2,5-dihydroxybenzoic acid and 2,3-dihydroxybenzoic acid

2,5-dihydroxybenzoic acid has been researched along with 2,3-dihydroxybenzoic acid in 109 studies

*2,3-dihydroxybenzoic acid: RN given refers to parent cpd [MeSH]

*2,3-dihydroxybenzoic acid: RN given refers to parent cpd [MeSH]

Research

Studies (109)

TimeframeStudies, this research(%)All Research%
pre-19904 (3.67)18.7374
1990's69 (63.30)18.2507
2000's21 (19.27)29.6817
2010's13 (11.93)24.3611
2020's2 (1.83)2.80

Authors

AuthorsStudies
Günzler, V; Hanauske-Abel, HM; Kivirikko, KI; Majamaa, K; Myllylä, R1
Fan, X; Lundell, D; Narula, S; Niu, X; Sun, J; Ting, P1
Chesson, A; Duthie, GG; Russell, WR; Scobbie, L1
Cohen, SM; Fullagar, JL; Jacobsen, JA; Miller, MT1
Ban, HS; Ishihara, K; Nabeyama, W; Nakamura, H; Wada, H1
Bredl, CR; Foerder, CA; Gmur, DJ; Schimpf, BA; Zager, RA1
Cavallo, G; Chessa, MA; Milazzotto, F; Natale, E; Pensa, V; Ricci, R; Tubaro, E; Tubaro, M1
De Mattia, G; Ferro-Luzzi, A; Ghiselli, A; Laurenti, O; Maiani, G1
Kahn, V; Schved, F1
Ariel, I; Chevion, M; Haskel, Y; Kitrossky, N; Udassin, R1
Ashraf, M; Onodera, T1
Birnbaum, LS; Blair, PC; Clark, AM; McMahon, TF; Stefanski, SA; Wilson, RE1
Halliwell, B; Ingelman-Sundberg, M; Kaur, H; Persson, JO; Terelius, Y1
Koppenol, WH; Maskos, Z; Rush, JD1
Davis, WB; Husney, RM; Mays, DC; Mohammed, BS; Mohammed, JR; Sagone, AL; She, ZW1
Floyd, RA; Henderson, R; Watson, JJ; Wong, PK1
Grootveld, M; Halliwell, B1
Alonso, O; Busto, R; Dietrich, WD; Ginsberg, MD; Globus, MY1
Bttner, T; Gerlach, M; Kuhn, W; Müller, T1
Kuo, JS; Lin, NN; Liu, L; Tsai, PJ; Yang, CS1
Busto, R; Ginsberg, MD; Globus, MY; Lin, B; Schnippering, H1
Coudray, C; Fatôme, M; Favier, A; Martin, S; Talla, M1
Ashraf, M; Cai, Q; Takemura, G1
Naoi, M; Ohkuwa, T; Sato, Y1
Király, I; Patthy, M; Sziráki, I1
Ito, T; Kondo, T; Sugita, Y1
Laxdal, VA; Prasad, K2
Hosokawa, H; Karashima, K; Obata, T; Soeda, T; Uchida, Y; Yamanaka, Y1
Almagro, UA; Dawson, CA; Effros, RM; Ghio, AJ; Hacker, AD; Morrisey, J; Schapira, RM1
Cross, M; Endre, ZH; Kadkhodaee, M; Towner, RA1
Giovanni, A; Hastings, TG; Liang, LP; Zigmond, MJ1
Hosokawa, H; Obata, T; Yamanaka, Y3
Okuyama, T; Tomita, M; Watanabe, H; Watanabe, S1
Berenshtein, E; Berman, ER; Chevion, M; Kitrossky, N; Ophir, A; Photiou, S; Rothman, Z1
Andrus, PK; Hall, ED; Zhang, JR1
Floyd, RA; Grammas, P; Liu, GJ; Wood, K1
Busto, R; Ginsberg, MD; Globus, MY; Martinez, E; Morimoto, T1
Gramsbergen, JB; Sloot, WN1
Boulu, RG; Callebert, J; Lancelot, E; Plotkine, M; Revaud, ML1
Kim, PM; Wells, PG1
Laxdal, VA; Prasad, K; Raney, BL; Yu, M2
Beal, MF; Matthews, RT2
Chevion, M; Drenger, B; Elami, A; Ginosar, Y; Glantz, L; Gozal, Y; Kitrossky, N; Navot, N1
Prasad, K1
Chevion, M; Grinberg, LN; Kitrossky, N; Rachmilewitz, EA1
Acworth, IN; Maher, TJ; McCabe, DR1
Obata, T; Tamura, M; Yamanaka, Y2
Aghabeigi, B; Haque, M; Harris, M; Henderson, B; Hodges, SJ; Wasil, M1
Obata, T; Yamanaka, Y2
Obata, T1
Chevion, M; Kitrossky, N; Nagler, RM1
Huang, NC; Quast, MJ; Wei, J1
Ferger, B; Kuschinsky, K; Seyfried, C; van Amsterdam, C1
Lee, KT; Liu, TZ; Tsai, LY1
Bullock, R; Di, X; Doppenberg, EM; Rice, MR; Woodward, JJ; Young, HF1
Hatori, K; Kondo, T; Mizuno, Y; Shimada, H; Sugita, Y1
Blacklock, C; Campbell, G; Lawrence, JR; Paterson, JR; Wiles, D1
Cann-Moisan, C; Caroff, J; Duine, JM; Floch, F; Mialon, P1
Hiramatsu, M; Komatsu, M1
Acworth, IN; Beal, MF; Bogdanov, MB; McCabe, DR1
Bardou, L; Berthou, F; Bodenez, P; Dreano, Y; Dupont, I; Guirriec, C; Lucas, D; Stephan, N1
Natoli, S; Violi, F1
Colado, MI; Esteban, B; Granados, R; Green, AR; O'Shea, E1
Blandini, F; Desideri, S; Godi, L; Mancini, F; Martignoni, E; Nappi, G; Pacchetti, C1
Kita, T; Kubo, K; Nakashima, T; Takahashi, M; Wagner, GC1
Floyd, RA; He, QP; Li, PA; Liu, GJ; Siesjö, BK1
Jantze, H; Rauca, C; Zerbe, R1
Bani, M; Brogin, G; Hengstler, JG; Oesch, F; Strolin-Benedetti, M1
Bartsch, H; Owen, RW; Spiegelhalder, B1
Amiridze, N; Brown, OR; Dang, Y1
Gronow, G; Mályusz, M; Moussavian, M1
Camp, DM; LeWitt, PA; Loeffler, DA1
Exner, M; Gmeiner, BM; Held, I; Hermann, M; Hofbauer, R; Kapiotis, S; Seelos, C; Speiser, W1
Hara, A; Kusakari, J; Senarita, M; Serizawa, F; Tabuchi, K1
Ferger, B; Teismann, P1
Mohanakumar, KP; Muralikrishnan, D; Thomas, B1
Brus, R; Kostrzewa, JP; Kostrzewa, RM1
Griffiths, RD; Jackson, MJ; McArdle, A; Pattwell, D1
Banerjee, R; Mohanakumar, KP; Sairam, K; Saravanan, KS1
Horiguchi, T; Inamasu, J; Kawase, T; Ogino, M; Shimizu, K; Suga, S1
Alessandri, B; Bullock, MR; Chao, DL; Kwon, TH; Malloy, K; Sun, D1
Adibhatla, RM; Dempsey, RJ; Hatcher, JF1
Keilhoff, G; Krug, M; Rauca, C; Wiswedel, I; Zerbe, R1
Berenshtein, E; Chevion, M; Drenger, B; Gozal, Y; Raphael, J; Rivo, J1
Dahchour, A; De Witte, P; Lallemand, F; Ward, RJ1
Burger, R; Gruber, M; Lindner, R; Wiesner, G1
Arai, M; Bao, N; Chen, XH; Fujiwara, H; Kobayashi, H; Maruyama, R; Minatoguchi, S; Misao, Y; Onogi, H; Takemura, G; Uno, Y; Yamaki, T; Yasuda, S1
Endo, T; Hara, S; Kuriiwa, F; Mizukami, H1
Bao, N; Fujiwara, H; Fujiwara, T; Iwasa, M; Kawamura, I; Kobayashi, H; Minatoguchi, S; Nishigaki, K; Sumi, S; Takemura, G; Yamada, Y; Yasuda, S; Zhang, Z1
Bosco, GM; Camporesi, EM; Chen, C; Xie, Y; Yang, ZJ1
Gołembiowska, K; Kuter, K; Nowak, P; Ossowska, K1
Lares-Asseff, I; Lazalde-Ramos, BP; Sosa-Macías, M; Villanueva-Fierro, I; Yahuaca-Mendoza, P; Zamora-Perez, A1
Gan, SS; Halitschke, R; Liu, CJ; Yin, C; Zhang, K1
Aldalati, AM; AlTinawi, BM; Azouz, HJ; Ganguly, P; Juurlink, BH1
Atwell, S; Chapple, C; Dilkes, BP; Li, X; Mo, H; Svedin, E1
Goyal, RN; Gupta, P; Purushotham, M1
Chen, HY; Li, X1
Berger, T; Botta, A; Huang, X; Liu, Y; Mak, TW; Perry, CGR; Ramos, SV; Song, E; Sung, HK; Sweeney, G; Turnbull, PC; Wheeler, MB; Wilson, DJ1
Chen, L; Hou, BK; Huang, XX; Li, YJ; Liu, Q; Zhu, GQ1
Dereziński, P; Muszalska-Kolos, I; Plewa, S; Wróblewska, KB1
Bhat, GJ; Kumar, DR; Patel, J; Sankaranarayanan, R1
Gupta, P; Rohatgi, A1

