2-2--azino-di-(3-ethylbenzothiazoline)-6-sulfonic-acid and nitroxyl

Polydopamine (PDA) materials are important due to their unique physicochemical properties and their potential as chemopreventive agents for diseases connected with oxidative stress. Although PDA has been suggested to display antioxidant activity, its efficacy is controversial and its mechanism of action is still unclear. Herein, we report that accurately purified PDA nanoparticles in water at pH 7.4 are unable to quench alkylperoxyls (ROO˙), which are the radicals responsible for the propagation of lipid peroxidation, despite PDA reacting with the model DPPH˙ and ABTS˙

Topics: Antioxidants; Benzothiazoles; Biphenyl Compounds; Indoles; Materials Testing; Molecular Structure; Nitrogen Oxides; Particle Size; Picrates; Polymers; Sulfonic Acids

Nitroxides and nitroxide-containing nanoparticles (RNP) are excellent antioxidants. However, they have relatively high reduction potentials, which make them behave like oxidants or show little activity in some antioxidant assays. We found that stable nitroxyl radicals (TEMPO and 4-amino-TEMPO) has low reactivity in the test of scavenging of 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) radical (ABTS

Topics: Adult; Antioxidants; Benzothiazoles; Cells, Cultured; Cyclic N-Oxides; Female; Humans; Molecular Structure; Nanoparticles; Nitrogen Oxides; Sulfonic Acids