2,3-bis(3'-hydroxybenzyl)butyrolactone and secoisolariciresinol

2,3-bis(3'-hydroxybenzyl)butyrolactone has been researched along with secoisolariciresinol in 22 studies

Compound Research Comparison

Studies (2,3-bis(3'-hydroxybenzyl)butyrolactone)	Trials (2,3-bis(3'-hydroxybenzyl)butyrolactone)	Recent Studies (post-2010) (2,3-bis(3'-hydroxybenzyl)butyrolactone)	Studies (secoisolariciresinol)	Trials (secoisolariciresinol)	Recent Studies (post-2010) (secoisolariciresinol)
319	32	124	158	5	78

Research

Studies (22)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (9.09)	18.2507
2000's	5 (22.73)	29.6817
2010's	13 (59.09)	24.3611
2020's	2 (9.09)	2.80

Authors

Authors	Studies
Barakzoy, E; Corbin, C; Doussot, J; Hano, C; Lainé, E; Lamblin, F; Molinié, R; Renouard, S	1
Fong, HH; Luyengi, L; Orcheson, LJ; Rickard, SE; Seidl, MM; Thompson, LU	1
Jacobs, E; Kulling, SE; Metzler, M; Pfeiffer, E	1
Adlercreutz, H; Kilkkinen, A; Pietinen, P; Stumpf, K; Valsta, LM; Virtamo, J	1
Eklund, PC; Mutanen, M; Oikarinen, SI; Pajari, AM; Sjöholm, RE; Smeds, AI	1
Blaut, M; Clavel, T; Doré, J; Engst, W; Henderson, G	1
Hu, C; Kitts, DD; Yuan, YV	1
Airio, M; Dings, RP; Mäkelä, S; Saarinen, NM; Smeds, AI; Wärri, A	1
Blaut, M; Clavel, T; Loh, G; Woting, A	1
Hattori, M; Jin, JS	1
Amaretti, A; Leonardi, A; Raimondi, S; Roncaglia, L; Rossi, M	1
Abarzua, S; Briese, V; Piechulla, B; Richter, DU; Serikawa, T; Szewczyk, M	1
Debouche, C; During, A; Larondelle, Y; Raas, T	1
Alcorn, J; Krol, ES; Michel, D; Muir, AD; Mukker, JK	1
Brown, NM; Heubi, JE; Jha, P; Setchell, KD; Wolfe, B; Zimmer-Nechemias, L	1
Alcorn, J; Krol, ES; Muir, AD; Mukker, JK; Singh, RS	1
Álvarez, AI; Espín, JC; García-Villalba, R; González-Lobato, L; Merino, G; Miguel, V; Otero, JA; Prieto, JG	1
Amaretti, A; García-Villalba, R; Leonardi, A; Quartieri, A; Raimondi, S; Rossi, M; Tomàs-Barberàn, F	1
Brecchia, G; Cartoni Mancinelli, A; Castellini, C; Dal Bosco, A; Mattioli, S; Ruggeri, S; Sebastiani, B	1
Gaya, P; Landete, JM; Medina, M; Peirotén, Á; Sánchez-Jiménez, A	1
Feng, X; Liu, L; Ma, CM; Xu, HY; Zhang, G; Zhang, L; Zheng, Z; Zhuang, CC	1
Alcorn, J; Guo, Y; Mustafa, R; Purdy, SK; Reaney, MJT; Shen, J; Tse, TJ; Yang, X	1

Trials

3 trial(s) available for 2,3-bis(3'-hydroxybenzyl)butyrolactone and secoisolariciresinol

Article	Year
Intake of lignans is associated with serum enterolactone concentration in Finnish men and women. The Journal of nutrition, 2003, Volume: 133, Issue:6 Topics: 4-Butyrolactone; Adult; Butylene Glycols; Diet; Female; Furans; Humans; Lignans; Male; Middle Aged; Osmolar Concentration	2003
Metabolism of secoisolariciresinol-diglycoside the dietary precursor to the intestinally derived lignan enterolactone in humans. Food & function, 2014, Volume: 5, Issue:3 Topics: 4-Butyrolactone; Aged; Butylene Glycols; Dietary Supplements; Female; Flax; Glycosides; Humans; Intestinal Mucosa; Lignans; Middle Aged; Postmenopause	2014
Technical note: Quantification of lignans in the urine, milk, and plasma of flaxseed cake-fed dairy sheep. Journal of dairy science, 2021, Volume: 104, Issue:1 Topics: 4-Butyrolactone; Animal Feed; Animals; Butylene Glycols; Flax; Glucosides; Lignans; Milk; Seeds; Sheep	2021

Other Studies

19 other study(ies) available for 2,3-bis(3'-hydroxybenzyl)butyrolactone and secoisolariciresinol

