2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine has been researched along with mannitol in 26 studies
| Studies (2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine) | Trials (2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine) | Recent Studies (post-2010) (2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine) | Studies (mannitol) | Trials (mannitol) | Recent Studies (post-2010) (mannitol) |
|---|---|---|---|---|---|
| 38 | 0 | 4 | 13,114 | 685 | 2,583 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (23.08) | 18.7374 |
| 1990's | 6 (23.08) | 18.2507 |
| 2000's | 11 (42.31) | 29.6817 |
| 2010's | 3 (11.54) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bogers, WM; Daha, MR; Janssen, DJ; Prins, FA; Stad, RK; van Es, LA; van Rooijen, N | 1 |
| Bruyneel, EA; De Mets, M; Di Virgilio, S; Dragonetti, CH; Hooghe, RJ; Mareel, MM | 1 |
| Cabezas, JA; Calvo, P; Chinchetru, MA | 1 |
| Bell, EA; Berrie, EM; Davis, JM; Hegarty, MP; Jeffries, DJ; Mobberley, MA; Nash, RJ; Ryder, TA; Taylor, DL; Tyms, AS | 1 |
| Fellows, LE; Fleet, GW; Nash, RJ; Scofield, AM | 1 |
| Barker, CG; Blakemore, WF; Dell, A; Palmer, AC; Tiller, PR; Winchester, BG | 1 |
| Evans, SV; Fellows, L; Friedlander, P; Herscovics, A; Romero, PA | 1 |
| Elbein, AD; Evans, SV; Fellows, LE; Mitchell, M; Sanford, BA | 1 |
| Elbein, AD; Fleet, GW; Hughes, DJ; Lawyer, CH; Molyneux, RJ; Pan, YT; Tropea, JE | 1 |
| Nishimura, Y | 1 |
| Depezay, JC; Dosbaa, I; Foglietti, MJ; Geoffroy, S; Le Merrer, Y; Poitout, L | 1 |
| Brault, A; Coté, J; Huet, PM; Imamura, H; Laberge, S | 1 |
| Stütz, AE; Withers, SG; Wrodnigg, TM | 1 |
| Cousins, RP; Cowley, A; Donohoe, TJ; Headley, CE | 1 |
| Diness, F; Gruber, C; Häusler, H; Lundt, I; Rupitz, K; Steiner, AJ; Stütz, AE; Tarling, CA; Withers, SG; Wölfler, H; Wrodnigg, TM | 1 |
| Asano, N; Butters, TD; Dwek, RA; Fleet, GW; Ikeda, K; Nash, RJ; Wang, MX; Winters, AL; Wormald, MR; Yu, CY | 1 |
| Cai, TB; Cao, X; Cheng, H; Fang, L; Ji, JJ; Sun, D; Tunac, JB; Wang, PG; Xian, M | 1 |
| Aguilar, M; García Fernández, JM; García-Moreno, MI; Ortiz Mellet, C | 1 |
| Stütz, AE; Tarling, CA; Withers, SG; Wrodnigg, TM | 1 |
| Horne, DB; Trost, BM; Woltering, MJ | 1 |
| Jung, YH; Kim, IS; Kim, SJ; Lee, JK; Li, QR | 1 |
| Adachi, I; Asano, N; Ikeda, K; Kato, A; Kato, N; Minoshima, Y; Miyauchi, S; Nash, RJ; Watson, AA | 1 |
| Bols, M; Lopez, O; Qing, FL; Wang, RW; Xu, J | 1 |
| Bing, F; Zhang, B; Zhang, G; Zhang, X | 1 |
| Auberger, N; Blériot, Y; Désiré, J; Jagadeesh, Y; Kato, A; Luo, B; Nakagawa, S; Sollogoub, M; Tran, AT; Zhang, Y | 1 |
| Carrero-Carralero, C; Martín-Ortiz, A; Ramos, S; Rodríguez-Sánchez, S; Sanz, ML; Soria, AC | 1 |
1 review(s) available for 2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine and mannitol
| Article | Year |
|---|---|
[Glycosidase inhibitors as anti-HIV agents].
Topics: 1-Deoxynojirimycin; Alkaloids; Animals; Antiviral Agents; CD4 Antigens; Glycoside Hydrolases; HIV; Humans; Imino Furanoses; Mannitol; Pyrrolidines | 1993 |
25 other study(ies) available for 2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine and mannitol
| Article | Year |
|---|---|
Kupffer cell depletion in vivo results in clearance of large-sized IgA aggregates in rats by liver endothelial cells.
Topics: Alkaloids; Animals; Antibodies, Monoclonal; Clodronic Acid; Drug Carriers; Endothelium; Fluorescent Antibody Technique; Imino Furanoses; Immunoglobulin A; Kinetics; Kupffer Cells; Liposomes; Liver; Macrophages; Male; Mannitol; Pyrrolidines; Rats; Rats, Inbred Strains | 1991 |
Effect of glycosylation inhibitors on N-glycosylpeptides and on invasion of malignant mouse MO4 cells in vitro.
