2'-fluorothymidine has been researched along with arabinofuranosyluracil in 179 studies
| Studies (2'-fluorothymidine) | Trials (2'-fluorothymidine) | Recent Studies (post-2010) (2'-fluorothymidine) | Studies (arabinofuranosyluracil) | Trials (arabinofuranosyluracil) | Recent Studies (post-2010) (arabinofuranosyluracil) |
|---|---|---|---|---|---|
| 9 | 0 | 4 | 602 | 43 | 75 |
| 187 | 18 | 39 | 602 | 43 | 75 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (16.20) | 18.7374 |
| 1990's | 25 (13.97) | 18.2507 |
| 2000's | 75 (41.90) | 29.6817 |
| 2010's | 48 (26.82) | 24.3611 |
| 2020's | 2 (1.12) | 2.80 |
| Authors | Studies |
|---|---|
| Grierson, JR; Kozawa, SM; Shields, AF; Zheng, M | 1 |
| Fourel, I; Fox, JJ; Hantz, O; Jacquet, C; Li, J; Trépo, C | 1 |
| Balasubramaniam, NK; Gentry, GA; Veerisetty, V | 1 |
| Chomel, B; Fourel, I; Fox, JJ; Hantz, O; Jacquet, C; Trepo, C; Watanabe, KA | 1 |
| Abbruzzese, JL; Castellanos, AM; Krakoff, IH; Legha, SS; Levy, JK; Raber, MN; Schmidt, S | 1 |
| Cheng, YC; Chou, TC; Fanucchi, MP; Fox, JJ; Kong, XB; Takahashi, K; Watanabe, KA | 1 |
| Gadler, H; Nawrot, B; Pankiewicz, KW; Price, RW; Watanabe, KA | 1 |
| Chou, TC; Gadler, H; Kalman, TI; Matulic-Adamic, J; Price, RW; Reddy, AR; Takahashi, K; Watanabe, KA | 1 |
| Hsiung, GD; Landry, ML; Mayo, DR; Zheng, ZM | 1 |
| Burchenal, JH; Fanucchi, MP; Fox, JJ; Leyland-Jones, B; Watanabe, KA; Young, CW | 1 |
| Coen, DM; Fleming, HE; Leslie, LK; Retondo, MJ | 1 |
| Campbell, NL; Matthews, TR; Smee, DF | 1 |
| Cheng, YC; Chiou, JF; Huang, ES; Mar, EC | 1 |
| Burns, WH; Chen, MS; Ghazzouli, I; McLaren, C; Saral, R | 1 |
| Machida, H | 1 |
| Rollinson, EA | 1 |
| Bentele, B; Betz, JL; Mitchell, DH; Pizer, LI | 1 |
| Sougawa, M; Tanaka, Y; Yoshii, G | 1 |
| Cantrell, C; Gerone, PJ; Soike, KF | 1 |
| Sapse, AM; Snyder, G | 1 |
| Calnek, BW; Schat, KA; Schinazi, RF | 1 |
| Friedman-Kien, AE; Klein, RJ | 1 |
| Hsiung, GD; Mayo, DR | 1 |
| Chou, TC; Feinberg, A; Fox, JJ; Philips, FS; Su, TL; Vidal, PM; Watanabe, KA | 1 |
| Cheng, YC; Lin, JC; Pagano, JS; Smith, MC | 1 |
| Fox, JJ; Lopez, C; Nesburn, AB; Su, TL; Trousdale, MD; Watanabe, KA | 1 |
| Nahmias, AJ; Peters, J; Schinazi, RF; Sokol, MK | 1 |
| Fox, JJ; Last-Barney, K; Merluzzi, VJ | 1 |
| Fox, JJ; Price, RW; Rubenstein, R; Saito, Y; Watanabe, KA | 1 |
| Marquardt, H; Westendorf, J | 1 |
| Burchenal, JH; Chou, TC; Fox, JJ; Lokys, L; Smith, RS; Su, TL; Watanabe, KA | 1 |
| Braun, TJ; Burchenal, JH; Chou, TC; Fox, JJ; Philips, FS; Schmid, FA; Su, TL; Watanabe, KA | 1 |
| Fox, JJ; Philips, FS; Price, RW; Rottenberg, DA; Saito, Y; Su, TL; Watanabe, KA | 1 |
| Cheng, YC; Chu, CK; Ma, T; Pai, SB; Shanmuganathan, K; Sommadossi, JP; Wang, C; Xiang, Y; Yao, GQ | 1 |
| Cui, L; Schinazi, RF; Sommadossi, JP; Yoon, S | 1 |
| Leonhardt, JA; Smee, DF | 1 |
| Alauddin, MM; Conti, PS; Fissekis, JR; Schmall, B; Watanabe, KA | 1 |
| Boudinot, FD; Chu, CK; Ma, T; Wright, JD | 2 |
| Cheng, YC; Chou, E; Chu, CK; Kukhanova, M; Liu, SH; Yao, GQ | 1 |
| Schinazi, RF; Yao, X | 1 |
| Cheng, YC; Chu, CK; Du, J; Kim, H; Lin, JS; Ma, T; Newton, MG; Pai, SB; Shanmuganathan, K; Wang, C; Zhu, YL | 1 |
| Eriksson, S; Wang, J | 1 |
| Balakrishna Pai, S; Cheng, YC; Chu, CK; Liu, SH; Zhu, YL | 1 |
| Cheng, YC; Chu, CK; Lin, JS; Ma, T; Newton, MG | 1 |
| Ascenzi, MA; Baldwin, BH; Boudinot, FD; Chu, CK; Du, JF; Tennant, BC; Witcher, JW | 1 |
| Aguesse-Germon, S; Borel, C; Cheng, YC; Chevallier, M; Chu, CK; Jamard, C; Liu, SH; Pichoud, C; Trépo, C; Zoulim, F | 1 |
| Cheng, YC; Grove, KL; Liu, SH | 1 |
| Berger, I; Egli, M; Ikeda, H; Marquez, VE; Tereshko, V | 1 |
| Chu, CK; London, RE; Xu, AS | 1 |
| Choi, Y; Chu, CK; Chun, BK; Du, J; Hong, JH; Lee, K | 1 |
| Cheng, YC; Fu, L; Liu, SH | 1 |
| Collins, JM; Katki, AG; Klecker, RW | 1 |
| Boudinot, FD; Cheng, YC; Choi, Y; Chu, CK; Cote, PJ; Gerin, JL; Hong, JH; Korba, BE; Peek, SF; Tennant, BC | 1 |
| de Vries, EF; Harmsen, MC; Hospers, GA; Mulder, NH; Vaalburg, W; van Waarde, A | 1 |
| Bading, JR; Bathija, P; Conti, PS; Shahinian, AH | 1 |
| Aldrich, CE; Cullen, J; Furman, PA; Jilbert, AR; Litwin, S; Mason, WS; Miller, DS; Saputelli, J; Yamamoto, T; Zhu, Y | 1 |
| Baldwin, BH; Chu, CK; Cote, PJ; Gerin, JL; Hornbuckle, WE; Jacob, JR; Korba, BE; Peek, SF; Tennant, BC; Toshkov, IA; Wells, FV | 1 |
| Cheng, YC | 1 |
| Kocic, I | 1 |
| Bock, T; Chin, R; Furman, P; Isom, H; Locarnini, S; Manns, M; Shaw, T; Sozzi, V; Torresi, J; Trautwein, C | 1 |
| Begley, JA; Cooks, RG; Lampert, B; Tao, WA; Wang, F; Wu, L | 1 |
| Condreay, L; Furman, P; Litwin, S; Mason, WS; Yamamoto, T; Zhou, T; Zhu, Y | 1 |
| Boyer, N; Castelneau, C; Marcellin, P | 1 |
| Hill, DL; Nan, L; Oliver, P; Rhie, JK; Wang, H; Wang, S; Wang, Z; Zhang, R | 1 |
| Almond, MR; Pesyan, A; Sznaidman, ML | 1 |
| Cote, PJ; Gerin, JL; Korba, BE; Menne, S; Roneker, CA; Tennant, BC | 2 |
| Addison, WR; Jewell, LD; Madej, D; Tyrrell, DL; Walters, KA; Wilson, JS; Wong, WW | 1 |
| Abdelhamed, AM; Furman, PA; Isom, HC; Kelley, CM; Miller, TG | 1 |
| Furman, P; Martin, P; Pichoud, C; Seignères, B; Trépo, C; Zoulim, F | 1 |
| Chong, Y; Chu, CK | 1 |
| Bergström, M; Fasth, KJ; Långström, B; Lu, L; Samuelsson, L; Sato, K | 1 |
| Abdelhamed, AM; Cable, EE; Furman, PA; Isom, HC; Kelley, CM; Miller, TG | 1 |
| Anderson, L; Klecker, RW; Mangner, TJ; Shields, AF | 1 |
| Jamard, C; Martin, P; Rimsky, L; Schorr, O; Seignères, B; Trépo, C; Werle, B; Zoulim, F | 1 |
| Grierson, JR; Jordan, R; Krohn, KA; Schwartz, JL; Tamura, Y | 1 |
| Mason, WS; Summers, J | 1 |
| Buti, M; Esteban, R | 2 |
| Hadziyannis, SJ; Papatheodoridis, GV | 1 |
| Alauddin, MM; Bading, JR; Bathija, P; Conti, PS; Fissekis, JD; Koda, RT; Koszalka, GW; Shahinian, AH; Vail, A | 1 |
| Avci, A; Erhardt, A; Häussinger, D; Heintges, T; Lörke, J; Sagir, A | 1 |
| Lok, AS | 1 |
| Chevallier, M; Guerret, S; Jacquard, AC; Jamard, C; Nassal, M; Peyrol, S; Pichoud, C; Ren, S; Rimsky, LT; Schultz, U; Trepo, C; Werle, B; Zoulim, F | 1 |
| Blum, MR; Bronowicki, JP; Conway, B; Lau, GK; Lee, HS; Marcellin, P; Mommeja-Marin, H; Mondou, E; Rousseau, F; Sacks, SL; Sereni, D; Snow, A; Sorbel, J; Trepo, C; Yoo, BC | 1 |
| Alauddin, MM; Conti, PS; Gordon, EM; Shahinian, A | 1 |
| Aldrich, CE; Cullen, JM; Jilbert, AR; Mason, WS; Miller, D; Saputelli, J; Seeger, C; Zhu, Y | 1 |
| Anderson, LW; Brown-Proctor, C; Collins, JM; Egorin, MJ; Eiseman, JL; Hamburger, DR; Joseph, E; Kinahan, PE; Klecker, RW; Mathis, CA; Pan, SS | 1 |
| Collins, JM; Douglas, K; Mangner, TJ; Muzik, O; Shields, AF; Sloan, A; Sun, H; Vaishampayan, U | 1 |
| Baldwin, BH; Cote, PJ; Gerin, JL; Korba, BE; Menne, S; Tennant, BC; Toshkov, I; Wells, FV | 1 |
| Collins, JM; Douglas, K; Mangner, TJ; Muzik, O; Shields, AF; Sun, H | 1 |
| Zoulim, F | 1 |
| Cheng, YC; Degrève, B; Dutschman, GE; Hu, R; Lam, W; Li, L | 1 |
| Hui, CK; Lau, GK | 1 |
| Casey, J; Chu, CK; Cote, PJ; Gerin, JL; Hornbuckle, WE; Korba, BE; Tennant, BC; Toshkov, IA | 1 |
| Kang, MJ; Kim, DH; Lee, HS; Lee, J; Yoo, BC; Yoo, HH; Yoo, HW | 1 |
| Morio, T | 1 |
| Byun, KS; Chung, YH; Han, JY; Lee, HS; Lee, JH; Lee, K; Paik, SW; Yoo, BC; Yoo, HW; Yoo, K | 1 |
| Chan, S; Kotzev, IA; Krastev, Z; Lim, SG; Mechkov, G; Mondou, E; Ng, TM; Rousseau, F; Snow, A; Sorbel, J | 1 |
| Furman, PA; Korba, BE; Otto, MJ | 1 |
