Page last updated: 2024-09-04

2'-fluorothymidine and uridine

2'-fluorothymidine has been researched along with uridine in 18 studies

Compound Research Comparison

Studies
(2'-fluorothymidine)
Trials
(2'-fluorothymidine)
Recent Studies (post-2010)
(2'-fluorothymidine)
Studies
(uridine)
Trials
(uridine)
Recent Studies (post-2010) (uridine)
187183912,749691,083

Protein Interaction Comparison

ProteinTaxonomy2'-fluorothymidine (IC50)uridine (IC50)
Sodium/nucleoside cotransporter 1Homo sapiens (human)5.8
Solute carrier family 28 member 3Homo sapiens (human)5.4

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-199017 (94.44)18.7374
1990's1 (5.56)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chomel, B; Fourel, I; Fox, JJ; Hantz, O; Jacquet, C; Trepo, C; Watanabe, KA1
Cheng, YC; Chou, TC; Fanucchi, MP; Fox, JJ; Kong, XB; Takahashi, K; Watanabe, KA1
Gadler, H; Nawrot, B; Pankiewicz, KW; Price, RW; Watanabe, KA1
Chou, TC; Gadler, H; Kalman, TI; Matulic-Adamic, J; Price, RW; Reddy, AR; Takahashi, K; Watanabe, KA1
Hsiung, GD; Landry, ML; Mayo, DR; Zheng, ZM1
Burchenal, JH; Fanucchi, MP; Fox, JJ; Leyland-Jones, B; Watanabe, KA; Young, CW1
Cantrell, C; Gerone, PJ; Soike, KF1
Sapse, AM; Snyder, G1
Hsiung, GD; Mayo, DR1
Chou, TC; Feinberg, A; Fox, JJ; Philips, FS; Su, TL; Vidal, PM; Watanabe, KA1
Cheng, YC; Lin, JC; Pagano, JS; Smith, MC1
Fox, JJ; Lopez, C; Nesburn, AB; Su, TL; Trousdale, MD; Watanabe, KA1
Nahmias, AJ; Peters, J; Schinazi, RF; Sokol, MK1
Fox, JJ; Last-Barney, K; Merluzzi, VJ1
Fox, JJ; Price, RW; Rubenstein, R; Saito, Y; Watanabe, KA1
Marquardt, H; Westendorf, J1
Braun, TJ; Burchenal, JH; Chou, TC; Fox, JJ; Philips, FS; Schmid, FA; Su, TL; Watanabe, KA1
Fox, JJ; Philips, FS; Price, RW; Rottenberg, DA; Saito, Y; Su, TL; Watanabe, KA1

Other Studies

18 other study(ies) available for 2'-fluorothymidine and uridine

ArticleYear
Inhibitory effects of 2'-fluorinated arabinosyl-pyrimidine nucleosides on woodchuck hepatitis virus replication in chronically infected woodchucks.
    Antimicrobial agents and chemotherapy, 1990, Volume: 34, Issue:3

    Topics: Administration, Oral; Animals; Antiviral Agents; Arabinofuranosyluracil; Chronic Disease; Cytarabine; Hepadnaviridae; Hepatitis, Viral, Animal; Uridine; Virus Replication

1990
Synthesis and biological effects of 2'-fluoro-5-ethyl-1-beta-D-arabinofuranosyluracil.
    Antimicrobial agents and chemotherapy, 1987, Volume: 31, Issue:9

    Topics: Antiviral Agents; Arabinofuranosyluracil; Cell Line; Cell Survival; DNA; Simplexvirus; Structure-Activity Relationship; Thymidine Kinase; Uridine

1987
Nucleosides. 146. 1-Methyl-5-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil, the C-nucleoside isostere of the potent antiviral agent 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)thymine (FMAU). Studies directed toward the synthesis of 2'-deoxy-2'-substit
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:12

    Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Female; Humans; Mice; Mice, Inbred BALB C; Simplexvirus; Uridine

1987
Nucleosides. 150. Synthesis and some biological properties of 5-monofluoromethyl, 5-difluoromethyl, and 5-trifluoromethyl derivatives of 2'-deoxyuridine and 2'-deoxy-2'-fluoro-beta-D-arabinofuranosyluracil.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:8

    Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Cell Division; Chemical Phenomena; Chemistry; Deoxyuridine; Encephalitis; Herpes Simplex; Nucleosides; Radionuclide Imaging; Rats; Simplexvirus; Structure-Activity Relationship; Thymidylate Synthase; Uridine

1988
Effect of 2'-fluoro-5-methyl-ara-uracil and cyclophosphamide on herpes simplex virus infection in guinea pigs.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1987, Volume: 8, Issue:2

    Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Cyclophosphamide; Dose-Response Relationship, Drug; Female; Guinea Pigs; Herpes Genitalis; Uridine

1987
Phase I trial of 1-(2'-deoxy-2'-fluoro-1-beta-D-arabinofuranosyl)-5-methyluracil (FMAU).
    Cancer treatment reports, 1985, Volume: 69, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents; Arabinofuranosyluracil; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Central Nervous System Diseases; Drug Evaluation; Female; Humans; Leukocyte Count; Lung Neoplasms; Male; Middle Aged; Nausea; Neoplasms; Platelet Count; Uridine; Vomiting

1985
Activity of 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodouracil against simian varicella virus infections in African green monkeys.
    Antimicrobial agents and chemotherapy, 1986, Volume: 29, Issue:1

