2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane has been researched along with methoxychlor in 30 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.33) | 18.2507 |
| 2000's | 17 (56.67) | 29.6817 |
| 2010's | 12 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ernst, B; Lill, MA; Vedani, A; Winiger, F | 1 |
| Gaido, KW; Hall, JM; Leonard, LS; Maness, SC; McDonnell, DP; Safe, S; Saville, B | 1 |
| Akingbemi, BT; Ge, RS; Gunsalus, GL; Hardy, MP; Klinefelter, GR | 1 |
| Dehal, SS; Gaido, KW; Kupfer, D; Maness, SC; McDonnell, DP; Safe, S | 1 |
| Gaido, KW; Safe, S; Waters, KM | 1 |
| Bartolucci, EJ; Casanova, M; Dorman, DC; Everitt, JI; Fryczynski, MW; Gaido, KW; Heck Hd, Hd; Ross, SM; You, L | 1 |
| Germann, SL; Golub, MS; Hogrefe, CE; Lasley, BL; Natarajan, K; Tarantal, AF | 1 |
| Gagne, PV; Hazai, E; Kupfer, D | 1 |
| Derk, RC; Murono, EP | 1 |
| Flaws, JA; Miller, KP; Symonds, DA; Tomic, D | 1 |
| James, MO; Kleinow, KM; Stegeman, JJ; Stuchal, LD | 1 |
| Uzumcu, M; Zachow, R | 1 |
| Flaws, JA; Gupta, RK; Miller, KP | 1 |
| Armenti, AE; Kuhn, PE; Marano, JE; Passantino, L; Uzumcu, M | 1 |
| Aberdeen, G; Albrecht, ED; Babus, JK; Flaws, JA; Gupta, RK | 1 |
| Blum, JL; Denslow, ND; James, MO; Stuchal, LD | 1 |
| Akgul, Y; Derk, RC; Meighan, T; Murono, EP; Rao, KM | 1 |
| Brooks, AI; Esmail, M; Harvey, CN; Uzumcu, M; Wang, Q; Zachow, R | 1 |
| Akingbemi, BT; Chu, Y; Ge, RS; Hu, GX; Li, XH; Zhao, B; Zheng, ZQ | 1 |
| Li, WS; Zhang, LK; Zhang, XY | 1 |
| Basavarajappa, MS; Flaws, JA; Hernández-Ochoa, I; Paulose, T; Peretz, J | 1 |
| Barouki, R; Desmots, S; Lemazurier, E; Quignot, N | 1 |
| Liu, W; Wen, Y; Zhang, C; Zhang, J; Zhuang, S | 1 |
| Chen, B; Chu, Y; Deng, H; Ge, RS; Guo, J; Li, H; Zhao, B; Zhu, Q | 1 |
| Aoyama, H; Chapin, RE | 1 |
| Akingbemi, BT; Chen, B; Chen, X; Ge, RS; Guo, J; Li, H; Li, X; Ye, L; Yu, L; Zhu, Q | 1 |
| Bagnell, CA; Chen, JC; Harvey, CN; Uzumcu, M | 1 |
| Chen, B; Chen, M; Dong, Y; Ge, RS; Hu, GX; Pan, P; Wang, L | 1 |
| Bai, Y; Ge, RS; Li, H; Li, X; Lian, Q; Liu, J; Liu, S; Mao, B | 1 |
| Broussard, C; Escalante Cobb, P; Godde, K; Leung-Gurung, L; Mourad, F; Muscato, Z; Sanchez, V; Zambrano, C | 1 |
1 review(s) available for 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane and methoxychlor
| Article | Year |
|---|---|
Reproductive toxicities of methoxychlor based on estrogenic properties of the compound and its estrogenic metabolite, hydroxyphenyltrichloroethane.
Topics: Animals; Biotransformation; Endocrine Disruptors; Environmental Pollutants; Estrogens, Non-Steroidal; Female; Fetal Development; Genitalia, Female; Genitalia, Male; Humans; Infertility, Female; Infertility, Male; Insecticides; Male; Methoxychlor; Phenols; Pregnancy; Sexual Development | 2014 |
29 other study(ies) available for 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane and methoxychlor
| Article | Year |
|---|---|
Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.