| Liu, K; Xie, L | 1 |
| Byun, KS; Cho, M; Cho, SH; Choi, JY; Choi, SK; Chon, CY; Chung, YH; Han, BH; Han, JY; Hwang, JS; Hwang, SG; Jeong, SH; Kim, BI; Kim, DG; Kim, HC; Kim, JH; Kim, TH; Kim, YS; Kweon, YO; Lee, HJ; Lee, HS; Lee, HY; Lee, KS; Lee, MS; Lee, YJ; Lee, YS; Paik, SW; Park, JW; Ryu, SH; Um, SH; Yang, JM; Yoo, BC; Yoo, HW; Yoo, K | 1 |
| Alauddin, MM; Bornmann, W; Gelovani, JG; Mukhopadhyay, U; Pal, A | 1 |
| Dannals, RF; Gao, Y; Holt, D; Horti, AG; Ravert, HT | 1 |
| Byun, KS; Chung, YH; Han, JY; Lee, HS; Lee, KS; Paik, SW; Yoo, BC; Yoo, HW; Yoo, K | 1 |
| Byun, KS; Cho, M; Cho, SH; Choi, JY; Choi, SK; Chon, CY; Chung, YH; Han, BH; Han, JY; Hwang, JS; Hwang, SG; Jeong, SH; Kim, BI; Kim, DG; Kim, HC; Kim, JH; Kim, TH; Kim, YS; Koh, KC; Kweon, YO; Lee, HJ; Lee, HS; Lee, HY; Lee, KS; Lee, MS; Lee, YJ; Lee, YS; Park, JW; Ryu, SH; Um, SH; Yang, JM; Yoo, BC; Yoo, HW; Yoo, K | 1 |
| Cote, PJ; Gerin, JL; Menne, S; Tennant, BC | 1 |
| Bozdayi, AM; Karaaslan, H; Karatayli, E; Karayalçin, S; Kayhan, H; Sahin, F; Türkyilmaz, AR; Yurdaydin, C | 1 |
| Douglas, KA; Heilbrun, LK; Lawhorn-Crews, JM; Mangner, TJ; Muzik, O; Shields, AF; Sun, H; Tehrani, OS | 1 |
| Alauddin, MM; Bornmann, W; Gelovani, JG; Mawlawi, O; Mukhopadhyay, U; Nishii, R; Pal, A; Volgin, AY | 1 |
| Alauddin, MM; Anderson, JH; Bading, JR; Conti, PS; Fissekis, JD; Hilton, J; Links, JM; Mouton, PP; Ravert, HT; Wong, DF | 1 |
| Douglas, KA; Lawhorn-Crews, JM; Shields, AF; Tehrani, OS | 1 |
| Blum, MR; Hann, HW; Lau, GK; Leung, N; Lim, SG; Marcellin, P; Mommeja-Marin, H; Moxham, C; Rousseau, F; Snow, A; Sorbel, J; Trepo, C | 1 |
| Furman, PA; Murakami, E; Niu, C | 1 |
| Cheong, JY | 1 |
| Yim, HJ | 1 |
| Asselah, T; Lada, O; Marcellin, P; Moucari, R | 1 |
| Cheong, JY; Cho, SW; Choi, YW; Kang, CJ; Kim, DH; Kim, MJ; Koh, KH | 1 |
| Choi, DJ; Hwang, YJ; Kim, GH; Kim, JH; Kim, YS; Kwon, OS | 1 |
| Zarski, JP | 1 |
| Jo, HY; Kim, DS; Kim, HS; Kim, SY; Lee, CH; Lee, DK; Park, MS; Seok, JI | 1 |
| Choe, WH; Kim, BK; Kim, KH; Ko, SY; Kwon, SY; Lee, CH | 1 |
| Lee, KS | 1 |
| Eun, JR; Hwang, JS; Jang, BK; Kim, BS; Lee, CH; Lee, HJ; Suh, JI | 1 |
| Anderson, DL | 1 |
| Choe, WH; Kim, BK; Ko, SY; Kwon, SY; Lee, CH; Lim, SD; Oh, J; Rhee, KH; Seo, TH | 1 |
| Fleischer, RD; Lok, AS | 1 |
| Bae, WK; Kim, HJ; Kim, KA; Kim, MH; Kim, NH; Lee, HW; Lee, JS; Moon, YS; Yun, SG | 1 |
| Bae, CH; Bae, M; Baik, SK; Choi, JH; Choi, SK; Chun, GJ; Gu, C; Gu, ES; Jang, DS; Kang, SS; Kim, HS; Kim, JH; Kim, JS; Lee, EJ; Lee, JS; Lee, KS; Lee, SH; Moon, SK; Park, ET; Park, NH; Park, SI; Shin, JW; Yu, BJ | 1 |
| Ahn, SH; Cho, ES; Choe, WH; Choi, HS; Kim, BK; Kim, KH; Ko, SY; Kwon, SY; Lee, CH; Park, ES; Park, YK; Shin, GC | 1 |
| Hwang, JH; Jang, JH; Jeong, SH; Kim, HS; Kim, JW; Kim, N; Lee, DH; Lee, SH; Myung, HJ; Park, YS | 1 |
| Kim, HS; Park, SA; Shin, YI; Yang, CY | 1 |
| Byun, KS; Jung, ES; Jung, YK; Kim, JH; Lee, HS; Seo, YS; Um, SH; Yeon, JE; Yim, HJ | 1 |
| Cho, YK; Jeon, WK; Kim, BI; Kim, HJ; Park, DI; Park, JH; Sohn, CI | 1 |
| Choi, CS; Kim, DG; Kim, HC; Kim, IH; Kim, SH; Kim, SW; Lee, S; Lee, SO; Lee, ST | 1 |
| Cho, CM; Jeon, SW; Jung, MK; Kweon, YO; Park, JY; Park, SY; Sohn, YK; Tak, WY | 1 |
| Bao, H; Furman, PA; Korba, B; Micolochick Steuer, HM; Murakami, E; Niu, C; Tolstykh, T | 1 |
| Shouval, D | 1 |
| Emerick, LE; Krohn, KA; Plotnik, DA; Schwartz, JL; Unadkat, JD | 1 |
| Lau, GK; Leung, N | 1 |
| Bae, SH; Baek, YH; Han, SY; Lee, SW | 1 |
| Chae, HB; Kang, YW; Kim, AN; Kim, HS; Kim, SB; Kim, SH; Lee, BS; Lee, HIe; Lee, HY; Lee, SH; Lee, TH; Nam, KW; Song, IH; Yang, HW | 1 |
| Byun, KS; Cho, M; Cho, SH; Chon, CY; Chung, YH; Han, BH; Han, CJ; Han, JY; Hwang, JS; Hwang, SG; Kim, BI; Kim, HC; Kim, JH; Kim, TH; Kim, YS; Koh, KC; Lee, HJ; Lee, HS; Lee, KS; Lee, MS; Lee, YS; Paik, SW; Ryu, SH; Um, SH; Yang, JM; Yoo, BC; Yoo, HW; Yoo, K | 1 |
| Choi, YY; Hwang, HS; Jang, SJ; Kim, YH; Lee, JA; Lee, MH; Paik, SS; Yoo, DH | 1 |
| Cai, H; Conti, PS; Li, Z | 1 |
| Auerbach, MS; Campbell, DO; Czernin, J; Herschman, H; Lavie, A; Lee, JT; Radu, CG; Satyamurthy, N; Su, Y; Yaghoubi, SS | 1 |
| Suzuki, F | 2 |
| Ahn, CM; Baik, SK; Chung, CH; Das, R; Jang, YO; Kim, MY; Kong, ID; Park, KS; Quan, X; Xu, S | 1 |
| Ding, C; Ge, Q; Li, Z; Liu, X; Wang, Y; Zhi, X; Zhou, Z | 1 |
| Li, J; Lorusso, P; Shields, AF; Wiegand, R; Wu, J | 1 |
| Chen, K; Conti, PS; Li, Z | 1 |
| Jang, TS; Kim, HY; Kwon, HD; Lee, HS; Lim, J | 1 |
| Choi, BS; Choi, SR; Chung, BH; Hong, YA; Kim, YS; Park, CW; Park, HS; Sun, IO; Yang, CW | 1 |
| Cheng, D; Cooper, AR; Gschweng, EH; Kohn, DB; McCracken, MN; McLaughlin, J; Nair-Gill, E; Nosala, C; Riedinger, M; Witte, ON | 1 |
| Chae, HB; Kang, HY; Kang, YW; Kim, AN; Kim, HS; Kim, SB; Kim, SH; Kim, YM; Lee, BS; Lee, ES; Lee, HIe; Lee, HY; Lee, SH; Lee, TH; Noh, R; Song, IH; Yang, HY | 1 |
| Choi, DJ; Jung, YK; Kim, JH; Kim, YS; Kwon, OS; Lee, JJ; Lee, JW; Lee, YJ | 1 |
| Tak, WY | 1 |
| Delaney, W; Furman, P; Hu, J; Jones, SA; Murakami, E | 1 |
| Alauddin, MM; Chan, PC; Chang, WT; Lin, CY; Lin, WJ; Liu, RS; Tseng, YL; Wang, HE; Wu, CY | 1 |
| Fung, J; Lai, CL; Seto, WK; Yuen, MF | 1 |
| Cho, HC; Cho, JY; Choi, MS; Gwak, GY; Koh, KC; Lee, JH; Paik, SW; Paik, YH; Sohn, W; Yoo, BC | 1 |
| Jang, JY; Kim, BH; Kim, JW; Lee, CK; Shim, JJ | 1 |
| Berg, T; van Bömmel, F | 1 |
| Hwang, JH; Jang, ES; Jeong, SH; Kim, JW; Kim, N; Lee, DH; Lee, SS; Min, BY; Park, YS; Seong, MH; Shin, CM; Sohn, HR; Song, JC | 1 |
| Chen, K; Jadvar, H; Ukimura, O | 1 |
| Ahn, SH; Chong, Y; Kang, HS; Kim, BK; Kim, DH; Kim, KH; Lee, AR; Park, ES; Park, S; Park, YK; Rhee, JK; Shin, GC; Yang, SI | 1 |
| Ahn, SH; Cho, EY; Hwang, SG; Jeong, SH; Jung, YK; Kim, HS; Kim, IH; Kim, JH; Kim, JW; Lee, JI; Lee, JM; Lee, JW; Lee, SH; Park, SJ; Seo, YS; Suh, SJ; Yim, HJ | 1 |
| Collins, JM; Douglas, KA; Jones, SK; Lawhorn-Crews, JM; Mangner, TJ; McHugh, CI; Modi, D; Shields, AF | 1 |
| Chen, K; Conti, P; Hughes, L; Jadvar, H; Park, R; Yap, LP | 1 |
| Dickow, B; Dobson, K; Heilbrun, LK; Lawhorn-Crews, JM; Shields, AF; Smith, D; Tehrani, OS; Vaishampayan, UN | 1 |
| He, L; Jiang, Y; Liu, X; Wang, X; Yang, Z; Zhang, S; Zhao, Y | 1 |
| Kim, JM | 1 |
| Cho, JY; Kim, NH; Koh, MS; Lee, JH; Park, KS; Park, SH | 1 |
| Alauddin, MM | 1 |
| Desai, B; Jadvar, H; Varghese, B; Velez, E | 1 |
| Gao, S; Jiang, Q; Li, S; Li, X; Liang, Q; Luan, J; Ruan, H; Yang, C; Zhang, F; Zhang, R; Zhou, H | 1 |
| Alcée, JB; Giguère, D; Tremblay, T | 1 |
22 review(s) available for 2'-fluorothymidine and arabinofuranosyluracil
| Article | Year |
|---|---|
Preclinical investigation of L-FMAU as an anti-hepatitis B virus agent.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Biological Availability; Cell Line; Deoxycytidine Kinase; Drug Evaluation, Preclinical; Ducks; Hepadnaviridae Infections; Hepatitis B virus; Hepatitis B Virus, Duck; Hepatitis B Virus, Woodchuck; Hepatitis B, Chronic; Lactic Acid; Lethal Dose 50; Marmota; Mice; Phosphorylation; Rats; Thymidine Kinase | 1998 |
Clevudine University of Georgia/Abbott/Bukwang/Triangle/Yale University.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Clinical Trials as Topic; Contraindications; Drugs, Investigational; Epstein-Barr Virus Infections; Hepatitis B; Humans; Structure-Activity Relationship | 2000 |
[New management strategies for hepatitis B].
