2,2,5,7,8-pentamethyl-1-hydroxychroman and d-alpha tocopherol

2,2,5,7,8-pentamethyl-1-hydroxychroman has been researched along with d-alpha tocopherol in 66 studies

Research

Studies (66)

Timeframe	Studies, this research(%)	All Research%
pre-1990	14 (21.21)	18.7374
1990's	18 (27.27)	18.2507
2000's	22 (33.33)	29.6817
2010's	11 (16.67)	24.3611
2020's	1 (1.52)	2.80

Authors

Authors	Studies
Aizawa, Y; Hasegawa, K; Iizuka, Y; Iwaoka, T; Kanai, T; Yamaguchi, T; Yoshioka, T	1
Alvey, L; Cole, ST; Janin, YL; Koch, M; Michel, S; Prado, S; Saint-Joanis, B; Tillequin, F	1
Gotoh, N; Niki, E	1
Forte, T; Kagan, VE; Packer, L; Scita, G; Serbinova, EA	1
Kagan, VE; Maguire, JJ; Packer, L	1
Alekseev, SM; Chudinova, VV; Evstigneeva, RP; Shuaipov, KA; Zakharova, EI	1
Catudioc, JD; Kagan, VE; Packer, L; Safadi, A; Serbinova, EA	1
Hebert, JS; Hruza, LL; Jacobs, SC; Morrison, AR; Packer, L; Pentland, AP	1
Alekseev, SM; Erin, AN; Gorbunov, NV; Kagan, VE	1
Kaneko, T; Matsuo, M; Nakano, S	1
Kagan, VE; Maguire, JJ; Mehlhorn, RJ; Packer, L; Serbinova, E	1
Kagan, VE	1
Hanaki, A; Ozawa, T	2
Kato, K; Ueno, Y; Yamauchi, R	1
Davitashvili, NG; Erin, AN; Kagan, VE; Sarycheva, IK; Zakharova, EI	1
Kagan, VE; Kozlov, IuP; Novikov, KN; Viner, RI	1
Burlakova, EB; Dzhafarov, AI; Goloshchapov, AN; Kerimov, RF	1
Buldygerova, NV; Erin, AN; Kovaleva, ES; Muranov, KO; Prilipko, LL	1
Bakalova, RA; Kagan, VE; Serbinova, EA; Stoĭchev, TsS	1
Kamiya, Y; Kawakami, A; Niki, E; Saito, M; Tsuchiya, J; Yamamoto, Y	1
Hanaki, A; Matsuo, M; Ozawa, T	1
Chida, H; Fukuzawa, K; Suzuki, A	1
Banba, N; Hattori, S; Hattori, Y; Kasai, K; Shimoda, S	1
Akiyama, J; Horton, AA; Kanno, T; Kobuchi, H; Takehara, Y; Utsumi, K; Utsumi, T; Yoshioka, T	1
Baca, M; Kohar, I; Southwell-Keely, PT; Stocker, R; Suarna, C	1
Pekiner, B; Pennock, JF	1
Kaji, K; Kaneko, T; Matsuo, M	1
Koga, T; Terao, J	1
Koga, T; Moro, K; Terao, J	1
Brenna, JT; Haggarty, P; Van Pelt, CK	1
Bergamini, S; Carta, G; Day, BW; Kagan, VE; Tyurin, VA; Tyurina, YY	1
Barclay, LR; Vinqvist, MR	1
Goffman, FD; Pujadas-Salvà, AJ; Velasco, L	1
Ho, H; Hook, JM; Soldevilla, J; Southwell-Keely, PT	1
Baba, N; Kaneko, T; Matsuo, M	1
Kanazawa, H; Matsumoto, S; Matsushima, Y; Mochizuki, M; Nagata, Y; Nishio, T	1
Southwell-Keely, PT; Srikendari, EW; Sunthomphanich, S	1
Thompson, TA; Wilding, G	1
Azzam, SA; Darby, WJ; Dinning, JS; Folkers, K; Majaj, AS; Shunk, CH	1
Alpstäg-Wöhrle, AL; Christen, B; Krämer, SD; Marenchino, M; Wunderli-Allenspach, H	1
Adelwöhrer, C; Gille, L; Grabner, G; Gregor, W; Rosenau, T	2
Gille, L; Gregor, W; Nohl, H; Rosenau, T; Staniek, K	1
Gill, PM; Lee, SB; Lin, CY; Webster, RD	1
Alonso, E; Chougnet, A; Grütter, C; Woggon, WD	1
Kelly, MJ; Mathie, AZ; Vallance, C	1
Chen, YC; Chou, DS; Hsiao, G; Lee, JJ; Lin, JH; Lin, KH; Shen, MY; Sheu, JR	1
Freiser, H; Jiang, Q; Wood, KV; Yin, X	1
Guo, Y; Xie, D; Xue, Y; Zhu, Y	1
Bisby, RH; Crisostomo, AG; Moreno, RB; Navaratnam, S; Wilkinson, JA	1
Amorati, R; Cavalli, A; Fumo, MG; Masetti, M; Menichetti, S; Pagliuca, C; Pedulli, GF; Viglianisi, C	1
Buss, A; Chapelat, J; Chougnet, A; Woggon, WD	1
Danielson, ML; Freiser, H; Huang, J; Jiang, Q; Lill, MA; Yin, X	1
Chougnet, A; Hengartner, U; Liu, K; Woggon, WD	1
Atkinson, J; Panagabko, C; West, R	1
Chang, CC; Chiang, CW; Hsiao, G; Hsieh, CY; Jayakumar, T; Lee, JJ; Sheu, JR	1
Granold, M; Moosmann, B; Ohlow, MJ; Schreckenberger, M	1
Cosa, G; Friedland, S; Krumova, K	1
Cheng, G; Dwinell, MB; Joseph, J; Kalyanaraman, B; Mackinnon, AC; McAllister, DM; Zielonka, J	1
Birringer, M; Cruciani, G; Funke, H; Galli, F; Lorkowski, S; Mosig, S; Pellegrino, RM; Rennert, K; Ristow, M; Wallert, M	1
Cardoso, Lde M; da Silva, LL; de Carvalho, CW; de Menezes, CB; Martino, HS; Pinheiro, SS; Pinheiro-Sant'Ana, HM; Queiroz, VA; Tardin, FD	1
Jodko-Piórecka, K; Litwinienko, G	1
Eickhoff, JC; Heath, EI; Kolesar, J; Kyriakopoulos, CE; Liu, G; Moll, T; Wilding, G; Yayehyirad, M	1
Huang, J; Jang, Y; Jiang, Q; Park, NY; Rostgaard-Hansen, AL	1
Hara, S; Iuchi, K; Katsuragi, H; Ogawa, S	1