Topics: Benzhydryl Compounds; Binding Sites; Diethylstilbestrol; Endocrine System; Hydrocarbons, Chlorinated; Ligands; Models, Molecular; Molecular Conformation; Phenols; Phytoestrogens; Quantitative Structure-Activity Relationship; Receptors, Androgen; Testosterone; Thermodynamics; Xenobiotics | 2005 |
Differential interaction of the methoxychlor metabolite 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane with estrogen receptors alpha and beta.
Topics: Animals; Carcinoma, Hepatocellular; Estrogen Antagonists; Estrogen Receptor alpha; Estrogen Receptor beta; Gene Expression; HeLa Cells; Humans; Liver Neoplasms; Methoxychlor; Phenols; Rats; Receptors, Estrogen; Transfection; Tumor Cells, Cultured | 1999 |
A metabolite of methoxychlor, 2,2-bis(p-hydroxyphenyl)-1,1, 1-trichloroethane, reduces testosterone biosynthesis in rat leydig cells through suppression of steady-state messenger ribonucleic acid levels of the cholesterol side-chain cleavage enzyme.
Topics: Animals; Cell Differentiation; Cell Survival; Cholesterol Side-Chain Cleavage Enzyme; Dose-Response Relationship, Drug; Estradiol; Estrogen Antagonists; Fulvestrant; Leydig Cells; Luteinizing Hormone; Male; Methoxychlor; Phenols; Rats; Rats, Sprague-Dawley; RNA, Messenger; Testosterone | 2000 |
Interaction of methoxychlor and related compounds with estrogen receptor alpha and beta, and androgen receptor: structure-activity studies.
Topics: Dose-Response Relationship, Drug; Estrogen Antagonists; Estrogen Receptor alpha; Estrogen Receptor beta; Humans; Insecticides; Methoxychlor; Phenols; Receptors, Androgen; Receptors, Estrogen; Structure-Activity Relationship; Transfection; Tumor Cells, Cultured | 2000 |
Differential gene expression in response to methoxychlor and estradiol through ERalpha, ERbeta, and AR in reproductive tissues of female mice.
Topics: Animals; DNA Primers; Drug Combinations; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Flutamide; Gene Expression Regulation; Genitalia, Female; Methoxychlor; Mice; Mice, Inbred C57BL; Ovary; Phenols; Receptors, Androgen; Receptors, Estrogen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Uterus | 2001 |
Combined effects of dietary phytoestrogen and synthetic endocrine-active compound on reproductive development in Sprague-Dawley rats: genistein and methoxychlor.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Interactions; Endocrine Glands; Estrogens, Non-Steroidal; Estrous Cycle; Female; Genistein; Humans; Isoflavones; Male; Methoxychlor; Motor Activity; Ovary; Phenols; Phytoestrogens; Plant Preparations; Pregnancy; Pregnancy Outcome; Rats; Rats, Sprague-Dawley; Receptors, Androgen; Receptors, Estrogen; Reproduction; Sexual Maturation; Tumor Cells, Cultured | 2002 |
Effects of exogenous estrogenic agents on pubertal growth and reproductive system maturation in female rhesus monkeys.
Topics: Aging; Animals; Body Weight; Diethylstilbestrol; Eating; Estrogen Receptor alpha; Estrogens; Estrogens, Non-Steroidal; Female; Genitalia, Female; Growth; Insecticides; Macaca mulatta; Menstruation; Methoxychlor; Nipples; Phenols; Receptors, Estrogen; Skin; Ultrasonography; Uterus | 2003 |
Glucuronidation of the oxidative cytochrome P450-mediated phenolic metabolites of the endocrine disruptor pesticide: methoxychlor by human hepatic UDP-glucuronosyl transferases.
Topics: Blotting, Western; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Glucuronosyltransferase; Humans; Hydrocarbons, Chlorinated; In Vitro Techniques; Insecticides; Mass Spectrometry; Methoxychlor; Microsomes, Liver; Oxidation-Reduction; Phenols; Stereoisomerism; Time Factors | 2004 |
The effects of the reported active metabolite of methoxychlor, 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane, on testosterone formation by cultured Leydig cells from young adult rats.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cells, Cultured; Cholesterol Side-Chain Cleavage Enzyme; Chorionic Gonadotropin; Dose-Response Relationship, Drug; Drug Combinations; Estrogen Antagonists; Flutamide; Insecticides; Leydig Cells; Male; Methoxychlor; Oxazoles; Phenols; Rats; Rats, Sprague-Dawley; Testosterone | 2004 |
Methoxychlor induces proliferation of the mouse ovarian surface epithelium.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Count; Cell Culture Techniques; Cell Proliferation; Cells, Cultured; Cyclin D2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Cyclins; Epithelium; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Female; Fulvestrant; Insecticides; Methoxychlor; Mice; Mice, Inbred Strains; Ovary; Phenols; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2 | 2005 |
Demethylation of the pesticide methoxychlor in liver and intestine from untreated, methoxychlor-treated, and 3-methylcholanthrene-treated channel catfish (Ictalurus punctatus): evidence for roles of CYP1 and CYP3A family isozymes.
