles; Arabidopsis; Fertility; Genes, Plant; Mutation | 1998 |
Targeted breakage of paracentromeric heterochromatin induces chromosomal instability.
Topics: 2-Aminopurine; Adenine Phosphoribosyltransferase; Azacitidine; B-Lymphocytes; Cell Line; Centromere; Chromosome Aberrations; Chromosomes, Human; Chromosomes, Human, Pair 16; Chromosomes, Human, Pair 17; DNA Damage; Heterochromatin; Humans; Hypoxanthine Phosphoribosyltransferase; In Situ Hybridization, Fluorescence; Interphase; Metaphase; Thymidine Kinase | 1998 |
Compression of the DNA minor groove is responsible for termination of DNA synthesis by HIV-1 reverse transcriptase.
Topics: 2-Aminopurine; Adenine; Base Sequence; DNA; DNA, Viral; HIV Reverse Transcriptase; HIV-1; Hydroxyl Radical; Molecular Sequence Data; Mutation; Nucleic Acid Conformation; RNA-Directed DNA Polymerase | 1999 |
Base pairing of anhydrohexitol nucleosides with 2,6-diaminopurine, 5-methylcytosine and uracil asbase moiety.
Topics: 2-Aminopurine; 5-Methylcytosine; Arabinonucleosides; Base Pairing; Cytosine; Models, Molecular; Nucleic Acid Denaturation; Nucleosides; Oligonucleotides; Purine Nucleosides; Pyrimidine Nucleosides; Sugar Alcohols; Uracil | 1999 |
Mechanism of action and in vitro activity of 1',3'-dioxolanylpurine nucleoside analogues against sensitive and drug-resistant human immunodeficiency virus type 1 variants.
Topics: 2-Aminopurine; Anti-HIV Agents; Cells, Cultured; Dioxolanes; Drug Interactions; Drug Resistance, Microbial; Guanosine; HIV Reverse Transcriptase; HIV-1; Humans; Leukocytes, Mononuclear; Microbial Sensitivity Tests | 1999 |
Base-pairing between 23S rRNA and tRNA in the ribosomal A site.
Topics: 2-Aminopurine; Base Pairing; Binding Sites; Conserved Sequence; Escherichia coli; Genes, Bacterial; Geobacillus stearothermophilus; Hydrogen Bonding; Kinetics; Mutagenesis, Site-Directed; Mutation; Nucleic Acid Conformation; Peptidyl Transferases; Puromycin; Ribosomes; RNA, Ribosomal, 23S; RNA, Transfer, Amino Acyl; Suppression, Genetic | 1999 |
Invasion of strongly binding oligonucleotides into tRNA structure.
Topics: 2-Aminopurine; 5-Methylcytosine; Cytosine; Deoxyuridine; Electrophoresis, Polyacrylamide Gel; Kinetics; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Oligonucleotides; RNA, Transfer, Phe; Time Factors; Yeasts | 2000 |
DNA recognition by quinoline antibiotics: use of base-modified DNA molecules to investigate determinants of sequence-specific binding of luzopeptin.
Topics: 2-Aminopurine; Antiprotozoal Agents; Base Pairing; Base Sequence; Binding Sites; Deoxyribonuclease I; DNA; DNA Footprinting; DNA Replication; DNA, Bacterial; Echinomycin; Electrophoresis, Polyacrylamide Gel; Hydrogen Bonding; Hydroxyquinolines; Inosine; Intercalating Agents; Molecular Sequence Data; Molecular Structure; Peptides, Cyclic; Polymerase Chain Reaction; Quinolines; Quinoxalines; Structure-Activity Relationship | 2000 |
Photolithographic synthesis of high-density oligonucleotide arrays.
Topics: 2-Aminopurine; Amides; Combinatorial Chemistry Techniques; Membrane Glycoproteins; Oligonucleotide Array Sequence Analysis; Oligonucleotides; Phosphoric Acids; Photolysis; Purine Nucleosides | 2001 |
Hamster and rat fetal cells have low spontaneous mutation frequencies and rates.
Topics: 2-Aminopurine; Animals; Brain; Breeding; Cell Survival; Cells, Cultured; Cricetinae; Diphtheria Toxin; Dose-Response Relationship, Drug; Drug Resistance; Female; Fetus; Gene Frequency; Male; Mesocricetus; Mutation; Ouabain; Pregnancy; Rats; Rats, Inbred F344; Thioguanine | 2001 |
Diaminopurine-acridine heterodimers for specific recognition of abasic site containing DNA. Influence on the biological activity of the position of the linker on the purine ring.
Topics: 2-Aminopurine; Acridines; Animals; Base Sequence; Carmustine; Cell Line; Dimerization; DNA Damage; Inhibitory Concentration 50; Intercalating Agents; Nucleic Acid Denaturation; Oligonucleotides; Purines; Thermodynamics | 2001 |
Nonenzymatic oligomerization reactions on templates containing inosinic acid or diaminopurine nucleotide residues.
Topics: 2-Aminopurine; Adenine; Adenosine; Adenosine Monophosphate; Base Pairing; Cytidine Monophosphate; Cytosine; DNA Primers; Evolution, Chemical; Evolution, Molecular; Exobiology; Guanine; Inosine Monophosphate; RNA; Templates, Genetic; Uracil; Uridine Monophosphate | 1999 |
2,6-diaminopurine in TNA: effect on duplex stabilities and on the efficiency of template-controlled ligations.