Reviews

1 review(s) available for 2,2,5,7,8-pentamethyl-1-hydroxychroman and d-alpha tocopherol

Article	Year
Tocopherol stabilizes membrane against phospholipase A, free fatty acids, and lysophospholipids. Annals of the New York Academy of Sciences, 1989, Volume: 570 Topics: Cell Membrane; Cell Membrane Permeability; Chemical Phenomena; Chemistry, Physical; Chromans; Fatty Acids, Nonesterified; Liposomes; Lysophospholipids; Membrane Proteins; Phospholipases; Phospholipases A; Temperature; Vitamin E	1989

Trials

1 trial(s) available for 2,2,5,7,8-pentamethyl-1-hydroxychroman and d-alpha tocopherol

Article	Year
A multicenter phase 1/2a dose-escalation study of the antioxidant moiety of vitamin E 2,2,5,7,8-pentamethyl-6-chromanol (APC-100) in men with advanced prostate cancer. Investigational new drugs, 2016, Volume: 34, Issue:2 Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Antioxidants; Chromans; Dose-Response Relationship, Drug; Humans; Male; Middle Aged; Neoplasm Staging; Prostatic Neoplasms; Vitamin E	2016

Article

Year

A multicenter phase 1/2a dose-escalation study of the antioxidant moiety of vitamin E 2,2,5,7,8-pentamethyl-6-chromanol (APC-100) in men with advanced prostate cancer.

Investigational new drugs, 2016, Volume: 34, Issue:2

Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Antioxidants; Chromans; Dose-Response Relationship, Drug; Humans; Male; Middle Aged; Neoplasm Staging; Prostatic Neoplasms; Vitamin E

2016

Other Studies

64 other study(ies) available for 2,2,5,7,8-pentamethyl-1-hydroxychroman and d-alpha tocopherol

