2'-deoxyuridylic acid has been researched along with folic acid in 35 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (20.00) | 18.7374 |
| 1990's | 19 (54.29) | 18.2507 |
| 2000's | 8 (22.86) | 29.6817 |
| 2010's | 1 (2.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Danenberg, PV; Lockshin, A | 1 |
| Finer-Moore, JS; Kamb, A; Stroud, RM | 1 |
| Calvert, AH; Finer-Moore, J; Kamb, A; Stroud, RM | 1 |
| Fauman, EB; Finer-Moore, JS; Hardy, L; Maley, F; Maley, GF; Montfort, WR; Perry, KM; Stroud, RM | 1 |
| Finer-Moore, JS; Montfort, WR; Stroud, RM | 1 |
| Danenberg, PV; Frösing, R; Gustavsson, BG; Hayes, AA; Shahinian, AH; Spears, CP | 1 |
| Houghton, JA; Houghton, PJ; Radparvar, S | 1 |
| Garvey, EP; Santi, DV | 1 |
| Ahmed, F; Dunlap, RB; Moore, MA | 1 |
| Danenberg, PV; Pogolotti, AL; Santi, DV | 1 |
| Reidy, JA | 1 |
| Aherne, GW; Boyle, FT; Brown, M; Gibson, W; Hardcastle, A; Jackman, AL; Kelland, LR; Kimbell, R | 1 |
| Erlichman, C; Mandelbaum, S; Mitrovski, B; Pressacco, J | 1 |
| Connick, TJ; Dunlap, RB; Ellis, PD; Reilly, RT | 1 |
| Dallas, WS; Dev, IK; Ferone, R; Hanlon, M; McKee, DD; Yates, BB | 1 |
| Aherne, W; Boyle, FT; Hardcastle, A; Jackman, AL; Kimbell, R | 1 |
| Birdsall, DL; Finer-Moore, J; Stroud, RM | 1 |
| Rutenber, EE; Sage, CR; Stout, TJ; Stroud, RM | 1 |
| Appleman, JR; Spencer, HT; Villafranca, JE | 1 |
| Jackson, CD; James, SJ; Miller, BJ; Weis, C | 1 |
| Changchien, L; Maley, F; Montfort, WR; Strop, P | 1 |
| Birdsall, DL; Finer-Moore, J; Huang, W; Santi, DV; Stroud, RM | 1 |
| Copp, AJ; Fleming, A | 1 |
| Sage, CR; Stout, TJ; Stroud, RM | 1 |
| Liu, Y; Santi, DV | 1 |
| Anderson, AC; DeLano, WL; O'Neil, RH; Stroud, RM | 1 |
| Anderson, AC; Freymann, DM; Perry, KM; Stroud, RM | 1 |
| Finer-Moore, JS; Fritz, TA; Liu, L; Stroud, RM | 1 |
| Fenech, M; Wang, X | 1 |
| Griffin, J; Iliffe-Lee, E; McClarty, G; Roshick, C | 1 |
| Chanama, M; Chitnumsub, P; Yuthavong, Y | 1 |
| Changchien, L; Maley, F; Montfort, WR; Sotelo-Mundo, RR | 1 |
| Kanaan, N; Kohen, A; Martí, S; Moliner, V | 1 |
| Aispuro-Hernandez, E; Arvizu-Flores, AA; Garcia-Orozco, KD; Maley, F; Rojo-Domínguez, A; Sotelo-Mundo, RR; Valenzuela-Soto, E; Varela-Romero, A; Velazquez-Contreras, EF; Yepiz-Plascencia, G | 1 |
| Briffotaux, J; Garg, D; Myllykallio, H; Skouloubris, S; Wade, RC | 1 |
35 other study(ies) available for 2'-deoxyuridylic acid and folic acid
| Article | Year |
|---|---|
Thymidylate synthetase and 2'-deoxyuridylate form a tight complex in the presence of pteroyltriglutamate.
Topics: Cell Line; Deoxyuracil Nucleotides; Folic Acid; Humans; Kinetics; Lacticaseibacillus casei; Leukemia; Methyltransferases; Protein Binding; Pteroylpolyglutamic Acids; Thymidylate Synthase | 1979 |
Cofactor triggers the conformational change in thymidylate synthase: implications for an ordered binding mechanism.
Topics: Binding Sites; Crystallization; Deoxyuracil Nucleotides; Escherichia coli; Folic Acid; Models, Molecular; Molecular Structure; Polyglutamic Acid; Protein Conformation; Quinazolines; Thymidylate Synthase; X-Ray Diffraction | 1992 |
Structural basis for recognition of polyglutamyl folates by thymidylate synthase.
