2-3-dehydrosilybin and silychristin

2-3-dehydrosilybin has been researched along with silychristin* in 3 studies

Other Studies

3 other study(ies) available for 2-3-dehydrosilybin and silychristin

ArticleYear
A pilot study of the UVA-photoprotective potential of dehydrosilybin, isosilybin, silychristin, and silydianin on human dermal fibroblasts.
    Archives of dermatological research, 2019, Volume: 311, Issue:6

    The exposure of naked unprotected skin to solar radiation may result in numerous acute and chronic undesirable effects. Evidence suggests that silymarin, a standardized extract from Silybum marianum (L.) Gaertn. seeds, and its major component silybin suppress UVB-induced skin damage. Here, we aimed to investigate the UVA-protective effects of silymarin's less abundant flavonolignans, specifically isosilybin (ISB), silychristin (SC), silydianin (SD), and 2,3-dehydrosilybin (DHSB). Normal human dermal fibroblasts (NHDF) pre-treated for 1 h with flavonolignans were then exposed to UVA light using a solar simulator. Their effects on reactive oxygen species (ROS), carbonylated proteins and glutathione (GSH) level, caspase-3 activity, single-strand breaks' (SSBs) formation and protein level of matrix metalloproteinase-1 (MMP-1), heme oxygenase-1 (HO-1), and heat shock protein (HSP70) were evaluated. The most pronounced preventative potential was found for DHSB, a minor component of silymarin, and SC, the second most abundant flavonolignan in silymarin. They had significant effects on most of the studied parameters. Meanwhile, a photoprotective effect of SC was mostly found at double the concentration of DHSB. ISB and SD protected against GSH depletion, the generation of ROS, carbonylated proteins and SSBs, and caspase-3 activation, but had no significant effect on MMP-1, HO-1, or HSP70. In summary, DHSB and to a lesser extent other silymarin flavonolignans are potent UVA-protective compounds. However, due to the in vitro phototoxic potential of DHSB published elsewhere, further studies are needed to exclude phototoxicity for humans as well as to confirm our results on human skin ex vivo and in vivo.

    Topics: Caspase 3; Cells, Cultured; Cytoprotection; DNA Breaks, Single-Stranded; Fibroblasts; Glutathione; Heme Oxygenase-1; HSP70 Heat-Shock Proteins; Humans; Matrix Metalloproteinase 1; Protein Carbonylation; Reactive Oxygen Species; Silymarin; Skin; Sunscreening Agents; Ultraviolet Rays

2019
Differential Effects of the Flavonolignans Silybin, Silychristin and 2,3-Dehydrosilybin on
    Molecules (Basel, Switzerland), 2018, Nov-16, Volume: 23, Issue:11

    Topics: Animals; Antioxidants; Hypoxia; In Vitro Techniques; Larva; Mesocestoides; Protective Agents; Silybin; Silymarin

2018
Silychristin: Skeletal Alterations and Biological Activities.
    Journal of natural products, 2016, Dec-23, Volume: 79, Issue:12

    Silychristin is the second most abundant flavonolignan (after silybin) present in the fruits of Silybum marianum. A group of compounds containing silychristin (3) and its derivatives such as 2,3-dehydrosilychristin (4), 2,3-dehydroanhydrosilychristin (5), anhydrosilychristin (6), silyhermin (7), and isosilychristin (8) were studied. Physicochemical data of these compounds acquired at high resolution were compared. The absolute configuration of silyhermin (7) was proposed to be identical to silychristin A (3a) in ring D (10R,11S). The preparation of 2,3-dehydrosilychristin (4) was optimized. The Folin-Ciocalteau reduction and DPPH and ABTS radical scavenging assays revealed silychristin and its analogues to be powerful antioxidants, which were found to be more potent than silybin and 2,3-dehydrosilybin. Compounds 4-6 exhibited inhibition of microsomal lipoperoxidation (IC

    Topics: Antioxidants; Fruit; Humans; Molecular Structure; Plant Extracts; Plant Roots; Silybin; Silybum marianum; Silymarin

2016