    Topics: Administration, Oral; Animals; Antiviral Agents; Arabinofuranosyluracil; Aspartate Aminotransferases; Chickenpox; Chlorocebus aethiops; Female; Injections, Intravenous; Male; Time Factors; Uridine

1986
Ab initio studies of the antiviral drug 1-(2-fluoro-2-deoxy-beta-D-arabinofuranosyl) thymine.
    Cancer investigation, 1985, Volume: 3, Issue:2

    Topics: Antiviral Agents; Arabinofuranosyluracil; Herpesviridae; Molecular Conformation; Structure-Activity Relationship; Uridine

1985
Treatment of primary acute genital herpes in guinea pigs by intraperitoneal administration of fluoropyrimidines.
    Antimicrobial agents and chemotherapy, 1984, Volume: 26, Issue:3

    Topics: Acyclovir; Animals; Antiviral Agents; Arabinofuranosyluracil; Cytarabine; Female; Foscarnet; Guinea Pigs; Herpes Genitalis; Injections, Intraperitoneal; Male; Phosphonoacetic Acid; Uridine; Virus Replication

1984
Distribution, metabolism, and excretion of 1-(2-fluoro-2-deoxy-beta-D- arabinofuranosyl)thymine and 1-(2-fluoro-2-deoxy-beta-D-arabinofuranosyl)-5- iodocytosine.
    Cancer research, 1983, Volume: 43, Issue:8

    Topics: Absorption; Animals; Arabinofuranosyluracil; Chromatography, High Pressure Liquid; Cytarabine; Digestive System; Dogs; Female; Kidney; Male; Metabolic Clearance Rate; Mice; Rats; Simplexvirus; Species Specificity; Tissue Distribution; Uridine; Virus Replication

1983
Epstein-Barr virus: inhibition of replication by three new drugs.
    Science (New York, N.Y.), 1983, Aug-05, Volume: 221, Issue:4610

    Topics: Acyclovir; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Cytarabine; DNA Replication; Herpesvirus 4, Human; Uridine; Virus Replication

1983
Activity of 1-(2'-fluoro-2'-deoxy-beta-D-arabinofuranosyl)thymine against herpes simplex virus in cell cultures and rabbit eyes.
    Antimicrobial agents and chemotherapy, 1983, Volume: 23, Issue:6

    Topics: Acyclovir; Animals; Antiviral Agents; Arabinofuranosyluracil; Cells, Cultured; Drug Resistance, Microbial; Idoxuridine; Keratitis, Dendritic; Male; Rabbits; Simplexvirus; Uridine; Vidarabine

1983
Therapeutic activities of 1-(2-fluoro-2-deoxy-beta-D-arabinofuranosyl)-5-iodocytosine and -thymine alone and in combination with acyclovir and vidarabine in mice infected intracerebrally with herpes simplex virus.
    Antimicrobial agents and chemotherapy, 1983, Volume: 24, Issue:1

    Topics: Acyclovir; Administration, Oral; Animals; Antiviral Agents; Arabinofuranosyluracil; Brain; Cytarabine; Drug Therapy, Combination; Encephalitis; Female; Herpes Simplex; Injections, Intraperitoneal; Mice; Uridine; Vidarabine

1983
Comparison of 2'-fluoro-arabinosyl pyrimidine nucleosides and 1-beta-D-arabinofuranosylcytosine on immunological parameters in vitro.
    International journal of immunopharmacology, 1983, Volume: 5, Issue:5

    Topics: Animals; Antibody Formation; Antibody-Producing Cells; Arabinofuranosyluracil; Cell Survival; Cytarabine; Immune Tolerance; Mice; Spleen; Uridine

1983
Diagnostic imaging of herpes simplex virus encephalitis using a radiolabeled antiviral drug: autoradiographic assessment in an animal model.
    Annals of neurology, 1984, Volume: 15, Issue:6

    Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Autoradiography; Blood-Brain Barrier; Brain; Carbon Radioisotopes; Cerebral Ventricles; Choroid Plexus; Encephalitis; Ependyma; Female; Herpes Simplex; Kinetics; Radionuclide Imaging; Rats; Uridine

1984
Potent antiviral 2'-fluoro-arabinosyl pyrimidine nucleosides: lack of mutagenic activity.
    Carcinogenesis, 1982, Volume: 3, Issue:5

    Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Cell Line; Cricetinae; Cricetulus; Cytarabine; DNA; Liver; Mutagenicity Tests; Rats; Rats, Inbred Strains; Salmonella typhimurium; Uridine

1982
Biochemical effects of 2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil and 2'-fluoro-5-iodo-1-beta-D-arabinofuranosylcytosine in mouse leukemic cells sensitive and resistant to 1-beta-D-arabinofuranosylcytosine.
    Cancer research, 1982, Volume: 42, Issue:10

    Topics: Animals; Arabinofuranosyluracil; Cell Survival; Cytarabine; Deoxycytidine; DNA Replication; Kinetics; Leukemia L1210; Leukemia, Experimental; Mice; Thymidine; Uridine

1982
Quantitative autoradiographic mapping of herpes simplex virus encephalitis with a radiolabeled antiviral drug.
    Science (New York, N.Y.), 1982, Sep-17, Volume: 217, Issue:4565

    Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Autoradiography; Cytarabine; Encephalitis; Herpes Simplex; Rats; Uridine

1982