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Deoxycytidine; Emtricitabine; Guanine; Hepatitis B; Humans; Lamivudine; Organophosphonates | 2002 |
Entecavir, FTC, L-FMAU, LdT and others.
Topics: Antiviral Agents; Arabinofuranosyluracil; Clinical Trials as Topic; Deoxycytidine; Emtricitabine; Guanine; Hepatitis B, Chronic; Humans; Randomized Controlled Trials as Topic; Thymidine | 2003 |
Treatment of HBeAg negative chronic hepatitis B with new drugs (adefovir and others).
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Deoxycytidine; Emtricitabine; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Nucleosides; Organophosphonates | 2003 |
[New approaches in the treatment of hepatitis B].
Topics: 2-Aminopurine; Adenine; Antiviral Agents; Arabinofuranosyluracil; Carcinoma, Hepatocellular; Contraindications; Deoxycytidine; Emtricitabine; Famciclovir; Guanine; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Liver Neoplasms; Organophosphonates; Organophosphorus Compounds; Polyethylene Glycols; Prodrugs; Prognosis; Recombinant Proteins; Tenofovir; Zalcitabine | 2004 |
New treatment of chronic hepatitis B.
Topics: Adenine; Animals; Antiviral Agents; Arabinofuranosyluracil; Deoxycytidine; Drug Resistance, Viral; Emtricitabine; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates; Organophosphorus Compounds; Pyrimidinones; Telbivudine; Tenofovir; Thymidine; Treatment Outcome | 2004 |
Combination of nucleoside analogues in the treatment of chronic hepatitis B virus infection: lesson from experimental models.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Deoxycytidine; Disease Models, Animal; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Nucleosides | 2005 |
Drugs in development for hepatitis B.
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Deoxycytidine; Emtricitabine; Guanine; Hepatitis B; Humans; Interferon alpha-2; Interferon-alpha; Nucleosides; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Tenofovir | 2005 |
Clevudine for the treatment of chronic hepatitis B virus infection.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Drug Evaluation, Preclinical; Hepatitis B virus; Hepatitis B, Chronic; Humans | 2005 |
[Therapeutic approach to EBV infection].
Topics: Antimicrobial Cationic Peptides; Antiviral Agents; Arabinofuranosyluracil; Benzimidazoles; Drug Design; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Humans; Hydroxyurea; Immunotherapy; Quinolines; Ribonucleosides; RNA, Small Interfering | 2006 |
Clevudine: a potent inhibitor of hepatitis B virus in vitro and in vivo.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Hepatitis B virus; Hepatitis B, Chronic; Humans | 2006 |
[Advances in the study of nucleoside antiviral drugs].
Topics: Adenine; Animals; Anti-HIV Agents; Antiviral Agents; Arabinofuranosyluracil; Cidofovir; Cytosine; Dioxolanes; Humans; Molecular Structure; Nucleosides; Organophosphonates; Purine Nucleosides; Tenofovir | 2006 |
[Management of chronic hepatitis B in treatment-naive patients].
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Guanine; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Korea; Lamivudine; Organophosphonates; Polyethylene Glycols; Practice Guidelines as Topic; Recombinant Proteins | 2008 |
[Management of antiviral-resistant chronic hepatitis B virus infection].
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Drug Resistance, Multiple, Viral; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Mutation; Nucleosides; Organophosphonates; Practice Guidelines as Topic; Pyrimidinones; Telbivudine; Thymidine; Treatment Outcome | 2008 |
Clevudine: a promising therapy for the treatment of chronic hepatitis B.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Drug Evaluation, Preclinical; Hepatitis B Vaccines; Hepatitis B, Chronic; Humans; Nucleosides | 2008 |
Clevudine for hepatitis B.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Hepatitis B, Chronic; Humans | 2009 |
Myopathy and neuropathy associated with nucleos(t)ide analog therapy for hepatitis B.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Creatine Kinase; Drug Discovery; Early Termination of Clinical Trials; Hepatitis B, Chronic; Humans; Lamivudine; Mitochondrial Myopathies; Muscular Diseases; Nervous System Diseases; Nucleosides; Nucleotides; Pyrimidinones; Republic of Korea; Telbivudine; Thymidine | 2009 |
[New drugs of treatment of patients with chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Deoxycytidine; Emtricitabine; Hepatitis B, Chronic; Humans; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Tenofovir; Thymidine | 2012 |
Extrahepatic effects of nucleoside and nucleotide analogues in chronic hepatitis B treatment.
Topics: Acidosis, Lactic; Adenine; Administration, Oral; Antiviral Agents; Arabinofuranosyluracil; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Humans; Kidney Diseases; Male; Muscular Diseases; Nervous System Diseases; Nucleosides; Nucleotides; Organophosphonates; Pharmacovigilance; Pregnancy; Telbivudine; Tenofovir; Thymidine | 2014 |
Efficacy of Nucleot(s)ide Analogs Therapy in Patients with Unresectable HBV-Related Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis.
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Carcinoma, Hepatocellular; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Neoplasms; Organophosphonates; Retrospective Studies; Survival Analysis; Telbivudine; Tenofovir; Thymidine | 2017 |
Journey of 2'-deoxy-2'-fluoro-5-methyl-1-β-D-arabinofuranosyluracil (FMAU): from Antiviral Drug to PET Imaging Agent.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Carbon Radioisotopes; Contrast Media; Fluorine Radioisotopes; Humans; Neoplasms; Positron-Emission Tomography; Radiopharmaceuticals | 2018 |
18 trial(s) available for 2'-fluorothymidine and arabinofuranosyluracil
| Article | Year |
|---|---|
A phase II dose-escalating trial of clevudine in patients with chronic hepatitis B.
Topics: Adult; Alanine Transaminase; Antibodies, Viral; Antiviral Agents; Arabinofuranosyluracil; Area Under Curve; DNA, Viral; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Gene Dosage; Genotype; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Predictive Value of Tests; Treatment Outcome | 2004 |
Imaging DNA synthesis with [18F]FMAU and positron emission tomography in patients with cancer.
Topics: Adult; Aged; Arabinofuranosyluracil; Biomarkers, Tumor; DNA, Neoplasm; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Neoplasms; Organ Specificity; Positron-Emission Tomography; Radiopharmaceuticals; Tissue Distribution | 2005 |
Rapid quantitative determination of L-FMAU-TP from human peripheral-blood mononuclear cells of hepatitis B virus-infected patients treated with L-FMAU by ion-pairing, reverse-phase, liquid chromatography/electrospray tandem mass spectrometry.
Topics: Adult; Antiviral Agents; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Chromatography, High Pressure Liquid; Half-Life; Hepatitis B; Humans; Mass Spectrometry; Middle Aged; Reproducibility of Results | 2006 |
A 12-week clevudine therapy showed potent and durable antiviral activity in HBeAg-positive chronic hepatitis B.
Topics: Adult; Antiviral Agents; Arabinofuranosyluracil; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Male; Time Factors | 2006 |
Randomized, double-blind study of emtricitabine (FTC) plus clevudine versus FTC alone in treatment of chronic hepatitis B.
Topics: Adult; Alanine Transaminase; Alkaline Phosphatase; Amylases; Antiviral Agents; Arabinofuranosyluracil; Aspartate Aminotransferases; Bicarbonates; Bilirubin; Blood Glucose; Creatine Kinase; Deoxycytidine; DNA, Viral; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Electrolytes; Emtricitabine; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; L-Lactate Dehydrogenase; Male; Middle Aged; Randomized Controlled Trials as Topic; Serum Albumin | 2006 |
Twenty-four-week clevudine therapy showed potent and sustained antiviral activity in HBeAg-positive chronic hepatitis B.
Topics: Adolescent; Adult; Alanine Transaminase; Antiviral Agents; Arabinofuranosyluracil; Double-Blind Method; Female; Hepatitis B; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Male; Middle Aged; Placebos | 2007 |
Clevudine therapy for 24 weeks further reduced serum hepatitis B virus DNA levels and increased ALT normalization rates without emergence of viral breakthrough than 12 weeks of clevudine therapy.
Topics: Alanine Transaminase; Antiviral Agents; Arabinofuranosyluracil; DNA, Viral; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Treatment Outcome | 2007 |
Clevudine is highly efficacious in hepatitis B e antigen-negative chronic hepatitis B with durable off-therapy viral suppression.
Topics: Adolescent; Adult; Alanine Transaminase; Antiviral Agents; Arabinofuranosyluracil; DNA, Viral; Dose-Response Relationship, Drug; Double-Blind Method; Drug Resistance, Viral; Female; Genotype; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Time Factors | 2007 |
Clinical trial: a phase II, randomized study evaluating the safety, pharmacokinetics and anti-viral activity of clevudine for 12 weeks in patients with chronic hepatitis B.
Topics: Adolescent; Adult; Antibodies, Viral; Antiviral Agents; Arabinofuranosyluracil; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Genotype; Hepatitis B, Chronic; Humans; Male; Middle Aged; Treatment Outcome | 2008 |
Clinical and virological responses to clevudine therapy in chronic hepatitis B patients: results at 1 year of an open-labelled prospective study.
Topics: Adult; Aged; Alanine Transaminase; Antiviral Agents; Arabinofuranosyluracil; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B Antigens; Hepatitis B, Chronic; Humans; Liver Cirrhosis; Longitudinal Studies; Male | 2009 |
[Long-term clevudine therapy in nucleos(t)ide-naïve and lamivudine-experienced patients with hepatitis B virus-related chronic liver diseases].
Topics: Adult; Aged; Aged, 80 and over; Antiviral Agents; Arabinofuranosyluracil; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; RNA-Directed DNA Polymerase | 2009 |
Clevudine demonstrates potent antiviral activity in naïve chronic hepatitis B patients.