Article	Year
Studies on hindered phenols and analogues. 2. 1,3-Benzoxathioles having SRS-A inhibiting activity. Journal of medicinal chemistry, 1990, Volume: 33, Issue:5 Topics: Animals; Asthma; Benzoxazoles; Chemical Phenomena; Chemistry; Guinea Pigs; Lipid Peroxidation; Lipoxygenase Inhibitors; Mice; Mice, Inbred C57BL; SRS-A; Structure-Activity Relationship	1990
Diversity-oriented synthesis of furo[3,2-f]chromanes with antimycobacterial activity. European journal of medicinal chemistry, 2009, Volume: 44, Issue:6 Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Benzopyrans; Candida tropicalis; Chlorocebus aethiops; Dose-Response Relationship, Drug; Drug Design; Furans; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium bovis; Mycobacterium tuberculosis; Stereoisomerism; Vero Cells	2009
Rates of interactions of superoxide with vitamin E, vitamin C and related compounds as measured by chemiluminescence. Biochimica et biophysica acta, 1992, Jan-23, Volume: 1115, Issue:3 Topics: Ascorbic Acid; Binding, Competitive; Chromans; Hydrogen-Ion Concentration; Hypoxanthine; Hypoxanthines; Kinetics; Liposomes; Luminescent Measurements; Phosphatidylcholines; Pyrazines; Superoxides; Vitamin E; Xanthine Oxidase	1992
Recycling of vitamin E in human low density lipoproteins. Journal of lipid research, 1992, Volume: 33, Issue:3 Topics: Ascorbic Acid; beta Carotene; Carotenoids; Chromans; Drug Synergism; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Humans; Linolenic Acids; Lipid Peroxidation; Lipoproteins, LDL; Lipoxygenase; Thioctic Acid; Ultraviolet Rays; Vitamin E	1992
Electron transport between cytochrome c and alpha tocopherol. Biochemical and biophysical research communications, 1992, Oct-15, Volume: 188, Issue:1 Topics: Animals; Antimycin A; Chromans; Cytochrome c Group; Electron Spin Resonance Spectroscopy; Electron Transport; Intracellular Membranes; Kinetics; Liposomes; Mitochondria, Liver; Oxidation-Reduction; Phosphatidylcholines; Phosphatidylserines; Rats; Submitochondrial Particles; Succinate Cytochrome c Oxidoreductase; Vitamin E	1992
[Transformation products of vitamin E and its analog--chroman C1 in an oxidizing ethyl linoleate medium]. Bioorganicheskaia khimiia, 1992, Volume: 18, Issue:7 Topics: Chromans; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Linoleic Acids; Magnetic Resonance Spectroscopy; Oxidation-Reduction; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Vitamin E	1992
NADPH-dependent inhibition of lipid peroxidation in rat liver microsomes. Biochemical and biophysical research communications, 1992, Jul-15, Volume: 186, Issue:1 Topics: Animals; Azo Compounds; Chromans; Chromatography, High Pressure Liquid; Deferoxamine; Kinetics; Lipid Peroxidation; Male; Microsomes, Liver; Models, Biological; NADP; Nitriles; Oxidation-Reduction; Rats; Rats, Inbred Strains; Vitamin E; Vitamin E Deficiency	1992
Tocopherol analogs suppress arachidonic acid metabolism via phospholipase inhibition. The Journal of biological chemistry, 1992, Aug-05, Volume: 267, Issue:22 Topics: Arachidonic Acids; Bradykinin; Calcimycin; Cells, Cultured; Chromans; Dinoprostone; Humans; Keratinocytes; Kinetics; Phospholipases; Prostaglandin-Endoperoxide Synthases; Structure-Activity Relationship; Tritium; Vitamin E	1992
[Role of isoprenoid chain of lateral mobility of alpha-tocopherol in lipid bilayer]. Biulleten' eksperimental'noi biologii i meditsiny, 1991, Volume: 112, Issue:7 Topics: Chromans; Fluorescence; Lipid Bilayers; Lipid Peroxidation; Membrane Lipids; Movement; Phospholipids; Vitamin E	1991
Protective effect of vitamin E on linoleic acid hydroperoxide-induced injury to human endothelial cells. Lipids, 1991, Volume: 26, Issue:5 Topics: Antioxidants; Cell Survival; Cells, Cultured; Chromans; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Kinetics; Linoleic Acids; Lipid Peroxides; Umbilical Veins; Vitamin E	1991
