2'-deoxyuridylic acid has been researched along with 5,10-methylenetetrahydrofolic acid in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (11.54) | 18.7374 |
| 1990's | 15 (57.69) | 18.2507 |
| 2000's | 4 (15.38) | 29.6817 |
| 2010's | 4 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Carreras, CW; Climie, SC; Santi, DV | 1 |
| Aull, JL; Bures, AK; Daron, HH | 1 |
| Aull, JL; Chen, SC; Daron, HH | 1 |
| Gustavsson, BG; Spears, CP | 1 |
| Cieśla, J; Machnicka, B; Rode, W; Zieliński, Z | 1 |
| Huang, W; Santi, DV | 1 |
| Ko, RC; So, NN; Wong, PC | 1 |
| Connick, TJ; Dunlap, RB; Ellis, PD; Reilly, RT | 1 |
| Carreras, CW; Chang, LC; Perry, KM; Santi, DV; Stroud, RM | 1 |
| Livi, LL; Santi, DV; Schellenberger, U | 1 |
| Birdsall, DL; Finer-Moore, J; Stroud, RM | 1 |
| Appleman, JR; Spencer, HT; Villafranca, JE | 1 |
| Adamowicz, L; Leś, A; Rode, W | 1 |
| Chiericatti, G; Santi, DV | 1 |
| Copp, AJ; Fleming, A | 1 |
| Landis, DM; Loeb, LA | 1 |
| Liu, Y; Santi, DV | 1 |
| Berger, SH; Dunlap, RB; Spencer, HT; Steadman, DJ | 1 |
| Berger, FG; Fantz, C; Forsthoefel, A; Jennings, W; Kitchens, M; Lebioda, L; Minor, W; Phan, J; Shaw, D; Spencer, HT | 1 |
| Lee, TT; Liu, Y; Santi, DV; Stroud, RM; Variath, P | 1 |
| Finer-Moore, JS; Fritz, TA; Liu, L; Stroud, RM | 1 |
| Gattis, SG; Palfey, BA | 1 |
| Kohen, A; Saeed, M; Sheff, D | 1 |
| Hannongbua, S; Kaiyawet, N; Rungrotmongkol, T | 1 |
| Abeysinghe, T; Kohen, A | 1 |
| Ghosh, AK; Kholodar, SA; Kohen, A; Moliner, V; Świderek, K | 1 |
26 other study(ies) available for 2'-deoxyuridylic acid and 5,10-methylenetetrahydrofolic acid
| Article | Year |
|---|---|
Thymidylate synthase with a C-terminal deletion catalyzes partial reactions but is unable to catalyze thymidylate formation.
Topics: Catalysis; Deoxyuracil Nucleotides; Escherichia coli; Idoxuridine; Lacticaseibacillus casei; Mutagenesis; Structure-Activity Relationship; Sulfhydryl Compounds; Tetrahydrofolates; Thymidine Monophosphate; Thymidylate Synthase | 1992 |
Inhibition of thymidylate synthase by glyceraldehyde 3-phosphate.
Topics: Binding, Competitive; Deoxyuracil Nucleotides; Glyceraldehyde 3-Phosphate; Kinetics; Lacticaseibacillus casei; Tetrahydrofolates; Thymidylate Synthase | 1991 |
Inhibition of thymidylate synthase by pyridoxal phosphate.
Topics: Binding, Competitive; Deoxyuracil Nucleotides; Lacticaseibacillus casei; Pyridoxal Phosphate; Spectrophotometry; Tetrahydrofolates; Thymidylate Synthase | 1989 |
Methods for thymidylate synthase pharmacodynamics: serial biopsy, free and total TS, FdUMP and dUMP, and H4PteGlu and CH2-H4PteGlu assays.
Topics: Biopsy, Needle; Cytosol; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Humans; Lacticaseibacillus casei; Neoplasms; Radioisotope Dilution Technique; Tetrahydrofolates; Thymidylate Synthase; Tritium | 1988 |
Thymidylate synthase activity in the development of Hymenolepis diminuta.
Topics: Animals; Chromatography, Gel; Deoxyuracil Nucleotides; Electrophoresis, Polyacrylamide Gel; Hydrogen-Ion Concentration; Hymenolepis; Kinetics; Macromolecular Substances; Molecular Weight; Tetrahydrofolates; Thymidylate Synthase; Tritium | 1987 |
Isolation of a covalent steady-state intermediate in glutamate 60 mutants of thymidylate synthase.
