Page last updated: 2024-08-18

2,5-hexanedione and n-hexane

2,5-hexanedione has been researched along with n-hexane in 86 studies

Research

Studies (86)

Timeframe	Studies, this research(%)	All Research%
pre-1990	23 (26.74)	18.7374
1990's	36 (41.86)	18.2507
2000's	16 (18.60)	29.6817
2010's	10 (11.63)	24.3611
2020's	1 (1.16)	2.80

Authors

Authors	Studies
Schaumburg, HH	1
Araki, T; Ikeya, Y; Sakai, T; Takeuchi, Y; Ushio, K	1
Horiguchi, S; Ikeda, M; Kawai, T; Mizunuma, K; Yasugi, T	2
Altenkirch, H; Boegner, F; Grüning, W; Marx, P; Stoltenburg-Didinger, G; Wagner, M	1
Amarnath, V; Anthony, DC; Graham, DG; St Clair, MB	1
Carenzi, A; Mariani, CB; Masotto, C; Pezzoli, G; Ricciardi, S	1
Horiguchi, S; Iguchi, H; Ikeda, M; Iwami, O; Kawai, T; Mizunuma, K; Uchida, Y; Yasugi, T	2
Iwamoto, T; Ogata, M; Taguchi, T	1
Hisanaga, N; Huang, J; Ono, Y; Saito, I; Shibata, E; Takeuchi, Y	2
Boekelheide, K; Eveleth, J; Neely, MD; Sioussat, TM	1
Filser, JG; Filser, M; Heilmaier, H; Kessler, W; Kreuzer, P; Shen, JH	1
Ikeda, M; Kawai, T; Mizunuma, K; Uchida, Y; Yasugi, T	1
Brugnone, F; Mozzo, P; Olivato, D; Perbellini, L	1
Goto, S; Ichikawa, Y; Lin, KM; Ogawa, Y; Okayama, A; Sugimoto, K	1
Bolt, HM; Fedtke, N	3
Couri, D; Milks, MM	1
Calisti, R; Colombi, A; Coppa, G; Governa, M; Tagliavento, G; Troni, W	1
Ahonen, I; Schimberg, RW	1
Bastone, A; Frontali, N; Mallozzi, C; Sbraccia, M; Settimi, L	1
DeCaprio, AP	1
Brugnone, F; Mozzo, P; Perbellini, L; Zedde, A	1
Abou-Donia, MB; Campbell, GM; Makkawy, HM	1
Abou-Donia, MB; Nomeir, AA	1
Anderson, RJ; Dunham, CB	1
Hisanaga, N; Iwata, M; Ono, Y; Takeuchi, Y	2
Abou-Donia, MB	1
Anthony, DC; Boekelheide, K; Graham, DG; Maschmann, NA; Richards, RG; Shaw, BR; Wolfram, JW	1
Gustafsson, JA; Halpert, J; Toftgård, R	1
Couri, D; Milks, M	1
Abou-Donia, MB; Graham, DG; Makkawy, HA	1
Amantini, MC; Brugnone, F; Frontali, N; Perbellini, L	1
DeCaprio, AP; Olajos, EJ; Weber, P	1
Goin, CJ; Mayer, VW	1
Abdel-Rahman, SM; Abou-Donia, MB; Ibrahim, S; Johnson, DJ; Lack, L	1
de Haan, W; de Wolff, FA; Kezić, S; Opdam, JJ; van Engelen, JG	1
Kawamoto, T; Kodama, Y; Kohno, K	1
Governa, M; Monaco, F; Valentino, M; Visonà, I	1
Capodaglio, E; Ghittori, S; Imbriani, M; Maestri, L	1
Cardona, A; Marhuenda, D; Marti, J; Pastore, C	1
Cardona, A; Luna, A; Marhuenda, D; Marti, J; Periago, JF; Roel, J; Villanueva, M	1
Takeuchi, Y	1
Brugnone, F; Canesi, M; Perbellini, L; Pezzoli, G	1
Brugnone, F; Cardona, A; Marhuenda, D; Martí, J; Perbellini, L; Roel, J	1
Bartolucci, GB; Casetta, B; Doretti, L; Gori, G; Parvoli, G; Sturaro, A; Troiano, R	1
Cardona, A; Marhuenda, D; Martí, J; Periago, JF; Prieto, MJ; Sánchez, JM	1
Bisiani, C; Camisasca, C; Canesi, M; Fonzi, N; Fusi, R; Mariani, CB; Masotto, C; Perbellini, L; Ricciardi, S; Scatturin, M	1
Csanády, GA; Dietz, W; Filser, JG; Kessler, W; Kreuzer, PE; Richter, M; Störmer, A	1
Binding, N; Madeja, M; Musshoff, U; Speckmann, EJ; Witting, U	1
Løkken, T; Mortensen, B; Nilsen, OG; Zahlsen, K	1
Mortensen, B; Nilsen, OG; Zahlsen, K	1
Ichihara, G; Kamijima, M; Saito, I; Shibata, E; Takeuchi, Y; Toida, M; Yu, X	1
Andreoli, R; Bergamaschi, E; Manini, P; Mutti, A; Niessen, WM	1
Andreoli, R; Bergamaschi, E; Franchini, I; Manini, P; Mutti, A	1
Higashikawa, K; Horiguchi, S; Ikeda, M; Kawai, T; Miyama, Y; Sakamoto, K; Zhang, ZW	1
Fung, J; Gonzalez, FJ; Iba, MM	1
Mayan, O; Pires, AF; Teixeira, JP	1
Cardona, A; Izura, V; Marhuenda, D; Pastore, C; Prieto, MJ; Roel, J	1
de Souza Nascimento, E; dos Santos, CR; Meyer Passarelli, MM	1
Baldasseroni, A; Bavazzano, P; Biggeri, A; Buiatti, E; Lanciotti, E; Li Donni, V; Lorini, C; Toti, S	1
Cardona, A; Marhuenda, D; Prieto, MJ; Roel, J	1
Hamelin, G; Tardif, R; Truchon, G	1
Charest-Tardif, G; Hamelin, G; Tardif, R; Truchon, G	1
Cardona, A; Felipo, V; Hernández-Viadel, ML; Marhuenda, D; Prieto-Castelló, MJ	1
Brochu, M; Nadeau, V; Tardif, R; Truchon, G	1
Kayton, R; Lasarev, M; Monterroso, V; Sabri, M; Spencer, P; Tshala-Katumbay, D	1
Bérubé, A; Charest-Tardif, G; Sari-Minodier, I; Tardif, R; Truchon, G	1
Maia, PP; Oliveira, AF; Paiva, MJ; Siqueira, ME	1
Gao, XC; Xie, KQ; Yin, HY; Yu, LH; Zhang, CL; Zhu, ZP	1
DeCaprio, AP; Kinney, EA; LoPachin, RM	1
Bin, P; Chen, H; Dai, Y; Duan, H; Liu, Q; Niu, Y; Zheng, Y	1
Chi, DF; Fu, QQ; Li, Y; Liu, Z; Xie, KQ; Yan, J; Yin, HY	1
Gao, Y; Kou, RR; Song, FY; Xie, KQ; Zou, CS	1
Gao, Y; Kou, R; Song, F; Xie, K; Zhang, Q; Zou, C	1
Guo, Y; Song, FY; Xie, KQ; Yin, HY; Zeng, T	1
Guo, Y; Xie, K; Yin, H; Zeng, T; Zhao, X	1
Boucard, S; Gagnaire, F	1
Batoréu, MC; Bronze, MR; dos Santos, AP; Gonçalves, LL; Mateus, ML; Torres, ME	1
Cai, R; Gu, S; Liu, L; Tang, F; Xie, Q	1
Li, M; Li, X; Wang, Q; Wang, S; Xie, K; Zhang, C	1
Li, M; Li, X; Liu, Z; Wang, Q; Wang, S; Xie, K; Yu, T	1

