2-5-dimethoxy-4-n-propylthiophenethylamine and 2-5-dimethoxy-4-ethylthiophenethylamine

The urinary metabolic profiles of three hallucinogenic 2,5-dimethoxy-4-alkylthiophenethylamine analogs: 2,5-dimethoxy-4-ethylthiophenethylamine (2C-T-2), 2,5-dimethoxy-4-isopropylthiophenethylamine (2C-T-4), and 2,5-dimethoxy-4-propylthiophenethylamine (2C-T-7), were investigated in rats. For each drug, four male Sprague-Dawley rats were orally administered 10 mg/kg of 2C-T-2, 2C-T-4, or 2C-T-7, and urine was collected 0-24 and 24-48 h after administration. The urine samples were processed by liquid-liquid extraction, and the extracts were analyzed by liquid chromatography/mass spectrometry to quantify the metabolites. The metabolic patterns of these drugs were different: for 2C-T-7, the principal metabolite was the β-hydroxylated-N-acetylated-sulfoxide, whereas for 2C-T-2 and 2C-T-4 the major metabolites were the N-acetylated-sulfoxide and S-methylated-N-acetylated-sulfoxide, respectively.

Topics: Animals; Anisoles; Chromatography, Liquid; Hallucinogens; Male; Mass Spectrometry; Phenethylamines; Rats, Sprague-Dawley; Sulfides

In recent years, the frequent appearance of phenethylamine designer drugs on the illicit drug market has been a matter of concern for all authorities involved. New phenethylamine drugs are being introduced because these compounds are not covered by existing legislation. Therefore, the new drugs cannot be considered illicit drugs until their names are officially recognized. This paper describes a method to screen for and quantify four 2,5-methylenedioxy-derivatives of 4-thio-phenethylamine (2C-T-series) in human plasma, using capillary electrophoresis coupled with electrospray ionisation-mass spectrometry (CE-ESI-MS). Prior to CE-MS analysis, a simple liquid extraction was used for sample cleanup. The method was validated according to international guidelines.

Topics: Anisoles; Designer Drugs; Electrophoresis, Capillary; Humans; Phenethylamines; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection; Sulfides