Topics: Alanine Transaminase; Antiviral Agents; Arabinofuranosyluracil; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Plasma; Treatment Failure; Treatment Outcome; Viral Load | 2010 |
Treatment outcomes of clevudine versus lamivudine at week 48 in naïve patients with HBeAg positive chronic hepatitis B.
Topics: Adult; Antiviral Agents; Arabinofuranosyluracil; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Treatment Outcome | 2010 |
Forty-eight weeks treatment with clevudine 30 mg qd versus lamivudine 100 mg qd for chronic hepatitis B infection: a double-blind randomized study.
Topics: Adult; Alanine Transaminase; Antiviral Agents; Arabinofuranosyluracil; DNA, Viral; Double-Blind Method; Drug Administration Schedule; Drug Resistance, Viral; Female; Genotype; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged | 2010 |
[Treatment efficacy of clevudine, entecavir and lamivudine in treatment-naive patients with HBeAg-positive chronic hepatitis B].
Topics: Adult; Alanine Transaminase; Antiviral Agents; Arabinofuranosyluracil; DNA, Viral; Drug Administration Schedule; Drug Resistance, Viral; Female; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Retrospective Studies; Treatment Outcome | 2010 |
Structure-guided engineering of human thymidine kinase 2 as a positron emission tomography reporter gene for enhanced phosphorylation of non-natural thymidine analog reporter probe.
Topics: Adult; Animals; Arabinofuranosyluracil; Female; Fluorine Radioisotopes; Genes, Reporter; Guanine; Herpesvirus 1, Human; Humans; Male; Mice; Middle Aged; Models, Molecular; Phosphorylation; Positron-Emission Tomography; Protein Conformation; Protein Engineering; Thymidine; Thymidine Kinase | 2012 |
Mathematical modeling of triphasic viral dynamics in patients with HBeAg-positive chronic hepatitis B showing response to 24-week clevudine therapy.
Topics: Adolescent; Adult; Antiviral Agents; Arabinofuranosyluracil; Computer Simulation; DNA, Viral; Female; Hepatitis B Antigens; Hepatitis B, Chronic; Hepatocytes; Humans; Immune System; Least-Squares Analysis; Male; Middle Aged; Models, Theoretical; Regression Analysis; Time Factors; Viral Load | 2012 |
A Pilot Trial Evaluating Zoledronic Acid Induced Changes in [
Topics: Aged; Arabinofuranosyluracil; Biomarkers, Tumor; Bone Neoplasms; Bone Remodeling; Diphosphonates; Fluorine Radioisotopes; Humans; Image Processing, Computer-Assisted; Imidazoles; Male; Middle Aged; Pilot Projects; Positron-Emission Tomography; Prostate-Specific Antigen; Prostatic Neoplasms; Reproducibility of Results; Tomography, X-Ray Computed; Zoledronic Acid | 2017 |
139 other study(ies) available for 2'-fluorothymidine and arabinofuranosyluracil
| Article | Year |
|---|---|
Development of labeled thymidine analogs for imaging tumor proliferation.
Topics: Animals; Antimetabolites, Antineoplastic; Arabinofuranosyluracil; Biotransformation; Dogs; Floxuridine; Fluorine Radioisotopes; In Vitro Techniques; Isotope Labeling; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neoplasms, Experimental; Thymidine; Tissue Distribution; Tomography, Emission-Computed | 1996 |
Effects of 2'-fluorinated arabinosyl-pyrimidine nucleosides on duck hepatitis B virus DNA level in serum and liver of chronically infected ducks.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Cytarabine; DNA, Viral; Drug Evaluation, Preclinical; Ducks; Hepatitis B Virus, Duck; Hepatitis, Viral, Animal; Liver; Virus Replication | 1992 |
Equine herpes virus 1 and pseudorabies virus resistance to 2'-fluoropyrimidine analogs and to bromovinyldeoxyuridine: implications for dTMP kinase activity.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Cytarabine; Drug Resistance, Microbial; Herpesviridae; Herpesvirus 1, Suid; Horses; Nucleoside-Phosphate Kinase; Pseudorabies; Pyrimidine Nucleosides; Substrate Specificity | 1990 |
Inhibitory effects of 2'-fluorinated arabinosyl-pyrimidine nucleosides on woodchuck hepatitis virus replication in chronically infected woodchucks.
Topics: Administration, Oral; Animals; Antiviral Agents; Arabinofuranosyluracil; Chronic Disease; Cytarabine; Hepadnaviridae; Hepatitis, Viral, Animal; Uridine; Virus Replication | 1990 |
Phase I trial of 1-(2'-deoxy-2'-fluoro-1-beta-D-arabinofuranosyl)-5-methyluracil (FMAU) terminated by severe neurologic toxicity.
Topics: Adult; Aged; Antineoplastic Agents; Arabinofuranosyluracil; Colonic Neoplasms; Drug Evaluation; Electroencephalography; Female; Fibrosarcoma; Hematologic Diseases; Humans; Male; Middle Aged; Neoplasm Metastasis; Neoplasms; Nervous System Diseases; Nervous System Neoplasms | 1989 |
Synthesis and biological effects of 2'-fluoro-5-ethyl-1-beta-D-arabinofuranosyluracil.
Topics: Antiviral Agents; Arabinofuranosyluracil; Cell Line; Cell Survival; DNA; Simplexvirus; Structure-Activity Relationship; Thymidine Kinase; Uridine | 1987 |
Nucleosides. 146. 1-Methyl-5-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil, the C-nucleoside isostere of the potent antiviral agent 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)thymine (FMAU). Studies directed toward the synthesis of 2'-deoxy-2'-substit
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Female; Humans; Mice; Mice, Inbred BALB C; Simplexvirus; Uridine | 1987 |
Nucleosides. 150. Synthesis and some biological properties of 5-monofluoromethyl, 5-difluoromethyl, and 5-trifluoromethyl derivatives of 2'-deoxyuridine and 2'-deoxy-2'-fluoro-beta-D-arabinofuranosyluracil.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Cell Division; Chemical Phenomena; Chemistry; Deoxyuridine; Encephalitis; Herpes Simplex; Nucleosides; Radionuclide Imaging; Rats; Simplexvirus; Structure-Activity Relationship; Thymidylate Synthase; Uridine | 1988 |
Effect of 2'-fluoro-5-methyl-ara-uracil and cyclophosphamide on herpes simplex virus infection in guinea pigs.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Cyclophosphamide; Dose-Response Relationship, Drug; Female; Guinea Pigs; Herpes Genitalis; Uridine | 1987 |
Phase I trial of 1-(2'-deoxy-2'-fluoro-1-beta-D-arabinofuranosyl)-5-methyluracil (FMAU).
Topics: Adult; Aged; Antineoplastic Agents; Arabinofuranosyluracil; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Central Nervous System Diseases; Drug Evaluation; Female; Humans; Leukocyte Count; Lung Neoplasms; Male; Middle Aged; Nausea; Neoplasms; Platelet Count; Uridine; Vomiting | 1985 |
Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus.
Topics: Acyclovir; Antiviral Agents; Arabinofuranosyluracil; Arabinonucleosides; Bromodeoxyuridine; DNA-Directed DNA Polymerase; Drug Resistance, Microbial; Foscarnet; Ganciclovir; Genes, Viral; Idoxuridine; Mutation; Phosphonoacetic Acid; Simplexvirus; Thymidine; Vidarabine | 1985 |
Comparative anti-herpesvirus activities of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, acyclovir, and two 2'-fluoropyrimidine nucleosides.
Topics: Acyclovir; Animals; Antiviral Agents; Arabinofuranosyluracil; Brain Diseases; Cell Line; Chlorocebus aethiops; Cytarabine; Encephalitis; Female; Ganciclovir; Guinea Pigs; Herpes Genitalis; Herpes Simplex; Kidney; Mice; Simplexvirus; Structure-Activity Relationship | 1985 |
Human cytomegalovirus-induced DNA polymerase and its interaction with the triphosphates of 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-methyluracil, -5-iodocytosine, and -5-methylcytosine.
Topics: Antiviral Agents; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Arabinonucleotides; Cytarabine; Cytomegalovirus; DNA Replication; DNA-Directed DNA Polymerase; Enzyme Induction; Humans; Kinetics; Nucleic Acid Synthesis Inhibitors; Substrate Specificity; Virus Replication | 1985 |
Drug resistance patterns of herpes simplex virus isolates from patients treated with acyclovir.
Topics: Acyclovir; Adult; Animals; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Cytarabine; Drug Resistance, Microbial; Female; Ganciclovir; Humans; Male; Mice; Mice, Inbred BALB C; Simplexvirus; Stomatitis, Herpetic; Thymidine Kinase; Virulence | 1985 |
Susceptibility of varicella-zoster virus to thymidine analogues.
Topics: Acyclovir; Antiviral Agents; Arabinofuranosyluracil; Cytarabine; Deoxyuridine; Fibroblasts; Herpesvirus 3, Human; Humans; Neutralization Tests; Simplexvirus; Thymidine | 1986 |
Comparative efficacy of three 2'-fluoropyrimidine nucleosides and 9-(1,3-dihydroxy-2-propoxymethyl)guanine (BW B759U) against pseudorabies and equine rhinopneumonitis virus infection in vitro and in laboratory animals.
Topics: Acyclovir; Animals; Antiviral Agents; Arabinofuranosyluracil; Cricetinae; Cytarabine; Ganciclovir; Herpesviridae Infections; Herpesvirus 1, Equid; Herpesvirus 1, Suid; Male; Mice; Pseudorabies; Pyrimidine Nucleosides | 1987 |
A mammalian cell line designed to test the mutagenic activity of anti-herpes nucleosides.
Topics: Acyclovir; Animals; Antiviral Agents; Arabinofuranosyluracil; Cell Division; Cell Line; Cricetinae; Cricetulus; Cytarabine; DNA, Viral; Idoxuridine; Mutagenicity Tests; Nucleosides; Simplexvirus; Thymidine Kinase; Transfection; Trifluridine | 1987 |
[Radiosensitization effects of nucleoside analogs].
Topics: Acyclovir; Animals; Antineoplastic Agents; Arabinofuranosyluracil; Cytarabine; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Nucleosides; Radiation-Sensitizing Agents; Vidarabine; Whole-Body Irradiation | 1986 |
Activity of 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodouracil against simian varicella virus infections in African green monkeys.
Topics: Administration, Oral; Animals; Antiviral Agents; Arabinofuranosyluracil; Aspartate Aminotransferases; Chickenpox; Chlorocebus aethiops; Female; Injections, Intravenous; Male; Time Factors; Uridine | 1986 |
Ab initio studies of the antiviral drug 1-(2-fluoro-2-deoxy-beta-D-arabinofuranosyl) thymine.
Topics: Antiviral Agents; Arabinofuranosyluracil; Herpesviridae; Molecular Conformation; Structure-Activity Relationship; Uridine | 1985 |
Cell-specific antiviral activity of 1-(2-fluoro-2-deoxy-beta-D-arabinofuranosyl)-5-iodocytosine (FIAC) against Marek's disease herpesvirus and turkey herpesvirus.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Arabinofuranosyluracil; Cells, Cultured; Cytarabine; Cytidine Deaminase; Herpesviridae Infections; Herpesvirus 2, Gallid; Marek Disease; Nucleoside Deaminases; Thymidine Kinase; Turkeys; Virus Replication | 1984 |
Effect of eight antiviral drugs on the reactivation of herpes simplex virus in explant cultures of latently infected mouse trigeminal ganglia.
