2,3-bis(3'-hydroxybenzyl)butyrolactone and equol

2,3-bis(3'-hydroxybenzyl)butyrolactone has been researched along with equol in 25 studies

Compound Research Comparison

Studies (2,3-bis(3'-hydroxybenzyl)butyrolactone)	Trials (2,3-bis(3'-hydroxybenzyl)butyrolactone)	Recent Studies (post-2010) (2,3-bis(3'-hydroxybenzyl)butyrolactone)	Studies (equol)	Trials (equol)	Recent Studies (post-2010) (equol)
319	32	124	672	90	348

Protein Interaction Comparison

Protein	Taxonomy	2,3-bis(3'-hydroxybenzyl)butyrolactone (IC50)	equol (IC50)
Estrogen receptor	Homo sapiens (human)		5.876
Estrogen receptor beta	Homo sapiens (human)		5.571

Research

Studies (25)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (12.00)	18.7374
1990's	10 (40.00)	18.2507
2000's	5 (20.00)	29.6817
2010's	5 (20.00)	24.3611
2020's	2 (8.00)	2.80

Authors

Authors	Studies
Adlercreutz, H; Bannwart, C; Brunow, G; Fotsis, T; Hase, T; Wähälä, K	1
Adlercreutz, H; Benassayag, C; Garreau, B; Mäkelä, T; Nunez, EA; Vallette, G; Wähälä, K	1
Adlercreutz, H; Bannwart, C; Brunow, G; Fotsis, T; Hase, T; Mäkelä, T; Musey, PI; Wähälä, K	1
Calaf, G; Jordan, VC; Koch, R; Murphy, CS; Welshons, WV	1
Adlercreutz, H; Dwyer, JT; Fotsis, T; Goldin, BR; Gorbach, SL; Heikkinen, R; Woods, M	1
Campbell, DR; Kirkman, LM; Lampe, JW; Martini, MC; Slavin, JL	1
Hutchins, AM; Lampe, JW; Slavin, JL	1
Joannou, GE; Kelly, GE; Nelson, C; Reeder, AY; Waring, MA	1
Griffiths, K; Morton, MS; Wahlqvist, ML; Wilcox, G	1
Abranches-Monteiro, L; Blacklock, N; Chan, PS; Cheng, C; Correia, R; Griffiths, K; Lloyd, S; Matos-Ferreira, A; Morton, MS	1
Ingram, D; Kolybaba, M; Lopez, D; Sanders, K	1
Adlercreutz, H; Akhmedkhanov, A; Toniolo, P; Zeleniuch-Jacquotte, A	1
Brüggemann-Rotgans, IE; Kardinaal, AF; Morton, MS; van Beresteijn, EC	1
Arisaka, O; Evans, BA; Miyake, N; Morgan, LD; Morton, MS	1
Bingham, SA; Botting, NP; Fryatt, T; Grace, PB; Oldfield, MF; Taylor, JI	1
Andre, F; Antignac, JP; Cariou, R; Cravedi, JP; Le Bizec, B	1
Bingham, SA; Day, NE; Doody, D; Dowsett, M; Dunning, AM; Folkerd, E; Grace, PB; Khaw, KT; Low, YL; Luben, RN; Mulligan, AA; Scollen, S; Taylor, JI; Wareham, NJ; Welch, AA	1
Alexander, FE; Bolton-Smith, C; Heald, CL; Morton, MS; Ritchie, MR	1
Chang, SH; Cho, LY; Choi, BY; Han, DS; Kang, D; Kim, YS; Ko, KP; Ma, SH; Park, SK; Shin, A; Shin, HR; Song, KS; Yang, JJ; Yoo, KY	1
Pfeiffer, CM; Rybak, ME; Sternberg, MR	1
Chang, SH; Cho, LY; Choi, BY; Han, DS; Kang, D; Kim, HJ; Kim, YS; Ko, KP; Ma, SH; Park, SK; Shin, A; Shin, HR; Song, KS; Yang, JJ; Yoo, KY	1
Hori, S; Nakagawa, H; Sugahara, T; Tamura, M; Yamauchi, S	1
Gaya, P; Landete, JM; Medina, M; Peirotén, Á; Sánchez-Jiménez, A	1
Kang, JY; Ko, KP; Lee, J; Park, SK	1
Chen, Y; Yang, F	1

Reviews

1 review(s) available for 2,3-bis(3'-hydroxybenzyl)butyrolactone and equol

Article	Year
Gene polymorphisms in the ornithine decarboxylase-polyamine pathway modify gastric cancer risk by interaction with isoflavone concentrations. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2015, Volume: 18, Issue:3 Topics: 4-Butyrolactone; Adenosylmethionine Decarboxylase; Asian People; Case-Control Studies; Equol; Gene-Environment Interaction; Genistein; Humans; Isoflavones; Lignans; Multicenter Studies as Topic; NAD(P)H Dehydrogenase (Quinone); Nitric Oxide Synthase Type II; Ornithine Decarboxylase; Phytoestrogens; Polyamines; Polymorphism, Single Nucleotide; Stomach Neoplasms	2015