Mitochondria and microsomal membranes have a free radical reductase activity that prevents chromanoxyl radical accumulation. Biochemical and biophysical research communications, 1989, Feb-28, Volume: 159, Issue:1 Topics: Animals; Arachidonic Acid; Arachidonic Acids; Ascorbic Acid; Benzopyrans; Cell Membrane; Chromans; Electron Spin Resonance Spectroscopy; Free Radicals; Glutathione; Liposomes; Lipoxygenase; Microsomes, Liver; Mitochondria, Liver; NAD; NADP; Oxidation-Reduction; Oxidoreductases; Photochemistry; Rats; Submitochondrial Particles; Ultraviolet Rays; Vitamin E	1989
Spectroscopic studies on the reaction of superoxide ion with tocopherol model compound, 6-hydroxy-2,2,5,7,8-pentamethylchroman. Biochemical and biophysical research communications, 1985, Jan-31, Volume: 126, Issue:2 Topics: Benzopyrans; Chemical Phenomena; Chemistry; Chromans; Electron Spin Resonance Spectroscopy; Free Radicals; Oxidation-Reduction; Spectrophotometry, Ultraviolet; Superoxides; Vitamin E	1985
Free radicals of tocopherol model compound, 6-hydroxy-2,2,5,7,8-pentamethylchroman which are produced from the reaction with superoxide ion, O2: studies by high-performance liquid chromatography. Biochemical and biophysical research communications, 1985, Jun-14, Volume: 129, Issue:2 Topics: Benzopyrans; Chromans; Chromatography, High Pressure Liquid; Free Radicals; Models, Chemical; Spectrophotometry, Ultraviolet; Superoxides; Vitamin E	1985
Formation of trimers of alpha-tocopherol and its model compound, 2,2,5,7,8-pentamethylchroman-6-ol, in autoxidizing methyl linoleate. Lipids, 1988, Volume: 23, Issue:8 Topics: Benzopyrans; Chromans; Chromatography, High Pressure Liquid; Linoleic Acids; Oxidation-Reduction; Polymers; Vitamin E	1988
[The role of isoprenoid chain of alpha-tocopherol in the protection of synaptosomes against lipid peroxidation and phospholipase A2-induced damage]. Biokhimiia (Moscow, Russia), 1988, Volume: 53, Issue:4 Topics: Animals; Brain; Chromans; Fluorescent Dyes; In Vitro Techniques; Kinetics; Lipid Peroxides; Phospholipases; Phospholipases A; Phospholipases A2; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Synaptosomes; Vitamin E	1988
[Does alpha-tocopherol interact with the active center of cytochrome P-450 in liver microsomes?]. Biulleten' eksperimental'noi biologii i meditsiny, 1987, Volume: 103, Issue:3 Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Binding Sites; Biotransformation; Catalysis; Chromans; Cytochrome P-450 Enzyme System; Drug Interactions; Kinetics; Microsomes, Liver; NAD; Oxygenases; Rats; Structure-Activity Relationship; Substrate Specificity; Vitamin E	1987
[Effect of the functional groups of tocopherol molecules on lipid viscosity of mitochondria]. Biulleten' eksperimental'noi biologii i meditsiny, 1987, Volume: 103, Issue:5 Topics: Animals; Chromans; Dose-Response Relationship, Drug; Lipid Bilayers; Membrane Fluidity; Membrane Lipids; Mice; Mitochondria, Liver; Spin Labels; Structure-Activity Relationship; Temperature; Viscosity; Vitamin E	1987
[Antioxidant-induced release of calcium in biological membranes]. Biulleten' eksperimental'noi biologii i meditsiny, 1987, Volume: 104, Issue:9 Topics: Animals; Antioxidants; Blood Platelets; Brain; Butylated Hydroxytoluene; Calcium; Chromans; Intracellular Membranes; Rats; Sarcoplasmic Reticulum; Synaptosomes; Vitamin E	1987
[Effectiveness of lipid peroxidation inhibition in biomembranes by antioxidants with and without hydrocarbon chains]. Biulleten' eksperimental'noi biologii i meditsiny, 1986, Volume: 102, Issue:10 Topics: Animals; Antioxidants; Butylated Hydroxytoluene; Chromans; Depression, Chemical; Intracellular Membranes; Lipid Peroxides; Male; Microsomes, Liver; Mitochondria, Liver; Oxidation-Reduction; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Vitamin E	1986
Effect of phytyl side chain of vitamin E on its antioxidant activity. The Journal of biological chemistry, 1985, Feb-25, Volume: 260, Issue:4 Topics: Butylated Hydroxytoluene; Chemical Phenomena; Chemistry; Chromans; Free Radicals; Linoleic Acids; Lipid Peroxides; Liposomes; Micelles; Oxidation-Reduction; Phosphatidylcholines; Solutions; Structure-Activity Relationship; Vitamin E	1985
