2,4-diamino-5-phenyl-6-methylpyrimidine has been researched along with pyrimethamine in 4 studies
*Pyrimethamine: One of the FOLIC ACID ANTAGONISTS that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis. [MeSH]
*Pyrimethamine: One of the FOLIC ACID ANTAGONISTS that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Intaraudom, C; Kamchonwongpaisan, S; Phupong, W; Sirawaraporn, W; Sirichaiwat, C; Tarnchompoo, B; Thebtaranonth, Y; Vanichtanankul, J; Yuthavong, Y | 1 |
| Ferrari, AM; Pacchioni, S; Parenti, MD; Rastelli, G | 1 |
| Bunyarataphan, S; Kamchonwongpaisan, S; Leartsakulpanich, U; Tarnchompoo, B; Taweechai, S; Yuthavong, Y | 1 |
| Kotb, MM | 1 |
4 other study(ies) available for 2,4-diamino-5-phenyl-6-methylpyrimidine and pyrimethamine
| Article | Year |
|---|---|
Development of 2,4-diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine-resistant Plasmodium falciparum.
Topics: Animals; Antimalarials; Binding, Competitive; Chlorocebus aethiops; Folic Acid Antagonists; Humans; KB Cells; Malaria, Falciparum; Plasmodium falciparum; Point Mutation; Pyrimethamine; Pyrimidines; Tetrahydrofolate Dehydrogenase; Vero Cells | 2002 |
Three-dimensional quantitative structure-activity relationship analysis of a set of Plasmodium falciparum dihydrofolate reductase inhibitors using a pharmacophore generation approach.
Topics: Aldehyde Reductase; Animals; Antimalarials; Binding Sites; Folic Acid Antagonists; Models, Molecular; Plasmodium falciparum; Quantitative Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 2004 |
Evaluation of the activities of pyrimethamine analogs against Plasmodium vivax and Plasmodium falciparum dihydrofolate reductase-thymidylate synthase using in vitro enzyme inhibition and bacterial complementation assays.
Topics: Animals; Antimalarials; Drug Resistance; Folic Acid Antagonists; Genetic Complementation Test; Mutation; Plasmids; Plasmodium falciparum; Plasmodium vivax; Pyrimethamine; Reverse Transcriptase Polymerase Chain Reaction; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 2006 |
[Characteristics of the injurious effects of a structural analog of the antimalarial drug chloridin (preparation IEM-687) on various stages of white rat embryogenesis].
Topics: Abdominal Muscles; Abnormalities, Drug-Induced; Abnormalities, Multiple; Amines; Animals; Bone and Bones; Brain Damage, Chronic; Diaphragm; Eye Abnormalities; Facial Bones; Female; Kidney; Limb Deformities, Congenital; Pregnancy; Pyrimethamine; Pyrimidines; Rats | 1972 |