Topics: Acyclovir; Animals; Antibodies, Viral; Antiviral Agents; Arabinofuranosyluracil; Arabinonucleosides; Bromodeoxyuridine; Culture Media; Culture Techniques; Cytarabine; Foscarnet; Mice; Mice, Hairless; Neutralization Tests; Phosphonoacetic Acid; Simplexvirus; Thymidine; Trigeminal Nerve; Vidarabine Phosphate; Virus Activation | 1984 |
Treatment of primary acute genital herpes in guinea pigs by intraperitoneal administration of fluoropyrimidines.
Topics: Acyclovir; Animals; Antiviral Agents; Arabinofuranosyluracil; Cytarabine; Female; Foscarnet; Guinea Pigs; Herpes Genitalis; Injections, Intraperitoneal; Male; Phosphonoacetic Acid; Uridine; Virus Replication | 1984 |
Distribution, metabolism, and excretion of 1-(2-fluoro-2-deoxy-beta-D- arabinofuranosyl)thymine and 1-(2-fluoro-2-deoxy-beta-D-arabinofuranosyl)-5- iodocytosine.
Topics: Absorption; Animals; Arabinofuranosyluracil; Chromatography, High Pressure Liquid; Cytarabine; Digestive System; Dogs; Female; Kidney; Male; Metabolic Clearance Rate; Mice; Rats; Simplexvirus; Species Specificity; Tissue Distribution; Uridine; Virus Replication | 1983 |
Epstein-Barr virus: inhibition of replication by three new drugs.
Topics: Acyclovir; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Cytarabine; DNA Replication; Herpesvirus 4, Human; Uridine; Virus Replication | 1983 |
Activity of 1-(2'-fluoro-2'-deoxy-beta-D-arabinofuranosyl)thymine against herpes simplex virus in cell cultures and rabbit eyes.
Topics: Acyclovir; Animals; Antiviral Agents; Arabinofuranosyluracil; Cells, Cultured; Drug Resistance, Microbial; Idoxuridine; Keratitis, Dendritic; Male; Rabbits; Simplexvirus; Uridine; Vidarabine | 1983 |
Therapeutic activities of 1-(2-fluoro-2-deoxy-beta-D-arabinofuranosyl)-5-iodocytosine and -thymine alone and in combination with acyclovir and vidarabine in mice infected intracerebrally with herpes simplex virus.
Topics: Acyclovir; Administration, Oral; Animals; Antiviral Agents; Arabinofuranosyluracil; Brain; Cytarabine; Drug Therapy, Combination; Encephalitis; Female; Herpes Simplex; Injections, Intraperitoneal; Mice; Uridine; Vidarabine | 1983 |
Comparison of 2'-fluoro-arabinosyl pyrimidine nucleosides and 1-beta-D-arabinofuranosylcytosine on immunological parameters in vitro.
Topics: Animals; Antibody Formation; Antibody-Producing Cells; Arabinofuranosyluracil; Cell Survival; Cytarabine; Immune Tolerance; Mice; Spleen; Uridine | 1983 |
Diagnostic imaging of herpes simplex virus encephalitis using a radiolabeled antiviral drug: autoradiographic assessment in an animal model.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Autoradiography; Blood-Brain Barrier; Brain; Carbon Radioisotopes; Cerebral Ventricles; Choroid Plexus; Encephalitis; Ependyma; Female; Herpes Simplex; Kinetics; Radionuclide Imaging; Rats; Uridine | 1984 |
Potent antiviral 2'-fluoro-arabinosyl pyrimidine nucleosides: lack of mutagenic activity.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Cell Line; Cricetinae; Cricetulus; Cytarabine; DNA; Liver; Mutagenicity Tests; Rats; Rats, Inbred Strains; Salmonella typhimurium; Uridine | 1982 |
Activity of 2-fluoro-5-methylarabinofuranosyluracil against mouse leukemias sensitive to and resistant to 1-beta-D-arabinofuranosylcytosine.
Topics: Animals; Arabinofuranosyluracil; Cells, Cultured; Cytarabine; Humans; Leukemia L1210; Leukemia P388; Leukemia, Experimental; Mice; Pyrimidine Nucleosides | 1982 |
Biochemical effects of 2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil and 2'-fluoro-5-iodo-1-beta-D-arabinofuranosylcytosine in mouse leukemic cells sensitive and resistant to 1-beta-D-arabinofuranosylcytosine.
Topics: Animals; Arabinofuranosyluracil; Cell Survival; Cytarabine; Deoxycytidine; DNA Replication; Kinetics; Leukemia L1210; Leukemia, Experimental; Mice; Thymidine; Uridine | 1982 |
Quantitative autoradiographic mapping of herpes simplex virus encephalitis with a radiolabeled antiviral drug.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Autoradiography; Cytarabine; Encephalitis; Herpes Simplex; Rats; Uridine | 1982 |
Use of 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil as a novel antiviral agent for hepatitis B virus and Epstein-Barr virus.
Topics: Antiviral Agents; Arabinofuranosyluracil; Cell Division; DNA, Mitochondrial; Hepatitis B virus; Herpesvirus 4, Human; Humans; Tumor Cells, Cultured | 1995 |
Cellular and molecular events leading to mitochondrial toxicity of 1-(2-deoxy-2-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil in human liver cells.
Topics: Adenosine Triphosphate; Antiviral Agents; Arabinofuranosyluracil; Carcinoma, Hepatocellular; Cell Division; Cell Nucleus; Chromatography, High Pressure Liquid; DNA, Mitochondrial; DNA, Neoplasm; Humans; Kinetics; Liver Neoplasms; Microscopy, Electron; Mitochondria; Mitochondria, Liver; Time Factors; Tumor Cells, Cultured | 1995 |
Vaccination against bovine herpes mammillitis virus infections in guinea pigs.
Topics: Administration, Intravaginal; Animals; Antiviral Agents; Arabinofuranosyluracil; Cattle; Female; Guinea Pigs; Herpes Genitalis; Herpes Simplex; Herpesvirus 2, Bovine; Injections, Subcutaneous; Vaccination; Vaginitis; Viral Vaccines | 1994 |
Synthesis of 2'-fluoro-5-[11C]-methyl-1-beta-D-arabinofuranosyluracil ([11C]-FMAU): a potential nucleoside analog for in vivo study of cellular proliferation with PET.
Topics: Animals; Arabinofuranosyluracil; Carbon Radioisotopes; Cell Division; Humans; Indicators and Reagents; Isotope Labeling; Kinetics; Models, Theoretical; Tomography, Emission-Computed | 1995 |
Pharmacokinetics of 1-(2-deoxy-2-fluoro-beta-L-arabinofuranosyl)-5-methyluracil (L-FMAU) in rats.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Injections, Intravenous; Male; Metabolic Clearance Rate; Rats; Rats, Sprague-Dawley; Stereoisomerism | 1995 |
Inhibition of Epstein-Barr virus replication by a novel L-nucleoside, 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil.
Topics: Arabinofuranosyluracil; Autoradiography; Base Sequence; Cells, Cultured; DNA; Herpesvirus 4, Human; Humans; Molecular Sequence Data; Virus Replication | 1996 |
Hydrocephalus induction in mice infected with herpes simplex virus type 2 after antiviral treatment.
Topics: Animals; Arabinofuranosyluracil; Brain; Disease Models, Animal; Female; Herpes Genitalis; Herpesvirus 2, Human; Hydrocephalus; Meningoencephalitis; Mice; Mice, Inbred BALB C | 1995 |
Structure--activity relationships of 1-(2-Deoxy-2-fluoro-beta-L-arabinofuranosyl)pyrimidine nucleosides as anti-hepatitis B virus agents.
Topics: Antiviral Agents; Arabinofuranosyluracil; Arabinonucleosides; Cell Line; Hepatitis B virus; Molecular Structure; Structure-Activity Relationship | 1996 |
Phosphorylation of the anti-hepatitis B nucleoside analog 1-(2'-deoxy-2'-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil (FIAU) by human cytosolic and mitochondrial thymidine kinase and implications for cytotoxicity.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Cattle; Cells, Cultured; Cytosol; Humans; Mitochondria; Phosphorylation; Substrate Specificity; Thymidine Kinase | 1996 |
Inhibition of hepatitis B virus by a novel L-nucleoside, 2'-fluoro-5-methyl-beta-L-arabinofuranosyl uracil.
Topics: Antiviral Agents; Arabinofuranosyluracil; Cell Division; Cell Line; DNA Replication; DNA, Viral; Hepatitis B Core Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Lactic Acid; Nucleic Acid Synthesis Inhibitors; Stereoisomerism; Transcription, Genetic; Virus Replication | 1996 |
Discontinuous oral absorption pharmacokinetic model and bioavailability of 1-(2-fluoro-5-methyl-beta-L-arabinofuranosyl)uracil (L-FMAU) in rats.
Topics: Absorption; Administration, Oral; Animals; Antiviral Agents; Arabinofuranosyluracil; Biological Availability; Cross-Over Studies; Injections, Intravenous; Male; Random Allocation; Rats; Rats, Sprague-Dawley | 1996 |
Synthesis and anti-hepatitis B virus activity of 9-(2-deoxy-2-fluoro-beta-L-arabinofuranosyl) purine nucleosides.
Topics: Antiviral Agents; Arabinofuranosyluracil; Hepatitis B virus; Models, Chemical; Models, Molecular; Software; Structure-Activity Relationship | 1997 |
Pharmacokinetics of 1-(2-fluoro-5-methyl-beta-L-arabinofuranosyl)uracil in woodchucks.
Topics: Administration, Oral; Animals; Antiviral Agents; Arabinofuranosyluracil; Area Under Curve; Chromatography, High Pressure Liquid; Injections, Intravenous; Male; Marmota | 1997 |
Inhibitory effect of 2'-fluoro-5-methyl-beta-L-arabinofuranosyl-uracil on duck hepatitis B virus replication.
Topics: Administration, Oral; Animals; Antiviral Agents; Arabinofuranosyluracil; DNA, Viral; Ducks; Hepadnaviridae Infections; Hepatitis B Virus, Duck; Liver; Virus Replication | 1998 |
Unique metabolism of a novel antiviral L-nucleoside analog, 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil: a substrate for both thymidine kinase and deoxycytidine kinase.
Topics: Antiviral Agents; Arabinofuranosyluracil; Biological Transport, Active; Biotransformation; Cytosol; Deoxycytidine Kinase; HeLa Cells; Humans; Mitochondria; Phosphorylation; Thymidine Kinase | 1998 |
Crystal structures of B-DNA with incorporated 2'-deoxy-2'-fluoro-arabino-furanosyl thymines: implications of conformational preorganization for duplex stability.
Topics: Arabinofuranosyluracil; Crystallography, X-Ray; DNA; Models, Molecular; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Water | 1998 |
19F NMR study of the uptake of 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil in erythrocytes: evidence of transport by facilitated and nonfacilitated pathways.
Topics: Antiviral Agents; Arabinofuranosyluracil; Biological Transport; Dipyridamole; Erythrocytes; Fluorine; Humans; Magnetic Resonance Spectroscopy | 1998 |
A practical synthesis of L-FMAU from L-arabinose.
Topics: Antiviral Agents; Arabinofuranosyluracil; Arabinose; Hepatitis, Viral, Human; Magnetic Resonance Spectroscopy; Molecular Structure; Nucleosides; Stereoisomerism | 1999 |
Sensitivity of L-(-)2,3-dideoxythiacytidine resistant hepatitis B virus to other antiviral nucleoside analogues.