Reviews

2 review(s) available for 2,5-dihydroxybenzoic acid and 2,3-dihydroxybenzoic acid

ArticleYear
Hydroxybenzoic acid isomers and the cardiovascular system.
    Nutrition journal, 2014, Jun-19, Volume: 13

    Topics: Aspirin; Benzyl Alcohols; Cardiovascular System; Diet; Gentisates; Glucosides; Humans; Hydroxybenzoates; Isothiocyanates; Oxidative Stress; Phytochemicals; Sulfoxides

2014
Do Aspirin and Flavonoids Prevent Cancer through a Common Mechanism Involving Hydroxybenzoic Acids?-The Metabolite Hypothesis.
    Molecules (Basel, Switzerland), 2020, May-10, Volume: 25, Issue:9

    Topics: Animals; Aspirin; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Flavonoids; Fruit; Gallic Acid; Gentisates; Humans; Hydroxybenzoates; MAP Kinase Signaling System

2020

Trials

2 trial(s) available for 2,5-dihydroxybenzoic acid and 2,3-dihydroxybenzoic acid

ArticleYear
Peripheral markers of oxidative stress in Parkinson's disease. The role of L-DOPA.
    Free radical biology & medicine, 1999, Volume: 27, Issue:3-4

    Topics: Antiparkinson Agents; Biomarkers; Blood Platelets; Dopamine; Female; Gentisates; Humans; Hydroxybenzoates; Hydroxyl Radical; In Vitro Techniques; Levodopa; Linear Models; Male; Middle Aged; Oxidative Stress; Parkinson Disease; Sodium Salicylate; Superoxide Dismutase; Tyrosine

1999
Graphene modified glassy carbon sensor for the determination of aspirin metabolites in human biological samples.
    Talanta, 2015, Oct-01, Volume: 143

    Topics: Adult; Aspirin; Carbon; Dielectric Spectroscopy; Electrodes; Female; Gentisates; Humans; Hydroxybenzoates; Limit of Detection; Male; Microscopy, Electron, Scanning; Young Adult

2015

Other Studies

105 other study(ies) available for 2,5-dihydroxybenzoic acid and 2,3-dihydroxybenzoic acid

ArticleYear
Partial identity of the 2-oxoglutarate and ascorbate binding sites of prolyl 4-hydroxylase.
    The Journal of biological chemistry, 1986, Jun-15, Volume: 261, Issue:17

    Topics: Animals; Ascorbic Acid; Binding Sites; Chick Embryo; Ketoglutaric Acids; Kinetics; Phenols; Procollagen-Proline Dioxygenase; Protein Binding; Structure-Activity Relationship; Substrate Specificity

1986
Inhibition of fucosyltransferase VII by gallic acid and its derivatives.
    Archives of biochemistry and biophysics, 2004, May-01, Volume: 425, Issue:1

    Topics: Catechin; Ellagic Acid; Enzymes; Fucosyltransferases; Gallic Acid; Humans; Manganese

2004
Inhibition of 15-lipoxygenase-catalysed oxygenation of arachidonic acid by substituted benzoic acids.
    Bioorganic & medicinal chemistry, 2008, Apr-15, Volume: 16, Issue:8

    Topics: Arachidonate 15-Lipoxygenase; Arachidonic Acid; Benzoates; Catalysis; Colon; Enzyme Inhibitors; Humans; Lipoxygenase Inhibitors; Oxidation-Reduction; Oxygen; Structure-Activity Relationship

2008
Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
    Journal of medicinal chemistry, 2011, Jan-27, Volume: 54, Issue:2

    Topics: Antigens, Bacterial; Bacterial Toxins; Chelating Agents; Copper; Drug Design; Humans; Hydroxyquinolines; Iron; Ligands; Lipoxygenase Inhibitors; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Monophenol Monooxygenase; Nitric Oxide Synthase Type II; Recombinant Proteins; Small Molecule Libraries; Structure-Activity Relationship; Sulfonamides; Zinc

2011
Discovery of (2-aminophenyl)methanol as a new molecular chaperone that rescues the localization of P123S mutant pendrin stably expressed in HEK293 cells.
    Bioorganic & medicinal chemistry, 2017, 05-01, Volume: 25, Issue:9

    Topics: Amino Acid Substitution; Benzyl Alcohols; Cell Membrane; Goiter, Nodular; Hearing Loss, Sensorineural; HEK293 Cells; Humans; Membrane Transport Proteins; Microscopy, Fluorescence; Salicylates; Sulfate Transporters

2017
Evidence against increased hydroxyl radical production during oxygen deprivation-reoxygenation proximal tubular injury.
    Journal of the American Society of Nephrology : JASN, 1992, Volume: 2, Issue:11

    Topics: Acute Kidney Injury; Animals; Free Radicals; Gentisates; Hydroxides; Hydroxybenzoates; Hydroxyl Radical; Hypoxia; In Vitro Techniques; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; Male; Rats; Rats, Inbred Strains; Reperfusion Injury

1992
Demonstration of the formation of hydroxyl radicals in acute myocardial infarction in man using salicylate as probe.
    Cardiology, 1992, Volume: 80, Issue:3-4

    Topics: Aspirin; Chromatography, High Pressure Liquid; Female; Free Radicals; Gentisates; Humans; Hydroxides; Hydroxybenzoates; Hydroxyl Radical; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Infarction; Tissue Plasminogen Activator

1992
Salicylate hydroxylation as an early marker of in vivo oxidative stress in diabetic patients.
    Free radical biology & medicine, 1992, Volume: 13, Issue:6

    Topics: Adult; Aspirin; Diabetes Mellitus, Type 1; Female; Gentisates; Humans; Hydroxybenzoates; Hydroxylation; Male; Oxidation-Reduction; Reactive Oxygen Species; Salicylates; Thiobarbiturates