Topics: Base Sequence; Binding Sites; Catalysis; Deoxyuracil Nucleotides; DNA Primers; Glutamates; Kinetics; Lacticaseibacillus casei; Molecular Sequence Data; Mutagenesis, Site-Directed; Structure-Activity Relationship; Tetrahydrofolates; Thymidylate Synthase | 1994 |
Angiostrongylus cantonensis: characterization of thymidylate synthetase.
Topics: Ammonium Sulfate; Angiostrongylus cantonensis; Animals; Chemical Fractionation; Chromatography, Affinity; Chromatography, Gel; Deoxyuracil Nucleotides; Electrophoresis, Polyacrylamide Gel; Kinetics; Methotrexate; Tetrahydrofolates; Thymidylate Synthase; Trimethoprim | 1994 |
Phosphorus-31 nuclear magnetic resonance studies of complexes of thymidylate synthase.
Topics: Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Folic Acid; Magnetic Resonance Spectroscopy; Phosphorus Isotopes; Quinazolines; Tetrahydrofolates; Thymidine Monophosphate; Thymidylate Synthase | 1994 |
Structures of thymidylate synthase with a C-terminal deletion: role of the C-terminus in alignment of 2'-deoxyuridine 5'-monophosphate and 5,10-methylenetetrahydrofolate.
Topics: Crystallization; Deoxyuracil Nucleotides; Hydrogen Bonding; Ligands; Models, Molecular; Protein Conformation; Protein Structure, Tertiary; Sequence Deletion; Tetrahydrofolates; Thymidylate Synthase | 1993 |
Cloning, expression, purification, and characterization of 2'-deoxyuridylate hydroxymethylase from phage SPO1.
Topics: Bacillus Phages; Bacillus subtilis; Base Sequence; Cloning, Molecular; Crystallization; Deoxyuracil Nucleotides; Escherichia coli; Gene Expression; Genes, Viral; Genetic Vectors; Hydroxymethyl and Formyl Transferases; Kinetics; Molecular Sequence Data; Molecular Weight; Plasmids; Protein Conformation; Pyridoxal Phosphate; Tetrahydrofolates; Transferases; Tritium | 1995 |
Entropy in bi-substrate enzymes: proposed role of an alternate site in chaperoning substrate into, and products out of, thymidylate synthase.
Topics: Binding Sites; Crystallography, X-Ray; Deoxyuracil Nucleotides; Folic Acid; Lacticaseibacillus casei; Models, Molecular; Protein Conformation; Quinazolines; Tetrahydrofolates; Thermodynamics; Thymidylate Synthase | 1996 |
Kinetic scheme for thymidylate synthase from Escherichia coli: determination from measurements of ligand binding, primary and secondary isotope effects, and pre-steady-state catalysis.
Topics: Catalysis; Deoxyuracil Nucleotides; Escherichia coli; Folic Acid; Folic Acid Antagonists; Kinetics; Ligands; Molecular Structure; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Quinazolines; Spectrometry, Fluorescence; Spectrophotometry; Tetrahydrofolates; Thermodynamics; Thymidine Monophosphate; Thymidylate Synthase | 1997 |
Modeling of reaction steps relevant to deoxyuridylate (dUMP) enzymatic methylation and thymidylate synthase mechanism-based inhibition.
Topics: Algorithms; Cysteine; Deoxycytidine Monophosphate; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Methylation; Models, Chemical; Quantum Theory; Sulfhydryl Compounds; Tetrahydrofolates; Thymidylate Synthase; Uracil; Water | 1998 |
Aspartate 221 of thymidylate synthase is involved in folate cofactor binding and in catalysis.
Topics: Aspartic Acid; Binding Sites; Catalysis; Coenzymes; Deoxyuracil Nucleotides; Escherichia coli; Fluorodeoxyuridylate; Genetic Complementation Test; Halogens; Kinetics; Lacticaseibacillus casei; Mutagenesis, Insertional; Tetrahydrofolates; Thymidine Monophosphate; Thymidylate Synthase | 1998 |
Embryonic folate metabolism and mouse neural tube defects.
Topics: Animals; Central Nervous System; Deoxyuracil Nucleotides; DNA-Binding Proteins; Embryo, Mammalian; Female; Folic Acid; Humans; Male; Methionine; Mice; Mice, Inbred CBA; Mutation; Neural Tube Defects; Paired Box Transcription Factors; PAX3 Transcription Factor; Pyrimidines; Tetrahydrofolates; Thymidine; Thymidine Monophosphate; Transcription Factors | 1998 |
Random sequence mutagenesis and resistance to 5-fluorouridine in human thymidylate synthases.