Reviews

4 review(s) available for 2,5-hexanedione and n-hexane

Article	Year
Molecular mechanisms of gamma-diketone neuropathy. Advances in experimental medicine and biology, 1991, Volume: 283 Topics: Animals; Axons; Biotransformation; Hexanes; Hexanones; Humans; Methyl n-Butyl Ketone; Peripheral Nervous System Diseases; Structure-Activity Relationship	1991
n-Hexane neurotoxicity: a mechanism involving pyrrole adduct formation in axonal cytoskeletal protein. Neurotoxicology, 1987,Spring, Volume: 8, Issue:1 Topics: Animals; Axons; Central Nervous System; Cross-Linking Reagents; Cytoskeletal Proteins; Hexanes; Hexanones; Ketones; Oxidation-Reduction; Pyrroles; Solvents	1987
Toxicity and metabolism of the neurotoxic hexacarbons n-hexane, 2-hexanone, and 2,5-hexanedione. Annual review of pharmacology and toxicology, 1982, Volume: 22 Topics: Animals; Biotransformation; Drug Synergism; Hexanes; Hexanones; Humans; Ketones; Lethal Dose 50; Methyl n-Butyl Ketone; Nervous System Diseases; Occupational Diseases; Rats; Solvents	1982
n-hexane polyneuropathy in Japan: a review of n-hexane poisoning and its preventive measures. Environmental research, 1993, Volume: 62, Issue:1 Topics: Animals; Hexanes; Hexanones; Humans; Japan; Nervous System Diseases; Occupational Exposure; Poisoning	1993

Trials

3 trial(s) available for 2,5-hexanedione and n-hexane

Article	Year
Human polymorphonuclear leukocyte chemotaxis as a tool in detecting biological early effects in workers occupationally exposed to low levels of n-hexane. Human & experimental toxicology, 1994, Volume: 13, Issue:10 Topics: Adolescent; Adult; Chemotaxis, Leukocyte; Cross-Linking Reagents; Female; Hexanes; Hexanones; Humans; Linear Models; Luminescent Measurements; Male; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Neurologic Examination; Neutrophils; Occupational Exposure; Reactive Oxygen Species; Respiratory Burst; Shoes	1994
Comparative estimation of the neurotoxic risks of N-hexane and N-heptane in rats and humans based on the formation of the metabolites 2,5-hexanedione and 2,5-heptanedione. Advances in experimental medicine and biology, 1996, Volume: 387 Topics: Administration, Inhalation; Adult; Animals; Body Burden; Cross-Linking Reagents; Half-Life; Heptanes; Hexanes; Hexanones; Humans; Ketones; Male; Nervous System Diseases; Pyrroles; Rats; Rats, Wistar; Risk Assessment	1996
Effect of physical exertion on the biological monitoring of exposure to various solvents following exposure by inhalation in human volunteers: II. n-Hexane. Journal of occupational and environmental hygiene, 2007, Volume: 4, Issue:7 Topics: Breath Tests; Environmental Monitoring; Exercise; Female; Hexanes; Hexanones; Humans; Inhalation Exposure; Kinetics; Male; Solvents	2007