1992
Effect of different isomers of dihydroxybenzoic acids (DBA) on the rate of DL-dopa oxidation by mushroom tyrosinase.
    Pigment cell research, 1992, Volume: 5, Issue:2

    Topics: Basidiomycota; Dihydroxyphenylalanine; Drug Synergism; Gentisates; Hydroxybenzoates; Isomerism; Kinetics; Levodopa; Models, Chemical; Monophenol Monooxygenase; Oxidation-Reduction; Plant Proteins; Structure-Activity Relationship

1992
Salicylate as an in vivo free radical trap: studies on ischemic insult to the rat intestine.
    Free radical biology & medicine, 1991, Volume: 10, Issue:1

    Topics: Animals; Disease Models, Animal; Free Radicals; Gentisates; Hydroxides; Hydroxybenzoates; Hydroxyl Radical; Intestines; Male; Rats; Reperfusion Injury; Salicylates; Salicylic Acid

1991
Detection of hydroxyl radicals in the post-ischemic reperfused heart using salicylate as a trapping agent.
    Journal of molecular and cellular cardiology, 1991, Volume: 23, Issue:3

    Topics: Animals; Chromatography, High Pressure Liquid; Gentisates; Hydroxides; Hydroxybenzoates; Hydroxyl Radical; Hydroxylation; In Vitro Techniques; Ischemia; Male; Myocardial Reperfusion; Oxygen; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid

1991
Comparative acute nephrotoxicity of salicylic acid, 2,3-dihydroxybenzoic acid, and 2,5-dihydroxybenzoic acid in young and middle aged Fischer 344 rats.
    Toxicology, 1991, Mar-11, Volume: 66, Issue:3

    Topics: Acetylglucosaminidase; Administration, Oral; Aging; Alanine Transaminase; Alkaline Phosphatase; Animals; Gentisates; Glycosuria; Hydroxybenzoates; Kidney; Male; Rats; Rats, Inbred F344; Salicylates; Salicylic Acid

1991
Hydroxylation of salicylate by microsomal fractions and cytochrome P-450. Lack of production of 2,3-dihydroxybenzoate unless hydroxyl radical formation is permitted.
    The Biochemical journal, 1991, Jun-15, Volume: 276 ( Pt 3)

    Topics: Animals; Cytochrome P-450 Enzyme System; Free Radical Scavengers; Gentisates; Hydroxides; Hydroxybenzoates; Hydroxylation; Lipid Bilayers; Microsomes, Liver; Rabbits; Rats; Salicylates; Salicylic Acid; Substrate Specificity

1991
The hydroxylation of the salicylate anion by a Fenton reaction and T-radiolysis: a consideration of the respective mechanisms.
    Free radical biology & medicine, 1990, Volume: 8, Issue:2

    Topics: Azides; Chemical Phenomena; Chemistry; Edetic Acid; Free Radicals; Gamma Rays; Gentisates; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydroxybenzoates; Hydroxylation; Iron; Kinetics; Oxidation-Reduction; Salicylates

1990
Hydroxylation of salicylate by activated neutrophils.
    Biochemical pharmacology, 1989, Nov-15, Volume: 38, Issue:22

    Topics: Amitrole; Azides; Chromatography, High Pressure Liquid; Cyanides; Gentisates; Glutathione; Humans; Hydroxybenzoates; Hydroxylation; Neutrophils; Peroxidase; Salicylates; Salicylic Acid; Superoxide Dismutase; Tetradecanoylphorbol Acetate

1989
Use of salicylate with high pressure liquid chromatography and electrochemical detection (LCED) as a sensitive measure of hydroxyl free radicals in adriamycin treated rats.
    Journal of free radicals in biology & medicine, 1986, Volume: 2, Issue:1

    Topics: Animals; Chromatography, High Pressure Liquid; Doxorubicin; Electrochemistry; Female; Free Radicals; Gentisates; Heart; Hydroxides; Hydroxybenzoates; Hydroxyl Radical; Rats; Rats, Inbred F344; Salicylates; Salicylic Acid

1986
Aromatic hydroxylation as a potential measure of hydroxyl-radical formation in vivo. Identification of hydroxylated derivatives of salicylate in human body fluids.
    The Biochemical journal, 1986, Jul-15, Volume: 237, Issue:2

    Topics: Adult; Chromatography, High Pressure Liquid; Electrochemistry; Free Radicals; Gentisates; Hippurates; Humans; Hydroxides; Hydroxybenzoates; Hydroxyl Radical; Hydroxylation; Male; Salicylates; Salicylic Acid; Synovial Fluid

1986
Glutamate release and free radical production following brain injury: effects of posttraumatic hypothermia.
    Journal of neurochemistry, 1995, Volume: 65, Issue:4

    Topics: Animals; Brain Injuries; Free Radicals; Gentisates; Glutamic Acid; Hydroxybenzoates; Hydroxyl Radical; Hypothermia; Male; Microdialysis; Rats; Rats, Sprague-Dawley

1995
Aspirin as a free radical scavenger: consequences for therapy of cerebrovascular ischemia.
    Stroke, 1995, Volume: 26, Issue:10

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Cerebrovascular Disorders; Cyclooxygenase Inhibitors; Female; Free Radical Scavengers; Gentisates; Humans; Hydroxybenzoates; Male; Neuroprotective Agents; Platelet Aggregation Inhibitors; Salicylates; Salicylic Acid

1995
Elevated extracellular glutamate levels increased the formation of hydroxyl radical in the striatum of anesthetized rat.
    Free radical biology & medicine, 1995, Volume: 19, Issue:4

    Topics: Anesthesia; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Extracellular Space; Gentisates; Glutamic Acid; Hydroxybenzoates; Hydroxyl Radical; Hydroxylation; Kinetics; Male; Rats; Rats, Sprague-Dawley; Salicylates; Salicylic Acid

1995
Detection of free radical activity during transient global ischemia and recirculation: effects of intraischemic brain temperature modulation.
    Journal of neurochemistry, 1995, Volume: 65, Issue:3

    Topics: Animals; Body Temperature; Corpus Striatum; Dialysis; Free Radicals; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Ischemic Attack, Transient; Kinetics; Male; Rats; Rats, Wistar; Reperfusion; Salicylates; Salicylic Acid

1995
High-performance liquid chromatography-electrochemical determination of salicylate hydroxylation products as an in vivo marker of oxidative stress.
    Analytical biochemistry, 1995, May-01, Volume: 227, Issue:1

    Topics: Adult; Aspirin; Calibration; Chromatography, High Pressure Liquid; Female; Free Radical Scavengers; Gentisates; Humans; Hydroxybenzoates; Hydroxyl Radical; Male; Oxidative Stress; Reproducibility of Results; Salicylates; Salicylic Acid; Thiobarbituric Acid Reactive Substances

1995
Antioxidative properties of histidine and its effect on myocardial injury during ischemia/reperfusion in isolated rat heart.
    Journal of cardiovascular pharmacology, 1995, Volume: 25, Issue:1

    Topics: Adenosine Triphosphate; Animals; Ascorbic Acid; Chromatography, High Pressure Liquid; Disease Models, Animal; Free Radical Scavengers; Gentisates; Glutaral; Heart Ventricles; Histidine; Hydrogen Peroxide; Hydroxybenzoates; Hydroxyl Radical; L-Lactate Dehydrogenase; Male; Myocardial Reperfusion Injury; Phosphates; Phosphocreatine; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxides; Tissue Embedding; Ventricular Function, Left

1995
Hydroxyl radical formation in diabetic rats induced by streptozotocin.
    Life sciences, 1995, Volume: 56, Issue:21

