2-4-2--trihydroxychalcone and 4-hydroxychalcone

2-4-2--trihydroxychalcone has been researched along with 4-hydroxychalcone* in 1 studies

Other Studies

1 other study(ies) available for 2-4-2--trihydroxychalcone and 4-hydroxychalcone

Article	Year
Design, synthesis and SAR study of hydroxychalcone inhibitors of human β-secretase (BACE1). Journal of enzyme inhibition and medicinal chemistry, 2011, Volume: 26, Issue:5 According to the structural characteristics of isoliquiritigenin from Glycyrrhiza uralensis, a series of hydroxychalcones has been designed, synthesized and evaluated for their in vitro inhibitory activities of β-secretase (BACE1). Structure-activity relationship study suggested that inhibitory activity against BACE1 was governed to a greater extent by the hydroxyl substituent on A- and B-ring of the chalcone, and the most active compound was substituted with four hydroxyl group (17, IC(50) = 0.27 μM). Topics: Amyloid Precursor Protein Secretases; Chalcones; Drug Design; Enzyme Activation; Enzyme Inhibitors; Glycyrrhiza uralensis; Humans; Inhibitory Concentration 50; Molecular Structure; Structure-Activity Relationship	2011

Article

Year

Design, synthesis and SAR study of hydroxychalcone inhibitors of human β-secretase (BACE1).

Journal of enzyme inhibition and medicinal chemistry, 2011, Volume: 26, Issue:5

According to the structural characteristics of isoliquiritigenin from Glycyrrhiza uralensis, a series of hydroxychalcones has been designed, synthesized and evaluated for their in vitro inhibitory activities of β-secretase (BACE1). Structure-activity relationship study suggested that inhibitory activity against BACE1 was governed to a greater extent by the hydroxyl substituent on A- and B-ring of the chalcone, and the most active compound was substituted with four hydroxyl group (17, IC(50) = 0.27 μM).

Topics: Amyloid Precursor Protein Secretases; Chalcones; Drug Design; Enzyme Activation; Enzyme Inhibitors; Glycyrrhiza uralensis; Humans; Inhibitory Concentration 50; Molecular Structure; Structure-Activity Relationship

2011