Other Studies

79 other study(ies) available for 2,5-hexanedione and n-hexane

Article	Year
Morphological studies of toxic distal axonopathy. Neurobehavioral toxicology, 1979, Volume: 1 Suppl 1 Topics: Acrylamide; Acrylamides; Animals; Axons; Cats; Hexanes; Hexanones; Nerve Degeneration; Peripheral Nerves	1979
[Effect of hydrolysis conditions on the determination of urinary 2,5-hexanedione in workers exposed or not exposed to N-hexane]. Sangyo igaku. Japanese journal of industrial health, 1992, Volume: 34, Issue:5 Topics: Adult; Female; Gas Chromatography-Mass Spectrometry; Hexanes; Hexanones; Humans; Hydrogen-Ion Concentration; Hydrolysis; Male; Middle Aged; Occupational Exposure	1992
Urinalysis vs. blood analysis, as a tool for biological monitoring of solvent exposure. Toxicology letters, 1992, Volume: 63, Issue:3 Topics: Acetates; Air Pollutants, Occupational; Environmental Monitoring; Half-Life; Hexanes; Hexanones; Hippurates; Humans; Male; Occupational Exposure; Sensitivity and Specificity; Toluene	1992
Specific neurotoxic effects of different organic solvents on dissociated cultures of the nervous system. Neurotoxicology, 1992,Spring, Volume: 13, Issue:1 Topics: Animals; Butanones; Cells, Cultured; Chick Embryo; Hexanes; Hexanones; Nervous System; Neurites; Neurons	1992
n-hexane induces parkinsonism in rodents. Brain research, 1990, Oct-29, Volume: 531, Issue:1-2 Topics: Animals; Corpus Striatum; Dopamine; Hexanes; Hexanones; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Mice; Mice, Inbred ICR; Motor Activity; Norepinephrine; Parkinson Disease, Secondary; Rats; Rats, Inbred Strains; Reference Values; Serotonin; Substantia Nigra	1990
Dose-dependent increase in 2,5-hexanedione in the urine of workers exposed to n-hexane. International archives of occupational and environmental health, 1991, Volume: 63, Issue:4 Topics: Chromatography, Gas; Dose-Response Relationship, Drug; Environmental Monitoring; Furans; Hexanes; Hexanones; Humans; Hydrolysis; Male; Occupational Exposure; Regression Analysis	1991
Urinary 2,5-hexanedione assay involving its conversion to 2,5-dimethylpyrrole. International archives of occupational and environmental health, 1991, Volume: 62, Issue:8 Topics: Benzaldehydes; Chromatography, Gas; Chromatography, High Pressure Liquid; Environmental Monitoring; Hexanes; Hexanones; Humans; Occupational Exposure; Pyrroles; Spectrophotometry	1991
Determination of urinary 2,5-hexanedione concentration by an improved analytical method as an index of exposure to n-hexane. British journal of industrial medicine, 1991, Volume: 48, Issue:8 Topics: Adhesives; Animals; Automobiles; Chromatography, Gas; Drug Stability; Female; Hexanes; Hexanones; Humans; Hydrogen-Ion Concentration; Hydrolysis; Industry; Male; Occupational Exposure; Rats; Temperature; Time Factors	1991
2-Acetylfuran, a confounder in urinalysis for 2,5-hexanedione as an n-hexane exposure indicator. International archives of occupational and environmental health, 1991, Volume: 63, Issue:3 Topics: Confounding Factors, Epidemiologic; Furans; Gas Chromatography-Mass Spectrometry; Hexanes; Hexanones; Humans; Hydrolysis; Male; Occupational Exposure; Regression Analysis	1991
Microtubule assembly is altered following covalent modification by the n-hexane metabolite 2,5-hexanedione. Advances in experimental medicine and biology, 1991, Volume: 283 Topics: Anilino Naphthalenesulfonates; Animals; Binding Sites; Cattle; Colchicine; Hexanes; Hexanones; In Vitro Techniques; Microtubules; Temperature; Tubulin	1991
Spectrophotometric determination of pyrrole-like substances in urine of rat and man: an assay for the evaluation of 2,5-hexanedione formed from n-hexane. Archives of toxicology, 1990, Volume: 64, Issue:3 Topics: Animals; Hexanes; Hexanones; Humans; Ketones; Kinetics; Male; Pyrroles; Rats; Rats, Inbred Strains; Sensitivity and Specificity; Spectrophotometry	1990
The method of choice for the determination of 2,5-hexanedione as an indicator of occupational exposure to n-hexane. International archives of occupational and environmental health, 1990, Volume: 62, Issue:5 Topics: Environmental Monitoring; Evaluation Studies as Topic; Hexanes; Hexanones; Humans; Hydrolysis; Male; Occupational Exposure; Reproducibility of Results	1990
Effects of MEK on kinetics of n-hexane metabolites in serum. Archives of toxicology, 1990, Volume: 64, Issue:3 Topics: Animals; Aorta, Abdominal; Butanones; Hexanes; Hexanones; Kinetics; Male; Rats; Rats, Inbred Strains	1990
"Dynamic" biological exposure indexes for n-hexane and 2,5-hexanedione, suggested by a physiologically based pharmacokinetic model. American Industrial Hygiene Association journal, 1990, Volume: 51, Issue:7 Topics: Hexanes; Hexanones; Humans; Ketones; Maximum Allowable Concentration; Models, Biological; Tissue Distribution	1990