Topics: Acyclovir; Adenine; Antiviral Agents; Arabinofuranosyluracil; DNA-Directed DNA Polymerase; Drug Resistance, Microbial; Drug Resistance, Multiple; Guanine; Hepatitis B virus; Lamivudine; Microbial Sensitivity Tests; Mutation; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Zalcitabine | 1999 |
Suicide prodrugs activated by thymidylate synthase: rationale for treatment and noninvasive imaging of tumors with deoxyuridine analogues.
Topics: Animals; Arabinofuranosyluracil; Cell Division; DNA; Floxuridine; Fluorine Radioisotopes; Humans; Methylation; Mice; Neoplasms; Phosphorylation; Prodrugs; Thymidylate Synthase; Tumor Cells, Cultured | 1999 |
[(11)C]FMAU and [(18)F]FHPG as PET tracers for herpes simplex virus thymidine kinase enzyme activity and human cytomegalovirus infections.
Topics: Antiviral Agents; Arabinofuranosyluracil; Cell Line; Cytomegalovirus Infections; Ganciclovir; Humans; Immunohistochemistry; Phosphotransferases (Alcohol Group Acceptor); Radiopharmaceuticals; Simplexvirus; Thymidine Kinase; Tomography, Emission-Computed | 2000 |
Pharmacokinetics of the thymidine analog 2'-fluoro-5-[(14)C]-methyl-1-beta-D-arabinofuranosyluracil ([(14)C]FMAU) in rat prostate tumor cells.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; DNA; Male; Prostatic Neoplasms; Rats; Thymidine; Tumor Cells, Cultured | 2000 |
Kinetics of hepadnavirus loss from the liver during inhibition of viral DNA synthesis.
Topics: Amino Acid Sequence; Animals; Antiviral Agents; Arabinofuranosyluracil; DNA, Circular; DNA, Viral; Drug Resistance; Hepatitis B Virus, Woodchuck; Hepatocytes; Kinetics; Lamivudine; Marmota; Molecular Sequence Data | 2001 |
Antiviral activity of clevudine [L-FMAU, (1-(2-fluoro-5-methyl-beta, L-arabinofuranosyl) uracil)] against woodchuck hepatitis virus replication and gene expression in chronically infected woodchucks (Marmota monax).
Topics: Animals; Antigens, Surface; Antiviral Agents; Arabinofuranosyluracil; DNA Replication; DNA, Circular; DNA, Viral; Dose-Response Relationship, Drug; Gene Expression; Genes, Viral; Hepatitis Antigens; Hepatitis B Virus, Woodchuck; Hepatitis B, Chronic; Hepatitis C Antigens; Marmota; RNA, Viral; Time Factors; Viremia; Virus Replication | 2001 |
Potential use of antiviral L(-)nucleoside analogues for the prevention or treatment of viral associated cancers.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Dioxolanes; Hepatitis B virus; Herpesvirus 4, Human; Humans; Neoplasms; Nucleosides; Stereoisomerism; Structure-Activity Relationship; Uracil; Virus Diseases; Zalcitabine | 2001 |
In vitro susceptibilities of wild-type or drug-resistant hepatitis B virus to (-)-beta-D-2,6-diaminopurine dioxolane and 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil.
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Dioxolanes; Drug Resistance, Microbial; Hepatitis B virus; Humans; Lamivudine; Microbial Sensitivity Tests; Mutagenesis, Site-Directed; Organophosphonates; Purine Nucleosides; Transfection; Tumor Cells, Cultured; Virus Replication | 2001 |
Rapid enantiomeric quantification of an antiviral nucleoside agent (D,L-FMAU, 2'-fluoro-5-methyl-beta,D,L-arabinofurano-syluracil) by mass spectrometry.
Topics: Antiviral Agents; Arabinofuranosyluracil; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism | 2001 |
Mutations of the woodchuck hepatitis virus polymerase gene that confer resistance to lamivudine and 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil.
Topics: Amino Acid Sequence; Animals; Antiviral Agents; Arabinofuranosyluracil; Binding Sites; DNA-Directed DNA Polymerase; Drug Resistance, Multiple, Viral; Drug Resistance, Viral; Genes, Viral; Hepatitis B Virus, Woodchuck; Humans; Lamivudine; Marmota; Molecular Sequence Data; Mutagenesis; Mutagenesis, Insertional; Sequence Homology, Amino Acid; Time Factors; Tumor Cells, Cultured; Virus Replication | 2002 |
Radiolabeled 2'-fluorodeoxyuracil-beta-D-arabinofuranoside (FAU) and 2'-fluoro-5-methyldeoxyuracil-beta -D-arabinofuranoside (FMAU) as tumor-imaging agents in mice.
Topics: Animals; Arabinofuranosyluracil; DNA, Neoplasm; Humans; Mice; Mice, SCID; Muscle, Skeletal; Neoplasm Transplantation; Neoplasms; Radiopharmaceuticals; Spleen; Thymidine; Tissue Distribution; Tomography, Emission-Computed; Transplantation, Heterologous | 2002 |
New synthesis of L-FMAU from L-arabinose.
Topics: Arabinofuranosyluracil; Arabinose | 2002 |
Immunization with surface antigen vaccine alone and after treatment with 1-(2-fluoro-5-methyl-beta-L-arabinofuranosyl)-uracil (L-FMAU) breaks humoral and cell-mediated immune tolerance in chronic woodchuck hepatitis virus infection.
Topics: Animals; Antibody Formation; Antigens, Surface; Antigens, Viral; Antiviral Agents; Arabinofuranosyluracil; Carrier State; Hepatitis B Vaccines; Hepatitis B Virus, Woodchuck; Hepatitis B, Chronic; Immune Tolerance; Immunity, Cellular; Marmota; Vaccination | 2002 |
Half-life of the duck hepatitis B virus covalently closed circular DNA pool in vivo following inhibition of viral replication.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; DNA, Circular; DNA, Viral; Ducks; Female; Half-Life; Hepadnaviridae Infections; Hepatitis B Virus, Duck; Hepatitis, Viral, Animal; Liver; Male; Molecular Sequence Data; Virus Replication | 2002 |
Rebound of hepatitis B virus replication in HepG2 cells after cessation of antiviral treatment.
Topics: Antiviral Agents; Arabinofuranosyluracil; Baculoviridae; Cell Line; DNA, Viral; Hepatitis B; Hepatitis B virus; Humans; Kinetics; Lamivudine; Recombination, Genetic; Virus Replication | 2002 |
Inhibitory activity of dioxolane purine analogs on wild-type and lamivudine-resistant mutants of hepadnaviruses.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Carcinoma, Hepatocellular; Cytidine Triphosphate; Dioxolanes; DNA Replication; DNA-Directed DNA Polymerase; DNA, Viral; Drug Resistance, Viral; Gene Expression Regulation, Viral; Guanosine; Hepadnaviridae Infections; Hepatitis B virus; Hepatitis B Virus, Duck; Hepatitis, Viral, Animal; Hepatocytes; Humans; Lamivudine; Liver Neoplasms; Mutation; Purine Nucleosides; Reverse Transcriptase Inhibitors; Thiophenes; Tumor Cells, Cultured | 2002 |
Understanding the unique mechanism of L-FMAU (clevudine) against hepatitis B virus: molecular dynamics studies.
Topics: Antiviral Agents; Arabinofuranosyluracil; Binding Sites; Computer Simulation; Databases, Factual; DNA Replication; Hepatitis B virus; Models, Molecular; Nucleic Acid Synthesis Inhibitors; Protein Binding; Protein Conformation; Virus Replication | 2002 |
Rat studies comparing 11C-FMAU, 18F-FLT, and 76Br-BFU as proliferation markers.
Topics: Animals; Arabinofuranosyluracil; Bromine Radioisotopes; Bromouracil; Cell Division; Dideoxynucleosides; DNA; Fluorine Radioisotopes; Male; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Tomography, Emission-Computed | 2002 |
Comparison of anti-hepatitis B virus activities of lamivudine and clevudine by a quantitative assay.
Topics: Antiviral Agents; Arabinofuranosyluracil; Cells, Cultured; DNA, Viral; Hepatitis B virus; Lamivudine; Virus Replication | 2003 |
Immunogenic effects of woodchuck hepatitis virus surface antigen vaccine in combination with antiviral therapy: breaking of humoral and cellular immune tolerance in chronic woodchuck hepatitis virus infection.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Hepatitis B Antibodies; Hepatitis B Vaccines; Hepatitis B Virus, Woodchuck; Hepatitis B, Chronic; Immunity, Cellular; Marmota; Vaccination | 2002 |
Synthesis of 2'-deoxy-2'-[18F]fluoro-beta-D-arabinofuranosyl nucleosides, [18F]FAU, [18F]FMAU, [18F]FBAU and [18F]FIAU, as potential PET agents for imaging cellular proliferation. Synthesis of [18F]labelled FAU, FMAU, FBAU, FIAU.
Topics: Antiviral Agents; Arabinofuranosyluracil; Arabinonucleosides; Fluorine Radioisotopes | 2003 |
Effects of pyrimidine and purine analog combinations in the duck hepatitis B virus infection model.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Blotting, Southern; Cell Survival; Deoxycytidine; Dioxolanes; Disease Models, Animal; Drug Therapy, Combination; Ducks; Emtricitabine; Hepadnaviridae Infections; Hepatitis B Virus, Duck; Hepatitis B, Chronic; Hepatitis, Viral, Animal; Hepatocytes; Polymerase Chain Reaction; Purine Nucleosides; Reverse Transcriptase Inhibitors; Viral Load; Virus Replication | 2003 |
Monitoring tumor cell proliferation by targeting DNA synthetic processes with thymidine and thymidine analogs.
Topics: Animals; Arabinofuranosyluracil; Cell Division; Cell Line, Tumor; Dideoxynucleosides; DNA; Drug Delivery Systems; Humans; Metabolic Clearance Rate; Mice; Neoplasm Staging; Neoplasms; Radiopharmaceuticals; Thymidine; Thymidine Kinase; Tomography, Emission-Computed; Tritium | 2003 |
Residual integrated viral DNA after hepadnavirus clearance by nucleoside analog therapy.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; DNA, Viral; Hepadnaviridae; Marmota | 2004 |
Pharmacokinetics of the thymidine analog 2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (FMAU) in tumor-bearing rats.
Topics: Adenocarcinoma; Animals; Arabinofuranosyluracil; Carbon Radioisotopes; Cell Line, Tumor; Colorectal Neoplasms; DNA, Neoplasm; Female; Male; Metabolic Clearance Rate; Organ Specificity; Prostatic Neoplasms; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Inbred F344; Thymidine; Tissue Distribution | 2004 |
Effect of a combination of clevudine and emtricitabine with adenovirus-mediated delivery of gamma interferon in the woodchuck model of hepatitis B virus infection.
Topics: Adenoviridae; Animals; Antiviral Agents; Arabinofuranosyluracil; Deoxycytidine; DNA-Directed DNA Polymerase; Drug Combinations; Emtricitabine; Genetic Therapy; Hepatitis B; Hepatitis B Core Antigens; Hepatitis B Virus, Woodchuck; Interferon-gamma; Liver; Marmota; Microscopy, Confocal; Microscopy, Electron; Mitochondria, Liver; Proliferating Cell Nuclear Antigen; Recombinant Proteins; Reverse Transcriptase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Viremia; Virus Replication | 2004 |
Direct comparison of radiolabeled probes FMAU, FHBG, and FHPG as PET imaging agents for HSV1-tk expression in a human breast cancer model.