Topics: 2-Aminopurine; Base Pairing; Chromatography, High Pressure Liquid; Crystallography, X-Ray; DNA; Furans; Ligands; Mass Spectrometry; Oligonucleotides; RNA; Spectrophotometry, Ultraviolet; Templates, Genetic | 2002 |
5-propynyluracil.diaminopurine: an efficient base-pair for non-enzymatic transcription of DNA.
Topics: 2-Aminopurine; Adenine; Alkynes; Autoradiography; Base Pairing; DNA Replication; Electrophoresis, Polyacrylamide Gel; Templates, Genetic; Transcription, Genetic; Uracil | 2002 |
Optimisation of the 10-23 DNAzyme-substrate pairing interactions enhanced RNA cleavage activity at purine-cytosine target sites.
Topics: 2-Aminopurine; Adenine; Base Pairing; Base Sequence; Catalysis; Cytosine; DNA, Catalytic; DNA, Single-Stranded; Guanine; Hydrogen Bonding; Kinetics; Nucleic Acid Conformation; RNA; RNA, Catalytic; Substrate Specificity | 2003 |
2,6-Diamino-5,8-diaza-7,9-dicarba-purine.
Topics: 2-Aminopurine; Aza Compounds; Crystallography, X-Ray; Purine Nucleosides; Purines; Spectrophotometry, Ultraviolet | 2003 |
C-Nucleosidations with 2,6-diamino-5,8-diaza-7,9-dicarba-purine.
Topics: 2-Aminopurine; Aza Compounds; Imines; Purine Nucleosides; Purines; Tetroses | 2003 |
Immunobiological activity of N-[2-(phosphonomethoxy)alkyl] derivatives of N6-substituted adenines, and 2,6-diaminopurines.
Topics: 2-Aminopurine; Adenine; Adjuvants, Immunologic; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Female; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2003 |
Reversible inhibition of cell division and enlargement in plant tissues by 2,6-diaminopurine.
Topics: 2-Aminopurine; Cell Division; Plants; Purines | 1953 |
Incorporation of 2,6-diaminopurine into the nucleoside phosphates of the mouse.
Topics: 2-Aminopurine; Animals; Metabolic Networks and Pathways; Mice; Nucleosides; Nucleotides; Phosphates; Purines | 1953 |
Studies of the influence of 2,6-diaminopurine upon the content of kappa in Paramecium aurelia, variety 4.
Topics: 2-Aminopurine; Ciliophora; Leadership; Paramecium aurelia; Purines; Pyrimidines | 1953 |
Cytological studies on the antimetabolite action of 2, 6-diaminopurine in Vicia faba roots.
Topics: 2-Aminopurine; Adenine; Adenosine; Antimetabolites; Cell Division; Deoxyadenosines; DNA; Growth; Guanine; Hypoxanthine; Purines; Vicia faba | 1955 |
[Effect of various purine antagonists (2-6-diaminopurine, 8-azaguanine and 6-mercaptopurine) on plant cell division].
Topics: 2-Aminopurine; Azaguanine; Cell Division; Mercaptopurine; Plants; Purines | 1956 |
Effect of 2-6 diaminopurine (2-6 DP): 6 chlorpurine (ClP) and thioguanine (ThG) on rat litter in utero.
Topics: 2-Aminopurine; Animals; Fetus; Purines; Rats; Thioguanine | 1957 |
Metabolism of 2,6-diaminopurine: S-adenosylmethionine as methyl donor for 2-methylamino-6-aminopurine synthesis.
Topics: 2-Aminopurine; Adenine; Adenosine; Metabolic Networks and Pathways; Methionine; Purines; S-Adenosylmethionine | 1959 |
Specificity and cross-reactions in a strain of pig kidney cells resistant to 2,6-diaminopurine.
Topics: 2-Aminopurine; Animals; Kidney; Purines; Sus scrofa; Swine; Tissue Culture Techniques | 1960 |
Mechanism of resistance to 2,6-diaminopurine in Salmonella typhimurium.
Topics: 2-Aminopurine; Biochemical Phenomena; Purines; Salmonella typhimurium | 1961 |
EFFECT OF PURINE ANALOGS ON ENCEPHALOMYOCARDITIS AND VACCINIA VIRUS GROWTH IN ANALOG SENSITIVE AND RESISTANT CELLS.
Topics: 2-Aminopurine; Antiviral Agents; Arboviruses; Azaguanine; Encephalomyocarditis virus; Pharmacology; Purines; Research; RNA; RNA, Viral; Tissue Culture Techniques; Vaccinia virus; Virus Cultivation | 1964 |
INFLUENCE OF MUTAGENS ON THE INITIATION OF SKIN CARCINOGENESIS.
Topics: 2-Aminopurine; Acridines; Adenine; Carcinogenesis; Carcinogens; Idoxuridine; Lung Neoplasms; Mice; Mutagens; Nucleosides; Pharmacology; Purines; Research; Skin Neoplasms; Thymidine; Toxicology; Tritium; Urethane | 1964 |
EFFECTS OF OTHER AGENTS ON THE BIOLOGIC RESPONSES TO VINCALEUKOBLASTINE.