n-hexane exposure and urinary concentration of 2,5-hexanedion. Medical journal of Osaka University, 1987, Volume: 36, Issue:3-4 Topics: Acetone; Adhesives; Adult; Female; Hexanes; Hexanones; Humans; Male; Middle Aged; Occupational Exposure; Toluene	1987
4,5-Dihydroxy-2-hexanone: a new metabolite of N-hexane and of 2,5-hexanedione in rat urine. Biomedical & environmental mass spectrometry, 1987, Volume: 14, Issue:10 Topics: Acetates; Administration, Inhalation; Animals; Chromatography, Gas; Glucuronates; Hexanes; Hexanones; Hydrolysis; Hydroxylamines; Injections, Intraperitoneal; Ketones; Male; Neurotoxins; Rats; Rats, Inbred Strains; Trimethylsilyl Compounds	1987
Hexacarbon neuropathy: tracking a toxin. Neurotoxicology, 1985,Winter, Volume: 6, Issue:4 Topics: Animals; Biotransformation; Hexanes; Hexanones; Humans; Intermediate Filament Proteins; Isomerism; Ketones; Methyl n-Butyl Ketone; Neurofilament Proteins; Occupational Diseases; Peripheral Nervous System Diseases; Pyrroles; Rats; Textile Industry	1985
Urinary excretion of 2,5-hexanedione and peripheral polyneuropathies workers exposed to hexane. Journal of toxicology and environmental health, 1987, Volume: 20, Issue:3 Topics: Adolescent; Adult; Electromyography; Female; Hexanes; Hexanones; Humans; Ketones; Male; Middle Aged; Occupational Diseases; Peripheral Nervous System Diseases; Shoes	1987
2,5-Hexanedione excretion after occupational exposure to n-hexane. British journal of industrial medicine, 1988, Volume: 45, Issue:2 Topics: Adult; Environmental Exposure; Female; Hexanes; Hexanones; Humans; Ketones; Middle Aged; Shoes	1988
The relevance of 4,5-dihydroxy-2-hexanone in the excretion kinetics of n-hexane metabolites in rat and man. Archives of toxicology, 1987, Volume: 61, Issue:2 Topics: Adult; Animals; Gas Chromatography-Mass Spectrometry; Hexanes; Hexanones; Humans; Male; Monitoring, Physiologic; Pharmacokinetics; Rats; Rats, Inbred Strains	1987
Cholinesterases in blood plasma and tissues of rats treated with n-hexane or with its neurotoxic metabolite 2,5-hexanedione. Archives of toxicology, 1987, Volume: 61, Issue:2 Topics: Animals; Centrifugation, Density Gradient; Cholinesterases; Electrophoresis, Polyacrylamide Gel; Hexanes; Hexanones; Ketones; Liver; Male; Monitoring, Physiologic; Motor Activity; Muscles; Rats; Rats, Inbred Strains; Respiration	1987
Physiologicomathematical model for studying human exposure to organic solvents: kinetics of blood/tissue n-hexane concentrations and of 2,5-hexanedione in urine. British journal of industrial medicine, 1986, Volume: 43, Issue:11 Topics: Adipose Tissue; Environmental Exposure; Hexanes; Hexanones; Humans; Kinetics; Mathematics; Models, Biological; Solvents; Time Factors	1986
Detection of 2,5-hexanedione in the urine of persons not exposed to n-hexane. International archives of occupational and environmental health, 1986, Volume: 57, Issue:2 Topics: Adult; Environmental Exposure; Female; Gas Chromatography-Mass Spectrometry; Hexanes; Hexanones; Humans; Hydrogen-Ion Concentration; Hydrolysis; Ketones; Male; Middle Aged	1986
Pattern of neurotoxicity of n-hexane, methyl n-butyl ketone, 2,5-hexanediol, and 2,5-hexanedione alone and in combination with O-ethyl O-4-nitrophenyl phenylphosphonothioate in hens. Journal of toxicology and environmental health, 1985, Volume: 16, Issue:1 Topics: Animals; Ataxia; Chickens; Cytochrome P-450 Enzyme System; Drug Synergism; Enzyme Induction; Female; Glycols; Hexanes; Hexanones; Insecticides; Ketones; Methyl n-Butyl Ketone; Nervous System; Peripheral Nerves; Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester; Phosphorylation; Skin Absorption; Spinal Cord	1985
Analysis of n-hexane, 2-hexanone, 2,5-hexanedione, and related chemicals by capillary gas chromatography and high-performance liquid chromatography. Analytical biochemistry, 1985, Volume: 151, Issue:2 Topics: Chromatography, Gas; Chromatography, High Pressure Liquid; Hexanes; Hexanones; Ketones; Methyl n-Butyl Ketone; Structure-Activity Relationship	1985
Electrophysiologic deficits in peripheral nerve as a discriminator of early hexacarbon neurotoxicity. Journal of toxicology and environmental health, 1984, Volume: 13, Issue:4-6 Topics: Animals; Hexanes; Hexanones; Ketones; Male; Membrane Potentials; Neural Conduction; Peripheral Nerves; Rats; Rats, Inbred Strains; Refractory Period, Electrophysiological	1984
Changes of n-hexane metabolites in urine of rats exposed to various concentrations of n-hexane and to its mixture with toluene or MEK. International archives of occupational and environmental health, 1983, Volume: 53, Issue:1 Topics: Animals; Butanones; Furans; Hexanes; Hexanols; Hexanones; Lactones; Male; Methyl n-Butyl Ketone; Rats; Rats, Inbred Strains; Toluene	1983
