Compounds > 2-2--azino-di-(3-ethylbenzothiazoline)-6-sulfonic-acid

2-2--azino-di-(3-ethylbenzothiazoline)-6-sulfonic-acid and chrysin

2-2--azino-di-(3-ethylbenzothiazoline)-6-sulfonic-acid has been researched along with chrysin* in 2 studies

Other Studies

2 other study(ies) available for 2-2--azino-di-(3-ethylbenzothiazoline)-6-sulfonic-acid and chrysin

Article	Year
Sulfonylpiperazines based on a flavone as antioxidant and cytotoxic agents. Archiv der Pharmazie, 2019, Volume: 352, Issue:9 Chrysin-based sulfonylpiperazines 7a-k were synthesized and investigated for their in vitro free radical scavenging potential as well as cytotoxic efficacies against selected cancer cell lines. Cytotoxicity of the new compounds toward noncancer cells was confirmed using the SRB assay against Madin-Darby Canine Kidney cells. Reaction of piperazine with different substituted benzenesulfonyl chlorides in triethylamine furnished sulfonylpiperazines (3a-k), which were then allowed to react with 7-(4-bromobutoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one (6) prepared reacting chrysin with 1,4-dibromobutane to give the final derivatives 7a-k. The results concluded that chrysin-sulfonylpiperazines exerted better antioxidant and anticancer efficacies than previously studied chrysin-piperazine precursors. For example, compounds 7h, 7j, and 7k with 4-OCF Topics: A549 Cells; Animals; Antineoplastic Agents; Antioxidants; Benzothiazoles; Biphenyl Compounds; Cell Survival; Dogs; Flavonoids; Free Radicals; HeLa Cells; HT29 Cells; Humans; Inhibitory Concentration 50; Madin Darby Canine Kidney Cells; Molecular Structure; Picrates; Sulfonic Acids	2019
Antioxidant capacity of reaction products limits the applicability of the Trolox Equivalent Antioxidant Capacity (TEAC) assay. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2004, Volume: 42, Issue:1 The Trolox Equivalent Antioxidant Capacity (TEAC) assay is based on the scavenging of the 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical (ABTS()) converting it into a colorless product. The degree of decolorization induced by a compound is related to that induced by trolox, giving the TEAC value. The assay is frequently used for constructing structure activity relationships (SARs). HPLC analysis of the reaction mixture, obtained after scavenging of ABTS() by the flavonoid chrysin, shows that a product is formed that also reacts with ABTS(). The product has a higher antioxidant capacity and reacts faster with ABTS() than the parent compound, chrysin. In contrast to the reaction product of chrysin, the reaction product of trolox, which is formed during scavenging of ABTS(), i.e. trolox quinone, does not react with ABTS(). The experiments show that the TEAC is the antioxidant capacity of the parent compound plus the potential antioxidant capacity of the reaction product(s). This means that the TEAC assay does not necessarily reflect the antioxidant effect of only one structure. This hampers the applicability of the assay for the construction of SARs and for ranking antioxidants. Topics: Antioxidants; Benzothiazoles; Chromans; Chromatography, High Pressure Liquid; Flavonoids; Free Radical Scavengers; Quinones; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Sulfonic Acids	2004

Article

Year

Sulfonylpiperazines based on a flavone as antioxidant and cytotoxic agents.

Archiv der Pharmazie, 2019, Volume: 352, Issue:9

Chrysin-based sulfonylpiperazines 7a-k were synthesized and investigated for their in vitro free radical scavenging potential as well as cytotoxic efficacies against selected cancer cell lines. Cytotoxicity of the new compounds toward noncancer cells was confirmed using the SRB assay against Madin-Darby Canine Kidney cells. Reaction of piperazine with different substituted benzenesulfonyl chlorides in triethylamine furnished sulfonylpiperazines (3a-k), which were then allowed to react with 7-(4-bromobutoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one (6) prepared reacting chrysin with 1,4-dibromobutane to give the final derivatives 7a-k. The results concluded that chrysin-sulfonylpiperazines exerted better antioxidant and anticancer efficacies than previously studied chrysin-piperazine precursors. For example, compounds 7h, 7j, and 7k with 4-OCF

Topics: A549 Cells; Animals; Antineoplastic Agents; Antioxidants; Benzothiazoles; Biphenyl Compounds; Cell Survival; Dogs; Flavonoids; Free Radicals; HeLa Cells; HT29 Cells; Humans; Inhibitory Concentration 50; Madin Darby Canine Kidney Cells; Molecular Structure; Picrates; Sulfonic Acids

2019

Antioxidant capacity of reaction products limits the applicability of the Trolox Equivalent Antioxidant Capacity (TEAC) assay.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2004, Volume: 42, Issue:1

The Trolox Equivalent Antioxidant Capacity (TEAC) assay is based on the scavenging of the 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical (ABTS(*)) converting it into a colorless product. The degree of decolorization induced by a compound is related to that induced by trolox, giving the TEAC value. The assay is frequently used for constructing structure activity relationships (SARs). HPLC analysis of the reaction mixture, obtained after scavenging of ABTS(*) by the flavonoid chrysin, shows that a product is formed that also reacts with ABTS(*). The product has a higher antioxidant capacity and reacts faster with ABTS(*) than the parent compound, chrysin. In contrast to the reaction product of chrysin, the reaction product of trolox, which is formed during scavenging of ABTS(*), i.e. trolox quinone, does not react with ABTS(*). The experiments show that the TEAC is the antioxidant capacity of the parent compound plus the potential antioxidant capacity of the reaction product(s). This means that the TEAC assay does not necessarily reflect the antioxidant effect of only one structure. This hampers the applicability of the assay for the construction of SARs and for ranking antioxidants.

Topics: Antioxidants; Benzothiazoles; Chromans; Chromatography, High Pressure Liquid; Flavonoids; Free Radical Scavengers; Quinones; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Sulfonic Acids

2004