Topics: 2-Aminopurine; Aminopterin; Animals; Aspartic Acid; Azaguanine; Biological Products; Colchicine; Cortisone; Glutamates; Leukemia; Leukemia L1210; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice; Pharmacology; Purines; Research; Tryptophan; Vinblastine | 1964 |
THE MUTAGENIC ACTIVITY OF 2-AMINOPURINE AND 2,6-DIAMINOPURINE ON PHAGE T4 GROWN ON NON-INHIBITED AND CHLORAMPHENICOL-INHIBITED CELLS OF ESCHERICHIA COLI B.
Topics: 2-Aminopurine; Bacteriolysis; Bacteriophage T4; Chloramphenicol; Coliphages; Escherichia coli; Mutation; Pharmacology; Purines; Research | 1964 |
ANTAGONISM BETWEEN PURINES IN PURINE-REQUIRING BACILLUS SUBTILIS MUTANTS.
Topics: 2-Aminopurine; Adenine; Adenine Nucleotides; Azaguanine; Bacillus subtilis; Guanine; Guanine Nucleotides; Hypoxanthines; Mercaptopurine; Metabolism; Mutation; Nucleosides; Nucleotides; Pharmacology; Purines; Research; Xanthines | 1964 |
BIOCHEMICALLY MARKED VARIANTS OF THE SYRIAN HAMSTER FIBROBLAST CELL LINE BHK21 AND ITS DERIVATIVES.
Topics: 2-Aminopurine; Amphotericin B; Animals; Antineoplastic Agents; Azaguanine; Bromodeoxyuridine; Carbon Isotopes; Cell Division; Cell Line; Cricetinae; Dactinomycin; Fibroblasts; Floxuridine; Fluorouracil; Hexoses; Hypoxanthines; Mercaptopurine; Mesocricetus; Metabolism; Mitomycin; Mitomycins; Mutation; Nucleosides; Pharmacology; Puromycin; Research; Thioguanine; Tissue Culture Techniques; Tritium; Vinblastine | 1965 |
Metabolic abnormalities of 2,6-diaminopurine-resistant mutants of Salmonella typhimurium.
Topics: 2-Aminopurine; Humans; Purines; Salmonella typhimurium | 1962 |
Synthesis of base substituted 2-hydroxy-3-(purin-9-yl)-propanoic acids and 4-(purin-9-yl)-3-butenoic acids.
Topics: 2-Aminopurine; Adenine; Antineoplastic Agents; Antiviral Agents; Butyrates; Guanine; Hypoxanthines; Lactic Acid; Magnetic Resonance Spectroscopy; Molecular Structure; Purines | 2003 |
[Antimitotic action, in the mouse, of lactate of 2-6 diaminopurine].
Topics: 2-Aminopurine; Amidines; Animals; Antimitotic Agents; Lactates; Lactic Acid; Mice; Pentamidine | 1950 |
Studies on 2,6-diaminopurine and related substances in cultures of embryonic and sarcomatous rodent tissues.
Topics: 2-Aminopurine; Humans; Neoplasms; Purines; Sarcoma | 1951 |
Antagonists of nucleic acid derivatives. IV. Reversal studies with 2-aminopurine and 2,6-diaminopurine.
Topics: 2-Aminopurine; Lacticaseibacillus casei; Nucleic Acids; Research | 1950 |
Observations on inhibition of nucleic acid synthesis resulting from administration of nitrogen mustard, urethan,. colchicine, 2,6-diaminopurine, 8-azaguanine, potassium arsenite, and cortisone.
Topics: 2-Aminopurine; Arsenicals; Arsenites; Azaguanine; Colchicine; Cortisone; Mechlorethamine; Nucleic Acids; Potassium; Potassium Compounds; Urethane | 1951 |
A comparison of the effects of 4-amino-N10-methyl-pteroylglutamic acid and 2,6-diaminopurine upon sensitive and resistant sublines of a strain of mouse leukemia.
Topics: 2-Aminopurine; Amino Acids; Animals; Folic Acid; Leukemia; Mice | 1951 |
The effects of the folic acid antagonists and 2,6-diaminopurine on neoplastic disease, with special reference to acute leukemia.
Topics: 2-Aminopurine; Folic Acid Antagonists; Leukemia; Neoplasms; Purines | 1951 |
Effect of 2,6-diaminopurine on virus of Russian spring summner encephalitis in tissue culture.
Topics: 2-Aminopurine; Encephalitis; Encephalitis, Arbovirus; Purines; Russia; Viruses | 1951 |
Effect of 2,6-diaminopurine on the course of Russian spring-summer encephalitis infection in the mouse.
Topics: 2-Aminopurine; Animals; Encephalitis; Encephalitis, Arbovirus; Encephalitis, Tick-Borne; Mice; Purines | 1951 |
An influence of 2,6-diaminopurine upon the content of kappa in Paramecium aurelia, variety 4.
Topics: 2-Aminopurine; Ciliophora; Leadership; Paramecium aurelia; Purines | 1951 |
Factors related to the growth of psittacosis virus (strain 6BC) II. Purines, pyrimidines, and other components related to nucleic acid.
Topics: 2-Aminopurine; Adenine; Benzimidazoles; Guanine; Nucleic Acids; Psittacosis; Pterins; Purines; Pyrimidines | 1952 |
LNA guanine and 2,6-diaminopurine. Synthesis, characterization and hybridization properties of LNA 2,6-diaminopurine containing oligonucleotides.