    Topics: Animals; Blood Glucose; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Male; Rats; Rats, Wistar; Streptozocin

1995
Separation of dihydroxybenzoates, indicators of in-vivo hydroxyl free radical formation, in the presence of transmitter amines and some metabolites in rodent brain, using high-performance liquid chromatography with electrochemical detection.
    Journal of chromatography. B, Biomedical applications, 1995, Feb-03, Volume: 664, Issue:1

    Topics: Animals; Biogenic Amines; Chromatography, High Pressure Liquid; Corpus Striatum; Electrochemistry; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Mice; Mice, Inbred C57BL

1995
Bromocriptine scavenges methamphetamine-induced hydroxyl radicals and attenuates dopamine depletion in mouse striatum.
    Annals of the New York Academy of Sciences, 1994, Nov-17, Volume: 738

    Topics: Animals; Bromocriptine; Corpus Striatum; Dopamine; Free Radical Scavengers; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Iron Chelating Agents; Kinetics; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Salicylates; Salicylic Acid

1994
Evaluation of hydroxyl radical-scavenging property of purpurogallin using high pressure liquid chromatography.
    Molecular and cellular biochemistry, 1994, Jun-29, Volume: 135, Issue:2

    Topics: Antioxidants; Benzocycloheptenes; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Food Preservatives; Free Radical Scavengers; Gentisates; Hydrogen Peroxide; Hydroxybenzoates; Hydroxyl Radical; Hydroxylation; Photolysis; Salicylates; Salicylic Acid; Ultraviolet Rays

1994
Hydroxyl radical-scavenging property of indomethacin.
    Molecular and cellular biochemistry, 1994, Jul-27, Volume: 136, Issue:2

    Topics: Chromatography, High Pressure Liquid; Free Radical Scavengers; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Indomethacin; Photolysis; Sensitivity and Specificity; Ultraviolet Rays

1994
Myocardial microdialysis of salicylic acid to detect hydroxyl radical generation during ischemia.
    Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 1995, Volume: 110, Issue:1

    Topics: Animals; Chromatography, High Pressure Liquid; Dogs; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Microchemistry; Microdialysis; Myocardial Contraction; Myocardial Ischemia; Salicylates; Salicylic Acid

1995
Hydroxyl radical production and lung injury in the rat following silica or titanium dioxide instillation in vivo.
    American journal of respiratory cell and molecular biology, 1995, Volume: 12, Issue:2

    Topics: Animals; Bronchoalveolar Lavage Fluid; Dust; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Hydroxylation; Lung; Lung Injury; Organ Size; Pulmonary Fibrosis; Rats; Rats, Sprague-Dawley; Salicylates; Salicylic Acid; Silicon Dioxide; Silicosis; Titanium

1995
Hydroxyl radical generation following ischaemia-reperfusion in cell-free perfused rat kidney.
    Biochimica et biophysica acta, 1995, Feb-23, Volume: 1243, Issue:2

    Topics: Animals; Chromatography, High Pressure Liquid; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Hypoxia; Ischemia; Kidney; Male; Rats; Rats, Wistar; Reperfusion; Salicylates

1995
Estimating hydroxyl radical content in rat brain using systemic and intraventricular salicylate: impact of methamphetamine.
    Journal of neurochemistry, 1995, Volume: 64, Issue:4

    Topics: Animals; Biogenic Monoamines; Brain; Corpus Striatum; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Hydroxylation; Injections, Intraperitoneal; Injections, Intraventricular; Methamphetamine; Rats; Rats, Sprague-Dawley; Salicylates; Salicylic Acid

1995
Effect of ferrous iron on the generation of hydroxyl free radicals by liver microdialysis perfusion of salicylate.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1993, Volume: 106, Issue:3

    Topics: Animals; Extracellular Space; Ferrous Compounds; Free Radicals; Gentisates; Hydroxybenzoates; Hydroxylation; Iron Chelating Agents; Liver; Metals; Microdialysis; Perfusion; Rats; Rats, Wistar; Salicylates; Salicylic Acid

1993
In vivo monitoring of norepinephrine and hydroxyl free radical generation by ferrous iron in the myocardium with a microdialysis technique.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1993, Volume: 106, Issue:3

    Topics: Animals; Chromatography, High Pressure Liquid; Electrochemistry; Ferrous Compounds; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Iron Chelating Agents; Male; Microdialysis; Myocardium; Norepinephrine; Perfusion; Rats; Rats, Wistar

1993
Quantitation of the hydroxyl radical adducts of salicylic acid by micellar electrokinetic capillary chromatography: oxidizing species formed by a Fenton reaction.
    Archives of toxicology, 1994, Volume: 68, Issue:7

    Topics: Chromatography; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Iron; Micelles; Salicylates; Salicylic Acid

1994
In vivo monitoring of norepinephrine and .OH generation on myocardial ischemic injury by dialysis technique.
    The American journal of physiology, 1994, Volume: 266, Issue:3 Pt 2

    Topics: Animals; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Microdialysis; Myocardial Ischemia; Myocardial Reperfusion; Norepinephrine; Rats; Rats, Wistar

1994
Hydroxyl radical generation in the cat retina during reperfusion following ischemia.
    Experimental eye research, 1993, Volume: 57, Issue:3

    Topics: Animals; Cats; Eye Proteins; Free Radicals; Gentisates; Hydroxybenzoates; Reactive Oxygen Species; Reperfusion Injury; Retina; Sodium Salicylate; Time Factors

1993
Age-related regional changes in hydroxyl radical stress and antioxidants in gerbil brain.
    Journal of neurochemistry, 1993, Volume: 61, Issue:5

    Topics: Aging; Animals; Antioxidants; Ascorbic Acid; Body Water; Brain; Cerebral Cortex; Corpus Striatum; Gentisates; Gerbillinae; Glutathione; Hippocampus; Hydroxybenzoates; Hydroxyl Radical; Male; Neurons; Organ Specificity; Oxidation-Reduction; Pyramidal Tracts; Vitamin E

1993
Anoxia/reoxygenation induces hydroxyl free radical formation in brain microvessels.
    Free radical biology & medicine, 1993, Volume: 14, Issue:5

    Topics: Animals; Brain; Catalase; Chromatography, High Pressure Liquid; Free Radicals; Gentisates; Hydroxides; Hydroxybenzoates; Hydroxyl Radical; Male; Microcirculation; Oxygen; Rats; Rats, Sprague-Dawley; Salicylates; Salicylic Acid; Superoxides

1993
Simultaneous measurement of salicylate hydroxylation and glutamate release in the penumbral cortex following transient middle cerebral artery occlusion in rats.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1996, Volume: 16, Issue:1

    Topics: Acid-Base Imbalance; Analysis of Variance; Animals; Cerebral Cortex; Cerebrovascular Circulation; Chromatography, High Pressure Liquid; Free Radical Scavengers; Gentisates; Glutamic Acid; Hydroxybenzoates; Hydroxylation; Iron Chelating Agents; Ischemic Attack, Transient; Laser-Doppler Flowmetry; Male; Rats; Rats, Sprague-Dawley; Regression Analysis; Salicylates; Salicylic Acid

1996
Detection of salicylate and its hydroxylated adducts 2,3- and 2,5-dihydroxybenzoic acids as possible indices for in vivo hydroxyl radical formation in combination with catechol- and indoleamines and their metabolites in cerebrospinal fluid and brain tissu
    Journal of neuroscience methods, 1995, Volume: 60, Issue:1-2

    Topics: Animals; Biogenic Amines; Catechols; Chromatography, High Pressure Liquid; Electrochemistry; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Indoles; Magnesium; Male; Manganese Poisoning; Neostriatum; Rats; Rats, Wistar; Reference Standards; Salicylates; Salicylic Acid; Spectrophotometry, Ultraviolet

