2'-fluorothymidine has been researched along with thymidine in 30 studies
*Thymidine: A nucleoside in which THYMINE is linked to DEOXYRIBOSE. [MeSH]
*Thymidine: A nucleoside in which THYMINE is linked to DEOXYRIBOSE. [MeSH]
| Studies (2'-fluorothymidine) | Trials (2'-fluorothymidine) | Recent Studies (post-2010) (2'-fluorothymidine) | Studies (thymidine) | Trials (thymidine) | Recent Studies (post-2010) (thymidine) |
|---|---|---|---|---|---|
| 9 | 0 | 4 | 33,410 | 241 | 1,117 |
| 10 | 0 | 8 | 33,410 | 241 | 1,117 |
| 187 | 18 | 39 | 33,410 | 241 | 1,117 |
| Protein | Taxonomy | 2'-fluorothymidine (IC50) | thymidine (IC50) |
|---|---|---|---|
| Thymidine kinase | Macacine alphaherpesvirus 1 | 4.1 | |
| Thymidine kinase, cytosolic | Homo sapiens (human) | 0.614 | |
| Thymidine kinase | Human alphaherpesvirus 1 strain SC16 | 1 | |
| Sterol O-acyltransferase 1 | Cricetulus griseus (Chinese hamster) | 1.8 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (13.33) | 18.7374 |
| 1990's | 3 (10.00) | 18.2507 |
| 2000's | 11 (36.67) | 29.6817 |
| 2010's | 12 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Albert, J; Cox, SW; Uhlén, M; Wahlberg, J; Wahren, B | 1 |
| Benseler, F; Eckstein, F; Williams, DM | 1 |
| Grierson, JR; Kozawa, SM; Shields, AF; Zheng, M | 1 |
| Krohn, KA; Mankoff, DA; Shields, AF | 1 |
| Byrom, M; Ellington, AD; Li, N; Nguyen, HH | 1 |
| Cass, CE; Eriksson, S; Knaus, EE; Kumar, P; Paproski, RJ; Sjuvarsson, EV; Sun, W; Wiebe, LI; Yang, J; Zhou, A | 1 |
| Choi, K; Heo, K; Jung, JE; Kim, EO; Kim, IH; Kim, S; Kim, YH; Koh, SS; Lee, JW; Lee, Y; Moon, JY; Rhee, SG; Sung, HJ | 1 |
| Andreasen, PA; Bjerregaard, N; Dupont, DM | 1 |
| Herdewijn, P; Munier-Lehmann, H; Pochet, S; Van Calenbergh, S; Van Rompaey, P; Vanheusden, V | 1 |
| Coen, DM; Fleming, HE; Leslie, LK; Retondo, MJ | 1 |
| Machida, H | 1 |
| Friedman-Kien, AE; Klein, RJ | 1 |
| Braun, TJ; Burchenal, JH; Chou, TC; Fox, JJ; Philips, FS; Schmid, FA; Su, TL; Watanabe, KA | 1 |
| Bading, JR; Bathija, P; Conti, PS; Shahinian, AH | 1 |
| Hill, DL; Nan, L; Oliver, P; Rhie, JK; Wang, H; Wang, S; Wang, Z; Zhang, R | 1 |
| Grierson, JR; Jordan, R; Krohn, KA; Schwartz, JL; Tamura, Y | 1 |
| Buti, M; Esteban, R | 1 |
| Alauddin, MM; Bading, JR; Bathija, P; Conti, PS; Fissekis, JD; Koda, RT; Koszalka, GW; Shahinian, AH; Vail, A | 1 |
| Lok, AS | 1 |
| Cheng, YC; Degrève, B; Dutschman, GE; Hu, R; Lam, W; Li, L | 1 |
| Yim, HJ | 1 |
| Fleischer, RD; Lok, AS | 1 |
| Bao, H; Furman, PA; Korba, B; Micolochick Steuer, HM; Murakami, E; Niu, C; Tolstykh, T | 1 |
| Emerick, LE; Krohn, KA; Plotnik, DA; Schwartz, JL; Unadkat, JD | 1 |
| Auerbach, MS; Campbell, DO; Czernin, J; Herschman, H; Lavie, A; Lee, JT; Radu, CG; Satyamurthy, N; Su, Y; Yaghoubi, SS | 1 |
| Suzuki, F | 2 |
| Fung, J; Lai, CL; Seto, WK; Yuen, MF | 1 |
| Berg, T; van Bömmel, F | 1 |
| He, L; Jiang, Y; Liu, X; Wang, X; Yang, Z; Zhang, S; Zhao, Y | 1 |
8 review(s) available for 2'-fluorothymidine and thymidine
| Article | Year |
|---|---|
PET imaging of cellular proliferation.