Topics: 2-Aminopurine; Guanine; Magnetic Resonance Spectroscopy; Nucleic Acid Hybridization; Oligonucleotides; Spectrometry, Mass, Electrospray Ionization | 2004 |
Syntheses and base-pairing properties of locked nucleic acid nucleotides containing hypoxanthine, 2,6-diaminopurine, and 2-aminopurine nucleobases.
Topics: 2-Aminopurine; Base Pairing; Hypoxanthine; Nucleic Acid Conformation; Oligonucleotides; Oligonucleotides, Antisense | 2004 |
In vitro selection of drug-resistant varicella-zoster virus (VZV) mutants (OKA strain): differences between acyclovir and penciclovir?
Topics: 2-Aminopurine; Acyclovir; Adenine; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Cidofovir; Cytosine; DNA-Directed DNA Polymerase; Drug Resistance, Multiple, Viral; Drug Resistance, Viral; Foscarnet; Guanine; Herpesvirus 3, Human; Humans; Microbial Sensitivity Tests; Mutation; Organophosphonates; Phenotype; Selection, Genetic; Thymidine Kinase; Viral Proteins | 2004 |
Influence of minor groove substituents on the structure of DNA Holliday junctions.
Topics: 2-Aminopurine; Base Pairing; Crystallization; Crystallography, X-Ray; Deoxyribonucleotides; DNA; DNA, Cruciform; Inosine; Models, Molecular; Nucleic Acid Conformation; Nucleic Acid Heteroduplexes; Solutions | 2004 |
Modified bases in RNA reduce secondary structure and enhance hybridization.
Topics: 2-Aminopurine; Bacteriophage T7; Base Composition; Base Pair Mismatch; Base Pairing; DNA Probes; DNA-Directed RNA Polymerases; Electrophoretic Mobility Shift Assay; Enzyme Stability; Hot Temperature; Inosine; Nucleic Acid Conformation; Nucleic Acid Heteroduplexes; Nucleic Acid Hybridization; RNA, Viral; Thiouracil; Viral Proteins | 2004 |
Actions of 2,6-diaminopurine in mice, rats, and dogs.
Topics: 2-Aminopurine; Acids; Animals; Dogs; Mice; Proteins; Purines; Rats | 1949 |
Studies of the effect of 2,6-diaminopurine on the blood and bone marrow of swine.
Topics: 2-Aminopurine; Anemia; Animals; Bone Marrow; Humans; Purines; Swine | 1950 |
On the role of 2,6-diaminopurine in the biosynthesis of nucleic acid guanine.
Topics: 2-Aminopurine; Guanine; Nucleic Acids; Purines | 1950 |
Atomic force microscopy study of the structural effects induced by echinomycin binding to DNA.
Topics: 2-Aminopurine; DNA; DNA, Circular; Echinomycin; Hydrogen Bonding; Intercalating Agents; Ligands; Microscopy, Atomic Force; Nucleic Acid Conformation; Plasmids | 2005 |
Evidence for Watson-Crick and not Hoogsteen or wobble base pairing in the selection of nucleotides for insertion opposite pyrimidines and a thymine dimer by yeast DNA pol eta.
Topics: 2-Aminopurine; Base Pair Mismatch; Base Pairing; Cytosine Nucleotides; Dimerization; DNA Polymerase I; DNA-Directed DNA Polymerase; Hydrogen Bonding; Inosine; Nucleotides; Oligodeoxyribonucleotides; Purines; Pyrenes; Pyrimidine Nucleotides; Saccharomyces cerevisiae Proteins; Static Electricity; Stereoisomerism; Substrate Specificity; Thymine Nucleotides | 2005 |
Unrestricted accessibility of short oligonucleotides to RNA.
Topics: 2-Aminopurine; Base Pairing; Guanine; Hypoxanthine; Nucleic Acid Conformation; Nucleic Acid Hybridization; Oligonucleotides; RNA; RNA Probes; Temperature; Thiouracil | 2005 |
Synthesis, characterisation and theoretical calculations of 2,6-diaminopurine etheno derivatives.
Topics: 2-Aminopurine; DNA Adducts; Fluorescence; Magnetic Resonance Spectroscopy; Models, Molecular | 2005 |
The kinetics of ligand binding by an adenine-sensing riboswitch.
Topics: 2-Aminopurine; 5' Untranslated Regions; Adenine; Bacillus subtilis; Bacterial Proteins; Dose-Response Relationship, Drug; Gene Expression Regulation, Bacterial; Genes, Reporter; Hot Temperature; Kinetics; Ligands; Microscopy, Fluorescence; Nucleic Acid Conformation; Protein Binding; RNA; RNA, Messenger; Temperature; Thermodynamics; Time Factors; Transcription, Genetic | 2005 |
Purine P1 receptor-dependent immunostimulatory effects of antiviral acyclic analogues of adenine and 2,6-diaminopurine.