Topics: Animals; Carbon Radioisotopes; Carcinogens; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP3A; Dealkylation; Drug Interactions; Endocrine Disruptors; Enzyme Induction; Female; Ictaluridae; Insecticides; Intestines; Kinetics; Liver; Male; Methoxychlor; Methylcholanthrene; Microsomes, Liver; Phenols | 2006 |
The methoxychlor metabolite, 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane, inhibits steroidogenesis in rat ovarian granulosa cells in vitro.
Topics: 3-Hydroxysteroid Dehydrogenases; Animals; Aromatase; Cells, Cultured; Cyclic CMP; Estradiol; Female; Follicle Stimulating Hormone; Granulosa Cells; Methoxychlor; Phenols; Phosphoproteins; Progesterone; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Up-Regulation | 2006 |
Methoxychlor metabolites may cause ovarian toxicity through estrogen-regulated pathways.
Topics: Animals; Estrogens; Female; Hydrocarbons, Chlorinated; Methoxychlor; Mice; Ovarian Follicle; Ovary; Phenols | 2006 |
Early postnatal methoxychlor exposure inhibits folliculogenesis and stimulates anti-Mullerian hormone production in the rat ovary.
Topics: Animals; Animals, Newborn; Anti-Mullerian Hormone; Blotting, Western; Female; Glycoproteins; Granulosa Cells; Immunohistochemistry; Insecticides; Methoxychlor; Ovarian Follicle; Ovary; Phenols; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Testicular Hormones | 2006 |
Methoxychlor and its metabolites inhibit growth and induce atresia of baboon antral follicles.
Topics: Animals; Dose-Response Relationship, Drug; Female; Insecticides; Methoxychlor; Ovarian Follicle; Papio; Phenols; Species Specificity | 2007 |
Stimulation of transactivation of the largemouth bass estrogen receptors alpha, beta-a, and beta-b by methoxychlor and its mono- and bis-demethylated metabolites in HepG2 cells.
Topics: Animals; Bass; DDT; Drug Combinations; Drug Evaluation, Preclinical; Drug Interactions; Endocrine Disruptors; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Humans; Methoxychlor; Phenols; Protein Isoforms; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 2008 |
The methoxychlor metabolite, HPTE, directly inhibits the catalytic activity of cholesterol side-chain cleavage (P450scc) in cultured rat ovarian cells.
Topics: Androgen Antagonists; Animals; Benzhydryl Compounds; Catalytic Domain; Cells, Cultured; Cholesterol Side-Chain Cleavage Enzyme; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Estrogens; Female; Flutamide; Fulvestrant; Gene Expression Regulation, Enzymologic; Gonadotropins, Equine; Methoxychlor; Ovary; Oxazoles; Phenols; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, Androgen; Receptors, Estrogen; RNA, Messenger | 2008 |
Effect of the methoxychlor metabolite HPTE on the rat ovarian granulosa cell transcriptome in vitro.
Topics: Animals; Cells, Cultured; Cyclic AMP; Estradiol; Female; Follicle Stimulating Hormone; Gene Expression; Gene Expression Profiling; Granulosa Cells; Insecticides; Methoxychlor; Models, Genetic; Oligonucleotide Array Sequence Analysis; Ovary; Phenols; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction | 2009 |
Effects of methoxychlor and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane on 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase-3 activities in human and rat testes.
Topics: 17-Hydroxysteroid Dehydrogenases; Animals; Humans; Inhibitory Concentration 50; Kinetics; Male; Methoxychlor; Microsomes; Phenols; Rats; Rats, Sprague-Dawley; Testis | 2011 |
[Determination of methoxychlor in rabbit serum and its metabolic products with high performance liquid chromatography].