Reactions of superoxide ion with tocopherol and its model compounds: correlation between the physiological activities of tocopherols and the concentration of chromanoxyl-type radicals. Biochemistry international, 1983, Volume: 6, Issue:5 Topics: Anions; Chromans; Electron Spin Resonance Spectroscopy; Free Radicals; Oxidation-Reduction; Superoxides; Vitamin E	1983
Fluorescence depolarization studies of phase transition and fluidity in lecithin liposomes containing alpha-tocopherol. Journal of nutritional science and vitaminology, 1980, Volume: 26, Issue:5 Topics: Cholesterol; Chromans; Diphenylhexatriene; Dose-Response Relationship, Drug; Fluorescence Polarization; Liposomes; Membrane Fluidity; Pulmonary Surfactants; Structure-Activity Relationship; Temperature; Vitamin E	1980
Pentamethyl-hydroxychromane, vitamin E derivative, inhibits induction of nitric oxide synthase by bacterial lipopolysaccharide. Biochemistry and molecular biology international, 1995, Volume: 35, Issue:1 Topics: Amino Acid Oxidoreductases; Animals; Antioxidants; Aorta; Cells, Cultured; Chromans; Enzyme Induction; Lipopolysaccharides; Macrophages; Mice; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Rats; RNA, Messenger; Time Factors; Vitamin E	1995
Inhibition of stimulus-specific neutrophil superoxide generation by alpha-tocopherol. Free radical research, 1995, Volume: 22, Issue:5 Topics: Animals; Antioxidants; Chromans; Guinea Pigs; Molecular Weight; Neutrophils; Phosphorylation; Rats; Stimulation, Chemical; Superoxides; Tetradecanoylphorbol Acetate; Vitamin E	1995
Is alpha-tocopherol a reservoir for alpha-tocopheryl hydroquinone? Free radical biology & medicine, 1995, Volume: 19, Issue:2 Topics: alpha-Tocopherol; Blood; Chloroform; Chromans; Ethanol; Flavin-Adenine Dinucleotide; Free Radicals; Humans; Hydrogen-Ion Concentration; Leukocytes, Mononuclear; Liposomes; NAD; Oxidation-Reduction; Peroxides; tert-Butylhydroperoxide; Vitamin E; Water	1995
Oxidation of human red blood cells by a free radical initiator and effects of radical scavengers. Biochemistry and molecular biology international, 1994, Volume: 33, Issue:6 Topics: Antioxidants; Azo Compounds; Chromans; Erythrocytes; Free Radical Scavengers; Free Radicals; Hemolysis; Humans; Liposomes; Oxidation-Reduction; Phosphatidylcholines; Structure-Activity Relationship; Valerates; Vitamin E	1994
Protection of linoleic acid hydroperoxide-induced cytotoxicity by phenolic antioxidants. Free radical biology & medicine, 1994, Volume: 16, Issue:3 Topics: Antioxidants; Butylated Hydroxytoluene; Cell Survival; Cells, Cultured; Chromans; Endothelium, Vascular; Free Radicals; Humans; Linoleic Acids; Lipid Peroxides; Phenols; Probucol; Structure-Activity Relationship; Vitamin E	1994
Antioxidant behaviors of vitamin E analogues in unilamellar vesicles. Bioscience, biotechnology, and biochemistry, 1996, Volume: 60, Issue:6 Topics: Antioxidants; Chromans; Glycerophospholipids; Liposomes; Molecular Structure; Phosphatidic Acids; Phosphatidylcholines; Time Factors; Vitamin E	1996
Protective effect of a vitamin E analog, phosphatidylchromanol, against oxidative hemolysis of human erythrocytes. Lipids, 1998, Volume: 33, Issue:6 Topics: Amidines; Antioxidants; Butylated Hydroxytoluene; Chromans; Erythrocyte Membrane; Erythrocytes; Free Radicals; Glycerophospholipids; Hemolysis; Humans; In Vitro Techniques; Oxidants; Oxidation-Reduction; Phosphatidic Acids; Probucol; Vitamin E	1998
Quantitative subfemtomole analysis of alpha-tocopherol and deuterated isotopomers in plasma using tabletop GC/MS/MS. Analytical chemistry, 1998, Oct-15, Volume: 70, Issue:20 Topics: Animals; Chromans; Deuterium; Female; Gas Chromatography-Mass Spectrometry; Pregnancy; Reference Standards; Reproducibility of Results; Sheep; Trimethylsilyl Compounds; Vitamin E	1998
beta-Carotene. An antioxidant or a target of oxidative stress in cells? Sub-cellular biochemistry, 1998, Volume: 30 Topics: Antioxidants; Azo Compounds; beta Carotene; Chromans; Fatty Acids, Unsaturated; Free Radicals; HL-60 Cells; Humans; Nitriles; Oxidative Stress; Peroxides; Phenol; Vitamin E	1998