Topics: Amino Acid Sequence; Animals; Binding Sites; Chemical Phenomena; Chemistry, Physical; Crystallization; Deoxyuracil Nucleotides; Electrochemistry; Escherichia coli; Folic Acid; Humans; Kinetics; Mice; Models, Molecular; Molecular Sequence Data; Molecular Structure; Protein Conformation; Quinazolines; Sequence Homology, Amino Acid; Structure-Activity Relationship; Thymidylate Synthase; X-Ray Diffraction | 1992 |
Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate.
Topics: Binding Sites; Crystallization; Deoxyuracil Nucleotides; Escherichia coli; Folic Acid; Folic Acid Antagonists; Models, Molecular; Molecular Conformation; Quinazolines; Thymidylate Synthase | 1990 |
Pairwise specificity and sequential binding in enzyme catalysis: thymidylate synthase.
Topics: Binding Sites; Deoxyuracil Nucleotides; Escherichia coli; Folic Acid; Models, Chemical; Models, Molecular; Molecular Conformation; Quinazolines; Stereoisomerism; Substrate Specificity; Thymidylate Synthase | 1990 |
Deoxyuridylate effects on thymidylate synthase-5-fluorodeoxyuridylate-folate ternary complex formation.
Topics: Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Folic Acid; Kinetics; Thymidylate Synthase | 1989 |
Characteristics of thymidylate synthase purified from a human colon adenocarcinoma.
Topics: Adenocarcinoma; Animals; Cell Line; Colonic Neoplasms; Deoxyuracil Nucleotides; Folic Acid; Humans; Kinetics; Mice; Stereoisomerism; Thymidylate Synthase; Transplantation, Heterologous | 1988 |
A stable binary complex between Leishmania major thymidylate synthase and the substrate deoxyuridylate. A slow-binding interaction.
Topics: Animals; Binding, Competitive; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Folic Acid; Kinetics; Leishmania tropica; Quinazolines; Thymidine Monophosphate; Thymidylate Synthase | 1987 |
Evidence for the existence of covalent nucleotide-thymidylate synthase complexes, identification of site of attachment, and enhancement by folates.
Topics: Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Folic Acid; Tetrahydrofolates; Thymidine Monophosphate; Thymidylate Synthase | 1986 |
Kinetics and mechanism of interaction of 10-propargyl-5,8-dideazafolate with thymidylate synthase.
Topics: Antineoplastic Agents; Carbon Radioisotopes; Deoxyuracil Nucleotides; Folic Acid; Kinetics; Leukemia, Experimental; Protein Denaturation; Quinazolines; Spectrophotometry, Ultraviolet; Thymidylate Synthase; Tritium | 1986 |
Deoxyuridine increases folate-sensitive fragile site expression in human lymphocytes.
Topics: Chromosome Fragile Sites; Chromosome Fragility; Deoxyuracil Nucleotides; Deoxyuridine; DNA; Folic Acid; Humans; In Vitro Techniques; Lymphocytes | 1987 |
Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines.
Topics: Animals; Antineoplastic Agents; Carrier Proteins; Deoxyuracil Nucleotides; Drug Resistance; Female; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Leukemia L1210; Lymphocytes; Methotrexate; Mice; Neoplasm Proteins; Ovarian Neoplasms; Peptide Synthases; Polyglutamic Acid; Proteins; Quinazolines; Receptors, Cell Surface; Thiophenes; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured | 1995 |
Biochemical effects of folate-based inhibitors of thymidylate synthase in MGH-U1 cells.
Topics: Cell Survival; Deoxyuracil Nucleotides; Deoxyuridine; Folic Acid; Folic Acid Antagonists; Glutamates; Humans; In Vitro Techniques; Indoles; Isoindoles; Quinazolines; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1994 |
Phosphorus-31 nuclear magnetic resonance studies of complexes of thymidylate synthase.
Topics: Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Folic Acid; Magnetic Resonance Spectroscopy; Phosphorus Isotopes; Quinazolines; Tetrahydrofolates; Thymidine Monophosphate; Thymidylate Synthase | 1994 |
Mode of binding of folate analogs to thymidylate synthase. Evidence for two asymmetric but interactive substrate binding sites.
Topics: Binding Sites; Carbon Radioisotopes; Deoxyuracil Nucleotides; Folic Acid; Folic Acid Antagonists; Humans; Indoles; Isoindoles; Kinetics; Macromolecular Substances; Mathematics; Protein Binding; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase | 1994 |
The duration of the inhibition of thymidylate synthase in intact L1210 cells exposed to two different classes of quinazoline analogues.
Topics: Animals; Antineoplastic Agents; Cell Division; Deoxyuracil Nucleotides; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Mice; Quinazolines; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase; Thymine Nucleotides | 1993 |
Entropy in bi-substrate enzymes: proposed role of an alternate site in chaperoning substrate into, and products out of, thymidylate synthase.
