2--hydroxy-5-9-dimethyl-2-allyl-6-7-benzomorphan and 1-2-3-4-tetrahydroisoquinoline

2--hydroxy-5-9-dimethyl-2-allyl-6-7-benzomorphan has been researched along with 1-2-3-4-tetrahydroisoquinoline* in 1 studies

Other Studies

1 other study(ies) available for 2--hydroxy-5-9-dimethyl-2-allyl-6-7-benzomorphan and 1-2-3-4-tetrahydroisoquinoline

Article	Year
Phencyclidine-like effects of tetrahydroisoquinolines and related compounds. Journal of medicinal chemistry, 1989, Volume: 32, Issue:6 A series of 1,2,3,4-tetrahydroisoquinolines, tetrahydrothieno[2,3-c]pyridines, and related compounds were evaluated for their ability to inhibit binding of [3H]-1-[1-(2-thienyl)piperidine and [3H]-N-allylnormetazocine to phencyclidine (PCP) and sigma receptors, respectively. A representative series of compounds was evaluated in behavioral assays to determine the ability of the compounds to induce PCP-like stereotyped behavior and ataxia. All of the compounds caused stereotyped behavior and ataxia, indicating their agonist actions at the PCP site. Topics: Animals; Ataxia; Behavior, Animal; Chemical Phenomena; Chemistry; Isoquinolines; Male; Molecular Structure; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Phencyclidine; Stereotyped Behavior; Structure-Activity Relationship; Tetrahydroisoquinolines	1989

Article

Year

Phencyclidine-like effects of tetrahydroisoquinolines and related compounds.

Journal of medicinal chemistry, 1989, Volume: 32, Issue:6

A series of 1,2,3,4-tetrahydroisoquinolines, tetrahydrothieno[2,3-c]pyridines, and related compounds were evaluated for their ability to inhibit binding of [3H]-1-[1-(2-thienyl)piperidine and [3H]-N-allylnormetazocine to phencyclidine (PCP) and sigma receptors, respectively. A representative series of compounds was evaluated in behavioral assays to determine the ability of the compounds to induce PCP-like stereotyped behavior and ataxia. All of the compounds caused stereotyped behavior and ataxia, indicating their agonist actions at the PCP site.

Topics: Animals; Ataxia; Behavior, Animal; Chemical Phenomena; Chemistry; Isoquinolines; Male; Molecular Structure; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Phencyclidine; Stereotyped Behavior; Structure-Activity Relationship; Tetrahydroisoquinolines

1989