Topics: Animals; Chromatography, High Pressure Liquid; Methoxychlor; Phenols; Rabbits | 2010 |
Increased sensitivity of estrogen receptor alpha overexpressing antral follicles to methoxychlor and its metabolites.
Topics: Animals; Cell Size; Cells, Cultured; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Estrogen Receptor alpha; Female; Gene Expression; Immunohistochemistry; Methoxychlor; Mice; Mice, Transgenic; Ovarian Follicle; Phenols; Reverse Transcriptase Polymerase Chain Reaction | 2011 |
A comparison of two human cell lines and two rat gonadal cell primary cultures as in vitro screening tools for aromatase modulation.
Topics: Androgen Antagonists; Animals; Aromatase; Atrazine; Benzhydryl Compounds; Cell Line, Tumor; Cells, Cultured; Endocrine Disruptors; Estrogens, Non-Steroidal; Female; Gene Expression Regulation, Enzymologic; Granulosa Cells; Humans; Leydig Cells; Male; Methoxychlor; Oxazoles; Phenols; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2012 |
Distinct mechanisms of endocrine disruption of DDT-related pesticides toward estrogen receptor α and estrogen-related receptor γ.
Topics: DDT; Dichlorodiphenyl Dichloroethylene; Dichlorodiphenyldichloroethane; Endocrine Disruptors; Estrogen Receptor alpha; Humans; Hydrogen Bonding; Methoxychlor; Molecular Conformation; Molecular Dynamics Simulation; Pesticides; Phenols; Protein Binding; Protein Structure, Secondary; Receptors, Estrogen | 2012 |
Effects of methoxychlor and its metabolite 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane on 11β-hydroxysteroid dehydrogenase activities in vitro.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; 11-beta-Hydroxysteroid Dehydrogenase Type 2; Adult; Animals; Enzyme Inhibitors; Female; Humans; Inhibitory Concentration 50; Kidney; Male; Methoxychlor; Microsomes, Liver; Pesticides; Phenols; Placenta; Pregnancy; Rats; Species Specificity | 2013 |
Effects of methoxychlor and its metabolite 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane on human and rat 17α-hydroxylase/17,20-lyase activity.
Topics: Aged; Animals; Humans; Inhibitory Concentration 50; Insecticides; Kinetics; Leydig Cells; Male; Methoxychlor; Microsomes; Phenols; Rats; Rats, Sprague-Dawley; Steroid 17-alpha-Hydroxylase; Testis | 2014 |
Methoxychlor and its metabolite HPTE inhibit cAMP production and expression of estrogen receptors α and β in the rat granulosa cell in vitro.
Topics: Animals; Cells, Cultured; Cyclic AMP; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogen Receptor Modulators; Female; Follicle Stimulating Hormone; Fulvestrant; Granulosa Cells; Insecticides; Methoxychlor; Nitriles; Phenols; Pyrazoles; Pyrimidines; Rats, Sprague-Dawley; RNA, Messenger | 2015 |
Effects of methoxychlor and 2,2-bis ( p -hydroxyphenyl)-1,1,1-trichloroethane on cytochrome P450 enzyme activities in human and rat livers.
Topics: Animals; Cytochrome P-450 Enzyme System; Humans; Insecticides; Liver; Male; Methoxychlor; Microsomes, Liver; Phenols; Rats, Sprague-Dawley | 2015 |
Effects of Methoxychlor and Its Metabolite Hydroxychlor on Human Placental 3β-Hydroxysteroid Dehydrogenase 1 and Aromatase in JEG-3 Cells.
Topics: Animals; Aromatase; Aromatase Inhibitors; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Dehydroepiandrosterone; Estradiol; Female; Humans; Insecticides; Methoxychlor; Multienzyme Complexes; Phenols; Placenta; Pregnancy; Progesterone; Progesterone Reductase; Steroid Isomerases | 2016 |
Methoxychlor metabolite HPTE alters viability and differentiation of embryonic thymocytes from C57BL/6 mice.
Topics: Animals; Cell Differentiation; Cell Survival; Cells, Cultured; Endocrine Disruptors; Female; Fetal Development; Fetus; Humans; Male; Methoxychlor; Mice; Mice, Inbred C57BL; Pesticides; Phenols; T-Lymphocytes; Thymocytes | 2018 |