Interaction between neurotoxicities induced by organophosphorus and long-chain hexacarbon compounds. Neurotoxicology, 1983,Winter, Volume: 4, Issue:4 Topics: Animals; Chickens; Drug Synergism; Female; Glycols; Hexanes; Hexanones; Insecticides; Ketones; Methyl n-Butyl Ketone; Nervous System Diseases; Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester	1983
Studies of the molecular pathogenesis of hexane neuropathy. II. Evidence that pyrrole derivatization of lysyl residues leads to protein crosslinking. Toxicology and applied pharmacology, 1982, Volume: 64, Issue:3 Topics: Cross-Linking Reagents; Electrophoresis, Polyacrylamide Gel; Hexanes; Hexanones; Lysine; Nervous System Diseases; Pyrroles	1982
A study on biological monitoring of n-hexane exposure. International archives of occupational and environmental health, 1983, Volume: 51, Issue:3 Topics: Adolescent; Adult; Aged; Chromatography, Gas; Environmental Exposure; Female; Furans; Hexanes; Hexanones; Humans; Japan; Lactones; Male; Mass Spectrometry; Middle Aged; Monitoring, Physiologic; Time Factors	1983
Xylene induces a cytochrome P-450 isozyme in rat liver similar to the major isozyme induced by phenobarbital. Molecular pharmacology, 1983, Volume: 23, Issue:1 Topics: Amino Acids; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexanes; Hexanones; Isoenzymes; Male; Microsomes, Liver; Phenobarbital; Rats; Substrate Specificity; Xylenes	1983
The relative neurotoxicities of n-hexane, methyl n-butyl ketone, 2,5-hexanediol, and 2,5-hexanedione following oral or intraperitoneal administration in hens. Toxicology and applied pharmacology, 1982, Mar-15, Volume: 62, Issue:3 Topics: Administration, Oral; Animals; Body Weight; Chickens; Female; Glycols; Hexanes; Hexanones; Injections, Intraperitoneal; Ketones; Methyl n-Butyl Ketone; Nervous System; Peripheral Nerves; Spinal Cord	1982
Urinary excretion of n-hexane metabolites. A comparative study in rat, rabbit and monkey. Archives of toxicology, 1982, Volume: 50, Issue:3-4 Topics: Animals; Biotransformation; Half-Life; Hexanes; Hexanones; Macaca; Macaca mulatta; Male; Rabbits; Rats; Rats, Inbred Strains; Species Specificity	1982
Covalent binding of a neurotoxic n-hexane metabolite: conversion of primary amines to substituted pyrrole adducts by 2,5-hexanedione. Toxicology and applied pharmacology, 1982, Sep-30, Volume: 65, Issue:3 Topics: Amines; Amino Acids; Animals; Chemical Phenomena; Chemistry; Chickens; Chromogenic Compounds; Female; Hexanes; Hexanones; Ketones; Nervous System Diseases; Proteins; Pyrroles	1982
Induction of chromosome loss in yeast by combined treatment with neurotoxic hexacarbons and monoketones. Mutation research, 1994, Volume: 341, Issue:2 Topics: Acetone; Aneuploidy; Butanones; Chromosome Deletion; Drug Synergism; Hexanes; Hexanones; Methyl n-Butyl Ketone; Neurotoxins; Saccharomyces cerevisiae	1994
Protein-bound pyrroles in rat hair following subchronic intraperitoneal injections of 2,5-hexanedione. Journal of toxicology and environmental health, 1995, Volume: 45, Issue:3 Topics: Animals; Environmental Monitoring; Hair; Hexanes; Hexanones; Male; Methyl n-Butyl Ketone; Occupational Exposure; Pyrroles; Rats; Rats, Sprague-Dawley; Vibrissae	1995
Determination of 2,5-hexanedione, a metabolite of n-hexane, in urine: evaluation and application of three analytical methods. Journal of chromatography. B, Biomedical applications, 1995, May-19, Volume: 667, Issue:2 Topics: Chromatography, Gas; Hexanes; Hexanones; Humans; Occupational Exposure; Sensitivity and Specificity	1995
Interlaboratory quality control and status of n-hexane biological monitoring in Japan. Archives of environmental contamination and toxicology, 1995, Volume: 28, Issue:4 Topics: Environmental Monitoring; Hexanes; Hexanones; Humans; Japan; Laboratories; Quality Control; Reproducibility of Results; Specimen Handling	1995
Determination of 2,5-hexandione by high-performance liquid chromatography after derivatization with dansylhydrazine. Journal of chromatography. B, Biomedical applications, 1994, Jul-01, Volume: 657, Issue:1 Topics: Acetonitriles; Buffers; Chromatography, High Pressure Liquid; Dansyl Compounds; Hexanes; Hexanones; Humans; Hydrazines; Hydrolysis; Occupational Exposure; Phosphates; Reference Values	1994
Early diagnosis of n-hexane-caused neuropathy. Muscle & nerve, 1994, Volume: 17, Issue:9 Topics: Action Potentials; Adult; Chromatography, Gas; Hexanes; Hexanones; Humans; Middle Aged; Neural Conduction; Neurologic Examination; Neurons, Afferent; Occupational Diseases; Occupational Exposure; Tibial Nerve; Ulnar Nerve	1994
Biological monitoring of occupational exposure to n-hexane by exhaled air analysis and urinalysis. International archives of occupational and environmental health, 1993, Volume: 65, Issue:4 Topics: Adhesives; Adolescent; Adult; Breath Tests; Dose-Response Relationship, Drug; Environmental Monitoring; Female; Hexanes; Hexanones; Humans; Male; Middle Aged; Occupational Exposure; Shoes	1993