Article

Year

Gene polymorphisms in the ornithine decarboxylase-polyamine pathway modify gastric cancer risk by interaction with isoflavone concentrations.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2015, Volume: 18, Issue:3

Topics: 4-Butyrolactone; Adenosylmethionine Decarboxylase; Asian People; Case-Control Studies; Equol; Gene-Environment Interaction; Genistein; Humans; Isoflavones; Lignans; Multicenter Studies as Topic; NAD(P)H Dehydrogenase (Quinone); Nitric Oxide Synthase Type II; Ornithine Decarboxylase; Phytoestrogens; Polyamines; Polymorphism, Single Nucleotide; Stomach Neoplasms

2015

Trials

2 trial(s) available for 2,3-bis(3'-hydroxybenzyl)butyrolactone and equol

Article	Year
Urinary lignan and isoflavonoid excretion in men and women consuming vegetable and soy diets. Nutrition and cancer, 1995, Volume: 24, Issue:1 Topics: 4-Butyrolactone; Adult; Chromans; Colon; Cross-Over Studies; Diet; Equol; Female; Gas Chromatography-Mass Spectrometry; Genistein; Glycine max; Humans; Isoflavones; Lignans; Male; Sex Characteristics; Vegetables	1995
Urinary isoflavonoid phytoestrogen and lignan excretion after consumption of fermented and unfermented soy products. Journal of the American Dietetic Association, 1995, Volume: 95, Issue:5 Topics: 4-Butyrolactone; Adult; Chromans; Cross-Over Studies; Defecation; Diet; Equol; Estrogens; Estrogens, Non-Steroidal; Fermentation; Food Handling; Genistein; Glycine max; Humans; Isoflavones; Lignans; Male; Phytoestrogens; Plant Preparations; Taste	1995

Article

Year

Urinary lignan and isoflavonoid excretion in men and women consuming vegetable and soy diets.

Nutrition and cancer, 1995, Volume: 24, Issue:1

Topics: 4-Butyrolactone; Adult; Chromans; Colon; Cross-Over Studies; Diet; Equol; Female; Gas Chromatography-Mass Spectrometry; Genistein; Glycine max; Humans; Isoflavones; Lignans; Male; Sex Characteristics; Vegetables

1995

Urinary isoflavonoid phytoestrogen and lignan excretion after consumption of fermented and unfermented soy products.

Journal of the American Dietetic Association, 1995, Volume: 95, Issue:5

Topics: 4-Butyrolactone; Adult; Chromans; Cross-Over Studies; Defecation; Diet; Equol; Estrogens; Estrogens, Non-Steroidal; Fermentation; Food Handling; Genistein; Glycine max; Humans; Isoflavones; Lignans; Male; Phytoestrogens; Plant Preparations; Taste

1995

Other Studies

22 other study(ies) available for 2,3-bis(3'-hydroxybenzyl)butyrolactone and equol