Do spin traps also act as classical chain-breaking antioxidants? A quantitative kinetic study of phenyl tert-butylnitrone (PBN) in solution and in liposomes. Free radical biology & medicine, 2000, Apr-01, Volume: 28, Issue:7 Topics: Antioxidants; Chromans; Cyclic N-Oxides; Free Radicals; Kinetics; Lipid Bilayers; Lipid Peroxidation; Liposomes; Nitriles; Nitrogen Oxides; Oxygen; Partial Pressure; Peroxides; Phospholipids; Solutions; Spin Labels; Spin Trapping; Vitamin E	2000
Fatty acids and tocochromanols in seeds of Orobanche. Phytochemistry, 2000, Volume: 54, Issue:3 Topics: Chromans; Fatty Acids, Nonesterified; Fatty Acids, Unsaturated; Plant Oils; Plants; Seeds; Species Specificity; Vitamin E	2000
Oxidation of 2,2,7,8-tetramethyl-6-chromanol, the model compound of gamma-tocopherol, by hypochlorous acid. Redox report : communications in free radical research, 2000, Volume: 5, Issue:1 Topics: Antioxidants; Chromans; Hypochlorous Acid; Models, Biological; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction; Spectrophotometry, Ultraviolet; Vitamin E	2000
Protective effect of phenolic antioxidants on the cytotoxicity induced by phosphatidylcholine hydroperoxide. Bioscience, biotechnology, and biochemistry, 2000, Volume: 64, Issue:6 Topics: Antioxidants; Butylated Hydroxytoluene; Cell Survival; Cells, Cultured; Chromans; Endothelium, Vascular; Ethanol; Humans; Phosphatidylcholines; Probucol; Vitamin E	2000
Reaction of 2,2,5,7,8-pentamethyl-6-chromanol, an alpha-tocopherol analogue, with NO in the presence of oxygen. Bioorganic & medicinal chemistry letters, 2000, Dec-18, Volume: 10, Issue:24 Topics: Antioxidants; Chromans; Nitric Oxide; Oxidation-Reduction; Oxygen; Vitamin E	2000
Co-oxidation of 2,2,5,7,8-pentamethyl-6-chromanol and diphenyl disulfide with 3-chloroperoxybenzoic acid. Redox report : communications in free radical research, 2001, Volume: 6, Issue:3 Topics: alpha-Tocopherol; Antioxidants; Chlorobenzoates; Chromans; Chromatography, High Pressure Liquid; Disulfides; Molecular Structure; Oxidants; Oxidation-Reduction; Phenols; Sulfhydryl Compounds; Thiones	2001
Androgen antagonist activity by the antioxidant moiety of vitamin E, 2,2,5,7,8-pentamethyl-6-chromanol in human prostate carcinoma cells. Molecular cancer therapeutics, 2003, Volume: 2, Issue:8 Topics: Androgen Antagonists; Antioxidants; Chromans; Humans; Male; Prostate-Specific Antigen; Prostatic Neoplasms; Tumor Cells, Cultured; Vitamin E	2003
RESPONSE OF MACROCYTIC ANEMIA IN CHILDREN TO THE COENZYME Q4-CHROMANOL. The American journal of clinical nutrition, 1963, Volume: 13 Topics: Anemia; Anemia, Macrocytic; Blood Chemical Analysis; Child; Chromans; Creatine; Creatinine; Erythrocyte Count; Humans; Infant; Ubiquinone; Urine; Vitamin E	1963
Alpha-tocopherol influences the lipid membrane affinity of desipramine in a pH-dependent manner. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2004, Volume: 21, Issue:2-3 Topics: alpha-Tocopherol; Antidepressive Agents, Tricyclic; Antioxidants; Cholesterol; Chromans; Desipramine; Hydrogen-Ion Concentration; Liposomes; Membrane Lipids; Phosphatidylcholines; Phosphatidylinositols; Potentiometry; Propranolol; Tocopherols; Warfarin	2004
Antioxidant properties of chromanols derived from vitamin E and ubiquinone. Annals of the New York Academy of Sciences, 2004, Volume: 1031 Topics: Antioxidants; Chromans; Electron Spin Resonance Spectroscopy; Kinetics; Molecular Structure; Photolysis; Structure-Activity Relationship; Ubiquinone; Vitamin E	2004
Antioxidant properties of natural and synthetic chromanol derivatives: study by fast kinetics and electron spin resonance spectroscopy. The Journal of organic chemistry, 2005, Apr-29, Volume: 70, Issue:9 Topics: alpha-Tocopherol; Antioxidants; Chromans; Electron Spin Resonance Spectroscopy; Kinetics; Molecular Structure; Oxidation-Reduction	2005
