2-2--(hydroxynitrosohydrazono)bis-ethanamine and 4-aminophenylphosphate

2-2--(hydroxynitrosohydrazono)bis-ethanamine has been researched along with 4-aminophenylphosphate* in 1 studies

Other Studies

1 other study(ies) available for 2-2--(hydroxynitrosohydrazono)bis-ethanamine and 4-aminophenylphosphate

ArticleYear
Rapid and irreversible inactivation of protein tyrosine phosphatases PTP1B, CD45, and LAR by peroxynitrite.
    Archives of biochemistry and biophysics, 1999, Sep-15, Volume: 369, Issue:2

    Protein tyrosine phosphatases (PTPs) contain an essential thiol in the active site which may be susceptible to attack by nitric oxide-derived biological oxidants. We assessed the effects of peroxynitrite, nitric oxide, and S-nitrosoglutathione on the activity of three human tyrosine phosphatases in vitro. The receptor-like T-cell tyrosine phosphatase (CD45), the non-receptor-like tyrosine phosphatase PTP1B, and leukocyte-antigen-related (LAR) phosphatase were all irreversibly inactivated by peroxynitrite in less than 1 s with IC(50) values of

    Topics: Aniline Compounds; Anions; Dithiothreitol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutathione; Humans; Leukocyte Common Antigens; Models, Molecular; Molsidomine; Nitrates; Nitric Oxide; Nitroso Compounds; Organophosphates; Organophosphorus Compounds; Protein Tyrosine Phosphatases; Receptor-Like Protein Tyrosine Phosphatases, Class 4; Receptors, Cell Surface; S-Nitrosoglutathione; Superoxide Dismutase; Tyrosine

1999