Page last updated: 2024-09-03

2,5-bis(3,4,5-trimethoxyphenyl)tetrahydrofuran and indomethacin

2,5-bis(3,4,5-trimethoxyphenyl)tetrahydrofuran has been researched along with indomethacin in 5 studies

Compound Research Comparison

Studies
(2,5-bis(3,4,5-trimethoxyphenyl)tetrahydrofuran)
Trials
(2,5-bis(3,4,5-trimethoxyphenyl)tetrahydrofuran)
Recent Studies (post-2010)
(2,5-bis(3,4,5-trimethoxyphenyl)tetrahydrofuran)
Studies
(indomethacin)
Trials
(indomethacin)
Recent Studies (post-2010) (indomethacin)
630029,5271,8383,396

Protein Interaction Comparison

ProteinTaxonomy2,5-bis(3,4,5-trimethoxyphenyl)tetrahydrofuran (IC50)indomethacin (IC50)
Chain A, membrane-associated prostaglandin E synthase-2Macaca fascicularis (crab-eating macaque)1000
Prostaglandin-H2 D-isomeraseMus musculus (house mouse)1.1
Multidrug resistance-associated protein 4Homo sapiens (human)5.8
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.9994
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.7764
Cytochrome c oxidase subunit 2Homo sapiens (human)0.34
Prostaglandin G/H synthase 1Ovis aries (sheep)0.5605
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.004
Interleukin-8Homo sapiens (human)0.05
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.004
Aldo-keto reductase family 1 member B1Homo sapiens (human)6
Aldo-keto reductase family 1 member B1Bos taurus (cattle)5
Prostaglandin G/H synthase 1Mus musculus (house mouse)0.011
Prostaglandin G/H synthase 1Homo sapiens (human)0.4848
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.2
Thromboxane-A synthase Homo sapiens (human)0.1
Indoleamine 2,3-dioxygenase 1Mus musculus (house mouse)0.082
Nitric oxide synthase, inducibleMus musculus (house mouse)4.5
Substance-P receptorCavia porcellus (domestic guinea pig)5.7
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.2
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.2
Prostaglandin G/H synthase 2Homo sapiens (human)1.5128
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5504
Aldo-keto reductase family 1 member C3Homo sapiens (human)3.4486
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.2
C-X-C chemokine receptor type 3Homo sapiens (human)0.05
Aldo-keto reductase family 1 member C2 Homo sapiens (human)8.97
Prostaglandin G/H synthase 2Ovis aries (sheep)3.4647
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.4233
Solute carrier family 22 member 6Homo sapiens (human)3
Sigma intracellular receptor 2Rattus norvegicus (Norway rat)0.49
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)7.7
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5461
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.96

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19902 (40.00)18.7374
1990's2 (40.00)18.2507
2000's1 (20.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hirasawa, N; Mue, S; Ohuchi, K; Omata, M; Tsurufuji, S; Watanabe, M; Yagi, M1
Piper, PJ; Stewart, AG1
Abbate, M; Bertani, T; Cucchi, M; Delaini, F; Perico, N; Remuzzi, G; Tagliaferri, M1
Ichinowatari, G; Ohuchi, K; Tanimoto, A; Yaginuma, H; Yamada, M1
Ichinowatari, G; Ohuchi, K; Tanimoto, A; Tsuyuki, K; Yaginuma, H; Yamada, M1

Other Studies

5 other study(ies) available for 2,5-bis(3,4,5-trimethoxyphenyl)tetrahydrofuran and indomethacin

ArticleYear
Stimulation of neutrophil adherence to vascular endothelial cells by histamine and thrombin and its inhibition by PAF antagonists and dexamethasone.
    British journal of pharmacology, 1991, Volume: 102, Issue:1

    Topics: Animals; Azepines; Cell Adhesion; Cells, Cultured; Dexamethasone; Endothelium, Vascular; Furans; Histamine; Humans; In Vitro Techniques; Indomethacin; Male; Neutrophils; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Inbred Strains; Thrombin; Triazoles

1991
Antagonism of vasoconstriction induced by platelet-activating factor in guinea-pig perfused hearts by selective platelet-activating factor receptor antagonists.
    British journal of pharmacology, 1987, Volume: 90, Issue:4

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Chromones; Coronary Vessels; Diterpenes; Furans; Ginkgolides; Guinea Pigs; In Vitro Techniques; Indomethacin; Lactones; Leukotriene B4; Male; Perfusion; Plant Extracts; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; SRS-A; Thromboxane A2; Time Factors; Vasoconstriction

1987
Effect of platelet-activating factor and its specific receptor antagonist on glomerular permeability to proteins in isolated perfused rat kidney.
    Laboratory investigation; a journal of technical methods and pathology, 1988, Volume: 58, Issue:2

    Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Antioxidants; Basement Membrane; Cell Membrane Permeability; Cyclooxygenase Inhibitors; Furans; Glomerular Filtration Rate; Indomethacin; Kidney Glomerulus; Lipoxygenase Inhibitors; Male; Microscopy, Electron; Perfusion; Phenothiazines; Platelet Activating Factor; Proteins; Proteinuria; Pyrazoles; Rats; Rats, Inbred Strains; Vascular Resistance

1988
Possible participation of intracellular platelet-activating factor in tumor necrosis factor-alpha production by rat peritoneal macrophages.
    European journal of pharmacology, 1999, Jun-25, Volume: 374, Issue:3

    Topics: Animals; Azepines; Cells, Cultured; Dinoprostone; Enzyme Inhibitors; Furans; Imidazoles; Indomethacin; Macrophages, Peritoneal; Male; Organophosphorus Compounds; Platelet Activating Factor; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thapsigargin; Triazoles; Tumor Necrosis Factor-alpha

1999
Participation of prostaglandin E2 and platelet-activating factor in thapsigargin-induced production of interleukin-6.
    European journal of pharmacology, 2002, Jan-11, Volume: 434, Issue:3

    Topics: Acetyltransferases; Acyl-Carrier Protein S-Acetyltransferase; Animals; Azepines; Cells, Cultured; Dinoprostone; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Furans; Imidazoles; Indomethacin; Interleukin-6; Macrophages, Peritoneal; Male; Organophosphorus Compounds; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Thapsigargin; Triazoles

2002