The protection of bioenergetic functions in mitochondria by new synthetic chromanols. Biochemical pharmacology, 2005, Nov-01, Volume: 70, Issue:9 Topics: Animals; Antioxidants; Chromans; Dose-Response Relationship, Drug; Energy Metabolism; Lipid Peroxidation; Male; Mitochondria; Oxygen Consumption; Proteins; Rats; Rats, Sprague-Dawley; Sulfhydryl Compounds; Vitamin E	2005
Transformation of alpha-tocopherol (vitamin E) and related chromanol model compounds into their phenoxonium ions by chemical oxidation with the nitrosonium cation. The Journal of organic chemistry, 2005, Dec-09, Volume: 70, Issue:25 Topics: Antioxidants; Chromans; Electrochemistry; Nitric Oxide; Oxidation-Reduction; Phenols; Spectroscopy, Fourier Transform Infrared; Vitamin E	2005
A biomimetic chromanol cyclization leading to alpha-tocopherol. Angewandte Chemie (International ed. in English), 2006, Feb-06, Volume: 45, Issue:7 Topics: alpha-Tocopherol; Aspartic Acid; Biomimetics; Chromans; Cyclization; Indicators and Reagents; Proline; Serine; Stereoisomerism	2006
A pharmacological action of vitamin E unrelated to its antioxidant capacity. Methods and findings in experimental and clinical pharmacology, 2006, Volume: 28, Issue:8 Topics: alpha-Tocopherol; Animals; Antioxidants; Ascorbic Acid; Chromans; Colon, Transverse; Dose-Response Relationship, Drug; Female; Guinea Pigs; Hypoxia; In Vitro Techniques; Isometric Contraction; Male; Methacrylates; Muscle Contraction; Muscle, Smooth; Phytol; Pyrogallol; Quantitative Structure-Activity Relationship; Stereoisomerism; Temperature; Terpenes	2006
Neuroprotective effects of PMC, a potent alpha-tocopherol derivative, in brain ischemia-reperfusion: reduced neutrophil activation and anti-oxidant actions. Biochemical pharmacology, 2007, Mar-01, Volume: 73, Issue:5 Topics: alpha-Tocopherol; Animals; Antioxidants; Caspase 3; Chromans; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Ischemia, Brain; Male; Molecular Structure; Neuroprotective Agents; Neutrophil Activation; Neutrophils; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Reperfusion Injury; Tyrosine	2007
Identification and quantitation of novel vitamin E metabolites, sulfated long-chain carboxychromanols, in human A549 cells and in rats. Journal of lipid research, 2007, Volume: 48, Issue:5 Topics: Animals; Cell Line; Chromans; Chromatography, High Pressure Liquid; Humans; Male; Molecular Structure; Rats; Rats, Wistar; Spectrometry, Fluorescence; Sulfates; Vitamin E	2007
A theoretical investigation on the geometry and vibrational spectra of 10,10,2,6,5-pentamethyl-1-hydroxychroman: a model of alpha-tocopherol. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2007, Dec-31, Volume: 68, Issue:5 Topics: alpha-Tocopherol; Chromans; Models, Chemical; Spectrophotometry, Infrared; Spectrum Analysis, Raman; Vibration	2007
Generation of superoxide and singlet oxygen from alpha-tocopherolquinone and analogues. Free radical research, 2007, Volume: 41, Issue:6 Topics: Antioxidants; Chromans; Lasers; Oxidation-Reduction; Pulse Radiolysis; Reactive Oxygen Species; Singlet Oxygen; Superoxides; Tryptophan; Vitamin E	2007
Kinetic and thermochemical study of the antioxidant activity of sulfur-containing analogues of vitamin E. Chemistry (Weinheim an der Bergstrasse, Germany), 2007, Volume: 13, Issue:29 Topics: Antioxidants; Chromans; Computational Biology; Crystallography, X-Ray; Kinetics; Molecular Structure; Oxidation-Reduction; Peroxides; Sulfur Compounds; Thermodynamics; Vitamin E	2007
Diastereoselective synthesis of alpha-tocopherol: a new concept for the formation of chromanols. Organic letters, 2008, Nov-20, Volume: 10, Issue:22 Topics: alpha-Tocopherol; Chromans; Epoxy Compounds; Stereoisomerism; Substrate Specificity	2008
Long-chain carboxychromanols, metabolites of vitamin E, are potent inhibitors of cyclooxygenases. Proceedings of the National Academy of Sciences of the United States of America, 2008, Dec-23, Volume: 105, Issue:51 Topics: Cell Line; Chromans; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Inhibitory Concentration 50; Structure-Activity Relationship; Vitamin E	2008