Article	Year
Isotope dilution gas chromatographic-mass spectrometric method for the determination of lignans and isoflavonoids in human urine, including identification of genistein. Clinica chimica acta; international journal of clinical chemistry, 1991, Jul-15, Volume: 199, Issue:3 Topics: 4-Butyrolactone; Butylene Glycols; Chromans; Equol; Female; Furans; Gas Chromatography-Mass Spectrometry; Genistein; Humans; Indicator Dilution Techniques; Isoflavones; Lignans; Lignin; Magnetic Resonance Spectroscopy; Male	1991
Phytoestrogens: new ligands for rat and human alpha-fetoprotein. Biochimica et biophysica acta, 1991, Sep-24, Volume: 1094, Issue:3 Topics: 4-Butyrolactone; Adult; alpha-Fetoproteins; Animals; Arachidonic Acid; Binding, Competitive; Butylene Glycols; Chromans; Equol; Estrogens; Estrogens, Non-Steroidal; Humans; Immunoelectrophoresis; Isoflavones; Ligands; Lignans; Masoprocol; Phytoestrogens; Plant Preparations; Rats; Rats, Inbred Strains	1991
Identification of lignans and phytoestrogens in urine of chimpanzees. Clinica chimica acta; international journal of clinical chemistry, 1986, Jul-30, Volume: 158, Issue:2 Topics: 4-Butyrolactone; Animals; Butylene Glycols; Chromans; Diet; Equol; Estrogens; Estrogens, Non-Steroidal; Isoflavones; Lignans; Male; Pan troglodytes; Phytoestrogens; Plant Extracts; Plant Preparations	1986
Stimulation of breast cancer cells in vitro by the environmental estrogen enterolactone and the phytoestrogen equol. Breast cancer research and treatment, 1987, Volume: 10, Issue:2 Topics: 4-Butyrolactone; Benzopyrans; Breast Neoplasms; Butylene Glycols; Cell Division; Chromans; Equol; Estrogens; Female; Furans; Humans; Isoflavones; Lignans; Receptors, Progesterone; Tumor Cells, Cultured	1987
Excretion of the lignans enterolactone and enterodiol and of equol in omnivorous and vegetarian postmenopausal women and in women with breast cancer. Lancet (London, England), 1982, Dec-11, Volume: 2, Issue:8311 Topics: 4-Butyrolactone; Aged; Benzopyrans; Breast Neoplasms; Butylene Glycols; Chromans; Diet; Diet, Vegetarian; Dietary Fiber; Energy Intake; Equol; Female; Furans; Humans; Isoflavones; Lignans; Menopause; Menstruation; Middle Aged; Plant Extracts	1982
The variable metabolic response to dietary isoflavones in humans. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1995, Volume: 208, Issue:1 Topics: 4-Butyrolactone; Adult; Chromans; Diet; Equol; Estrogens, Non-Steroidal; Female; Glycine max; Humans; Isoflavones; Lignans; Male; Middle Aged; Phytoestrogens; Plant Preparations	1995
Determination of lignans and isoflavonoids in human female plasma following dietary supplementation. The Journal of endocrinology, 1994, Volume: 142, Issue:2 Topics: 4-Butyrolactone; Australia; Chromans; Diet; Equol; Estrogens; Female; Food, Fortified; Gas Chromatography-Mass Spectrometry; Genistein; Glycine max; Humans; Isoflavones; Lignans; Linseed Oil; Middle Aged; Monoamine Oxidase Inhibitors; Neoplasms; Plants, Edible; Postmenopause	1994
Lignans and isoflavonoids in plasma and prostatic fluid in men: samples from Portugal, Hong Kong, and the United Kingdom. The Prostate, 1997, Jul-01, Volume: 32, Issue:2 Topics: 4-Butyrolactone; Adult; Aged; Chromans; Equol; Gas Chromatography-Mass Spectrometry; Hong Kong; Humans; Isoflavones; Lignans; Male; Middle Aged; Portugal; Prostate; Semen; United Kingdom	1997
Case-control study of phyto-oestrogens and breast cancer. Lancet (London, England), 1997, Oct-04, Volume: 350, Issue:9083 Topics: 4-Butyrolactone; Breast Neoplasms; Case-Control Studies; Chromans; Diet; Equol; Estrogens, Non-Steroidal; Female; Humans; Isoflavones; Lignans; Middle Aged; Phytoestrogens; Plant Preparations; Plants; Risk Factors	1997
Reliability of serum measurements of lignans and isoflavonoid phytoestrogens over a two-year period. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1998, Volume: 7, Issue:10 Topics: 4-Butyrolactone; Adult; Age Factors; Aged; Bias; Breast Neoplasms; Chromans; Equol; Feasibility Studies; Female; Genistein; Humans; Isoflavones; Lignans; Middle Aged; New York City; Pilot Projects; Postmenopause; Premenopause; Reference Values; Reproducibility of Results; Sensitivity and Specificity; Time Factors	1998
Phyto-oestrogen excretion and rate of bone loss in postmenopausal women. European journal of clinical nutrition, 1998, Volume: 52, Issue:11 Topics: 4-Butyrolactone; Aging; Bone Density; Chromans; Equol; Estrogens, Non-Steroidal; Female; Gas Chromatography-Mass Spectrometry; Genistein; Humans; Isoflavones; Lignans; Linear Models; Middle Aged; Osteoporosis, Postmenopausal; Phytoestrogens; Plant Preparations; Postmenopause; Prospective Studies; Time Factors	1998
