Compounds > 2-2-3-3-tetramethylcyclopropanecarbonylurea

2-2-3-3-tetramethylcyclopropanecarbonylurea and 2-2-3-3-tetramethylcyclopropane-carboxamide

2-2-3-3-tetramethylcyclopropanecarbonylurea has been researched along with 2-2-3-3-tetramethylcyclopropane-carboxamide* in 1 studies

Other Studies

1 other study(ies) available for 2-2-3-3-tetramethylcyclopropanecarbonylurea and 2-2-3-3-tetramethylcyclopropane-carboxamide

Article	Year
Synthesis and anticonvulsant activity of aromatic tetramethylcyclopropanecarboxamide derivatives. Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11 As part of our ongoing research on potential new antiepileptic drugs (AEDs), a series of tetramethylcyclopropanecarboxamide derivatives containing benzene ring were designed, synthesized, and evaluated for anticonvulsant activities in the murine maximal electroshock (MES) and subcutaneous pentylenetetrazole (scMet) seizure tests. The most potent compound emerging from this study was N-(2,2,3,3-tetramethylcyclopropanecarboxamide)-p-phenyl-sulfonamide (21), possessing an ED(50) value of 26mg/kg in the rat-MES test and a remarkable PI (PI=TD(50)/ED(50)) value above 19. The better anticonvulsant potency of compound 21 and its wider safety margin compared to valproic acid (VPA) and zonisamide make it a potential candidate to become a new AED second-generation to VPA. Topics: Administration, Oral; Amides; Animals; Anticonvulsants; Cyclopropanes; Electroshock; Isoxazoles; Mice; Motor Activity; Rats; Seizures; Sulfonamides; Urea; Valproic Acid; Zonisamide	2008

Article

Year

Synthesis and anticonvulsant activity of aromatic tetramethylcyclopropanecarboxamide derivatives.

Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11

As part of our ongoing research on potential new antiepileptic drugs (AEDs), a series of tetramethylcyclopropanecarboxamide derivatives containing benzene ring were designed, synthesized, and evaluated for anticonvulsant activities in the murine maximal electroshock (MES) and subcutaneous pentylenetetrazole (scMet) seizure tests. The most potent compound emerging from this study was N-(2,2,3,3-tetramethylcyclopropanecarboxamide)-p-phenyl-sulfonamide (21), possessing an ED(50) value of 26mg/kg in the rat-MES test and a remarkable PI (PI=TD(50)/ED(50)) value above 19. The better anticonvulsant potency of compound 21 and its wider safety margin compared to valproic acid (VPA) and zonisamide make it a potential candidate to become a new AED second-generation to VPA.

Topics: Administration, Oral; Amides; Animals; Anticonvulsants; Cyclopropanes; Electroshock; Isoxazoles; Mice; Motor Activity; Rats; Seizures; Sulfonamides; Urea; Valproic Acid; Zonisamide

2008