2,2-(2-chlorophenyl-4'-chlorophenyl)acetic acid has been researched along with mitotane in 9 studies
*Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression. [MeSH]
*Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Inouye, M; Mio, T; Sumino, K | 1 |
| Andersen, A; Kasperlik-Zaluska, AA; Warren, DJ | 1 |
| Cichocki, A; Kasperlik-Zaluska, AA | 1 |
| Allolio, B; Baudin, E; Berruti, A; Chadarevian, R; Daffara, F; den Hartigh, J; Fassnacht, M; Haak, HR; Hermsen, IG; Houterman, S; Leboulleux, S; Schlumberger, M; Terzolo, M | 1 |
| Al Ghuzlan, A; Baudin, E; Brailly-Tabard, S; Hescot, S; Lombès, M; Paci, A; Seck, A; Slama, A; Trabado, S; Viengchareun, S; Young, J | 1 |
| Fassnacht, M; Heinz, W; Kendl, S; Klinker, H; Kroiss, M; Lapa, C; Plonné, D; Ronchi, CL; Sbiera, S; Schirbel, A; Schirmer, D; Zink, M | 1 |
| Haralampiev, I; Huster, D; Kroiss, M; Müller, P; Sbiera, S; Scheidt, HA; Schirbel, A; Theisgen, S | 1 |
| Allegra, S; Berruti, A; Carrella, S; Cusato, J; D'Avolio, A; Daffara, FC; De Francia, S; De Martino, F; Di Carlo, F; Ferrero, A; Piccione, FM; Pirro, E; Tampellini, M; Terzolo, M | 1 |
| Bach de Assis, C; Cavalcante de Figueiredo, B; Cruz Bonk, B; de Almeida Veiga, A; de Toledo Nogueira, B; Lada Degaut Pontes, F; Mera de Souza, L; Regina Rocha Martins, L; Rita Corso, C; Stadler, G | 1 |
1 trial(s) available for 2,2-(2-chlorophenyl-4'-chlorophenyl)acetic acid and mitotane
| Article | Year |
|---|---|
Determination of mitotane (o,p-DDD) and its metabolites o,p-DDA and o,p-DDE in plasma by high-performance liquid chromatography.
Topics: Adrenal Cortex Neoplasms; Adrenergic Agents; Adult; Aged; Antineoplastic Agents, Hormonal; Chromatography, High Pressure Liquid; Drug Stability; Female; Humans; Linear Models; Male; Middle Aged; Mitotane | 1999 |
8 other study(ies) available for 2,2-(2-chlorophenyl-4'-chlorophenyl)acetic acid and mitotane
| Article | Year |
|---|---|
Use of GC/MS/SIM for rapid determination of plasma levels of o,p'-DDD, o,p'-DDE and o,p'-DDA.
Topics: Circadian Rhythm; Gas Chromatography-Mass Spectrometry; Humans; Mitotane | 1987 |
Clinical role of determination of plasma mitotane and its metabolites levels in patients with adrenal cancer: results of a long-term follow-up.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Antineoplastic Agents, Hormonal; Child; Female; Follow-Up Studies; Humans; Male; Middle Aged; Mitotane | 2005 |
Plasma concentrations of o,p'DDD, o,p'DDA, and o,p'DDE as predictors of tumor response to mitotane in adrenocortical carcinoma: results of a retrospective ENS@T multicenter study.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Female; Humans; Male; Middle Aged; Mitotane; Predictive Value of Tests; Retrospective Studies; Sensitivity and Specificity | 2011 |
The lack of antitumor effects of o,p'DDA excludes its role as an active metabolite of mitotane for adrenocortical carcinoma treatment.
Topics: Adrenal Cortex; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Apoptosis; Cell Line, Tumor; Cell Proliferation; Electron Transport Complex IV; Enzyme Activation; Humans; Mitochondrial Turnover; Mitotane; Oxidative Stress; Steroids | 2014 |
Association of mitotane with chylomicrons and serum lipoproteins: practical implications for treatment of adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Aged; Antineoplastic Agents, Hormonal; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; Chyle; Chylomicrons; Cohort Studies; Endoplasmic Reticulum Stress; Female; Gastrointestinal Absorption; Humans; Lipoproteins; Lipoproteins, HDL2; Lipoproteins, IDL; Lipoproteins, LDL; Lipoproteins, VLDL; Male; Middle Aged; Mitotane | 2016 |
The adrenal specific toxicant mitotane directly interacts with lipid membranes and alters membrane properties depending on lipid composition.
Topics: Adrenal Glands; Ascorbic Acid; Biological Assay; Electron Spin Resonance Spectroscopy; Fluorescence; Lipid Bilayers; Lipids; Mitotane; Organ Specificity; Phosphatidylcholines; Phosphatidylethanolamines; Proton Magnetic Resonance Spectroscopy; Unilamellar Liposomes | 2016 |
Circannual variation of mitotane and its metabolites plasma levels in patients with adrenocortical carcinoma.
Topics: Adipose Tissue; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Antineoplastic Agents, Hormonal; Chemotherapy, Adjuvant; Chromatography, High Pressure Liquid; Female; Humans; Male; Middle Aged; Mitotane; Seasons; Sex Factors; Time Factors; Young Adult | 2017 |
Two-dimensional chromatography for enantiomeric analysis of mitotane and its metabolite o,p'-DDA in patients with adrenocortical carcinoma indicates enantioselective metabolism.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Chromatography, High Pressure Liquid; Humans; Mitotane; Stereoisomerism | 2023 |