Phytoestrogen concentrations in serum from Japanese men and women over forty years of age. The Journal of nutrition, 2002, Volume: 132, Issue:10 Topics: 4-Butyrolactone; Adult; Aged; Aged, 80 and over; Breast Neoplasms; Chromans; Diet; Equol; Estrogens, Non-Steroidal; Female; Gas Chromatography-Mass Spectrometry; Genistein; Humans; Isoflavones; Japan; Lignans; Male; Middle Aged; Phytoestrogens; Plant Preparations; Prostatic Neoplasms; United Kingdom	2002
Quantification of isoflavones and lignans in urine using gas chromatography/mass spectrometry. Analytical biochemistry, 2003, Apr-01, Volume: 315, Issue:1 Topics: 4-Butyrolactone; Equol; Female; Gas Chromatography-Mass Spectrometry; Genistein; Humans; Isoflavones; Lignans; Molecular Structure; Phytoestrogens; Plant Preparations; Reproducibility of Results; Sensitivity and Specificity	2003
Identification of phytoestrogens in bovine milk using liquid chromatography/electrospray tandem mass spectrometry. Rapid communications in mass spectrometry : RCM, 2003, Volume: 17, Issue:12 Topics: 4-Butyrolactone; Animals; Cattle; Chromans; Chromatography, Liquid; Coumestrol; Equol; Estrogens, Non-Steroidal; Genistein; Ions; Isoflavones; Lignans; Milk; Molecular Structure; Phytoestrogens; Plant Preparations; Spectrometry, Mass, Electrospray Ionization	2003
Polymorphisms in the CYP19 gene may affect the positive correlations between serum and urine phytoestrogen metabolites and plasma androgen concentrations in men. The Journal of nutrition, 2005, Volume: 135, Issue:11 Topics: 4-Butyrolactone; Aged; Androgens; Androstane-3,17-diol; Aromatase; Diet; Equol; Genistein; Genotype; Humans; Isoflavones; Lignans; Male; Middle Aged; Phytoestrogens; Polymorphism, Genetic; Sex Hormone-Binding Globulin; Testosterone	2005
Phyto-oestrogens and risk of prostate cancer in Scottish men. The British journal of nutrition, 2007, Volume: 98, Issue:2 Topics: 4-Butyrolactone; Aged; Case-Control Studies; Diet; Diet Surveys; Energy Intake; Equol; Genistein; Humans; Isoflavones; Lignans; Male; Middle Aged; Phytoestrogens; Prostatic Neoplasms; Risk Assessment; Scotland	2007
Interaction effects between genes involved in the AKT signaling pathway and phytoestrogens in gastric carcinogenesis: a nested case-control study from the Korean Multi-Center Cancer Cohort. Molecular nutrition & food research, 2012, Volume: 56, Issue:11 Topics: 4-Butyrolactone; Aged; Anticarcinogenic Agents; Asian People; Case-Control Studies; CDC2 Protein Kinase; Equol; fas Receptor; Female; Gene-Environment Interaction; Genetic Predisposition to Disease; Genistein; Humans; Isoflavones; Lignans; Male; MAP Kinase Kinase Kinase 1; Middle Aged; Odds Ratio; Phytoestrogens; Polymorphism, Single Nucleotide; Proto-Oncogene Proteins c-akt; Republic of Korea; Signal Transduction; Stomach Neoplasms	2012
Sociodemographic and lifestyle variables are compound- and class-specific correlates of urine phytoestrogen concentrations in the U.S. population. The Journal of nutrition, 2013, Volume: 143, Issue:6 Topics: 4-Butyrolactone; Adult; Age Factors; Alcohol Drinking; Body Mass Index; Equol; Exercise; Female; Humans; Isoflavones; Life Style; Lignans; Male; Middle Aged; Nutrition Surveys; Phytoestrogens; Sex Factors; Smoking; Socioeconomic Factors; United States	2013
Effects of an equol-producing bacterium isolated from human faeces on isoflavone and lignan metabolism in mice. Journal of the science of food and agriculture, 2016, Volume: 96, Issue:9 Topics: 4-Butyrolactone; Actinobacteria; Animals; Equol; Feces; Female; Gastrointestinal Microbiome; Humans; Isoflavones; Lignans; Lipids; Mice; Mice, Inbred ICR; Phytoestrogens	2016
Incomplete metabolism of phytoestrogens by gut microbiota from children under the age of three. International journal of food sciences and nutrition, 2018, Volume: 69, Issue:3 Topics: 4-Butyrolactone; Adult; Butylene Glycols; Case-Control Studies; Child, Preschool; Coumarins; Equol; Feces; Female; Furans; Gastrointestinal Microbiome; Humans; Hydrolyzable Tannins; Infant; Isoflavones; Lignans; Male; Phytoestrogens; Polyphenols	2018
The Association between Plasma Concentration of Phytoestrogens and Hypertension within the Korean Multicenter Cancer Cohort. Nutrients, 2021, Dec-05, Volume: 13, Issue:12 Topics: 4-Butyrolactone; Asian People; Biomarkers; Case-Control Studies; Cohort Studies; Equol; Female; Humans; Hypertension; Lignans; Logistic Models; Male; Phytoestrogens; Republic of Korea; Risk	2021
Urinary phytoestrogens and the risk of uterine leiomyomata in US women. BMC women's health, 2023, 05-13, Volume: 23, Issue:1 Topics: Bayes Theorem; Cross-Sectional Studies; Equol; Female; Genistein; Humans; Leiomyoma; Nutrition Surveys; Phytoestrogens	2023