2--o-methyl-2-thiouridine and 2-thiothymidine

2--o-methyl-2-thiouridine has been researched along with 2-thiothymidine* in 1 studies

Other Studies

1 other study(ies) available for 2--o-methyl-2-thiouridine and 2-thiothymidine

Article	Year
Triplex forming ability of oligonucleotides containing 2'-O-methyl-2-thiouridine or 2-thiothymidine. Bioorganic & medicinal chemistry letters, 2006, Jun-15, Volume: 16, Issue:12 The triplex forming ability of oligonucleotides containing 2'-O-methyl-2-thiouridine (s2Um) and 2-thiothymidine (s2T) was studied. The UV melting experiments revealed that triplex forming oligonucleotides (TFOs) containing both s2Um or s2T stabilized significantly parallel triplexes. The main reason for stabilization of triplexes was due to the stacking effect of the 2-thiocarbonyl group. Moreover, it turned out that these modified TFOs had a high selectivity in recognition of a matched Hoogsteen base from a mismatched one. Topics: Base Sequence; Nucleic Acid Conformation; Oligonucleotides; Thiouridine; Thymidine; Transition Temperature	2006

Article

Year

Triplex forming ability of oligonucleotides containing 2'-O-methyl-2-thiouridine or 2-thiothymidine.

Bioorganic & medicinal chemistry letters, 2006, Jun-15, Volume: 16, Issue:12

The triplex forming ability of oligonucleotides containing 2'-O-methyl-2-thiouridine (s2Um) and 2-thiothymidine (s2T) was studied. The UV melting experiments revealed that triplex forming oligonucleotides (TFOs) containing both s2Um or s2T stabilized significantly parallel triplexes. The main reason for stabilization of triplexes was due to the stacking effect of the 2-thiocarbonyl group. Moreover, it turned out that these modified TFOs had a high selectivity in recognition of a matched Hoogsteen base from a mismatched one.

Topics: Base Sequence; Nucleic Acid Conformation; Oligonucleotides; Thiouridine; Thymidine; Transition Temperature

2006