Topics: 2-Aminopurine; Adenine; Adjuvants, Immunologic; Animals; Anti-HIV Agents; Caffeine; Cell Survival; Cells, Cultured; Chemokine CCL3; Chemokine CCL4; Chemokine CCL5; Dihydropyridines; Dose-Response Relationship, Drug; Female; Flavins; Humans; Interleukin-10; Lipopolysaccharides; Macrophage Inflammatory Proteins; Macrophages; Mice; Mice, Inbred C57BL; Molecular Structure; Organophosphonates; Purinergic P1 Receptor Antagonists; Quinazolines; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Theophylline; Triazoles; Tumor Necrosis Factor-alpha | 2006 |
Exposure of mice to arsenic and/or benzo[a]pyrene does not increase the frequency of Aprt-deficient cells recovered from explanted skin of Aprt heterozygous mice.
Topics: 2-Aminopurine; Adenine Phosphoribosyltransferase; Animals; Arsenic; Benzo(a)pyrene; Cells, Cultured; Female; Loss of Heterozygosity; Male; Mice; Mice, Transgenic; Mutagens; Skin | 2006 |
Recombination R-triplex: H-bonds contribution to stability as revealed with minor base substitutions for adenine.
Topics: 2-Aminopurine; Adenine; DNA; Hydrogen Bonding; Nucleic Acid Conformation; Recombination, Genetic; Thermodynamics; Tubercidin | 2006 |
Highly efficient strand invasion by peptide nucleic acid bearing optically pure lysine residues in its backbone.
Topics: 2-Aminopurine; DNA; Electrophoretic Mobility Shift Assay; GC Rich Sequence; Isomerism; Lysine; Peptide Nucleic Acids; Static Electricity; Thiouracil | 2006 |
Density functional and experimental studies on the FT-IR and FT-Raman spectra and structure of 2,6-diamino purine and 6-methoxy purine.
Topics: 2-Aminopurine; Models, Chemical; Molecular Conformation; Purines; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Thermodynamics; Vibration | 2008 |
2,6-Diaminopurine, a precursor of nucleic acid guanine.
Topics: 2-Aminopurine; Guanine; Nucleic Acids | 1948 |
Preliminary studies on the effect of 2,6-diaminopurine on transplanted mouse leukemia.
Topics: 2-Aminopurine; Animals; Leukemia; Leukemia, Experimental | 1949 |
Chiral introduction of positive charges to PNA for double-duplex invasion to versatile sequences.
Topics: 2-Aminopurine; AT Rich Sequence; Base Pair Mismatch; Base Sequence; DNA; GC Rich Sequence; Peptide Nucleic Acids; Static Electricity; Stereoisomerism; Thiouracil | 2008 |
Inhibition of the replication of hepatitis B virus in vitro by a novel 2,6-diaminopurine analog, beta-LPA.
Topics: 2-Aminopurine; Antiviral Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Hepatitis B virus; Humans; Virus Replication | 2008 |
Solid-phase synthesis of pseudo-complementary peptide nucleic acids.
Topics: 2-Aminopurine; Molecular Structure; Peptide Nucleic Acids; Thiouracil | 2008 |
Inversing the natural hydrogen bonding rule to selectively amplify GC-rich ADAR-edited RNAs.
Topics: 2-Aminopurine; Adenosine Deaminase; Alu Elements; Animals; AT Rich Sequence; Base Sequence; Cell Line; Chlorocebus aethiops; DNA; GC Rich Sequence; Gene Rearrangement, B-Lymphocyte; Hydrogen Bonding; Immunoglobulin Variable Region; Inosine Triphosphate; Measles virus; Molecular Sequence Data; Nucleic Acid Denaturation; Polymerase Chain Reaction; RNA Editing; RNA-Binding Proteins; RNA, Messenger; Vero Cells | 2008 |
Dissecting direct and indirect readout of cAMP receptor protein DNA binding using an inosine and 2,6-diaminopurine in vitro selection system.
Topics: 2-Aminopurine; Base Sequence; Binding Sites; Consensus Sequence; Deoxyribonucleotides; DNA; DNA Footprinting; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Escherichia coli Proteins; Gene Library; Inosine; Polymerase Chain Reaction; Protein Binding; Receptors, Cyclic AMP; Sequence Alignment | 2008 |
Stability and mismatch discrimination of DNA duplexes containing 2,6-diaminopurine and 2-thiothymidine locked nucleic acid bases.
Topics: 2-Aminopurine; Base Pair Mismatch; Calorimetry, Differential Scanning; DNA; Oligonucleotide Probes; Oligonucleotides; Spectrophotometry, Ultraviolet; Thermodynamics; Thymidine | 2008 |
RecA-mediated strand invasion of DNA by oligonucleotides substituted with 2-aminoadenine and 2-thiothymine.
Topics: 2-Aminopurine; Adenosine Triphosphate; Base Pair Mismatch; Base Pairing; DNA; Models, Genetic; Nucleic Acid Hybridization; Oligodeoxyribonucleotides; Oligonucleotides; Peptide Nucleic Acids; Rec A Recombinases; Recombination, Genetic; Thymine | 2008 |
An ab initio study of substituent effects on the excited states of purine derivatives.
Topics: 2-Aminopurine; Adenine; Electrons; Gases; Guanine; Hypoxanthine; Isomerism; Purines; Quantum Theory; Xanthine | 2008 |
Monitoring RNA-ligand interactions using isothermal titration calorimetry.