1995
Detection of hydroxyl radicals in rat striatum during transient focal cerebral ischemia: possible implication in tissue damage.
    Neuroscience letters, 1995, Sep-08, Volume: 197, Issue:2

    Topics: Analysis of Variance; Animals; Cerebral Infarction; Corpus Striatum; Disease Models, Animal; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Ischemic Attack, Transient; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury

1995
Phenytoin-initiated hydroxyl radical formation: characterization by enhanced salicylate hydroxylation.
    Molecular pharmacology, 1996, Volume: 49, Issue:1

    Topics: Animals; Biotransformation; Female; Gentisates; Glucuronidase; Hydrolysis; Hydroxybenzoates; Hydroxyl Radical; Hydroxylation; Mice; Paraquat; Phenytoin; Salicylates; Salicylic Acid; Teratogens

1996
Antioxidant activity of allicin, an active principle in garlic.
    Molecular and cellular biochemistry, 1995, Jul-19, Volume: 148, Issue:2

    Topics: Animals; Antioxidants; Chromatography, High Pressure Liquid; Disulfides; Free Radical Scavengers; Garlic; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Lipid Peroxidation; Liver; Malondialdehyde; Plants, Medicinal; Rabbits; Reactive Oxygen Species; Salicylates; Salicylic Acid; Sulfinic Acids; Tablets

1995
Evaluation of hydroxyl radical-scavenging property of garlic.
    Molecular and cellular biochemistry, 1996, Jan-12, Volume: 154, Issue:1

    Topics: Animals; Chromatography, High Pressure Liquid; Free Radical Scavengers; Garlic; Gentisates; Hot Temperature; Hydroxybenzoates; Hydroxyl Radical; Lipid Peroxidation; Liver; Malondialdehyde; Photolysis; Plant Extracts; Plants, Medicinal; Rabbits; Salicylates; Salicylic Acid; Sensitivity and Specificity; Superoxides; Ultraviolet Rays

1996
Increased 3-nitrotyrosine in brains of Apo E-deficient mice.
    Brain research, 1996, Apr-29, Volume: 718, Issue:1-2

    Topics: Animals; Apolipoproteins E; Biomarkers; Brain Chemistry; Free Radical Scavengers; Free Radicals; Gentisates; Hydroxybenzoates; Mice; Mice, Inbred C57BL; Oxidative Stress; Salicylates; Salicylic Acid; Tyrosine

1996
Halothane prevents postischemic production of hydroxyl radicals in the canine heart.
    Anesthesiology, 1997, Volume: 86, Issue:2

    Topics: Anesthetics, Inhalation; Animals; Dogs; Gentisates; Halothane; Hydroxybenzoates; Hydroxyl Radical; Myocardial Ischemia; Myocardium

1997
Hydroxyl radical-scavenging property of secoisolariciresinol diglucoside (SDG) isolated from flax-seed.
    Molecular and cellular biochemistry, 1997, Volume: 168, Issue:1-2

    Topics: Butylene Glycols; Chromatography, High Pressure Liquid; Free Radical Scavengers; Gentisates; Glucosides; Hydroxybenzoates; Hydroxyl Radical; Lipid Peroxidation; Seeds; Sensitivity and Specificity; Ultraviolet Rays

1997
Hydroxyl radical generation in beta-thalassemic red blood cells.
    Free radical biology & medicine, 1995, Volume: 18, Issue:3

    Topics: beta-Thalassemia; Catechols; Erythrocytes; Gentisates; Humans; Hydroxybenzoates; Hydroxyl Radical; In Vitro Techniques; Iron; Oxidation-Reduction; Salicylates; Salicylic Acid

1995
Improved method for the estimation of hydroxyl free radical levels in vivo based on liquid chromatography with electrochemical detection.
    Journal of chromatography. B, Biomedical sciences and applications, 1997, Mar-28, Volume: 691, Issue:1

    Topics: Animals; Benzoates; Cerebral Cortex; Chromatography, High Pressure Liquid; Corpus Striatum; Dizocilpine Maleate; Drug Stability; Excitatory Amino Acid Antagonists; Free Radicals; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Hydroxylation; Kidney; Liver; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Salicylates; Sensitivity and Specificity

1997
Comparative study of .OH generation in brain, heart and liver using microdialysis.
    Journal of physiology, Paris, 1997, Volume: 91, Issue:1

    Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Liver; Male; Microdialysis; Myocardium; Rats; Rats, Wistar; Salicylates

1997
The role of oxygen free radicals in idiopathic facial pain.
    The British journal of oral & maxillofacial surgery, 1997, Volume: 35, Issue:3

    Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Chronic Disease; Cytokines; Dinoprostone; Facial Pain; Female; Free Radicals; Gentisates; Humans; Hydroxybenzoates; Hydroxyeicosatetraenoic Acids; Iron Chelating Agents; Leukotriene B4; Male; Mastication; Middle Aged; Reactive Oxygen Species; Synovial Fluid; Temporomandibular Joint; Temporomandibular Joint Dysfunction Syndrome; Thiobarbituric Acid Reactive Substances

1997
Cardiac microdialysis of salicylic acid .OH generation on nonenzymatic oxidation by norepinephrine in rat heart.
    Biochemical pharmacology, 1997, May-09, Volume: 53, Issue:9

    Topics: Animals; Dose-Response Relationship, Drug; Gentisates; Hydroxybenzoates; Hydroxyl Radical; In Vitro Techniques; Male; Microdialysis; Monoamine Oxidase Inhibitors; Myocardium; Norepinephrine; Pargyline; Rats; Rats, Wistar; Salicylates; Salicylic Acid

1997
Use of microdialysis for in-vivo monitoring of hydroxyl free-radical generation in the rat.
    The Journal of pharmacy and pharmacology, 1997, Volume: 49, Issue:7

    Topics: Animals; Brain; Chromatography, High Pressure Liquid; Electric Stimulation; Gentisates; Hydrogen Peroxide; Hydroxybenzoates; Hydroxyl Radical; Iron; Ischemia; Jejunum; Liver; Male; Microdialysis; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Myocardium; Norepinephrine; Pargyline; Rats; Rats, Wistar; Reperfusion Injury; Salicylates; Superoxides; Sympathetic Nervous System

1997
Coenzyme Q10 in the central nervous system and its potential usefulness in the treatment of neurodegenerative diseases.
    Molecular aspects of medicine, 1997, Volume: 18 Suppl

    Topics: Administration, Oral; Animals; Antioxidants; Brain; Coenzymes; Corpus Striatum; Electron Transport; Gentisates; Humans; Hydroxybenzoates; Injections; Liver; Male; Malonates; Neurodegenerative Diseases; Neuroprotective Agents; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Sprague-Dawley; Salicylates; Salicylic Acid; Ubiquinone

1997
Antioxidant activity of rat parotid saliva.
    Archives of otolaryngology--head & neck surgery, 1997, Volume: 123, Issue:9

    Topics: Ancitabine; Animals; Antimetabolites, Antineoplastic; Antioxidants; Ascorbic Acid; Catechols; Copper; Free Radicals; Gentisates; Hydroxybenzoates; Iron; Iron Chelating Agents; Male; Manganese; Metals; Oxidation-Reduction; Parasympathomimetics; Parotid Gland; Pilocarpine; Protein Binding; Rats; Rats, Wistar; Salicylates; Saliva; Salivary Proteins and Peptides; Wound Healing

1997
Hydroxyl radical formation in hyperglycemic rats during middle cerebral artery occlusion/reperfusion.
    Free radical biology & medicine, 1997, Volume: 23, Issue:7

