2,4-diamino-6-benzyloxy-5-nitrosopyrimidine and o(6)-benzylguanine

2,4-diamino-6-benzyloxy-5-nitrosopyrimidine has been researched along with o(6)-benzylguanine in 2 studies

*O(6)-benzylguanine: a suicide inhibitor of O(6)-methylguanine-DNA methyltransferase activity [MeSH]

Compound Research Comparison

Studies (2,4-diamino-6-benzyloxy-5-nitrosopyrimidine)	Trials (2,4-diamino-6-benzyloxy-5-nitrosopyrimidine)	Recent Studies (post-2010) (2,4-diamino-6-benzyloxy-5-nitrosopyrimidine)	Studies (o(6)-benzylguanine)	Trials (o(6)-benzylguanine)	Recent Studies (post-2010) (o(6)-benzylguanine)
5	0	1	361	28	69

Protein Interaction Comparison

Protein	Taxonomy	2,4-diamino-6-benzyloxy-5-nitrosopyrimidine (IC50)	o(6)-benzylguanine (IC50)
Methylated-DNA--protein-cysteine methyltransferase	Homo sapiens (human)		0.5196

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (100.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Chae, MY; Dolan, ME; Kanugula, S; Moschel, RC; Pegg, AE; Swenn, K	1
Kohda, K; Terashima, I	1

Other Studies

2 other study(ies) available for 2,4-diamino-6-benzyloxy-5-nitrosopyrimidine and o(6)-benzylguanine

Article	Year
8-Substituted O6-benzylguanine, substituted 6(4)-(benzyloxy)pyrimidine, and related derivatives as inactivators of human O6-alkylguanine-DNA alkyltransferase. Journal of medicinal chemistry, 1995, Jan-20, Volume: 38, Issue:2 Topics: Cells, Cultured; DNA Repair; Guanine; Humans; In Vitro Techniques; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Pyrimidines; Structure-Activity Relationship	1995
Inhibition of human O6-alkylguanine-DNA alkyltransferase and potentiation of the cytotoxicity of chloroethylnitrosourea by 4(6)-(benzyloxy)-2,6(4)-diamino-5-(nitro or nitroso)pyrimidine derivatives and analogues. Journal of medicinal chemistry, 1998, Feb-12, Volume: 41, Issue:4 Topics: Cell Survival; Cloning, Molecular; Drug Synergism; Enzyme Inhibitors; Ethylnitrosourea; HeLa Cells; Humans; Indicators and Reagents; Kinetics; O(6)-Methylguanine-DNA Methyltransferase; Pyrimidines; Recombinant Proteins; Structure-Activity Relationship	1998

Article

Year

8-Substituted O6-benzylguanine, substituted 6(4)-(benzyloxy)pyrimidine, and related derivatives as inactivators of human O6-alkylguanine-DNA alkyltransferase.

Journal of medicinal chemistry, 1995, Jan-20, Volume: 38, Issue:2

Topics: Cells, Cultured; DNA Repair; Guanine; Humans; In Vitro Techniques; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Pyrimidines; Structure-Activity Relationship

1995

Inhibition of human O6-alkylguanine-DNA alkyltransferase and potentiation of the cytotoxicity of chloroethylnitrosourea by 4(6)-(benzyloxy)-2,6(4)-diamino-5-(nitro or nitroso)pyrimidine derivatives and analogues.

Journal of medicinal chemistry, 1998, Feb-12, Volume: 41, Issue:4

Topics: Cell Survival; Cloning, Molecular; Drug Synergism; Enzyme Inhibitors; Ethylnitrosourea; HeLa Cells; Humans; Indicators and Reagents; Kinetics; O(6)-Methylguanine-DNA Methyltransferase; Pyrimidines; Recombinant Proteins; Structure-Activity Relationship

1998