Topics: 1-Deoxynojirimycin; Alkaloids; Animals; Antiviral Agents; Cell Transformation, Viral; Chick Embryo; Glucosamine; Glucosylceramidase; Glycosylation; Imino Furanoses; Indolizines; Mannitol; Mannosidases; Mice; Mice, Inbred C3H; Neoplasm Invasiveness; Peptides; Polysaccharides; Pyrrolidines; Swainsonine; Tumor Cells, Cultured | 1990 |
Purification and characterization of a broad specificity beta-glucosidase from sheep liver.
Topics: Alkaloids; Animals; beta-Galactosidase; beta-Glucosidase; Glucosidases; Hydrogen-Ion Concentration; Imino Furanoses; Kinetics; Liver; Mannitol; Molecular Weight; Pyrrolidines; Sheep; Substrate Specificity; Thermodynamics | 1989 |
Castanospermine and other plant alkaloid inhibitors of glucosidase activity block the growth of HIV.
Topics: 1-Deoxynojirimycin; Alkaloids; Animals; beta-Glucosidase; Cattle; Glucosamine; Glucosidases; HIV; Humans; Imino Furanoses; In Vitro Techniques; Indolizines; Mannitol; Plants, Medicinal; Pyrrolidines | 1987 |
Inhibition of mammalian digestive disaccharidases by polyhydroxy alkaloids.
Topics: Alkaloids; Animals; Chemical Phenomena; Chemistry; Disaccharidases; Female; Imino Furanoses; In Vitro Techniques; Indolizines; Intestinal Mucosa; Intestines; Mannitol; Mice; Pyrrolidines; Swainsonine | 1986 |
GM1 gangliosidosis (type 1) in a cat.
Topics: Alkaloids; Animals; beta-Galactosidase; Carbohydrate Metabolism; Cat Diseases; Cats; Chromatography, Thin Layer; Gangliosidoses; Hydrogen-Ion Concentration; Imino Furanoses; Liver; Lysosomes; Male; Mannitol; Pyrrolidines; Tissue Distribution | 1986 |
Effects of manno-1-deoxynojirimycin and 2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine on N-linked oligosaccharide processing in intestinal epithelial cells.
Topics: 1-Deoxynojirimycin; Alkaloids; Animals; Chromatography, High Pressure Liquid; Epithelium; Glucosamine; Glycoproteins; Imino Furanoses; Intestinal Mucosa; Mannitol; Oligosaccharides; Protein Processing, Post-Translational; Pyrrolidines; Rats; Structure-Activity Relationship | 1985 |
The pyrrolidine alkaloid, 2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine, inhibits glycoprotein processing.
Topics: Alkaloids; Animals; Cattle; Cell Line; Cell Transformation, Viral; Galactose; Glycopeptides; Glycoproteins; Imino Furanoses; Influenza A virus; Kidney; Kinetics; Mannitol; Mannose; Plants; Protein Processing, Post-Translational; Pyrrolidines; Tritium | 1984 |
2-Hydroxymethyl-3,4-dihydroxy-6-methyl-pyrrolidine (6-deoxy-DMDP), an alkaloid beta-mannosidase inhibitor from seeds of Angylocalyx pynaertii.
Topics: Alkaloids; beta-Mannosidase; Cameroon; Fabaceae; Imino Furanoses; Magnetic Resonance Spectroscopy; Mannitol; Mannosidases; Mass Spectrometry; Molecular Conformation; Plants, Medicinal; Pyrrolidines; Seeds | 1993 |
Synthesis of azasugars as potent inhibitors of glycosidases.
Topics: 1-Deoxynojirimycin; Alkaloids; Animals; Cattle; Enzyme Inhibitors; Geobacillus stearothermophilus; Glycoside Hydrolase Inhibitors; Glycoside Hydrolases; Imino Furanoses; Isomerism; Kidney; Kinetics; Mannitol; Models, Chemical; Piperidines; Pyrrolidines | 1997 |
Immunogenic role of Kupffer cells in a rat model of acute liver allograft rejection.
Topics: Acute Disease; Alkaloids; Animals; Biopsy; Disease Models, Animal; Graft Rejection; Graft Survival; Imino Furanoses; Immunohistochemistry; Kupffer Cells; Liver Transplantation; Male; Mannitol; Pyrrolidines; Rats; Rats, Inbred ACI; Rats, Inbred Lew; Transplantation, Homologous | 1995 |
Novel, lipophilic derivatives of 2,5-dideoxy-2,5-imino-D-mannitol (DMDP) are powerful beta-glucosidase inhibitors.
Topics: Alkaloids; Amides; beta-Glucosidase; Coumarins; Fatty Acids; Imino Furanoses; Mannitol; Pyrrolidines; Rhizobium | 2001 |
Flexibility in the partial reduction of 2,5-disubstituted pyrroles: application to the synthesis of DMDP.