Topics: Cell Division; Humans; Neoplasms; Positron-Emission Tomography; Thymidine | 2005 |
Entecavir, FTC, L-FMAU, LdT and others.
Topics: Antiviral Agents; Arabinofuranosyluracil; Clinical Trials as Topic; Deoxycytidine; Emtricitabine; Guanine; Hepatitis B, Chronic; Humans; Randomized Controlled Trials as Topic; Thymidine | 2003 |
New treatment of chronic hepatitis B.
Topics: Adenine; Animals; Antiviral Agents; Arabinofuranosyluracil; Deoxycytidine; Drug Resistance, Viral; Emtricitabine; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates; Organophosphorus Compounds; Pyrimidinones; Telbivudine; Tenofovir; Thymidine; Treatment Outcome | 2004 |
[Management of antiviral-resistant chronic hepatitis B virus infection].
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Drug Resistance, Multiple, Viral; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Mutation; Nucleosides; Organophosphonates; Practice Guidelines as Topic; Pyrimidinones; Telbivudine; Thymidine; Treatment Outcome | 2008 |
Myopathy and neuropathy associated with nucleos(t)ide analog therapy for hepatitis B.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Creatine Kinase; Drug Discovery; Early Termination of Clinical Trials; Hepatitis B, Chronic; Humans; Lamivudine; Mitochondrial Myopathies; Muscular Diseases; Nervous System Diseases; Nucleosides; Nucleotides; Pyrimidinones; Republic of Korea; Telbivudine; Thymidine | 2009 |
[New drugs of treatment of patients with chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Deoxycytidine; Emtricitabine; Hepatitis B, Chronic; Humans; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Tenofovir; Thymidine | 2012 |
Extrahepatic effects of nucleoside and nucleotide analogues in chronic hepatitis B treatment.
Topics: Acidosis, Lactic; Adenine; Administration, Oral; Antiviral Agents; Arabinofuranosyluracil; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Humans; Kidney Diseases; Male; Muscular Diseases; Nervous System Diseases; Nucleosides; Nucleotides; Organophosphonates; Pharmacovigilance; Pregnancy; Telbivudine; Tenofovir; Thymidine | 2014 |
Efficacy of Nucleot(s)ide Analogs Therapy in Patients with Unresectable HBV-Related Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis.
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Carcinoma, Hepatocellular; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Neoplasms; Organophosphonates; Retrospective Studies; Survival Analysis; Telbivudine; Tenofovir; Thymidine | 2017 |
1 trial(s) available for 2'-fluorothymidine and thymidine
| Article | Year |
|---|---|
Structure-guided engineering of human thymidine kinase 2 as a positron emission tomography reporter gene for enhanced phosphorylation of non-natural thymidine analog reporter probe.
Topics: Adult; Animals; Arabinofuranosyluracil; Female; Fluorine Radioisotopes; Genes, Reporter; Guanine; Herpesvirus 1, Human; Humans; Male; Mice; Middle Aged; Models, Molecular; Phosphorylation; Positron-Emission Tomography; Protein Conformation; Protein Engineering; Thymidine; Thymidine Kinase | 2012 |
21 other study(ies) available for 2'-fluorothymidine and thymidine
| Article | Year |
|---|---|
Loss of synergistic response to combinations containing AZT in AZT-resistant HIV-1.
Topics: Antiviral Agents; Cells, Cultured; Didanosine; Drug Resistance, Microbial; Drug Synergism; HIV-1; Humans; Thymidine; Zidovudine | 1992 |
Properties of 2'-fluorothymidine-containing oligonucleotides: interaction with restriction endonuclease EcoRV.