Biochemical and physiological aspects of 2,5-hexanedione: endogenous or exogenous product? International archives of occupational and environmental health, 1993, Volume: 65, Issue:1 Topics: Circadian Rhythm; Hexanes; Hexanones; Humans; Occupational Exposure; Solvents	1993
Biological monitoring of occupational exposure to n-hexane by measurement of urinary 2,5-hexanedione. International archives of occupational and environmental health, 1993, Volume: 65, Issue:1 Topics: Adolescent; Adult; Biotransformation; Butanones; Drug Interactions; Environmental Monitoring; Female; Hexanes; Hexanones; Humans; Male; Middle Aged; Occupational Exposure; Regression Analysis; Shoes; Skin Absorption; Solvents; Toluene	1993
Comparative evaluation of blood and urine analysis as a tool for biological monitoring of n-hexane and toluene. International archives of occupational and environmental health, 1993, Volume: 65, Issue:1 Suppl Topics: Air Pollutants, Occupational; Environmental Monitoring; Hexanes; Hexanones; Hippurates; Humans; Male; Occupational Exposure; Regression Analysis; Solvents; Toluene	1993
High-performance liquid chromatographic determination of urinary 2,5-hexanedione as mono-2,4-dinitrophenylhydrazone using ultraviolet detection. Journal of chromatography. B, Biomedical applications, 1995, Nov-17, Volume: 673, Issue:2 Topics: Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Hexanes; Hexanones; Humans; Hydrazones; Hydrogen-Ion Concentration; Hydrolysis; Occupational Exposure; Quality Control; Reference Values	1995
Behaviour of urinary 2,5-hexanedione in occupational co-exposure to n-hexane and acetone. International archives of occupational and environmental health, 1996, Volume: 68, Issue:2 Topics: Acetone; Breath Tests; Drug Interactions; Environmental Monitoring; Hexanes; Hexanones; Humans; Occupational Exposure	1996
Effects of acute n-hexane and 2,5-hexanedione treatment on the striatal dopaminergic system in mice. Journal of neural transmission. Supplementum, 1995, Volume: 45 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Hexanes; Hexanones; Homovanillic Acid; Injections, Intraperitoneal; Male; Mice; Mice, Inbred ICR; Time Factors	1995
Effects of n-hexane and its metabolites on cloned voltage-operated neuronal potassium channels. Archives of toxicology, 1997, Volume: 71, Issue:4 Topics: Animals; Hexanes; Hexanols; Hexanones; Oocytes; Patch-Clamp Techniques; Potassium Channels; Transfection; Xenopus laevis	1997
Comparison and in vivo relevance of two different in vitro head space metabolic systems: liver S9 and liver slices. Pharmacology & toxicology, 1997, Volume: 81, Issue:1 Topics: Acetone; Animals; Benzoates; Benzoic Acid; Biotransformation; Chelating Agents; Ditiocarb; Hexanes; Hexanols; Hexanones; Hippurates; Hypnotics and Sedatives; In Vitro Techniques; Liver; Male; Phenobarbital; Rats; Rats, Sprague-Dawley; Solvents; Toluene	1997
Metabolic interaction of n-hexane and methyl ethyl ketone in vitro in a head space rat liver S9 vial equilibration system. Pharmacology & toxicology, 1998, Volume: 82, Issue:2 Topics: Animals; Butanones; Chromatography, Gas; Drug Interactions; Enzyme Induction; Hexanes; Hexanones; In Vitro Techniques; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley	1998
Urinary 2,5-hexanedione increases with potentiation of neurotoxicity in chronic coexposure to n-hexane and methyl ethyl ketone. International archives of occupational and environmental health, 1998, Volume: 71, Issue:2 Topics: Animals; Butanones; Drug Interactions; Hexanes; Hexanones; Inhalation Exposure; Male; Rats; Rats, Wistar; Solvents	1998
Determination of n-hexane metabolites by liquid chromatography/mass spectrometry. 1. 2,5-hexanedione and other phase I metabolites in untreated and hydrolyzed urine samples by atmospheric pressure chemical ionization. Rapid communications in mass spectrometry : RCM, 1998, Volume: 12, Issue:19 Topics: Air Ionization; Air Pressure; Animals; Chromatography, High Pressure Liquid; Hexanes; Hexanones; Humans; Hydrolysis; Male; Mass Spectrometry; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Solvents	1998
Determination of free and glucuronated hexane metabolites without prior hydrolysis by liquid- and gas-chromatography coupled with mass spectrometry. Toxicology letters, 1999, Sep-05, Volume: 108, Issue:2-3 Topics: Acids; Animals; Chromatography, Gas; Chromatography, Liquid; Enzymes; Gas Chromatography-Mass Spectrometry; Glucuronates; Hexanes; Hexanols; Hexanones; Rats; Rats, Sprague-Dawley	1999
Possible metabolic interaction between hexane and other solvents co-exposed at sub-occupational exposure limit levels. International archives of occupational and environmental health, 2000, Volume: 73, Issue:7 Topics: Acetates; Acetone; Adhesives; Chromatography, Gas; Drug Interactions; Hexanes; Hexanones; Humans; Male; Neurotoxins; Occupational Exposure; Solvents; Toluene	2000