Topics: 2-Aminopurine; Base Sequence; Calorimetry; Ligands; Molecular Sequence Data; Nucleic Acid Conformation; RNA; Titrimetry | 2009 |
Reactions of Pd(II) with chelate-tethered 2,6-diaminopurine derivatives: N3-coordination and reaction of the purine system.
Topics: 2-Aminopurine; Chelating Agents; Crystallography, X-Ray; Ligands; Models, Molecular; Organometallic Compounds; Palladium | 2009 |
Long-range charge transfer through DNA by replacing adenine with diaminopurine.
Topics: 2-Aminopurine; Adenine; DNA; Electron Transport | 2010 |
Preparation of the 2'-deoxynucleosides of 2,6-diaminopurine and isoguanine by direct glycosylation.
Topics: 2-Aminopurine; Adenosine; Glycosylation; Guanine; Guanosine; Molecular Structure; Nucleosides; Purine Nucleosides; Stereoisomerism; Structure-Activity Relationship | 2010 |
Effect of substituents on the excited-state dynamics of the modified DNA bases 2,4-diaminopyrimidine and 2,6-diaminopurine.
Topics: 2-Aminopurine; DNA; Models, Theoretical; Photoelectron Spectroscopy; Pyrimidines; Quantum Theory | 2010 |
Comparisons between chemical mapping and binding to isoenergetic oligonucleotide microarrays reveal unexpected patterns of binding to the Bacillus subtilis RNase P RNA specificity domain.
Topics: 2-Aminopurine; Bacillus subtilis; Binding Sites; Oligonucleotide Array Sequence Analysis; Oligonucleotide Probes; Oligonucleotides; Ribonuclease P; RNA; Sensitivity and Specificity | 2010 |
Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines.
Topics: 2-Aminopurine; 3T3 Cells; Adenine; Animals; Antiviral Agents; Cells, Cultured; Crystallography, X-Ray; Dose-Response Relationship, Drug; HIV-1; HIV-2; Humans; Mice; Mice, Inbred C3H; Moloney murine sarcoma virus; Organophosphonates; Purines; Structure-Activity Relationship | 2011 |
Two isomorphous transition metal complexes containing a protonated diaminopurine ligand: diaquabis(2,6-diamino-7H-purin-1-ium-κN9)bis(homophthalato-κO)nickel(II) tetrahydrate and the cobalt(II) analogue.
Topics: 2-Aminopurine; Cobalt; Coordination Complexes; Crystallography, X-Ray; Hydrogen Bonding; Ligands; Molecular Conformation; Molecular Structure; Nickel; Organometallic Compounds; Transition Elements | 2011 |
Synthesis and oligomerization of Fmoc/Boc-protected PNA monomers of 2,6-diaminopurine, 2-aminopurine and thymine.
Topics: 2-Aminopurine; DNA; Peptide Nucleic Acids; Spectrometry, Fluorescence; Thymine | 2012 |
Long lifetime of hydrogen-bonded DNA basepairs by force spectroscopy.
Topics: 2-Aminopurine; Adenine; Base Pairing; DNA; Hydrogen Bonding; Kinetics; Spectrum Analysis; Thermodynamics; Thymine; Time Factors | 2012 |
Simulations of A-RNA duplexes. The effect of sequence, solute force field, water model, and salt concentration.
Topics: 2-Aminopurine; Inosine; Models, Molecular; Molecular Dynamics Simulation; Nucleic Acid Conformation; RNA; Salts; Solvents; Water | 2012 |
Formation and helicity control of ssDNA templated porphyrin nanoassemblies.
Topics: 2-Aminopurine; DNA, Single-Stranded; Hydrogen Bonding; Molecular Structure; Nanostructures; Porphyrins | 2013 |
Structural destabilization of DNA duplexes containing single-base lesions investigated by nanopore measurements.
Topics: 2-Aminopurine; Adenine; Base Pairing; Cytosine; DNA; Guanidines; Hydantoins; Hydrogen Bonding; Kinetics; Models, Theoretical; Nanopores; Nanotechnology | 2013 |
Transdermal delivery and cutaneous targeting of antivirals using a penetration enhancer and lysolipid prodrugs.
Topics: 2-Aminopurine; Administration, Cutaneous; Antiviral Agents; Drug Delivery Systems; Female; Humans; Liposomes; Organ Culture Techniques; Prodrugs; Skin Absorption | 2014 |
2,6-diaminopurine nucleoside derivative of 9-ethyloxy-2-oxo-1,3-diazaphenoxazine (2-amino-Adap) for recognition of 8-oxo-dG in DNA.
Topics: 2-Aminopurine; Humans; Molecular Structure; Nucleosides; Oxazines | 2014 |
Mechanical properties of base-modified DNA are not strictly determined by base stacking or electrostatic interactions.
Topics: 2-Aminopurine; Base Pairing; DNA; Hydrogen Bonding; Nucleic Acid Conformation; Nucleosides; Static Electricity; Stress, Mechanical | 2014 |
Roles of the amino group of purine bases in the thermodynamic stability of DNA base pairing.
Topics: 2-Aminopurine; Base Pairing; DNA; Hydrogen Bonding; Magnesium; Oligodeoxyribonucleotides; Purines; Sodium; Solvents; Thermodynamics | 2014 |
β-D-2'-C-Methyl-2,6-diaminopurine Ribonucleoside Phosphoramidates are Potent and Selective Inhibitors of Hepatitis C Virus (HCV) and Are Bioconverted Intracellularly to Bioactive 2,6-Diaminopurine and Guanosine 5'-Triphosphate Forms.