Topics: Animals; Arabinofuranosyluracil; Breast Neoplasms; Carbon Radioisotopes; Diagnostic Imaging; Female; Ganciclovir; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Viral; Guanine; Herpesvirus 1, Human; Humans; Mice; Mice, Nude; Models, Biological; Neoplasm Transplantation; Positron-Emission Tomography; Radiopharmaceuticals; Thymidine Kinase; Time Factors; Tissue Distribution; Tumor Cells, Cultured | 2004 |
Adenovirus-based gene therapy during clevudine treatment of woodchucks chronically infected with woodchuck hepatitis virus.
Topics: Adenoviridae; Animals; Antiviral Agents; Arabinofuranosyluracil; Baculoviridae; beta-Galactosidase; Cell Line; Combined Modality Therapy; Genetic Therapy; Hepatitis B Virus, Woodchuck; Hepatitis B, Chronic; Interferon-gamma; Marmota; Treatment Outcome; Tumor Necrosis Factor-alpha | 2004 |
Distribution of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) uracil in mice bearing colorectal cancer xenografts: rationale for therapeutic use and as a positron emission tomography probe for thymidylate synthase.
Topics: Animals; Arabinofuranosyluracil; Colorectal Neoplasms; DNA, Neoplasm; Female; Fluorouracil; HT29 Cells; Humans; Mice; Mice, SCID; Positron-Emission Tomography; Thymidylate Synthase; Time Factors; Tissue Distribution; Tritium; Xenograft Model Antitumor Assays | 2004 |
Clevudine therapy with vaccine inhibits progression of chronic hepatitis and delays onset of hepatocellular carcinoma in chronic woodchuck hepatitis virus infection.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Carcinoma, Hepatocellular; Disease Progression; Female; Hepatitis B Vaccines; Hepatitis B Virus, Woodchuck; Hepatitis B, Chronic; Humans; Liver Neoplasms; Male; Marmota; Viral Load | 2004 |
Imaging DNA synthesis in vivo with 18F-FMAU and PET.
Topics: Animals; Arabinofuranosyluracil; DNA; Dogs; Drug Evaluation, Preclinical; Metabolic Clearance Rate; Organ Specificity; Positron-Emission Tomography; Radiopharmaceuticals; Tissue Distribution | 2005 |
Behavior of thymidylate kinase toward monophosphate metabolites and its role in the metabolism of 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-methyluracil (Clevudine) and 2',3'-didehydro-2',3'-dideoxythymidine in cells.
Topics: Antiviral Agents; Arabinofuranosyluracil; Cell Line; Cloning, Molecular; Enzyme Induction; Humans; Immunoblotting; Microscopy, Confocal; Phosphates; Phosphorylation; Thymidine; Thymidine Kinase; Thymine Nucleotides | 2005 |
Clevudine inhibits hepatitis delta virus viremia: a pilot study of chronically infected woodchucks.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Hepatitis Antigens; Hepatitis B Virus, Woodchuck; Hepatitis B, Chronic; Hepatitis Delta Virus; Kinetics; Marmota; Pilot Projects; Time Factors; United States; Viremia | 2005 |
Radiosynthesis of 2'-deoxy-2'-[18F]-fluoro-5-methyl-1-beta-L-arabinofuranosyluracil ([18F]-L-FMAU) for PET.
Topics: Arabinofuranosyluracil; Fluorine Radioisotopes; Isotope Labeling; Positron-Emission Tomography; Radiopharmaceuticals | 2007 |
6-Chloro-3-(((1-[11C]methyl)-2-(S)-pyrrolidinyl)methoxy)-5-(2-fluoropyridin-4-yl)pyridine ([11C]JHU85270), a potent ligand for nicotinic acetylcholine receptor imaging by positron emission tomography.
Topics: Animals; Arabinofuranosyluracil; Brain; Fluorine Radioisotopes; Humans; Isotope Labeling; Positron-Emission Tomography; Pyridines; Pyrrolidines; Radiopharmaceuticals; Receptors, Nicotinic | 2007 |
Chemoimmunotherapy of chronic hepatitis B virus infection in the woodchuck model overcomes immunologic tolerance and restores T-cell responses to pre-S and S regions of the viral envelope protein.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Carrier State; Combined Modality Therapy; Disease Models, Animal; Epitopes; Female; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Hepatitis B Vaccines; Hepatitis B Virus, Woodchuck; Hepatitis B, Chronic; Immune Tolerance; Immunotherapy; Marmota; T-Lymphocytes; Vaccination; Viral Envelope Proteins | 2007 |
A novel mutation pattern emerging during lamivudine treatment shows cross-resistance to adefovir dipivoxil treatment.
Topics: Adenine; Adult; Arabinofuranosyluracil; Base Sequence; Cell Line, Tumor; Cloning, Molecular; Deoxycytidine; DNA Mutational Analysis; DNA, Viral; Dose-Response Relationship, Drug; Drug Resistance, Multiple, Viral; Emtricitabine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Molecular Sequence Data; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Tenofovir; Time Factors; Transfection; Treatment Outcome; Viral Load; Virus Replication | 2007 |
Tumor imaging using 1-(2'-deoxy-2'-18F-fluoro-beta-D-arabinofuranosyl)thymine and PET.
Topics: Arabinofuranosyluracil; Brain Neoplasms; Humans; Male; Positron-Emission Tomography; Prostatic Neoplasms; Radiopharmaceuticals | 2007 |
Evaluation of 2'-deoxy-2'-[18F]fluoro-5-methyl-1-beta-L: -arabinofuranosyluracil ([18F]-L: -FMAU) as a PET imaging agent for cellular proliferation: comparison with [18F]-D: -FMAU and [18F]FLT.
Topics: Animals; Arabinofuranosyluracil; Cell Proliferation; Dideoxynucleosides; Fluorine Radioisotopes; Humans; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Invasiveness; Positron-Emission Tomography; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity | 2008 |
In vivo measurement of cell proliferation in canine brain tumor using C-11-labeled FMAU and PET.
Topics: Animals; Arabinofuranosyluracil; Brain Neoplasms; Carbon Radioisotopes; Cell Proliferation; Dogs; Phosphorylation; Positron-Emission Tomography; Tissue Distribution | 2008 |
Tracking cellular stress with labeled FMAU reflects changes in mitochondrial TK2.
Topics: Arabinofuranosyluracil; Cell Line, Tumor; Humans; Mitochondria; Neoplasms; Oxidative Stress; Radionuclide Imaging; Radiopharmaceuticals; Thymidine Kinase; Tritium | 2008 |
Clevudine is efficiently phosphorylated to the active triphosphate form in primary human hepatocytes.
Topics: Adolescent; Aged; Antiviral Agents; Arabinofuranosyluracil; Cell Line, Tumor; Cells, Cultured; Dose-Response Relationship, Drug; Female; Half-Life; Hepatocytes; Humans; Male; Middle Aged; Phosphorylation; Polyphosphates | 2008 |
[Development of clevudine resistance after switching from lamivudine in a patient with chronic hepatitis B].
Topics: Adenine; Adult; Amino Acid Substitution; Antiviral Agents; Arabinofuranosyluracil; Base Sequence; DNA, Viral; Drug Resistance, Multiple, Viral; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Organophosphonates; Reverse Transcriptase Inhibitors | 2008 |
Early development of clevudine resistance during clevudine therapy in a patient with chronic hepatitis B who received prior lamivudine therapy.
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation, Missense; Organophosphonates; Sequence Analysis, DNA | 2009 |
[New molecules in the treatment of chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Hepatitis B Vaccines; Hepatitis B, Chronic; Humans; Organophosphonates; Tenofovir | 2009 |
Long-term therapy with clevudine for chronic hepatitis B can be associated with myopathy characterized by depletion of mitochondrial DNA.
Topics: Adult; Antiviral Agents; Arabinofuranosyluracil; Chronic Disease; DNA, Mitochondrial; Female; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mitochondrial Myopathies; Time Factors | 2009 |
[Clevudine therapy in patients with chronic hepatitis B].
Topics: Antiviral Agents; Arabinofuranosyluracil; Drug Resistance, Viral; Hepatitis B, Chronic; Humans; Lamivudine; Practice Guidelines as Topic | 2009 |
Clevudine myopathy in patients with chronic hepatitis B.
Topics: Adult; Antiviral Agents; Arabinofuranosyluracil; Creatine Kinase; DNA, Viral; Electromyography; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Middle Aged; Muscular Diseases | 2009 |
[Efficacy of 48-week clevudine therapy for chronic hepatitis B].
Topics: Adult; Antiviral Agents; Arabinofuranosyluracil; DNA, Viral; Drug Administration Schedule; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Retrospective Studies; Treatment Outcome | 2009 |
Identification and characterization of clevudine-resistant mutants of hepatitis B virus isolated from chronic hepatitis B patients.
Topics: Adult; Amino Acid Substitution; Antiviral Agents; Arabinofuranosyluracil; DNA Mutational Analysis; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Mutation, Missense; RNA-Directed DNA Polymerase; Sequence Analysis, DNA; Serum; Treatment Failure; Viral Proteins | 2010 |
Clevudine for chronic hepatitis B: antiviral response, predictors of response, and development of myopathy.
Topics: Adult; Aged; Antiviral Agents; Arabinofuranosyluracil; DNA, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Muscular Diseases; Prognosis; Republic of Korea; Retrospective Studies; Treatment Outcome; Viral Load | 2011 |
Polymyositis in patients taking antiviral clevudine therapy: a report of two cases.
Topics: Adult; Antiviral Agents; Arabinofuranosyluracil; Creatine Kinase; Female; Hepatitis B; Humans; Male; Middle Aged; Polymyositis | 2010 |
Virologic and biochemical responses to clevudine in patients with chronic HBV infection-associated cirrhosis: data at week 48.
Topics: Adult; Alanine Transaminase; Antiviral Agents; Arabinofuranosyluracil; DNA, Viral; Female; Hepatitis B, Chronic; Humans; Korea; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Treatment Outcome; Viral Load | 2011 |
Comparison between clevudine and entecavir treatment for antiviral-naïve patients with chronic hepatitis B.
Topics: Adult; Alanine Transaminase; Antiviral Agents; Arabinofuranosyluracil; Biomarkers; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Muscular Diseases; Republic of Korea; Retrospective Studies; Time Factors; Treatment Outcome; Viral Load; Virus Replication | 2010 |
Clinical, biochemical, and pathological characteristics of clevudine-associated myopathy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antiviral Agents; Arabinofuranosyluracil; Biopsy; Creatine Kinase; Dose-Response Relationship, Drug; Exercise Tolerance; Female; Follow-Up Studies; Hepatitis B, Chronic; Humans; L-Lactate Dehydrogenase; Lactates; Male; Middle Aged; Muscle Weakness; Muscle, Skeletal; Muscular Diseases; Prospective Studies; Retrospective Studies; Young Adult | 2010 |
Evaluation of the in vitro anti-HBV activity of clevudine in combination with other nucleoside/nucleotide inhibitors.
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Arabinofuranosyluracil; Cell Line; Cells, Cultured; Drug Antagonism; Drug Synergism; Drug Therapy, Combination; Guanine; Hepatitis B virus; Hepatocytes; Humans; Lamivudine; Microbial Sensitivity Tests; Nucleosides; Nucleotides; Organophosphonates; Pyrimidinones; Reverse Transcriptase Inhibitors; Telbivudine; Tenofovir; Thymidine | 2010 |
Focus.