Asymmetric synthesis of alpha-tocopherol. Chemistry (Weinheim an der Bergstrasse, Germany), 2010, Jan-25, Volume: 16, Issue:4 Topics: alpha-Tocopherol; Chromans; Cyclization; Stereoisomerism	2010
Synthesis and characterization of BODIPY-alpha-tocopherol: a fluorescent form of vitamin E. The Journal of organic chemistry, 2010, May-07, Volume: 75, Issue:9 Topics: alpha-Tocopherol; Binding Sites; Boron Compounds; Carrier Proteins; Cells, Cultured; Cholesterol; Chromans; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Humans; Molecular Structure; Tocopherols; Vinyl Compounds	2010
Inhibitory effect of PMC, a potent hydrophilic α-tocopherol derivative, on vascular smooth muscle cell proliferation: the pivotal role of PKC-α translocation. Pharmaceutical biology, 2010, Volume: 48, Issue:8 Topics: alpha-Tocopherol; Animals; Cell Division; Cell Proliferation; Cells, Cultured; Chromans; G2 Phase; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Protein Kinase C-alpha; Protein Transport; Rats; Rats, Wistar	2010
Is the chromanol head group of vitamin E nature's final truth on chain-breaking antioxidants? FEBS letters, 2012, Mar-23, Volume: 586, Issue:6 Topics: Amines; Animals; Antioxidants; Chromans; Free Radical Scavengers; Free Radicals; Lipid Bilayers; Lipid Peroxidation; Molecular Structure; Phenols; Vitamin E	2012
How lipid unsaturation, peroxyl radical partitioning, and chromanol lipophilic tail affect the antioxidant activity of α-tocopherol: direct visualization via high-throughput fluorescence studies conducted with fluorogenic α-tocopherol analogues. Journal of the American Chemical Society, 2012, Jun-20, Volume: 134, Issue:24 Topics: alpha-Tocopherol; Antioxidants; Boron Compounds; Chromans; Fluorescent Dyes; Free Radicals; High-Throughput Screening Assays; Liposomes; Peroxides; Spectrometry, Fluorescence	2012
Mitochondria-targeted vitamin E analogs inhibit breast cancer cell energy metabolism and promote cell death. BMC cancer, 2013, Jun-13, Volume: 13 Topics: Animals; Breast Neoplasms; Cell Death; Cell Line, Tumor; Chromans; Chromatography, High Pressure Liquid; Energy Metabolism; Female; Humans; Mice; Mitochondria; Vitamin E; Xenograft Model Antitumor Assays	2013
Long-chain metabolites of α-tocopherol occur in human serum and inhibit macrophage foam cell formation in vitro. Free radical biology & medicine, 2014, Volume: 68 Topics: alpha-Tocopherol; Antioxidants; CD36 Antigens; Chromans; Foam Cells; Humans; In Vitro Techniques; Lipoproteins, LDL; Macrophages; RNA, Messenger	2014
Tocochromanols and carotenoids in sorghum (Sorghum bicolor L.): diversity and stability to the heat treatment. Food chemistry, 2015, Apr-01, Volume: 172 Topics: Carotenoids; Chromans; Cooking; Genetic Variation; Genotype; Hot Temperature; Sorghum; Vitamin E	2015
Antioxidant activity of dopamine and L-DOPA in lipid micelles and their cooperation with an analogue of α-tocopherol. Free radical biology & medicine, 2015, Volume: 83 Topics: alpha-Tocopherol; Antioxidants; Catecholamines; Chromans; Dopamine; Dopamine Agents; Free Radical Scavengers; Humans; Kinetics; Levodopa; Linoleic Acids; Lipid Peroxidation; Liposomes; Micelles; Oxidation-Reduction; Oxidative Stress; Oxygen Consumption	2015
Vitamin E metabolite 13'-carboxychromanols inhibit pro-inflammatory enzymes, induce apoptosis and autophagy in human cancer cells by modulating sphingolipids and suppress colon tumor development in mice. Free radical biology & medicine, 2016, Volume: 95 Topics: Animals; Apoptosis; Arachidonate 5-Lipoxygenase; Autophagy; Chromans; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Garcinia kola; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Mice; Sphingolipids; Tocopherols; Vitamin E	2016
Clarification of the Complexation Behaviour of 2,6-di-O-Methylated β-Cyclodextrin and Vitamin E and Radical Scavenging Ability of the Complex in Aqueous Solution. Journal of oleo science, 2021, Oct-05, Volume: 70, Issue:10 Topics: beta-Cyclodextrins; Chromans; Cyclodextrins; Drug Combinations; Drug Interactions; Free Radical Scavengers; Solubility; Solutions; Vitamin E; Water	2021