    Topics: Animals; Arterial Occlusive Diseases; Cerebral Arteries; Cerebral Infarction; Enzyme Inhibitors; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Hyperglycemia; In Vitro Techniques; Magnetic Resonance Imaging; Male; Microdialysis; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Reperfusion Injury

1997
Evidence of hydroxyl free radical generation by calcium overload in rat myocardium.
    The Journal of pharmacy and pharmacology, 1997, Volume: 49, Issue:8

    Topics: Animals; Calcium; Cardiotonic Agents; Dose-Response Relationship, Drug; Gentisates; Heart; Heart Ventricles; Hydroxybenzoates; Hydroxyl Radical; Hydroxylation; Male; Microdialysis; Mixed Function Oxygenases; Myocardium; Ouabain; Rats; Rats, Wistar; Salicylates; Salicylic Acid

1997
Effects of alpha-phenyl-tert-butylnitrone and selegiline on hydroxyl free radicals in rat striatum produced by local application of glutamate.
    Journal of neurochemistry, 1998, Volume: 70, Issue:1

    Topics: Administration, Topical; Animals; Corpus Striatum; Cyclic N-Oxides; Free Radical Scavengers; Gentisates; Glutamic Acid; Hydroxybenzoates; Hydroxyl Radical; Male; Microdialysis; Monoamine Oxidase Inhibitors; Nitrogen Oxides; Rats; Rats, Wistar; Selegiline

1998
Evidence for accelerated generation of hydroxyl radicals in experimental obstructive jaundice of rats.
    Free radical biology & medicine, 1998, Mar-15, Volume: 24, Issue:5

    Topics: Animals; Cholestasis, Intrahepatic; Common Bile Duct Diseases; Constriction; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Leukocyte Count; Male; Rats; Rats, Wistar

1998
Increased free radical production due to subdural hematoma in the rat: effect of increased inspired oxygen fraction.
    Journal of neurotrauma, 1998, Volume: 15, Issue:5

    Topics: Acute Disease; Animals; Blood Gas Analysis; Free Radicals; Gentisates; Hematoma, Subdural; Hydroxybenzoates; Male; Oxygen; Oxyhemoglobins; Rats; Rats, Sprague-Dawley; Time Factors

1998
Talipexole protects dopaminergic neurons from methamphetamine toxicity in C57BL/6N mouse.
    Neuroscience letters, 1998, May-15, Volume: 247, Issue:2-3

    Topics: Animals; Azepines; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Dopamine; Dopamine Agonists; Enzyme Induction; Free Radical Scavengers; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Parkinson Disease, Secondary; Receptors, Dopamine D2; Salicylates; Salicylic Acid; Tyrosine 3-Monooxygenase

1998
The identification of salicylates as normal constituents of serum: a link between diet and health?
    Journal of clinical pathology, 1998, Volume: 51, Issue:7

    Topics: Chromatography, High Pressure Liquid; Diet; Gas Chromatography-Mass Spectrometry; Gentisates; Humans; Hydroxybenzoates; Salicylates; Salicylic Acid

1998
Simultaneous measurement of monoamines, their metabolites and 2,3- and 2,5-dihydroxybenzoates by high-performance liquid chromatography with electrochemical detection. Application to rat brain dialysates.
    Journal of chromatography. B, Biomedical sciences and applications, 1998, Sep-25, Volume: 716, Issue:1-2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Monoamines; Corpus Striatum; Dopamine; Gentisates; Homovanillic Acid; Hydroxybenzoates; Hydroxyindoleacetic Acid; Hydroxyl Radical; Methoxyhydroxyphenylglycol; Norepinephrine; Oxygen; Rats; Restraint, Physical; Serotonin

1998
Glibenclamide, an antagonist of ATP sensitive K+ channels, blocks free radical generation in the rat myocardium.
    Neuroscience letters, 1998, Nov-20, Volume: 257, Issue:1

    Topics: Allopurinol; Animals; Enzyme Inhibitors; Free Radicals; Gentisates; Glyburide; Heart; Hydroxybenzoates; Male; Microdialysis; Myocardium; Perfusion; Potassium Channel Blockers; Potassium Channels; Potassium Chloride; Rats; Rats, Wistar; Sodium Salicylate; Sucrose

1998
Measurement of hydroxyl radical by salicylate in striatum of intact brain.
    Methods in enzymology, 1999, Volume: 300

    Topics: Animals; Chromatography, High Pressure Liquid; Convulsants; Corpus Striatum; Gentisates; Glutarates; Hydroxybenzoates; Hydroxyl Radical; Male; Methylguanidine; Microdialysis; Rats; Rats, Wistar; Salicylates

1999
Estimation of hydroxyl free radical levels in vivo based on liquid chromatography with electrochemical detection.
    Methods in enzymology, 1999, Volume: 300

    Topics: Chromatography, Liquid; Electrochemistry; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Models, Chemical; Oxidative Stress; Parabens; Salicylic Acid; Tyrosine

1999
Involvement of cytochromes P-450 2E1 and 3A4 in the 5-hydroxylation of salicylate in humans.
    Drug metabolism and disposition: the biological fate of chemicals, 1999, Volume: 27, Issue:3

    Topics: Alcoholism; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Gentisates; Humans; Hydroxybenzoates; Hydroxylation; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Salicylates

1999
[Oxidative stress and hypercholesterolemia: increase of radical hydroxyl in patients with hypercholesterolemia].
    Cardiologia (Rome, Italy), 1999, Volume: 44, Issue:2

    Topics: Adult; Aged; Cholesterol; Chromatography, High Pressure Liquid; Chromatography, Liquid; Data Interpretation, Statistical; Female; Gentisates; Humans; Hydroxybenzoates; Hydroxyl Radical; Hypercholesterolemia; Leukocytes; Male; Middle Aged; Oxidative Stress

1999
In vivo evidence against clomethiazole being neuroprotective against MDMA ('ecstasy')-induced degeneration of rat brain 5-HT nerve terminals by a free radical scavenging mechanism.
    Neuropharmacology, 1999, Volume: 38, Issue:2

    Topics: Animals; Biotransformation; Body Temperature; Brain; Cerebral Cortex; Chlormethiazole; Corpus Striatum; Free Radical Scavengers; Gentisates; Hippocampus; Hydroxybenzoates; Hydroxyindoleacetic Acid; Kinetics; Male; Microdialysis; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Degeneration; Nerve Endings; Neuroprotective Agents; Paroxetine; Rats; Salicylic Acid; Serotonin

1999
Hydroxyl radical formation following methamphetamine administration to rats.
    Pharmacology & toxicology, 1999, Volume: 85, Issue:3

    Topics: Animals; Body Temperature; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Gentisates; Hippocampus; Hydroxybenzoates; Hydroxyl Radical; Injections, Intraventricular; Male; Methamphetamine; Rats; Rats, Wistar; Salicylates; Serotonin

1999
Production of hydroxyl free radical by brain tissues in hyperglycemic rats subjected to transient forebrain ischemia.
    Free radical biology & medicine, 1999, Volume: 27, Issue:9-10

    Topics: Animals; Brain; Brain Injuries; Brain Ischemia; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Hyperglycemia; Male; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury; Salicylic Acid; Tissue Distribution

1999
Formation of free hydroxyl radicals after pentylenetetrazol-induced seizure and kindling.
    Brain research, 1999, Nov-20, Volume: 847, Issue:2

    Topics: Animals; Brain; Convulsants; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Kindling, Neurologic; Male; Pentylenetetrazole; Rats; Rats, Wistar; Seizures

1999
Association of cytochrome P450 induction with oxidative stress in vivo as evidenced by 3-hydroxylation of salicylate.
    Xenobiotica; the fate of foreign compounds in biological systems, 1999, Volume: 29, Issue:11

