2'3'-didehydro-2'3'-dideoxyadenosine has been researched along with dideoxyadenosine in 18 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (16.67) | 18.7374 |
| 1990's | 5 (27.78) | 18.2507 |
| 2000's | 9 (50.00) | 29.6817 |
| 2010's | 1 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Balzarini, J; Dalley, NK; De Clercq, E; Herdewijn, P; Robins, MJ; Wood, SG | 1 |
| Baba, M; Balzarini, J; Broder, S; De Clercq, E; Herdewijn, P; Pauwels, R; Vanderhaeghe, H | 1 |
| Baba, M; Balzarini, J; De Clercq, E; Herdewijn, P; Pauwels, R | 1 |
| Eriksson, S; Gosselin, G; Imbach, JL; Maury, G; Pélicano, H; Pierra, C | 1 |
| Balzarini, J; De Clercq, E; Knispel, T; Meier, C | 1 |
| Ballatore, C; Balzarini, J; De Clercq, E; McGuigan, C; Siddiqui, AQ; Wedgwood, O | 1 |
| Balzarini, J; Bentrude, WG; De Clercq, E; Mullah, KB; Rao, TS | 1 |
| Aquaro, S; Balzarini, J; De Clercq, E; Heijtink, R; Kruining, J; McGuigan, C; Naesens, L; Pannecouque, C; Perno, CF; Wedgwood, O; Witvrouw, M | 1 |
| Gurjar, MK; Maheshwar, K | 1 |
| Jiang, FC; Liang, KH; Lin, JS; Wu, JM; Xie, N | 1 |
| Jiang, FC; Liang, KH; Lin, JS; Wu, JM; Zhang, JY | 1 |
| Liang, KH; Lin, JS; Wu, JM; Xie, N | 1 |
| Hu, XM; Lin, JS; Qiu, GF; Wu, JM; Xie, N | 1 |
| Chang, Y; He, XX; Li, Y; Lin, JS; Wang, XY; Zhang, YH | 1 |
| Gao, LL; Li, Y; Lin, JS; Wang, XY; Zhang, YH | 1 |
| Chang, Y; Cheng, XM; He, XX; Li, Y; Lin, JS; Wang, XY; Xu, D; Zhang, YH | 1 |
| Deng, F; Gao, LL; Hu, ZH; Jin, JS; Wang, HL; Wang, XY | 1 |
| Hovorun, DM; Ponomareva, AG; van Mourik, T; Yurenko, YP; Zhurakivsky, RO | 1 |
18 other study(ies) available for 2'3'-didehydro-2'3'-dideoxyadenosine and dideoxyadenosine
| Article | Year |
|---|---|
Nucleic acid related compounds. 57. Synthesis, x-ray crystal structure, lipophilic partition properties, and antiretroviral activities of anomeric 3'-azido-2',3'-dideoxy-2,6-diaminopurine ribosides.
Topics: Animals; Antiviral Agents; Cell Transformation, Viral; Chemical Phenomena; Chemistry; Dideoxyadenosine; Dideoxynucleosides; Mice; Microbial Sensitivity Tests; Models, Molecular; Retroviridae; Solubility; X-Ray Diffraction | 1989 |
3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents.
Topics: Antiviral Agents; Cell Line; Chemical Phenomena; Chemistry; Cytopathogenic Effect, Viral; Deoxyribonucleosides; HIV; Humans; Structure-Activity Relationship; T-Lymphocytes; Virus Replication | 1987 |
Synthesis and anti-HIV activity of various 2'- and 3'-substituted 2',3'-dideoxyadenosines: a structure-activity analysis.
Topics: Antiviral Agents; Deoxyadenosines; Dideoxyadenosine; HIV; Structure-Activity Relationship | 1987 |
Enzymatic properties of the unnatural beta-L-enantiomers of 2',3'-dideoxyadenosine and 2',3'-didehydro-2',3'-dideoxyadenosine.
Topics: Adenosine Deaminase; Adenosine Kinase; Animals; Anti-HIV Agents; Antiviral Agents; Cattle; Deoxycytidine Kinase; Dideoxyadenosine; Drug Stability; Hepatitis B virus; HIV; Humans; Purine-Nucleoside Phosphorylase; Stereoisomerism; Structure-Activity Relationship | 1997 |
cycloSal-Pronucleotides of 2',3'-dideoxyadenosine and 2', 3'-dideoxy-2',3'-didehydroadenosine: synthesis and antiviral evaluation of a highly efficient nucleotide delivery system.