Article	Year
Flaxseed (Linum usitatissimum L.) extract as well as (+)-secoisolariciresinol diglucoside and its mammalian derivatives are potent inhibitors of α-amylase activity. Bioorganic & medicinal chemistry letters, 2013, May-15, Volume: 23, Issue:10 Topics: alpha-Glucosidases; Animals; Butylene Glycols; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flax; Glucosides; Glycoside Hydrolase Inhibitors; Intestines; Lignans; Molecular Structure; Pancreatic alpha-Amylases; Plant Extracts; Rats; Structure-Activity Relationship; Swine	2013
Dose-dependent production of mammalian lignans in rats and in vitro from the purified precursor secoisolariciresinol diglycoside in flaxseed. The Journal of nutrition, 1996, Volume: 126, Issue:8 Topics: 4-Butyrolactone; Animals; Butylene Glycols; Colon; Dietary Fiber; Female; Glycosides; In Vitro Techniques; Lignans; Lignin; Rats; Rats, Sprague-Dawley; Regression Analysis; Seeds	1996
Studies on the genotoxicity of the mammalian lignans enterolactone and enterodiol and their metabolic precursors at various endpoints in vitro. Mutation research, 1998, Aug-07, Volume: 416, Issue:1-2 Topics: 4-Butyrolactone; Aneuploidy; Animals; Bacteria; Butylene Glycols; Cattle; Cell Line; Cell-Free System; Cricetinae; Estrogens; Furans; Hypoxanthine Phosphoribosyltransferase; Intestinal Mucosa; Intestines; Lignans; Male; Micronucleus Tests; Microtubules; Mitosis; Mutagenicity Tests; Mutagens	1998
The plant lignans matairesinol and secoisolariciresinol administered to Min mice do not protect against intestinal tumor formation. Cancer letters, 2006, Feb-28, Volume: 233, Issue:2 Topics: 4-Butyrolactone; Adenomatous Polyposis Coli Protein; Animals; Butylene Glycols; Diet; Disease Models, Animal; Female; Furans; Intestinal Neoplasms; Lignans; Male; Mice; Mice, Inbred C57BL; Plants	2006
Phylogeny of human intestinal bacteria that activate the dietary lignan secoisolariciresinol diglucoside. FEMS microbiology ecology, 2006, Volume: 55, Issue:3 Topics: 4-Butyrolactone; Bacteria, Anaerobic; Butylene Glycols; Culture Media; Glucosides; Humans; Intestines; Lignans; Phylogeny	2006
Antioxidant activities of the flaxseed lignan secoisolariciresinol diglucoside, its aglycone secoisolariciresinol and the mammalian lignans enterodiol and enterolactone in vitro. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2007, Volume: 45, Issue:11 Topics: 4-Butyrolactone; Animals; Biphenyl Compounds; Butylene Glycols; Flax; Free Radical Scavengers; Glucosides; Hydrazines; Lignans; Liposomes; Mammals; Molecular Structure; Picrates; Seeds	2007
Dietary lariciresinol attenuates mammary tumor growth and reduces blood vessel density in human MCF-7 breast cancer xenografts and carcinogen-induced mammary tumors in rats. International journal of cancer, 2008, Sep-01, Volume: 123, Issue:5 Topics: 4-Butyrolactone; 9,10-Dimethyl-1,2-benzanthracene; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Butylene Glycols; Carcinogens; Cell Proliferation; Dietary Supplements; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Furans; Gene Expression Regulation, Neoplastic; Humans; Lignans; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Ovariectomy; Phytoestrogens; Rats; Receptors, Progesterone; Transplantation, Heterologous	2008
Bacterial transformation of dietary lignans in gnotobiotic rats. FEMS microbiology ecology, 2010, Volume: 72, Issue:3 Topics: 4-Butyrolactone; Animals; Biotransformation; Butylene Glycols; Cecum; Diet; Feces; Flax; Germ-Free Life; Gram-Positive Bacteria; Lignans; Rats; Rats, Sprague-Dawley	2010
Human intestinal bacterium, strain END-2 is responsible for demethylation as well as lactonization during plant lignan metabolism. Biological & pharmaceutical bulletin, 2010, Volume: 33, Issue:8 Topics: 4-Butyrolactone; Bacteria, Anaerobic; Biotransformation; Butylene Glycols; Chromatography, High Pressure Liquid; Feces; Humans; Intestines; Lignans; Mass Spectrometry; Methylation; Molecular Structure; Stereoisomerism; Substrate Specificity	2010
