2-3-dehydrosilybin and taxifolin

2-3-dehydrosilybin has been researched along with taxifolin* in 2 studies

Other Studies

2 other study(ies) available for 2-3-dehydrosilybin and taxifolin

Article	Year
Influence of silymarin and its flavonolignans on H(2)O(2)-induced oxidative stress in human keratinocytes and mouse fibroblasts. Burns : journal of the International Society for Burn Injuries, 2006, Volume: 32, Issue:8 The administration of antioxidants has been shown to enhance repair and healing processes in cutaneous tissue. Silymarin, an extract from Silybum marianum has been reported to be beneficial in the treatment of chemically-induced oxidative stress in mouse. In this study, we investigated the protective effects of silymarin, its flavonolignans silybin and dehydrosilybin and flavonoids quercetin and taxifolin against hydrogen peroxide-induced damage to human keratinocytes and mouse fibroblasts. The results showed that the cytotoxicity of hydrogen peroxide was dose-dependent in both cell lines. Pre-treatment with test compounds decreased oxidative injury. Dehydrosilybin and quercetin were the most powerful protectants. Silymarin was comparable to silybinin, its main component. This correlates with the antioxidant potential of the compounds. Our findings suggest that silymarin, flavonolignans and flavonoids may be useful as agents for improving skin tissue regeneration. Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Fibroblasts; Flavonolignans; Flavonols; Humans; Hydrogen Peroxide; Keratinocytes; Mice; Mice, Inbred BALB C; Oxidants; Oxidative Stress; Phytotherapy; Plant Extracts; Protective Agents; Quercetin; Silybin; Silymarin	2006
The flavanolignan silybin and its hemisynthetic derivatives, a novel series of potential modulators of P-glycoprotein. Bioorganic & medicinal chemistry letters, 2000, Jan-17, Volume: 10, Issue:2 A new series of potential flavonoidic modulators of P-glycoprotein activity has been prepared. The flavanolignan silybin was first oxidised to dehydrosilybin and then C-alkylated with either prenyl or geranyl bromide. The resulting isoprenoid dehydrosilybins were shown to display high in vitro affinities for direct binding to P-glycoprotein, which ranged them among the best flavonoids ever tested. Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Drug Resistance, Multiple; Flavonoids; Flavonols; Magnetic Resonance Spectroscopy; Molecular Structure; Plants, Medicinal; Protein Binding; Quercetin; Silybum marianum; Silymarin	2000

Article

Year

Influence of silymarin and its flavonolignans on H(2)O(2)-induced oxidative stress in human keratinocytes and mouse fibroblasts.

Burns : journal of the International Society for Burn Injuries, 2006, Volume: 32, Issue:8

The administration of antioxidants has been shown to enhance repair and healing processes in cutaneous tissue. Silymarin, an extract from Silybum marianum has been reported to be beneficial in the treatment of chemically-induced oxidative stress in mouse. In this study, we investigated the protective effects of silymarin, its flavonolignans silybin and dehydrosilybin and flavonoids quercetin and taxifolin against hydrogen peroxide-induced damage to human keratinocytes and mouse fibroblasts. The results showed that the cytotoxicity of hydrogen peroxide was dose-dependent in both cell lines. Pre-treatment with test compounds decreased oxidative injury. Dehydrosilybin and quercetin were the most powerful protectants. Silymarin was comparable to silybinin, its main component. This correlates with the antioxidant potential of the compounds. Our findings suggest that silymarin, flavonolignans and flavonoids may be useful as agents for improving skin tissue regeneration.

Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Fibroblasts; Flavonolignans; Flavonols; Humans; Hydrogen Peroxide; Keratinocytes; Mice; Mice, Inbred BALB C; Oxidants; Oxidative Stress; Phytotherapy; Plant Extracts; Protective Agents; Quercetin; Silybin; Silymarin

2006

The flavanolignan silybin and its hemisynthetic derivatives, a novel series of potential modulators of P-glycoprotein.

Bioorganic & medicinal chemistry letters, 2000, Jan-17, Volume: 10, Issue:2

A new series of potential flavonoidic modulators of P-glycoprotein activity has been prepared. The flavanolignan silybin was first oxidised to dehydrosilybin and then C-alkylated with either prenyl or geranyl bromide. The resulting isoprenoid dehydrosilybins were shown to display high in vitro affinities for direct binding to P-glycoprotein, which ranged them among the best flavonoids ever tested.

Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Drug Resistance, Multiple; Flavonoids; Flavonols; Magnetic Resonance Spectroscopy; Molecular Structure; Plants, Medicinal; Protein Binding; Quercetin; Silybum marianum; Silymarin

2000