Topics: 2-Aminopurine; Amides; Antiviral Agents; Cell Line; Cells, Cultured; Guanosine Triphosphate; Hepacivirus; Hepatitis C; Humans; Methylation; Phosphoric Acids; Prodrugs; Ribonucleosides | 2015 |
Molecular recognition between adenine or 2,6-diaminopurine and copper(II) chelates with N,O2,S-tripodal tetradentate chelators having thioether or disulfide donor groups.
Topics: 2-Aminopurine; Adenine; Chelating Agents; Copper; Crystallography, X-Ray; Disulfides; Molecular Structure; Nitrogen; Oxygen; Sulfides; Sulfur | 2015 |
Antiviral activities of 2,6-diaminopurine-based acyclic nucleoside phosphonates against herpesviruses: In vitro study results with pseudorabies virus (PrV, SuHV-1).
Topics: 2-Aminopurine; Animals; Antiviral Agents; Cell Line; DNA Replication; Dogs; Herpesviridae; In Vitro Techniques; Madin Darby Canine Kidney Cells; Microscopy, Electron, Transmission; Organophosphonates; Pseudorabies; Vero Cells | 2016 |
Merging Two Strategies for Mixed-Sequence Recognition of Double-Stranded DNA: Pseudocomplementary Invader Probes.
Topics: 2-Aminopurine; Base Pairing; DNA; Molecular Biology; Nucleic Acids; Oligonucleotides; Peptide Nucleic Acids; Thermodynamics; Thymine | 2016 |
Aminopurine and aminoquinazoline scaffolds for development of potential dengue virus inhibitors.
Topics: 2-Aminopurine; Antiviral Agents; Dengue Virus; Drug Design; Molecular Docking Simulation; Protein Conformation; Quinazolines; Viral Nonstructural Proteins | 2017 |
Continuous Fluorescence Assays for Reactions Involving Adenine.
Topics: 2-Aminopurine; Adenine; Adenine Phosphoribosyltransferase; Enzyme Assays; Fluorescence; Humans; Kinetics; Saccharomyces cerevisiae; Substrate Specificity | 2016 |
Structure-Activity Relationships of Acyclic Selenopurine Nucleosides as Antiviral Agents.
Topics: 2-Aminopurine; Acyclovir; Antiviral Agents; Cytomegalovirus; Guanine; Herpesvirus 1, Human; Herpesvirus 2, Human; Humans; Nucleosides; Organoselenium Compounds; Prodrugs; Purines; Simplexvirus; Structure-Activity Relationship | 2017 |
Introduction of 2,6-Diaminopurines into Serinol Nucleic Acid Improves Anti-miRNA Performance.
Topics: 2-Aminopurine; HeLa Cells; Humans; MicroRNAs; Nucleic Acids; Oligonucleotides; Propanolamines; Propylene Glycols | 2017 |
Evidence of a General Acid-Base Catalysis Mechanism in the 8-17 DNAzyme.
Topics: 2-Aminopurine; Base Sequence; Catalytic Domain; DNA, Catalytic; Hydrogen-Ion Concentration; Inosine; Kinetics; Oligonucleotides; RNA; Structure-Activity Relationship | 2018 |
Purine-Derived Nitroxides for Noncovalent Spin-Labeling of Abasic Sites in Duplex Nucleic Acids.
Topics: 2-Aminopurine; Adenine; Cyclic N-Oxides; Cytosine; DNA; Guanine; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acids; Purines; RNA; Spin Labels; Thymine | 2018 |
Identification of Broad-Spectrum Dengue/Zika Virus Replication Inhibitors by Functionalization of Quinoline and 2,6-Diaminopurine Scaffolds.
Topics: 2-Aminopurine; Antiviral Agents; Coinfection; Dengue; Dengue Virus; Drug Design; Drug Discovery; Humans; Models, Molecular; Quinolines; Virus Replication; Zika Virus; Zika Virus Infection | 2018 |
Design and synthesis of a novel lanthanide fluorescent probe (Tb
Topics: 2-Aminopurine; Carbon-13 Magnetic Resonance Spectroscopy; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Pentetic Acid; Proton Magnetic Resonance Spectroscopy; Solutions; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Terbium; Uric Acid | 2018 |
Translation of non-standard codon nucleotides reveals minimal requirements for codon-anticodon interactions.
Topics: 2-Aminopurine; Anticodon; Bacteriophage T7; Base Sequence; Codon; Cytidine; DNA-Directed RNA Polymerases; Escherichia coli; HEK293 Cells; Humans; Hydrogen Bonding; Inosine; Protein Biosynthesis; Pyridones; Receptor, Serotonin, 5-HT2C; Ribosomes; RNA, Transfer, Gly; Viral Proteins | 2018 |
Nanomechanics of Diaminopurine-Substituted DNA.
Topics: 2-Aminopurine; Biomechanical Phenomena; DNA; Mechanical Phenomena; Nucleic Acid Conformation; Nucleic Acid Hybridization; Transition Temperature | 2019 |
Base-Pairing Properties of Double-Headed Nucleotides.
