2'-deoxyuridylic acid has been researched along with raltitrexed in 11 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (45.45) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aherne, GW; Boyle, FT; Brown, M; Gibson, W; Hardcastle, A; Jackman, AL; Kelland, LR; Kimbell, R | 1 |
| Erlichman, C; Mandelbaum, S; Mitrovski, B; Pressacco, J | 1 |
| Aherne, W; Boyle, FT; Hardcastle, A; Jackman, AL; Kimbell, R | 1 |
| Aherne, GW; Hardcastle, A; Jackman, AL; Raynaud, F | 1 |
| Ciesla, J; Dzik, JM; Hardy, LW; Maley, F; Maley, GF; Montfort, WR; Rode, W; Sotelo-Mundo, RR | 1 |
| Almog, R; Maley, F; Maley, GF; Van Roey, P; Waddling, CA | 1 |
| Berger, SH; Dunlap, RB; Koli, S; Lebioda, L; Minor, W; Phan, J | 1 |
| Berger, SH; Johnson, SR; Lebioda, L; Luo, B; Repalli, J; Yousef, AM | 1 |
| JarmuĊa, A; Rode, W | 1 |
| Dong, Y; Guan, Z; Niu, B; Wang, J; Wang, X; Xu, L; Zhang, J; Zhang, T | 1 |
| Chen, D; Jansson, A; Larsson, A; Nordlund, P; Sim, D | 1 |
11 other study(ies) available for 2'-deoxyuridylic acid and raltitrexed
| Article | Year |
|---|---|
Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines.
Topics: Animals; Antineoplastic Agents; Carrier Proteins; Deoxyuracil Nucleotides; Drug Resistance; Female; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Leukemia L1210; Lymphocytes; Methotrexate; Mice; Neoplasm Proteins; Ovarian Neoplasms; Peptide Synthases; Polyglutamic Acid; Proteins; Quinazolines; Receptors, Cell Surface; Thiophenes; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured | 1995 |
Biochemical effects of folate-based inhibitors of thymidylate synthase in MGH-U1 cells.
Topics: Cell Survival; Deoxyuracil Nucleotides; Deoxyuridine; Folic Acid; Folic Acid Antagonists; Glutamates; Humans; In Vitro Techniques; Indoles; Isoindoles; Quinazolines; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1994 |
The duration of the inhibition of thymidylate synthase in intact L1210 cells exposed to two different classes of quinazoline analogues.
Topics: Animals; Antineoplastic Agents; Cell Division; Deoxyuracil Nucleotides; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Mice; Quinazolines; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase; Thymine Nucleotides | 1993 |
Immunoreactive dUMP and TTP pools as an index of thymidylate synthase inhibition; effect of tomudex (ZD1694) and a nonpolyglutamated quinazoline antifolate (CB30900) in L1210 mouse leukaemia cells.
Topics: Animals; Deoxyuracil Nucleotides; Dipeptides; Dose-Response Relationship, Drug; Folic Acid Antagonists; Leukemia, Experimental; Mice; Mice, Inbred Strains; Quinazolines; Radioimmunoassay; Thiophenes; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured | 1996 |
Crystal structures of rat thymidylate synthase inhibited by Tomudex, a potent anticancer drug.
Topics: Animals; Antimetabolites, Antineoplastic; Bacterial Proteins; Carcinoma, Hepatocellular; Computer Simulation; Crystallography, X-Ray; Deoxyuracil Nucleotides; Humans; Ligands; Models, Molecular; Protein Conformation; Quinazolines; Rats; Recombinant Proteins; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1999 |
Crystal structure of a deletion mutant of human thymidylate synthase Delta (7-29) and its ternary complex with Tomudex and dUMP.
Topics: Binding Sites; Catalytic Domain; Crystallography, X-Ray; Cysteine; Deoxyuracil Nucleotides; Drug Design; Enzyme Inhibitors; Escherichia coli; Humans; Models, Molecular; Protein Binding; Protein Structure, Secondary; Quinazolines; Sequence Deletion; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase | 2001 |
Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug.
Topics: Binding Sites; Computer Simulation; Crystallization; Crystallography, X-Ray; Deoxyuracil Nucleotides; Dimerization; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Ligands; Macromolecular Substances; Models, Molecular; Protein Conformation; Quinazolines; Thiophenes; Thymidylate Synthase | 2001 |
Human thymidylate synthase with loop 181-197 stabilized in an inactive conformation: ligand interactions, phosphorylation, and inhibition profiles.
Topics: Amino Acid Motifs; Casein Kinase II; Circular Dichroism; Deoxyuracil Nucleotides; Diphosphonates; Humans; Ligands; Mutation; Phosphorylation; Protein Binding; Protein Structure, Secondary; Quinazolines; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase | 2011 |
Computational study of the effects of protein tyrosine nitrations on the catalytic activity of human thymidylate synthase.
Topics: Deoxyuracil Nucleotides; Humans; Models, Molecular; Molecular Dynamics Simulation; Protein Processing, Post-Translational; Quinazolines; Thiophenes; Thymidylate Synthase; Tyrosine | 2013 |
Raltitrexed's effect on the development of neural tube defects in mice is associated with DNA damage, apoptosis, and proliferation.
Topics: Animals; Apoptosis; Blotting, Western; Cell Proliferation; Deoxyuracil Nucleotides; DNA Damage; Embryo, Mammalian; Female; Folic Acid Antagonists; Gestational Age; Histones; Injections, Intraperitoneal; Male; Mice, Inbred C57BL; Neural Tube Defects; Phosphorylation; Pregnancy; Protein Subunits; Quinazolines; Replication Protein A; Thiophenes; Thymidine Monophosphate; Thymidylate Synthase | 2015 |
Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states.
Topics: Allosteric Site; Amino Acid Substitution; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Deoxyuracil Nucleotides; Dimerization; Enzyme Activation; Enzyme Stability; Folic Acid Antagonists; Humans; Ligands; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Peptide Fragments; Protein Conformation; Protein Folding; Quinazolines; Recombinant Proteins; Thiophenes; Thymidylate Synthase | 2017 |