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Enzyme Inhibitors; Gentisates; Hydroxybenzoates; Hydroxylation; Male; Oxidative Stress; Oxidoreductases, N-Demethylating; Phenobarbital; Proadifen; Rats; Rats, Sprague-Dawley; Salicylates

1999
Generation of reactive oxygen species by the faecal matrix.
    Gut, 2000, Volume: 46, Issue:2

    Topics: Ascorbic Acid; Bacteria; Catechols; Chromatography, High Pressure Liquid; Edetic Acid; Feces; Free Radical Scavengers; Gentisates; Humans; Hydroxybenzoates; Hydroxyl Radical; Hypoxanthine; Phytic Acid; Reactive Oxygen Species; Salicylic Acid; Xanthine Oxidase

2000
Hydroxyl radicals detected via brain microdialysis in rats breathing air and during hyperbaric oxygen convulsions.
    Redox report : communications in free radical research, 1999, Volume: 4, Issue:4

    Topics: Air; Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Corpus Striatum; Electron Spin Resonance Spectroscopy; Epilepsy, Tonic-Clonic; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Hyperbaric Oxygenation; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Salicylates

1999
Effect of hydroxyl radical scavengers in renal cortical cells.
    Advances in experimental medicine and biology, 1999, Volume: 471

    Topics: Animals; Benzoates; Free Radical Scavengers; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Hydroxylation; Kidney Cortex; Rats; Rats, Wistar

1999
L-DOPA does not enhance hydroxyl radical formation in the nigrostriatal dopamine system of rats with a unilateral 6-hydroxydopamine lesion.
    Journal of neurochemistry, 2000, Volume: 74, Issue:3

    Topics: Animals; Cerebellum; Corpus Striatum; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Injections; Levodopa; Male; Mesencephalon; Methamphetamine; Microdialysis; Osmolar Concentration; Oxidopamine; Rats; Rats, Sprague-Dawley; Salicylates; Substantia Nigra

2000
The salicylate metabolite gentisic acid, but not the parent drug, inhibits glucose autoxidation-mediated atherogenic modification of low density lipoprotein.
    FEBS letters, 2000, Mar-17, Volume: 470, Issue:1

    Topics: Arteriosclerosis; Aspirin; Cells, Cultured; Diabetic Angiopathies; Endothelium, Vascular; Gentisates; Glucose; Humans; Hydroxybenzoates; Iron Chelating Agents; Lipoproteins, LDL; Male; Oxidation-Reduction; Prodrugs; Reactive Oxygen Species; Salicylic Acid; Thromboplastin

2000
Hydroxyl radical formation in the perilymph of asphyxic guinea pig.
    Hearing research, 2000, Volume: 143, Issue:1-2

    Topics: Animals; Asphyxia; Chromatography, High Pressure Liquid; Electrochemistry; Gentisates; Guinea Pigs; Hydroxybenzoates; Hydroxyl Radical; Perilymph; Salicylates

2000
The salicylate hydroxylation assay to measure hydroxyl free radicals induced by local application of glutamate in vivo or induced by the Fenton reaction in vitro.
    Brain research. Brain research protocols, 2000, Volume: 5, Issue:2

    Topics: Animals; Dose-Response Relationship, Drug; Gentisates; Glutamic Acid; Hydroxybenzoates; Hydroxyl Radical; Hydroxylation; Male; Methods; Microdialysis; Rats; Rats, Wistar; Salicylates

2000
Neuroprotection by sodium salicylate against 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-induced neurotoxicity.
    Brain research, 2000, May-12, Volume: 864, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Catalepsy; Cyclooxygenase Inhibitors; Dopamine; Dopamine Agents; Dyskinesia, Drug-Induced; Female; Free Radical Scavengers; Gentisates; Glutathione; Homovanillic Acid; Hydroxybenzoates; Hydroxyl Radical; Male; Mice; Mice, Inbred BALB C; Monoamine Oxidase; MPTP Poisoning; Neostriatum; Neuroprotective Agents; Sodium Salicylate; Substantia Nigra

2000
Dopaminergic denervation enhances susceptibility to hydroxyl radicals in rat neostriatum.
    Amino acids, 2000, Volume: 19, Issue:1

    Topics: Animals; Carbidopa; Chromatography, High Pressure Liquid; Denervation; Dihydroxyphenylalanine; Dopamine; Female; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Neostriatum; Pregnancy; Rats; Salicylic Acid; Serotonin

2000
Measurement of free radical production by in vivo microdialysis during ischemia/reperfusion injury to skeletal muscle.
    Free radical biology & medicine, 2001, May-01, Volume: 30, Issue:9

    Topics: Animals; Cytochrome c Group; Female; Free Radicals; Gentisates; Hydroxybenzoates; Microdialysis; Muscle, Skeletal; Rats; Rats, Wistar; Salicylic Acid; Superoxides

2001
Non-steroidal anti-inflammatory drug sodium salicylate, but not diclofenac or celecoxib, protects against 1-methyl-4-phenyl pyridinium-induced dopaminergic neurotoxicity in rats.
    Brain research, 2003, Mar-21, Volume: 966, Issue:2

    Topics: 1-Methyl-4-phenylpyridinium; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Corpus Striatum; Diclofenac; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Gentisates; Hydroxybenzoates; Hydroxyl Radical; In Vitro Techniques; Male; Mortality; Neurodegenerative Diseases; Neuroprotective Agents; Pyrazoles; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Sodium Salicylate; Sulfonamides

2003
Postischemic hypothermia inhibits the generation of hydroxyl radical following transient forebrain ischemia in rats.
    Journal of neurotrauma, 2003, Volume: 20, Issue:5

    Topics: Animals; Brain; Brain Chemistry; Cerebrovascular Circulation; Corpus Striatum; Extracellular Space; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Hypothermia, Induced; Ischemic Attack, Transient; Male; Microdialysis; Rats; Rats, Wistar; Xanthine

2003
Tempol, a novel stable nitroxide, reduces brain damage and free radical production, after acute subdural hematoma in the rat.
    Journal of neurotrauma, 2003, Volume: 20, Issue:4

    Topics: Animals; Antioxidants; Brain Chemistry; Brain Damage, Chronic; Cyclic N-Oxides; Disease Models, Animal; Drug Stability; Free Radicals; Gentisates; Hematoma, Subdural, Acute; Hydroxybenzoates; Male; Rats; Rats, Sprague-Dawley; Time Factors

2003
Phospholipase A2, hydroxyl radicals, and lipid peroxidation in transient cerebral ischemia.
    Antioxidants & redox signaling, 2003, Volume: 5, Issue:5

    Topics: Animals; Arachidonic Acid; Calcium; Cardiolipins; Cell Membrane; Chromatography, High Pressure Liquid; Cytidine Diphosphate Choline; Gentisates; Gerbillinae; Hippocampus; Hydroxybenzoates; Hydroxyl Radical; Intracellular Membranes; Ischemic Attack, Transient; Lipid Peroxidation; Male; Malondialdehyde; Mitochondria; Models, Biological; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipases A; Phospholipases A2; Salicylic Acid

2003
The role of superoxide dismutase and alpha-tocopherol in the development of seizures and kindling induced by pentylenetetrazol - influence of the radical scavenger alpha-phenyl-N-tert-butyl nitrone.
    Brain research, 2004, May-29, Volume: 1009, Issue:1-2

    Topics: alpha-Tocopherol; Analysis of Variance; Animals; Blotting, Western; Chromatography, High Pressure Liquid; Convulsants; Cyclic N-Oxides; Disease Models, Animal; Drug Administration Schedule; Gentisates; Hydroxybenzoates; Kindling, Neurologic; Male; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrogen Oxides; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Superoxide Dismutase; Time Factors