Topics: Albumins; Antiviral Agents; Arabinofuranosyluracil; Cholangitis, Sclerosing; Cholestasis; Dialysis Solutions; Gastrointestinal Neoplasms; Hepatitis B; Humans; Incidence; Muscular Diseases; Pruritus; Renal Dialysis; Risk Factors | 2010 |
Different modes of transport for 3H-thymidine, 3H-FLT, and 3H-FMAU in proliferating and nonproliferating human tumor cells.
Topics: Arabinofuranosyluracil; Biological Transport; Cell Line, Tumor; Cell Proliferation; Dideoxynucleosides; Equilibrative Nucleoside Transport Proteins; Humans; Kinetics; Neoplasms; Positron-Emission Tomography; Thymidine; Tritium | 2010 |
Efficacy of initial treatment with clevudine in naive patients with chronic hepatitis B.
Topics: Adult; Alanine Transaminase; Antiviral Agents; Arabinofuranosyluracil; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Male; Middle Aged; Retrospective Studies | 2010 |
Clevudine-induced viral response, associated with continued reduction of HBsAg titer, was durable after the withdrawal of therapy.
Topics: Alanine Transaminase; Antiviral Agents; Arabinofuranosyluracil; DNA, Viral; Follow-Up Studies; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Viral Load | 2011 |
18F-FDG PET/CT of drug-induced myopathy in a patient with chronic hepatitis B on long-term clevudine therapy.
Topics: Adult; Arabinofuranosyluracil; Fluorodeoxyglucose F18; Hepatitis B, Chronic; Humans; Male; Muscular Diseases; Positron-Emission Tomography; Time Factors; Tomography, X-Ray Computed | 2011 |
Automated synthesis of 2'-deoxy-2'-[18F]fluoro-5-methyl-1-β-D-arabinofuranosyluracil ([18F]-FMAU) using a one reactor radiosynthesis module.
Topics: Arabinofuranosyluracil; Automation; Chromatography, High Pressure Liquid; Iodine Radioisotopes; Radiochemistry | 2011 |
[New drugs of treatment of patients with chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Deoxycytidine; Emtricitabine; Hepatitis B, Chronic; Humans; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Tenofovir; Thymidine | 2011 |
High-dose clevudine impairs mitochondrial function and glucose-stimulated insulin secretion in INS-1E cells.
Topics: Adenosine Triphosphate; Animals; Antiviral Agents; Arabinofuranosyluracil; Cell Line; DNA Copy Number Variations; DNA, Mitochondrial; Dose-Response Relationship, Drug; Electron Transport Complex IV; Glucose; Hep G2 Cells; Humans; Insulin; Insulin-Secreting Cells; Lactates; Mitochondria; Rats; RNA, Messenger | 2012 |
Normal-phase liquid chromatography coupled with electrospray ionization mass spectrometry for chiral separation and quantification of clevudine and its enantiomer in human plasma.
Topics: Arabinofuranosyluracil; Chromatography, High Pressure Liquid; Drug Stability; Humans; Least-Squares Analysis; Limit of Detection; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism | 2012 |
Simultaneous determination of 1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl) uracil (FAU) and 1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl) 5-methyluracil (FMAU) in human plasma by liquid chromatography/tandem mass spectrometry.
Topics: Arabinofuranosyluracil; Chromatography, Liquid; Humans; Limit of Detection; Reference Standards; Reproducibility of Results; Tandem Mass Spectrometry | 2012 |
Microwave-assisted one-pot radiosynthesis of 2'-deoxy-2'-[18F]fluoro-5-methyl-1-β-d-arabinofuranosyluracil ([18F]-FMAU).
Topics: Arabinofuranosyluracil; Chemistry Techniques, Synthetic; Fluorine Radioisotopes; Microwaves; Radiochemistry | 2012 |
Experience of anti-viral therapy in hepatitis B-associated membranous nephropathy, including Lamivudine-resistant strains.
Topics: Adenine; Adult; Antiviral Agents; Arabinofuranosyluracil; Drug Resistance, Viral; Female; Glomerulonephritis, Membranous; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Young Adult | 2012 |
Long-term in vivo monitoring of mouse and human hematopoietic stem cell engraftment with a human positron emission tomography reporter gene.
Topics: Animals; Arabinofuranosyluracil; Blotting, Western; Cell Line, Tumor; Deoxycytidine Kinase; Female; Fluorine Radioisotopes; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Immunohistochemistry; Interleukin Receptor Common gamma Subunit; Kaplan-Meier Estimate; Luminescent Proteins; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Inbred Strains; Mice, Knockout; Mice, SCID; Mutation; Positron-Emission Tomography; Thymus Gland; Time Factors; Transplantation, Heterologous | 2013 |
Long-term treatment outcomes of clevudine in antiviral-naive patients with chronic hepatitis B.
Topics: Adult; Alanine Transaminase; Antiviral Agents; Arabinofuranosyluracil; DNA, Viral; Female; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation; Retrospective Studies; Treatment Outcome | 2012 |
[Efficacy of entecavir switching therapy in chronic hepatitis B patients with clevudine-induced myopathy].
Topics: Adult; Aged; Alanine Transaminase; Antiviral Agents; Arabinofuranosyluracil; Creatine Kinase; DNA, Viral; Drug Resistance, Viral; Female; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Muscular Diseases | 2013 |
[Antiviral effect of entecavir switching therapy in chronic hepatitis B patients with clevudine-associated myopathy].
Topics: Antiviral Agents; Arabinofuranosyluracil; Female; Guanine; Hepatitis B, Chronic; Humans; Male; Muscular Diseases | 2013 |
Noncompetitive inhibition of hepatitis B virus reverse transcriptase protein priming and DNA synthesis by the nucleoside analog clevudine.
Topics: Adenine; Arabinofuranosyluracil; DNA, Viral; Guanine; HEK293 Cells; Hepatitis B virus; Humans; Organophosphonates; Protein Binding; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Tenofovir; Viral Proteins | 2013 |
Monitoring tumor response with [18F]FMAU in a sarcoma-bearing mouse model after liposomal vinorelbine treatment.
Topics: Animals; Arabinofuranosyluracil; Biological Transport; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Female; Fluorine Radioisotopes; Humans; Liposomes; Mice; Positron-Emission Tomography; Proliferating Cell Nuclear Antigen; Sarcoma; Tomography, Emission-Computed, Single-Photon; Treatment Outcome; Vinblastine; Vinorelbine; Xenograft Model Antitumor Assays | 2013 |
Patients with chronic hepatitis B treated with oral antiviral therapy retain a higher risk for HCC compared with patients with inactive stage disease.
Topics: Adult; Antiviral Agents; Arabinofuranosyluracil; Carcinoma, Hepatocellular; Female; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Incidence; Kaplan-Meier Estimate; Lamivudine; Liver; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Outcome Assessment, Health Care; Patient Acuity; Republic of Korea; Retrospective Studies; Risk Assessment; Risk Factors; Time | 2014 |
Oral antiviral therapy improves the diagnostic accuracy of alpha-fetoprotein levels in patients with chronic hepatitis B.
Topics: Administration, Oral; Adult; Aged; alpha-Fetoproteins; Antiviral Agents; Arabinofuranosyluracil; Biomarkers; Carcinoma, Hepatocellular; Female; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Liver Neoplasms; Male; Middle Aged; Predictive Value of Tests; Retrospective Studies; Sensitivity and Specificity; Time Factors | 2014 |
Antiviral therapy of chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Carcinoma, Hepatocellular; Gene Products, pol; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver; Liver Cirrhosis; Liver Neoplasms; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Telbivudine; Tenofovir; Thymidine; Treatment Outcome; Virus Replication | 2014 |
Off-treatment virologic relapse and outcomes of re-treatment in chronic hepatitis B patients who achieved complete viral suppression with oral nucleos(t)ide analogs.
Topics: Adult; Aged; Antiviral Agents; Arabinofuranosyluracil; Drug Resistance, Viral; Female; Genotype; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Multivariate Analysis; Recurrence; Retrospective Studies; Treatment Outcome | 2014 |
Targeted Prostate Gland Biopsy With Combined Transrectal Ultrasound, mpMRI, and 18F-FMAU PET/CT.
Topics: Arabinofuranosyluracil; Endoscopic Ultrasound-Guided Fine Needle Aspiration; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multimodal Imaging; Positron-Emission Tomography; Prostatic Neoplasms; Radiopharmaceuticals; Tomography, X-Ray Computed | 2015 |
Substitution at rt269 in Hepatitis B Virus Polymerase Is a Compensatory Mutation Associated with Multi-Drug Resistance.
Topics: Adenine; Amino Acid Substitution; Antiviral Agents; Arabinofuranosyluracil; Cell Line, Tumor; Drug Resistance, Multiple, Viral; Gene Products, pol; Guanine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Microbial Sensitivity Tests; Models, Molecular; Organophosphonates; Tenofovir; Virus Replication | 2015 |
Management of Clevudine-Resistant Chronic Hepatitis B: A Multicenter Cohort Study.
Topics: Adenine; Adult; Aged; Antiviral Agents; Arabinofuranosyluracil; Cohort Studies; Disease Management; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Viral Load | 2017 |
Effects of capecitabine treatment on the uptake of thymidine analogs using exploratory PET imaging agents:
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Arabinofuranosyluracil; Capecitabine; Dideoxynucleosides; Female; Humans; Male; Middle Aged; Neoplasms; Positron-Emission Tomography; Radiopharmaceuticals | 2016 |
Effect of Androgen on Normal Biodistribution of [
Topics: Androgens; Animals; Arabinofuranosyluracil; Delayed-Action Preparations; Dihydrotestosterone; Fluorine Radioisotopes; Male; Mice; Mice, Nude; Orchiectomy; Positron Emission Tomography Computed Tomography; Radiopharmaceuticals; Tissue Distribution | 2017 |
Myopathy, Drugs, and Mitochondria.
Topics: Arabinofuranosyluracil; Humans; Mitochondria; Mitochondrial Myopathies; Muscular Diseases | 2017 |
Clevudine Induced Mitochondrial Myopathy.
Topics: Adult; Aged; Antiviral Agents; Arabinofuranosyluracil; Creatine Kinase; Databases, Factual; Electromyography; Female; Hepatitis B; Humans; L-Lactate Dehydrogenase; Lower Extremity; Male; Middle Aged; Mitochondrial Myopathies; Muscle, Skeletal; Neck | 2017 |
Incidental Detection of Meningioma by 18F-FMAU PET/CT in a Patient With Suspected Prostate Cancer.
Topics: Aged; Arabinofuranosyluracil; Fluorine Radioisotopes; Humans; Incidental Findings; Magnetic Resonance Imaging; Male; Meningeal Neoplasms; Meningioma; Positron Emission Tomography Computed Tomography; Prostatic Neoplasms; Radiopharmaceuticals | 2018 |
Clevudine attenuates bleomycin-induced early pulmonary fibrosis via regulating M2 macrophage polarization.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Bleomycin; Cell Differentiation; Cytokines; Disease Models, Animal; Humans; Macrophages; Male; Mice; Mice, Inbred C57BL; Pulmonary Fibrosis; RAW 264.7 Cells; Respiratory Mucosa; Th2 Cells | 2021 |
Protecting-group-free synthesis of clevudine (L-FMAU), a treatment of the hepatitis B virus.
Topics: Antiviral Agents; Arabinofuranosyluracil; Hepatitis B virus; Reverse Transcriptase Inhibitors | 2022 |