2--hydroxychalcone and thiazolyl-blue

2--hydroxychalcone has been researched along with thiazolyl-blue* in 1 studies

Other Studies

1 other study(ies) available for 2--hydroxychalcone and thiazolyl-blue

Article	Year
Synthesis and PPAR-gamma ligand-binding activity of the new series of 2'-hydroxychalcone and thiazolidinedione derivatives. Chemical & pharmaceutical bulletin, 2006, Volume: 54, Issue:3 Fifteen chalcones and three thiazolidinedione (TZD) chalcones were prepared to evaluate their peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligand-binding activities. Among the three TZDs, one compound possessed PPAR-gamma transactivation potential, while the others showed antagonistic activity against PPAR-gamma transactivation. Among the chalcones, compound 5 was the most potent, and structure-activity relationship studies indicated that a methoxyl group in position C-4 and hydroxyl group in position C-4' or 5' in chalcone plays a key role in determining the potency of PPAR-gamma activation. Topics: Chalcone; Chalcones; Indicators and Reagents; Ligands; Luciferases; PPAR gamma; Reverse Transcriptase Polymerase Chain Reaction; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles; Thiazolidinediones; Transfection	2006

Article

Year

Synthesis and PPAR-gamma ligand-binding activity of the new series of 2'-hydroxychalcone and thiazolidinedione derivatives.

Chemical & pharmaceutical bulletin, 2006, Volume: 54, Issue:3

Fifteen chalcones and three thiazolidinedione (TZD) chalcones were prepared to evaluate their peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligand-binding activities. Among the three TZDs, one compound possessed PPAR-gamma transactivation potential, while the others showed antagonistic activity against PPAR-gamma transactivation. Among the chalcones, compound 5 was the most potent, and structure-activity relationship studies indicated that a methoxyl group in position C-4 and hydroxyl group in position C-4' or 5' in chalcone plays a key role in determining the potency of PPAR-gamma activation.

Topics: Chalcone; Chalcones; Indicators and Reagents; Ligands; Luciferases; PPAR gamma; Reverse Transcriptase Polymerase Chain Reaction; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles; Thiazolidinediones; Transfection

2006