Functional Cyp2e1 is required for substantial in vivo formation of 2,5-hexanedione from n-hexane in the mouse. Archives of toxicology, 2000, Volume: 74, Issue:10 Topics: Adhesives; Animals; Biotransformation; Cytochrome P-450 CYP2E1; Hexanes; Hexanols; Hexanones; Homozygote; Injections, Intraperitoneal; Male; Mice; Mice, Knockout	2000
Biological monitoring of n-hexane exposure in Portuguese shoe manufacturing workers. Applied occupational and environmental hygiene, 2001, Volume: 16, Issue:7 Topics: Adhesives; Adult; Air Pollution, Indoor; Biomarkers; Case-Control Studies; Hexanes; Hexanones; Humans; Male; Manufactured Materials; Middle Aged; Occupational Health; Shoes	2001
Partial conduction blocks in N-hexane neuropathy. Muscle & nerve, 2002, Volume: 26, Issue:1 Topics: Action Potentials; Adolescent; Adult; Electrodiagnosis; Environmental Monitoring; Female; Hexanes; Hexanones; Humans; Industry; Inhalation Exposure; Median Nerve; Neural Conduction; Occupational Exposure; Polyneuropathies; Tibial Nerve; Time	2002
Evaluation of 2,5-hexanedione in urine of workers exposed to n-hexane in Brazilian shoe factories. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2002, Oct-05, Volume: 778, Issue:1-2 Topics: Brazil; Calibration; Chromatography, Gas; Female; Hexanes; Hexanones; Humans; Male; Occupational Exposure; Quality Control; Sensitivity and Specificity	2002
Occupational exposure to n-hexane in Italy--analysis of a registry of biological monitoring. International archives of occupational and environmental health, 2003, Volume: 76, Issue:4 Topics: Adolescent; Adult; Aged; Air Pollutants, Occupational; Environmental Monitoring; Female; Hexanes; Hexanones; Humans; Italy; Male; Middle Aged; Occupational Exposure; Regression Analysis; Retrospective Studies; Solvents; Time Factors	2003
Free and total 2,5-hexanedione in biological monitoring of workers exposed to n-hexane in the shoe industry. Toxicology letters, 2003, Dec-10, Volume: 145, Issue:3 Topics: Adolescent; Adult; Air Pollutants, Occupational; Environmental Monitoring; Female; Hexanes; Hexanones; Humans; Industry; Linear Models; Male; Middle Aged; Occupational Exposure; Shoes; Spain	2003
Comparison of unchanged n-hexane in alveolar air and 2,5-hexanedione in urine for the biological monitoring of n-hexane exposure in human volunteers. International archives of occupational and environmental health, 2004, Volume: 77, Issue:4 Topics: Adult; Atmosphere Exposure Chambers; Breath Tests; Environmental Monitoring; Female; Hexanes; Hexanones; Humans; Male; Occupational Exposure; Pulmonary Alveoli	2004
Physiologically based modeling of n-hexane kinetics in humans following inhalation exposure at rest and under physical exertion: impact on free 2,5-hexanedione in urine and on n-hexane in alveolar air. Journal of occupational and environmental hygiene, 2005, Volume: 2, Issue:2 Topics: Exercise; Forecasting; Hexanes; Hexanones; Humans; Inhalation Exposure; Kinetics; Models, Biological; Neurotoxins; Occupational Exposure; Pulmonary Alveoli; Respiration; Workload	2005
Activation of soluble guanylate cyclase by nitric oxide is increased in lymphocytes from both rats chronically exposed to 2,5-hexanedione and workers chronically exposed to n-hexane. Toxicology, 2007, Jan-05, Volume: 229, Issue:1-2 Topics: Adhesives; Adult; Animals; Cyclic GMP; Environmental Monitoring; Enzyme Activation; Female; Guanylate Cyclase; Hexanes; Hexanones; Humans; Inhalation Exposure; Lymphocytes; Male; Middle Aged; Nitric Oxide; Occupational Exposure; Penicillamine; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Water Supply	2007
Probing mechanisms of axonopathy. Part II: Protein targets of 2,5-hexanedione, the neurotoxic metabolite of the aliphatic solvent n-hexane. Toxicological sciences : an official journal of the Society of Toxicology, 2009, Volume: 107, Issue:2 Topics: Acetophenones; Amino Acids; Animals; Axons; Biomarkers; Cell Shape; Electrophoresis, Polyacrylamide Gel; Hexanes; Hexanones; Isoelectric Focusing; Male; Nerve Tissue Proteins; Neurofilament Proteins; Neurotoxicity Syndromes; Neurotoxins; Proteomics; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spinal Cord	2009
The effect of workload on biological monitoring of occupational exposure to toluene and n-Hexane: contribution of physiologically based toxicokinetic modeling. Journal of occupational and environmental hygiene, 2009, Volume: 6, Issue:7 Topics: Air Pollutants, Occupational; Computer Simulation; Cresols; Environmental Monitoring; Hexanes; Hexanones; Humans; Kinetics; Models, Biological; Occupational Exposure; Software; Time Factors; Toluene; Workload	2009