2004
Isoflurane does not mimic ischaemic preconditioning in decreasing hydroxyl radical production in the rabbit.
    British journal of anaesthesia, 2005, Volume: 95, Issue:4

    Topics: Anesthetics, Inhalation; Animals; Gentisates; Hemodynamics; Hydroxybenzoates; Hydroxyl Radical; Ischemic Preconditioning, Myocardial; Isoflurane; Myocardial Infarction; Rabbits

2005
Production of reactive oxygen species following acute ethanol or acetaldehyde and its reduction by acamprosate in chronically alcoholized rats.
    European journal of pharmacology, 2005, Sep-27, Volume: 520, Issue:1-3

    Topics: Acamprosate; Acetaldehyde; Alcohol Deterrents; Alcoholism; Animals; Disease Models, Animal; Ethanol; Gentisates; Hippocampus; Hydroxybenzoates; Hydroxyl Radical; Male; Microdialysis; Rats; Rats, Wistar; Salicylic Acid; Substance Withdrawal Syndrome; Taurine; Time Factors

2005
The salicylate trapping method: is oxidation of salicylic acid solution oxygen and time dependent and metal catalysed?
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2006, Feb-02, Volume: 831, Issue:1-2

    Topics: Aluminum; Catalysis; Catechols; Chromatography, Liquid; Gentisates; Hydroxybenzoates; Metals; Microdialysis; Oxidation-Reduction; Oxygen; Salicylic Acid; Time Factors

2006
Edaravone reduces myocardial infarct size and improves cardiac function and remodelling in rabbits.
    Clinical and experimental pharmacology & physiology, 2006, Volume: 33, Issue:11

    Topics: Animals; Antipyrine; Blood Pressure; Edaravone; Enzyme Inhibitors; Free Radical Scavengers; Gentisates; Heart Rate; Hydroxybenzoates; Myocardial Infarction; Myocardial Reperfusion Injury; NG-Nitroarginine Methyl Ester; Rabbits; Superoxides; Ventricular Remodeling

2006
Hydroxyl radical generation dependent on extracellular ascorbate in rat striatum, as determined by microdialysis.
    Toxicology, 2009, Apr-05, Volume: 258, Issue:1

    Topics: Animals; Ascorbic Acid; Behavior, Animal; Corpus Striatum; Dehydroascorbic Acid; Extracellular Space; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Male; Microdialysis; Rats; Rats, Sprague-Dawley

2009
Acarbose reduces myocardial infarct size by preventing postprandial hyperglycemia and hydroxyl radical production and opening mitochondrial KATP channels in rabbits.
    Journal of cardiovascular pharmacology, 2009, Volume: 54, Issue:1

    Topics: Acarbose; Animals; Blood Glucose; Catechols; Enzyme Inhibitors; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Hyperglycemia; Male; Myocardial Infarction; Potassium Channels; Rabbits

2009
Hyperbaric oxygenation alleviates MCAO-induced brain injury and reduces hydroxyl radical formation and glutamate release.
    European journal of applied physiology, 2010, Volume: 108, Issue:3

    Topics: Animals; Blood Pressure; Brain; Brain Injuries; Gentisates; Glutamates; Hydroxybenzoates; Hydroxyl Radical; Hyperbaric Oxygenation; Infarction, Middle Cerebral Artery; Male; Models, Animal; Rats; Rats, Sprague-Dawley; Reperfusion Injury

2010
Increased reactive oxygen species production in the brain after repeated low-dose pesticide paraquat exposure in rats. A comparison with peripheral tissues.
    Neurochemical research, 2010, Volume: 35, Issue:8

    Topics: Animals; Brain; Catechols; Dopamine; Dose-Response Relationship, Drug; Gentisates; Herbicides; Hydroxybenzoates; Male; Microdialysis; Organ Specificity; Parabens; Paraquat; Rats; Rats, Wistar; Reactive Oxygen Species; Salicylic Acid

2010
HPLC method for quantification of oxidative stress by salicilate hydroxylation in human plasma.
    Journal of chromatographic science, 2010, Volume: 48, Issue:8

    Topics: Biomarkers; Catechols; Chromatography, High Pressure Liquid; Drug Stability; Gentisates; Humans; Hydroxybenzoates; Hydroxylation; Linear Models; Oxidative Stress; Reproducibility of Results; Salicylates; Sensitivity and Specificity

2010
Salicylic acid 3-hydroxylase regulates Arabidopsis leaf longevity by mediating salicylic acid catabolism.
    Proceedings of the National Academy of Sciences of the United States of America, 2013, Sep-03, Volume: 110, Issue:36

    Topics: Amino Acid Sequence; Arabidopsis; Arabidopsis Proteins; Biocatalysis; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Gentisates; Hydroxybenzoates; Kinetics; Mass Spectrometry; Mixed Function Oxygenases; Molecular Sequence Data; Molecular Structure; Mutation; Phylogeny; Plant Leaves; Plants, Genetically Modified; RNA, Messenger; Salicylic Acid; Sequence Homology, Amino Acid

2013
Exploiting natural variation of secondary metabolism identifies a gene controlling the glycosylation diversity of dihydroxybenzoic acids in Arabidopsis thaliana.
    Genetics, 2014, Volume: 198, Issue:3

    Topics: Arabidopsis; Chromatography, High Pressure Liquid; Genes, Plant; Genetic Variation; Gentisates; Glycosides; Glycosylation; Hydrolysis; Hydroxybenzoates; Pentosyltransferases; Plant Leaves; Quantitative Trait Loci; Secondary Metabolism

2014
Identification of a residue responsible for UDP-sugar donor selectivity of a dihydroxybenzoic acid glycosyltransferase from Arabidopsis natural accessions.
    The Plant journal : for cell and molecular biology, 2017, Volume: 89, Issue:2

    Topics: Arabidopsis; Arabidopsis Proteins; Gentisates; Glucuronosyltransferase; Hydroxybenzoates; Mutagenesis, Site-Directed; Polymorphism, Genetic; Structural Homology, Protein; Structure-Activity Relationship; Substrate Specificity

2017
Holo-lipocalin-2-derived siderophores increase mitochondrial ROS and impair oxidative phosphorylation in rat cardiomyocytes.
    Proceedings of the National Academy of Sciences of the United States of America, 2018, 02-13, Volume: 115, Issue:7

    Topics: Animals; Gentisates; Hydroxybenzoates; Iron; Lipocalin-2; Male; Mice; Mice, Knockout; Mitochondria; Myocytes, Cardiac; Oxidative Phosphorylation; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury; Siderophores

2018
Modulation of Plant Salicylic Acid-Associated Immune Responses via Glycosylation of Dihydroxybenzoic Acids.
    Plant physiology, 2018, Volume: 176, Issue:4

    Topics: Arabidopsis; Disease Resistance; Gene Expression Regulation, Plant; Gentisates; Glycosylation; Glycosyltransferases; Homeostasis; Hydroxybenzoates; Plant Diseases; Plants, Genetically Modified; Pseudomonas syringae; Salicylic Acid

2018
Choline Salicylate Analysis: Chemical Stability and Degradation Product Identification.
    Molecules (Basel, Switzerland), 2019, Dec-22, Volume: 25, Issue:1

    Topics: Choline; Chromatography, High Pressure Liquid; Drug Combinations; Drug Stability; Gentisates; Hydrolysis; Hydroxybenzoates; Molecular Structure; Photolysis; Salicylates; Tandem Mass Spectrometry

2019
Benzoic acid derivatives as potent antibiofilm agents against Klebsiella pneumoniae biofilm.
    Journal of bioscience and bioengineering, 2023, Volume: 136, Issue:3

    Topics: Adhesins, Bacterial; Benzoic Acid; Biofilms; Humans; Klebsiella pneumoniae

2023