Topics: 2-Aminopurine; Adenine; Base Pair Mismatch; Base Pairing; Cytosine; DNA; Guanine; Hypoxanthine; Models, Molecular; Nucleic Acid Conformation; Nucleotides; Thymine | 2019 |
Effect of mutations on binding of ligands to guanine riboswitch probed by free energy perturbation and molecular dynamics simulations.
Topics: 2-Aminopurine; Bacillus subtilis; Bacterial Proteins; Gene Expression Regulation, Bacterial; Guanine; Hypoxanthine; Ligands; Membrane Transport Proteins; Models, Molecular; Molecular Dynamics Simulation; Molecular Structure; Point Mutation; Riboswitch; Structure-Activity Relationship; Thermodynamics | 2019 |
Protein unties the pseudoknot: S1-mediated unfolding of RNA higher order structure.
Topics: 2-Aminopurine; Binding Sites; Escherichia coli; Guanine; Ligands; Nucleic Acid Conformation; Pyrimidinones; Pyrroles; Ribosomal Proteins; Ribosomes; Riboswitch; RNA; RNA Folding; Single Molecule Imaging | 2020 |
Incorporation of Pseudo-complementary Bases 2,6-Diaminopurine and 2-Thiouracil into Serinol Nucleic Acid (SNA) to Promote SNA/RNA Hybridization.
Topics: 2-Aminopurine; Base Pairing; Hydrogen Bonding; Nucleic Acid Hybridization; Oligonucleotides; Phase Transition; Propanolamines; Propylene Glycols; RNA; Thiouracil; Transition Temperature | 2020 |
2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations.
Topics: 2-Aminopurine; Animals; Codon, Nonsense; Disease Models, Animal; Drug Discovery; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; Genes, p53; HEK293 Cells; HeLa Cells; Humans; Lepisma; Mice; Mice, Nude; Mutation; RNA, Transfer; tRNA Methyltransferases | 2020 |
Dual miRNases for Triple Incision of miRNA Target: Design Concept and Catalytic Performance.
Topics: 2-Aminopurine; Base Sequence; Biocatalysis; Catalytic Domain; Humans; Hydrogen-Ion Concentration; MicroRNAs; Oligonucleotides; Peptides; Ribonucleases; RNA Stability | 2020 |
How cyanophage S-2L rejects adenine and incorporates 2-aminoadenine to saturate hydrogen bonding in its DNA.
Topics: 2-Aminopurine; Adenine; Bacteriophages; Binding Sites; Biocatalysis; Cyanobacteria; DNA Primase; DNA-Directed DNA Polymerase; DNA, Viral; Hydrogen Bonding; Models, Molecular; Molecular Structure; Protein Domains; Synechococcus; Viral Proteins | 2021 |
A third purine biosynthetic pathway encoded by aminoadenine-based viral DNA genomes.
Topics: 2-Aminopurine; Adenylosuccinate Synthase; Bacteriophages; Biosynthetic Pathways; Crystallography, X-Ray; DNA, Viral; Genome, Viral; Phylogeny; Viral Nonstructural Proteins | 2021 |
Noncanonical DNA polymerization by aminoadenine-based siphoviruses.
Topics: 2-Aminopurine; DNA Replication; DNA-Directed DNA Polymerase; DNA, Viral; Genome, Viral; Phylogeny; Polymerization; Siphoviridae; Viral Nonstructural Proteins | 2021 |
2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions.
Topics: 2-Aminopurine; Adenine; DNA; DNA Repair; Molecular Dynamics Simulation; Nucleic Acids; Nucleotides; Pyrimidine Dimers; RNA; Ultraviolet Rays | 2021 |
Characterization of a triad of genes in cyanophage S-2L sufficient to replace adenine by 2-aminoadenine in bacterial DNA.
Topics: 2-Aminopurine; Adenylosuccinate Synthase; Bacteriophages; Base Pairing; Crystallography, X-Ray; Deoxyadenosines; DNA, Bacterial; DNA, Viral; Escherichia coli; Genes, Viral; Genome, Viral; Metabolic Networks and Pathways; Models, Molecular; Phosphoric Monoester Hydrolases; Podoviridae; Protein Conformation; Recombinant Proteins; Siphoviridae; Static Electricity; Viral Proteins | 2021 |
Structural dynamics and determinants of 2-aminoadenine specificity in DNA polymerase DpoZ of vibriophage ϕVC8.
Topics: 2-Aminopurine; Base Pairing; DNA-Directed DNA Polymerase; DNA, Viral; Molecular Dynamics Simulation; Podoviridae; Protein Binding; Siphoviridae; Viral Proteins | 2021 |
Photostability of 2,6-diaminopurine and its 2'-deoxyriboside investigated by femtosecond transient absorption spectroscopy.
Topics: 2-Aminopurine; Pyrimidine Dimers; Quantum Theory; Spectrum Analysis; Ultraviolet Rays | 2022 |
Transcriptional Perturbations of 2,6-Diaminopurine and 2-Aminopurine.
Topics: 2-Aminopurine; DNA; DNA Repair; Humans; RNA Polymerase II; Transcription, Genetic | 2022 |
A Chemical Approach to Introduce 2,6-Diaminopurine and 2-Aminoadenine Conjugates into Oligonucleotides without Need for Protecting Groups.
Topics: 2-Aminopurine; Adenine; Oligonucleotides | 2022 |