Topics: Base Sequence; Deoxyribonucleases, Type II Site-Specific; Indicators and Reagents; Molecular Sequence Data; Molecular Structure; Nucleic Acid Denaturation; Oligodeoxyribonucleotides; Substrate Specificity; Thermodynamics; Thymidine | 1991 |
Development of labeled thymidine analogs for imaging tumor proliferation.
Topics: Animals; Antimetabolites, Antineoplastic; Arabinofuranosyluracil; Biotransformation; Dogs; Floxuridine; Fluorine Radioisotopes; In Vitro Techniques; Isotope Labeling; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neoplasms, Experimental; Thymidine; Tissue Distribution; Tomography, Emission-Computed | 1996 |
Inhibition of cell proliferation by an anti-EGFR aptamer.
Topics: Antineoplastic Agents; Aptamers, Nucleotide; Base Sequence; Biological Transport; Cell Line, Tumor; Cell Proliferation; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Neoplastic; Humans; Phosphorylation; Substrate Specificity; Thymidine | 2011 |
Biochemistry and biology of 2'-Fluoro-2'-deoxythymidine (FT), a putative highly selective substrate for thymidine kinase type 2 (TK2).
Topics: Animals; Antineoplastic Agents; Autoradiography; Bone Neoplasms; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Membrane Transport Proteins; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Osteosarcoma; Phosphorylation; Positron-Emission Tomography; Radiopharmaceuticals; Thymidine; Thymidine Kinase; Transgenes | 2012 |
An RNA aptamer that specifically binds pancreatic adenocarcinoma up-regulated factor inhibits migration and growth of pancreatic cancer cells.
Topics: Animals; Aptamers, Nucleotide; Base Sequence; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Humans; Intercellular Signaling Peptides and Proteins; Lectins; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Sequence Data; Pancreatic Neoplasms; Protein Binding; Thymidine; Tumor Burden; Xenograft Model Antitumor Assays | 2011 |
A Conjugate of Two tPA-Binding RNA Aptamers Efficiently Inhibits Fibrinolysis.
Topics: Aptamers, Nucleotide; Base Pairing; Binding Sites; Catalytic Domain; Fibrinolysis; HEK293 Cells; Humans; Kinetics; Plasminogen Activator Inhibitor 1; Protein Binding; Recombinant Proteins; Thymidine; Transcription, Genetic | 2017 |
Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.
Topics: Antitubercular Agents; Enzyme Inhibitors; Inhibitory Concentration 50; Kinetics; Mycobacterium tuberculosis; Nucleoside-Phosphate Kinase; Structure-Activity Relationship; Thymidine; Thymine Nucleotides | 2003 |
Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus.
Topics: Acyclovir; Antiviral Agents; Arabinofuranosyluracil; Arabinonucleosides; Bromodeoxyuridine; DNA-Directed DNA Polymerase; Drug Resistance, Microbial; Foscarnet; Ganciclovir; Genes, Viral; Idoxuridine; Mutation; Phosphonoacetic Acid; Simplexvirus; Thymidine; Vidarabine | 1985 |
Susceptibility of varicella-zoster virus to thymidine analogues.
Topics: Acyclovir; Antiviral Agents; Arabinofuranosyluracil; Cytarabine; Deoxyuridine; Fibroblasts; Herpesvirus 3, Human; Humans; Neutralization Tests; Simplexvirus; Thymidine | 1986 |
Effect of eight antiviral drugs on the reactivation of herpes simplex virus in explant cultures of latently infected mouse trigeminal ganglia.
Topics: Acyclovir; Animals; Antibodies, Viral; Antiviral Agents; Arabinofuranosyluracil; Arabinonucleosides; Bromodeoxyuridine; Culture Media; Culture Techniques; Cytarabine; Foscarnet; Mice; Mice, Hairless; Neutralization Tests; Phosphonoacetic Acid; Simplexvirus; Thymidine; Trigeminal Nerve; Vidarabine Phosphate; Virus Activation | 1984 |
Biochemical effects of 2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil and 2'-fluoro-5-iodo-1-beta-D-arabinofuranosylcytosine in mouse leukemic cells sensitive and resistant to 1-beta-D-arabinofuranosylcytosine.