Topics: Binding Sites; Crystallography, X-Ray; Deoxyuracil Nucleotides; Folic Acid; Lacticaseibacillus casei; Models, Molecular; Protein Conformation; Quinazolines; Tetrahydrofolates; Thermodynamics; Thymidylate Synthase | 1996 |
An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q.
Topics: Amino Acid Sequence; Binding Sites; Crystallization; Crystallography, X-Ray; Deoxyuracil Nucleotides; Enzyme Inhibitors; Escherichia coli; Folic Acid; Glutamic Acid; Hydrogen Bonding; Models, Molecular; Mutagenesis, Site-Directed; Point Mutation; Protein Conformation; Quinazolines; Recombinant Proteins; Thymidylate Synthase; Water | 1996 |
Kinetic scheme for thymidylate synthase from Escherichia coli: determination from measurements of ligand binding, primary and secondary isotope effects, and pre-steady-state catalysis.
Topics: Catalysis; Deoxyuracil Nucleotides; Escherichia coli; Folic Acid; Folic Acid Antagonists; Kinetics; Ligands; Molecular Structure; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Quinazolines; Spectrometry, Fluorescence; Spectrophotometry; Tetrahydrofolates; Thermodynamics; Thymidine Monophosphate; Thymidylate Synthase | 1997 |
Dietary nucleotides: effects on cell proliferation following partial hepatectomy in rats fed NIH-31, AIN-76A, or folate/methyl-deficient diets.
Topics: Animal Feed; Animals; Cell Division; Deoxyribonucleotides; Deoxyuracil Nucleotides; Diet; Folic Acid; Folic Acid Deficiency; Food, Formulated; Hepatectomy; Male; Rats; Rats, Inbred F344; Thymine Nucleotides; Weaning | 1997 |
Crystal structures of a marginally active thymidylate synthase mutant, Arg 126-->Glu.
Topics: Antineoplastic Agents; Arginine; Binding Sites; Catalysis; Crystallization; Crystallography, X-Ray; Deoxyuracil Nucleotides; Dimerization; Folic Acid; Folic Acid Antagonists; Glutamic Acid; Hydrogen Bonding; Kinetics; Models, Molecular; Molecular Structure; Mutation; Phosphates; Quinazolines; Thymidylate Synthase | 1997 |
The separate effects of E60Q in Lactobacillus casei thymidylate synthase delineate between mechanisms for formation of intermediates in catalysis.
Topics: Amino Acid Substitution; Asparagine; Binding Sites; Catalysis; Crystallography, X-Ray; Deoxyuracil Nucleotides; Folic Acid; Glutamic Acid; Glutamine; Lacticaseibacillus casei; Mutation; Nucleotides; Protein Binding; Protein Conformation; Pyrimidines; Quinazolines; Structure-Activity Relationship; Substrate Specificity; Thymidylate Synthase | 1998 |
Embryonic folate metabolism and mouse neural tube defects.
Topics: Animals; Central Nervous System; Deoxyuracil Nucleotides; DNA-Binding Proteins; Embryo, Mammalian; Female; Folic Acid; Humans; Male; Methionine; Mice; Mice, Inbred CBA; Mutation; Neural Tube Defects; Paired Box Transcription Factors; PAX3 Transcription Factor; Pyrimidines; Tetrahydrofolates; Thymidine; Thymidine Monophosphate; Transcription Factors | 1998 |
The additivity of substrate fragments in enzyme-ligand binding.
Topics: Crystallography, X-Ray; Deoxyuracil Nucleotides; Deoxyuridine; Escherichia coli; Folic Acid; Models, Molecular; Mutagenesis, Site-Directed; Phosphates; Protein Conformation; Quinazolines; Recombinant Proteins; Ribose; Structure-Activity Relationship; Thymidylate Synthase; Uridine | 1998 |
A continuous spectrophotometric assay for thymidine and deoxycytidine kinases.
Topics: Deoxycytidine Kinase; Deoxycytidine Monophosphate; Deoxyuracil Nucleotides; Deoxyuridine; Folic Acid; Herpesvirus 1, Human; Hydrogen-Ion Concentration; Kinetics; Methylation; Spectrophotometry; Tetrahydrofolates; Thymidine Kinase; Thymidylate Synthase | 1998 |
The structural mechanism for half-the-sites reactivity in an enzyme, thymidylate synthase, involves a relay of changes between subunits.
Topics: Binding Sites; Crystallography, X-Ray; Deoxyuracil Nucleotides; Dimerization; Enzyme Activation; Enzyme Inhibitors; Folic Acid; Ligands; Models, Molecular; Peptide Fragments; Pneumocystis; Protein Conformation; Quinazolines; Solutions; Spectrometry, Fluorescence; Thymidylate Synthase | 1999 |
The crystal structure of thymidylate synthase from Pneumocystis carinii reveals a fungal insert important for drug design.
