2-2-2-trifluorodiazoethane has been researched along with 3-hydroxybutanal* in 1 studies
1 other study(ies) available for 2-2-2-trifluorodiazoethane and 3-hydroxybutanal
| Article | Year |
|---|---|
Copper-catalyzed one-pot denitrogenative-dehydrogenative-decarboxylative coupling of β-ketoacids with trifluorodiazoethane: facile access to trifluoromethylated aldol products.
A novel copper-catalyzed one-pot cross-coupling of β-ketoacids with in situ generated trifluorodiazoethane has been developed. This reaction provides a direct and efficient method, in which one C-C bond and one C-O bond were formed in a carbenoid center with concomitant denitrogenation-dehydrogenation-decarboxylation, to afford trifluoromethylated aldol products. In several preliminary experiments, good to high enantioselectivities were also obtained. Topics: Aldehydes; Azo Compounds; Catalysis; Copper; Crystallography, X-Ray; Decarboxylation; Hydrocarbons, Fluorinated; Keto Acids; Methylation; Molecular Conformation; Stereoisomerism | 2014 |