Topics: 3T3 Cells; Adenosine Deaminase; Adenosine Monophosphate; AMP Deaminase; Animals; Anti-HIV Agents; Cell Line; Cell Transformation, Viral; Deoxyadenine Nucleotides; Dideoxynucleotides; Drug Delivery Systems; Drug Evaluation, Preclinical; HIV-1; HIV-2; Humans; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Mice; Organophosphates; Prodrugs; Structure-Activity Relationship; Virus Replication | 1999 |
Simple mono-derivatisation of the aryl moiety of D4A and DDA-based phosphoramidate prodrugs significantly enhances their anti-HIV potency in cell culture.
Topics: Anti-HIV Agents; Cells, Cultured; Dideoxyadenosine; HIV-1; HIV-2; Humans; Structure-Activity Relationship | 1999 |
Potential prodrug derivatives of 2',3'-didehydro-2',3'-dideoxynucleosides. Preparations and antiviral activities.
Topics: Antiviral Agents; Cytopathogenic Effect, Viral; Dideoxyadenosine; Dideoxynucleosides; HIV-1; Humans; Microbial Sensitivity Tests; Prodrugs; Tumor Cells, Cultured; Virus Replication; Viruses | 1992 |
Conversion of 2',3'-dideoxyadenosine (ddA) and 2',3'-didehydro-2',3'-dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus.
Topics: Adenosine Monophosphate; Alanine; Animals; Anti-HIV Agents; Antiviral Agents; Cell Line; Cells, Cultured; Dideoxyadenosine; Hepatitis B virus; HIV; Humans; Leukocytes, Mononuclear; Macrophages; Molecular Structure; Moloney murine sarcoma virus; Simian Immunodeficiency Virus; Transfection; Tumor Cells, Cultured | 1997 |
Stereoselective synthesis of a novel carbocyclic nucleoside.
Topics: Adenosine; Antiviral Agents; Dideoxyadenosine; Stereoisomerism | 2001 |
[Effect and mechanism of beta-L-D4A (a novel nucleoside analog) against hepatitis B virus].
Topics: Antiviral Agents; Dideoxyadenosine; DNA, Viral; Dose-Response Relationship, Drug; Hepatitis B virus; Humans; Liver Neoplasms; Nucleic Acid Synthesis Inhibitors; Tumor Cells, Cultured; Virus Replication | 2003 |
[Inhibition of the replication of hepatitis B virus in vitro by a novel nucleoside analogue (beta-L-D4A)].
Topics: Antiviral Agents; Dideoxyadenosine; Hepatitis B virus; Virus Replication | 2003 |
Inhibition of hepatitis B virus by a novel L-nucleoside, beta-L-D4A and related analogues.
Topics: Dideoxyadenosine; Dose-Response Relationship, Drug; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Structure-Activity Relationship; Tumor Cells, Cultured; Virus Replication | 2003 |
[Synthesis of a novel L-nucleoside, beta-L-D4A and its inhibition on the replication of hepatitis B virus in vitro].
Topics: Antiviral Agents; Cell Line, Tumor; Cell Proliferation; Dideoxyadenosine; DNA Replication; DNA, Viral; Genome, Viral; Hepatitis B virus; Humans; Liver Neoplasms; Transfection; Virus Replication | 2005 |
Effect and mechanism of beta-L-D4A on DNA polymerase alpha.
Topics: Chromatography, DEAE-Cellulose; Chromatography, Ion Exchange; Dideoxyadenosine; DNA Polymerase I; Enzyme Activation; Female; HeLa Cells; Hepatitis B; Hepatitis B virus; Humans; Nucleosides; Virus Replication | 2007 |
Efficacies of beta-L-D4A against Hepatitis B virus in 2.2.15 cells.
Topics: Antiviral Agents; Cell Line; Dideoxyadenosine; DNA Replication; DNA, Viral; Dose-Response Relationship, Drug; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Lamivudine; Models, Chemical; Tetrazolium Salts; Thiazoles; Virus Replication | 2008 |
Effects of two novel nucleoside analogues on different hepatitis B virus promoters.
Topics: 2-Aminopurine; Cell Line; Dideoxyadenosine; Green Fluorescent Proteins; Hepatitis B virus; Humans; Molecular Structure; Promoter Regions, Genetic | 2008 |
Inhibition of reverse transcriptase activity of hepatitis B virus polymerase by β-l-D4A-TP.
Topics: Dideoxyadenosine; Down-Regulation; Enzyme Inhibitors; Hepatitis B virus; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Viral Proteins | 2008 |
Structural and energetic properties of the potential HIV-1 reverse transcriptase inhibitors d4A and d4G: a comprehensive theoretical investigation.
Topics: Dideoxyadenosine; Dideoxynucleosides; DNA; HIV Reverse Transcriptase; HIV-1; Models, Molecular; Molecular Conformation; Protein Conformation; Reverse Transcriptase Inhibitors | 2014 |