Topics: Amino Acid Sequence; Binding Sites; Crystallography, X-Ray; Deoxyuracil Nucleotides; Dimerization; Drug Design; Enzyme Inhibitors; Folic Acid; Humans; Hydrogen Bonding; Models, Molecular; Molecular Sequence Data; Mutagenesis, Insertional; Pneumocystis; Protein Binding; Protein Conformation; Quinazolines; Sequence Alignment; Species Specificity; Substrate Specificity; Thymidylate Synthase | 2000 |
Tryptophan 80 and leucine 143 are critical for the hydride transfer step of thymidylate synthase by controlling active site access.
Topics: Binding Sites; Biological Transport; Deoxyuracil Nucleotides; Escherichia coli; Folic Acid; Leucine; Models, Chemical; Point Mutation; Protons; Quinazolines; Tetrahydrofolates; Thymidylate Synthase; Tryptophan | 2002 |
A comparison of folic acid and 5-methyltetrahydrofolate for prevention of DNA damage and cell death in human lymphocytes in vitro.
Topics: Adult; Biological Availability; Carrier Proteins; Cell Division; Cells, Cultured; Choline; Chromosome Breakage; Chromosomes, Human; Deoxyuracil Nucleotides; DNA; DNA Damage; DNA Methylation; DNA Replication; Female; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Lymphocyte Activation; Lymphocytes; Membrane Transport Proteins; Methionine; Micronucleus Tests; Middle Aged; Oxidation-Reduction; Phytohemagglutinins; Prodrugs; Receptors, Cell Surface; Reduced Folate Carrier Protein; Tetrahydrofolates; Uracil | 2003 |
Catalytic mechanism of Chlamydia trachomatis flavin-dependent thymidylate synthase.
Topics: Amino Acid Sequence; Catalysis; Chlamydia trachomatis; Cloning, Molecular; Deoxyuracil Nucleotides; Drug Design; Escherichia coli; Flavins; Folic Acid; Genetic Complementation Test; Kinetics; Molecular Sequence Data; NADP; Open Reading Frames; Oxidation-Reduction; Recombinant Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substrate Specificity; Thymidine Monophosphate; Thymidylate Synthase | 2005 |
Subunit complementation of thymidylate synthase in Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase.
Topics: Animals; Binding Sites; Deoxyuracil Nucleotides; Dimerization; Folic Acid; Genetic Complementation Test; Multienzyme Complexes; Mutation, Missense; Plasmodium falciparum; Protein Structure, Tertiary; Protein Subunits; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 2005 |
Crystal structures of thymidylate synthase mutant R166Q: structural basis for the nearly complete loss of catalytic activity.
Topics: Amino Acid Substitution; Arginine; Binding Sites; Catalysis; Crystallization; Crystallography, X-Ray; Deoxyuracil Nucleotides; Dimerization; Escherichia coli; Folic Acid; Folic Acid Antagonists; Hydrogen Bonding; Kinetics; Ligands; Models, Molecular; Molecular Structure; Protein Binding; Protein Conformation; Recombinant Proteins; Thymidine Monophosphate; Thymidylate Synthase | 2006 |
QM/MM study of thymidylate synthase: enzymatic motions and the temperature dependence of the rate limiting step.
Topics: Catalysis; Deoxyuracil Nucleotides; Energy Transfer; Escherichia coli; Folic Acid; Models, Chemical; Substrate Specificity; Temperature; Tetrahydrofolates; Thymidylate Synthase | 2009 |
Functional identity of the active sites of crustacean and viral thymidylate synthases.
Topics: Amino Acid Sequence; Animals; Base Sequence; Catalytic Domain; Cloning, Molecular; Deoxyuracil Nucleotides; Folic Acid; Folic Acid Antagonists; Isoindoles; Kinetics; Models, Molecular; Molecular Sequence Data; Penaeidae; Phylogeny; Quinazolines; Sequence Alignment; Thymidylate Synthase; White spot syndrome virus 1 | 2009 |
Conservation and Role of Electrostatics in Thymidylate Synthase.
Topics: Binding Sites; Buchnera; Catalytic Domain; Cloning, Molecular; Deoxyuracil Nucleotides; Enzyme Assays; Escherichia coli; Folic Acid; Gene Expression; Humans; Kinetics; Models, Molecular; Mutation; Protein Multimerization; Protein Structure, Secondary; Recombinant Proteins; Static Electricity; Structural Homology, Protein; Substrate Specificity; Thymidylate Synthase; Wigglesworthia | 2015 |