Topics: Animals; Arabinofuranosyluracil; Cell Survival; Cytarabine; Deoxycytidine; DNA Replication; Kinetics; Leukemia L1210; Leukemia, Experimental; Mice; Thymidine; Uridine | 1982 |
Pharmacokinetics of the thymidine analog 2'-fluoro-5-[(14)C]-methyl-1-beta-D-arabinofuranosyluracil ([(14)C]FMAU) in rat prostate tumor cells.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; DNA; Male; Prostatic Neoplasms; Rats; Thymidine; Tumor Cells, Cultured | 2000 |
Radiolabeled 2'-fluorodeoxyuracil-beta-D-arabinofuranoside (FAU) and 2'-fluoro-5-methyldeoxyuracil-beta -D-arabinofuranoside (FMAU) as tumor-imaging agents in mice.
Topics: Animals; Arabinofuranosyluracil; DNA, Neoplasm; Humans; Mice; Mice, SCID; Muscle, Skeletal; Neoplasm Transplantation; Neoplasms; Radiopharmaceuticals; Spleen; Thymidine; Tissue Distribution; Tomography, Emission-Computed; Transplantation, Heterologous | 2002 |
Monitoring tumor cell proliferation by targeting DNA synthetic processes with thymidine and thymidine analogs.
Topics: Animals; Arabinofuranosyluracil; Cell Division; Cell Line, Tumor; Dideoxynucleosides; DNA; Drug Delivery Systems; Humans; Metabolic Clearance Rate; Mice; Neoplasm Staging; Neoplasms; Radiopharmaceuticals; Thymidine; Thymidine Kinase; Tomography, Emission-Computed; Tritium | 2003 |
Pharmacokinetics of the thymidine analog 2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (FMAU) in tumor-bearing rats.
Topics: Adenocarcinoma; Animals; Arabinofuranosyluracil; Carbon Radioisotopes; Cell Line, Tumor; Colorectal Neoplasms; DNA, Neoplasm; Female; Male; Metabolic Clearance Rate; Organ Specificity; Prostatic Neoplasms; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Inbred F344; Thymidine; Tissue Distribution | 2004 |
Behavior of thymidylate kinase toward monophosphate metabolites and its role in the metabolism of 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-methyluracil (Clevudine) and 2',3'-didehydro-2',3'-dideoxythymidine in cells.
Topics: Antiviral Agents; Arabinofuranosyluracil; Cell Line; Cloning, Molecular; Enzyme Induction; Humans; Immunoblotting; Microscopy, Confocal; Phosphates; Phosphorylation; Thymidine; Thymidine Kinase; Thymine Nucleotides | 2005 |
Evaluation of the in vitro anti-HBV activity of clevudine in combination with other nucleoside/nucleotide inhibitors.
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Arabinofuranosyluracil; Cell Line; Cells, Cultured; Drug Antagonism; Drug Synergism; Drug Therapy, Combination; Guanine; Hepatitis B virus; Hepatocytes; Humans; Lamivudine; Microbial Sensitivity Tests; Nucleosides; Nucleotides; Organophosphonates; Pyrimidinones; Reverse Transcriptase Inhibitors; Telbivudine; Tenofovir; Thymidine | 2010 |
Different modes of transport for 3H-thymidine, 3H-FLT, and 3H-FMAU in proliferating and nonproliferating human tumor cells.
Topics: Arabinofuranosyluracil; Biological Transport; Cell Line, Tumor; Cell Proliferation; Dideoxynucleosides; Equilibrative Nucleoside Transport Proteins; Humans; Kinetics; Neoplasms; Positron-Emission Tomography; Thymidine; Tritium | 2010 |
[New drugs of treatment of patients with chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Deoxycytidine; Emtricitabine; Hepatitis B, Chronic; Humans; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Tenofovir; Thymidine | 2011 |
Antiviral therapy of chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Carcinoma, Hepatocellular; Gene Products, pol; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver; Liver Cirrhosis; Liver Neoplasms; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Telbivudine; Tenofovir; Thymidine; Treatment Outcome; Virus Replication | 2014 |