Determination of 2,5-hexanedione in urine by headspace solid-phase microextraction and gas chromatography. Journal of analytical toxicology, 2009, Volume: 33, Issue:4 Topics: Adhesives; Biomarkers; Biotransformation; Calibration; Chromatography, Gas; Environmental Monitoring; Flame Ionization; Hexanes; Hexanones; Humans; Occupational Exposure; Reproducibility of Results; Shoes; Solid Phase Microextraction	2009
[Effects of garlic oil on n-hexane metabolized to 2, 5-hexanedione in mice serum]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 2009, Volume: 27, Issue:5 Topics: Allyl Compounds; Animals; Biotransformation; Female; Hexanes; Hexanones; Male; Mice; Sulfides	2009
Comparative covalent protein binding of 2,5-hexanedione and 3-acetyl-2,5-hexanedione in the rat. Journal of toxicology and environmental health. Part A, 2009, Volume: 72, Issue:14 Topics: Animals; Axons; Cytoskeletal Proteins; Ergosterol; Hexanes; Hexanones; Male; Molecular Structure; Neurotoxicity Syndromes; Rats; Rats, Wistar; Spinal Cord	2009
The effect of 2,5-hexanedione on permeability of blood-nerve barrier in rats. Human & experimental toxicology, 2010, Volume: 29, Issue:6 Topics: Animals; Blood-Nerve Barrier; Body Weight; Disease Models, Animal; Evans Blue; Fluorescent Dyes; Gait; Hexanes; Hexanones; Male; Organ Specificity; Peripheral Nervous System Agents; Peripheral Nervous System Diseases; Permeability; Random Allocation; Rats; Rats, Wistar; Sciatic Nerve; Severity of Illness Index; Tibial Nerve; Time Factors	2010
[Effects of garlic oil, age and sex on n-hexane metabolism in rats]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 2011, Volume: 29, Issue:1 Topics: Age Factors; Animals; Antioxidants; Female; Garlic; Hexanes; Hexanones; Male; Plant Oils; Rats; Rats, Wistar; Sex Factors	2011
[Effect of 2,5-hexanedione on light-molecular-weight neurofilaments (NF-L) degradation of rat nerve tissues]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 2012, Volume: 30, Issue:6 Topics: Animals; Hexanes; Hexanones; Male; Nerve Tissue; Neurofilament Proteins; Rats; Rats, Wistar; Sciatic Nerve	2012
2,5-hexanedione altered the degradation of low-molecular-weight neurofilament in rat nerve tissues. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2012, Volume: 50, Issue:12 Topics: Animals; Blotting, Western; Hexanes; Hexanones; Male; Molecular Weight; Nerve Tissue; Neurofilament Proteins; Rats; Rats, Wistar; Sciatic Nerve; Spinal Cord	2012
Toxicokinetic study of pyrrole adducts and its potential application for biological monitoring of 2,5-hexanedione subacute exposure. International archives of occupational and environmental health, 2014, Volume: 87, Issue:6 Topics: Animals; Area Under Curve; Biomarkers; Environmental Monitoring; Hexanes; Hexanones; Male; Neurotoxins; Pyrroles; Rats; Rats, Wistar; Spectrophotometry; Toxicokinetics	2014
Correlation between levels of 2, 5-hexanedione and pyrrole adducts in tissues of rats exposure to n-hexane for 5-days. PloS one, 2013, Volume: 8, Issue:9 Topics: Animals; Benzaldehydes; Biomarkers; Chromatography, Gas; Dose-Response Relationship, Drug; Hexanes; Hexanones; Linear Models; Liver; Male; Pyrroles; Rats; Rats, Wistar	2013
Olfactory mucosal necrosis in rats following acute intraperitoneal administration of 1,2-diethylbenzene, 1,2-diacetylbenzene and 2,5-hexanedione. Neurotoxicology, 2014, Volume: 41 Topics: Acetophenones; Animals; Benzene Derivatives; Drug Combinations; Hexanes; Hexanones; Injections, Intraperitoneal; Male; Necrosis; Olfactory Nerve; Rats; Rats, Sprague-Dawley; Time Factors	2014
Alternative biomarkers of n-hexane exposure: characterization of aminoderived pyrroles and thiol-pyrrole conjugates in urine of rats exposed to 2,5-hexanedione. Toxicology letters, 2014, Jan-03, Volume: 224, Issue:1 Topics: Animals; Biomarkers; Colorimetry; Environmental Monitoring; Hexanes; Hexanones; Male; Pyrroles; Rats; Rats, Wistar; Tandem Mass Spectrometry	2014
[Investigation of determination of 2, 5-acetyl butyryl in blood and biological limit value for occupational exposure to -hexane]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 2014, Volume: 32, Issue:6 Topics: Hexanes; Hexanones; Humans; Occupational Exposure	2014
Hair pyrrole adducts serve as biomarkers for peripheral nerve impairment induced by 2,5-hexanedione and n-hexane in rats. PloS one, 2018, Volume: 13, Issue:12 Topics: Animals; Biomarkers; Hair; Hexanes; Hexanones; Male; Peripheral Nervous System Diseases; Pyrroles; Rats; Rats, Wistar	2018
Diallyl sulfide-induced attenuation of n-hexane-induced peripheral nerve impairment is associated with metabolic inhibition of n-hexane. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2020, Volume: 137 Topics: Allyl Compounds; Animals; Body Weight; Hair; Hexanes; Hexanones; Male; Neuroprotective Agents; Neurotoxicity Syndromes; Pyrroles; Rats, Wistar; Sciatic Nerve; Sulfides	2020