Topics: Alkaloids; Enzyme Inhibitors; Glycoside Hydrolases; Imino Furanoses; Isomerism; Mannitol; Molecular Structure; Pyrroles; Pyrrolidines | 2003 |
Probing the aglycon binding site of a beta-glucosidase: a collection of C-1-modified 2,5-dideoxy-2,5-imino-D-mannitol derivatives and their structure-activity relationships as competitive inhibitors.
Topics: beta-Glucosidase; Binding, Competitive; Enzyme Inhibitors; Imino Pyranoses; Mannitol; Molecular Structure; Rhizobium; Structure-Activity Relationship | 2004 |
Looking glass inhibitors: L-DMDP, a more potent and specific inhibitor of alpha-glucosidases than the enantiomeric natural product DMDP.
Topics: Alkaloids; Enzyme Inhibitors; Glucosyltransferases; Glycoside Hydrolase Inhibitors; Imino Furanoses; Mannitol; Molecular Structure; Pyrrolidines; Stereoisomerism; Sugar Acids | 2004 |
Synthesis and enzyme-specific activation of carbohydrate-geldanamycin conjugates with potent anticancer activity.
Topics: Alkaloids; Antineoplastic Agents; Benzoquinones; beta-Galactosidase; beta-Glucosidase; Cell Line, Tumor; Drug Screening Assays, Antitumor; Galactose; Humans; Imino Furanoses; Lactams, Macrocyclic; Lactose; Mannitol; Pyrrolidines; Quinones; Solubility; Structure-Activity Relationship; Water | 2005 |
Intramolecular benzyl protection delivery: a practical synthesis of DMDP and DGDP from D-fructose.
Topics: Cyclization; Ethers, Cyclic; Fructose; Glycoside Hydrolases; Imino Pyranoses; Mannitol; Models, Molecular; Molecular Structure; Sorbitol; Stereoisomerism | 2006 |
Fine tuning of beta-glucosidase inhibitory activity in the 2,5-dideoxy-2,5-imino-D-mannitol (DMDP) system.
Topics: beta-Glucosidase; Imino Pyranoses; Kinetics; Mannitol; Rhizobium; Structure-Activity Relationship | 2006 |
Palladium-catalyzed DYKAT of butadiene monoepoxide: enantioselective total synthesis of (+)-DMDP, (-)-bulgecinine, and (+)-broussonetine G.
Topics: Alkaloids; Alkylation; Catalysis; Epoxy Compounds; Glycopeptides; Imino Pyranoses; Mannitol; Nuclear Magnetic Resonance, Biomolecular; Palladium; Pyrrolidines; Stereoisomerism | 2006 |
Synthesis of (2R,5S)-dihydroxymethyl-(3R,4R)-dihydroxypyrrolidine (DGDP) via stereoselective amination using chlorosulfonyl isocyanate.
Topics: Alkaloids; Amination; Derris; Imino Furanoses; Isocyanates; Mannitol; Pyrrolidines; Stereoisomerism | 2007 |
Iminosugars from Baphia nitida Lodd.
Topics: Alkaloids; Animals; beta-Galactosidase; beta-Glucosidase; Candida; Carbohydrate Conformation; Cattle; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Fabaceae; Glycoside Hydrolase Inhibitors; Imino Furanoses; Imino Sugars; Intestines; Liver; Mannitol; Oryza; Plant Extracts; Plant Leaves; Rats; Stereoisomerism; Sucrase; Swine | 2008 |
Difluoromethylenated polyhydroxylated pyrrolidines: facile synthesis, crystal structure and biological evaluation.
Topics: alpha-Galactosidase; Crystallography, X-Ray; Enzyme Inhibitors; Fluorine; Hydrogen Bonding; Imino Pyranoses; Mannitol; Molecular Conformation; Pyrrolidines | 2009 |
Homonojirimycin, an alkaloid from dayflower inhibits the growth of influenza A virus in vitro.
Topics: 1-Deoxynojirimycin; Alkaloids; Animals; Antiviral Agents; Chromatography, High Pressure Liquid; Commelina; Dogs; Harmine; Imino Furanoses; Influenza A Virus, H1N1 Subtype; Madin Darby Canine Kidney Cells; Mannitol | 2013 |
γ-Aminoalcohol rearrangement applied to pentahydroxylated azepanes provides pyrrolidines epimeric to homoDMDP.
Topics: alpha-Glucosidases; Amino Alcohols; Azepines; Glycoside Hydrolase Inhibitors; Imino Pyranoses; Mannitol; Molecular Structure; Pyrrolidines; Structure-Activity Relationship | 2015 |
Pressurized liquid extraction of Aglaonema sp. iminosugars: Chemical composition, bioactivity, cell viability and thermal stability.
Topics: 1-Deoxynojirimycin; alpha-Glucosidases; Araceae; Caco-2 Cells; Carbohydrates; Cell Survival; Chemical Phenomena; Gas Chromatography-Mass Spectrometry; Glycoside Hydrolase Inhibitors; Humans; Imino Pyranoses; Mannitol; Molecular Weight; Plant Extracts; Pressure | 2016 |