Role of bifidobacteria in the activation of the lignan secoisolariciresinol diglucoside. Applied microbiology and biotechnology, 2011, Volume: 92, Issue:1 Topics: 4-Butyrolactone; Bifidobacterium; Biotransformation; Butylene Glycols; Glucosides; Lignans	2011
Antiproliferative activity of lignans against the breast carcinoma cell lines MCF 7 and BT 20. Archives of gynecology and obstetrics, 2012, Volume: 285, Issue:4 Topics: 4-Butyrolactone; Anticarcinogenic Agents; Breast Neoplasms; Butylene Glycols; Cell Line, Tumor; Cell Proliferation; Estradiol; Estrogens; Female; Furans; Humans; Lignans; Phytoestrogens; Selective Estrogen Receptor Modulators; Tamoxifen	2012
Among plant lignans, pinoresinol has the strongest antiinflammatory properties in human intestinal Caco-2 cells. The Journal of nutrition, 2012, Volume: 142, Issue:10 Topics: 4-Butyrolactone; Anti-Inflammatory Agents; Butylene Glycols; Caco-2 Cells; Cell Differentiation; Chemokine CCL2; Chromatography, High Pressure Liquid; Cyclooxygenase 2; Furans; Glucosides; Humans; Interleukin-1beta; Interleukin-6; Interleukin-8; Intestines; Lignans; NF-kappa B; Plant Extracts; Signal Transduction	2012
Permeability and conjugative metabolism of flaxseed lignans by Caco-2 human intestinal cells. Journal of natural products, 2014, Jan-24, Volume: 77, Issue:1 Topics: 4-Butyrolactone; Algorithms; Butylene Glycols; Caco-2 Cells; Chromatography, High Pressure Liquid; Flax; Glucosides; Humans; Intestinal Mucosa; Lignans; Molecular Structure; Permeability	2014
Comparative pharmacokinetics of purified flaxseed and associated mammalian lignans in male Wistar rats. The British journal of nutrition, 2015, Mar-14, Volume: 113, Issue:5 Topics: 4-Butyrolactone; Administration, Oral; Animals; Biological Availability; Butylene Glycols; Dietary Supplements; Dose-Response Relationship, Drug; Estrogens; Flax; Glucosides; Half-Life; Injections, Intravenous; Intestinal Absorption; Kinetics; Lignans; Male; Metabolic Clearance Rate; Phytoestrogens; Random Allocation; Rats, Wistar; Seeds	2015
Effect of bovine ABCG2 polymorphism Y581S SNP on secretion into milk of enterolactone, riboflavin and uric acid. Animal : an international journal of animal bioscience, 2016, Volume: 10, Issue:2 Topics: 4-Butyrolactone; Animals; ATP-Binding Cassette Transporters; Biological Transport; Butylene Glycols; Cattle; Dogs; Female; Lactation; Lignans; Madin Darby Canine Kidney Cells; Milk; Mitoxantrone; Polymorphism, Single Nucleotide; Riboflavin; Uric Acid	2016
Detection of novel metabolites of flaxseed lignans in vitro and in vivo. Molecular nutrition & food research, 2016, Volume: 60, Issue:7 Topics: 4-Butyrolactone; Adult; Bifidobacterium pseudocatenulatum; Butylene Glycols; Dietary Supplements; Feces; Female; Flax; Furans; Gastrointestinal Microbiome; Glucosides; Humans; Intestinal Mucosa; Intestines; Lignans; Male; Middle Aged; Prebiotics; Probiotics; Young Adult	2016
Performance and egg quality of laying hens fed flaxseed: highlights on n-3 fatty acids, cholesterol, lignans and isoflavones. Animal : an international journal of animal bioscience, 2017, Volume: 11, Issue:4 Topics: 4-Butyrolactone; alpha-Linolenic Acid; Animal Feed; Animals; Butylene Glycols; Chickens; Cholesterol; Diet; Dietary Supplements; Eggs; Fatty Acids; Fatty Acids, Omega-3; Female; Flax; Isoflavones; Lignans; Phytoestrogens; Seeds	2017
Incomplete metabolism of phytoestrogens by gut microbiota from children under the age of three. International journal of food sciences and nutrition, 2018, Volume: 69, Issue:3 Topics: 4-Butyrolactone; Adult; Butylene Glycols; Case-Control Studies; Child, Preschool; Coumarins; Equol; Feces; Female; Furans; Gastrointestinal Microbiome; Humans; Hydrolyzable Tannins; Infant; Isoflavones; Lignans; Male; Phytoestrogens; Polyphenols	2018
Oral Pharmacokinetics of Enriched Secoisolariciresinol Diglucoside and Its Polymer in Rats. Journal of natural products, 2021, 06-25, Volume: 84, Issue:6 Topics: 4-Butyrolactone; Animals; Biological Availability; Butylene Glycols; Female; Flax; Glucosides; Lignans; Molecular Structure; Polymers; Rats; Rats, Wistar; Seeds	2021