Topics: Amino Acid Sequence; Binding Sites; Cell Survival; Deoxyuracil Nucleotides; Drug Resistance; Enzyme Inhibitors; Escherichia coli; Humans; Kinetics; Molecular Sequence Data; Mutagenesis; Mutation; Protein Binding; Sequence Analysis, DNA; Tetrahydrofolates; Thymidylate Synthase; Uridine | 1998 |
A continuous spectrophotometric assay for thymidine and deoxycytidine kinases.
Topics: Deoxycytidine Kinase; Deoxycytidine Monophosphate; Deoxyuracil Nucleotides; Deoxyuridine; Folic Acid; Herpesvirus 1, Human; Hydrogen-Ion Concentration; Kinetics; Methylation; Spectrophotometry; Tetrahydrofolates; Thymidine Kinase; Thymidylate Synthase | 1998 |
Substitution at residue 214 of human thymidylate synthase alters nucleotide binding and isomerization of ligand-protein complexes.
Topics: Amino Acid Substitution; Binding Sites; Deoxyuracil Nucleotides; Enzyme Activation; Glutamine; Humans; Isoenzymes; Kinetics; Ligands; Macromolecular Substances; Mutagenesis, Site-Directed; Spectrometry, Fluorescence; Tetrahydrofolates; Thermodynamics; Thymidine Monophosphate; Thymidylate Synthase | 1999 |
Drug-resistant variants of Escherichia coli thymidylate synthase: effects of substitutions at Pro-254.
Topics: Amino Acid Substitution; Crystallography, X-Ray; Deoxyuracil Nucleotides; Drug Resistance; Drug Resistance, Microbial; Enzyme Inhibitors; Escherichia coli; Fluorodeoxyuridylate; Folic Acid Antagonists; Humans; Kinetics; Mutation; Proline; Protein Conformation; Quinazolines; Tetrahydrofolates; Thymidylate Synthase; Transfection | 2000 |
Effects of subunit occupancy on partitioning of an intermediate in thymidylate synthase mutants.
Topics: Alanine; Arginine; Catalysis; Deoxyuracil Nucleotides; Escherichia coli; Glycine; Kinetics; Lacticaseibacillus casei; Models, Chemical; Mutagenesis, Site-Directed; Peptide Fragments; Tetrahydrofolates; Thymidine Monophosphate; Thymidylate Synthase; Valine | 2000 |
Tryptophan 80 and leucine 143 are critical for the hydride transfer step of thymidylate synthase by controlling active site access.
Topics: Binding Sites; Biological Transport; Deoxyuracil Nucleotides; Escherichia coli; Folic Acid; Leucine; Models, Chemical; Point Mutation; Protons; Quinazolines; Tetrahydrofolates; Thymidylate Synthase; Tryptophan | 2002 |
Direct observation of the participation of flavin in product formation by thyX-encoded thymidylate synthase.
Topics: Campylobacter jejuni; Deoxyuracil Nucleotides; Flavin-Adenine Dinucleotide; Oxidation-Reduction; Spectrophotometry; Tetrahydrofolates; Thymidine Monophosphate; Thymidylate Synthase | 2005 |
Novel positron emission tomography tracer distinguishes normal from cancerous cells.
Topics: Cell Division; Cell Line, Tumor; Deoxyuracil Nucleotides; DNA Replication; DNA, Neoplasm; Humans; Methylation; Neoplasm Proteins; Neoplasms; Positron-Emission Tomography; Radioactive Tracers; Radiography; Tetrahydrofolates; Thymidine Monophosphate; Thymidylate Synthase | 2011 |
Effect of halogen substitutions on dUMP to stability of thymidylate synthase/dUMP/mTHF ternary complex using molecular dynamics simulation.
Topics: Deoxyuracil Nucleotides; Enzyme Stability; Escherichia coli; Halogenation; Molecular Dynamics Simulation; Tetrahydrofolates; Thymidylate Synthase | 2013 |
Role of long-range protein dynamics in different thymidylate synthase catalyzed reactions.
Topics: Catalysis; Deoxyuracil Nucleotides; Escherichia coli; Kinetics; Proteins; Protons; Temperature; Tetrahydrofolates; Thermodynamics; Thymidylate Synthase | 2015 |
Parallel reaction pathways and noncovalent intermediates in thymidylate synthase revealed by experimental and computational tools.
Topics: Catalysis; Deoxyuracil Nucleotides; Escherichia coli Proteins; Kinetics; Molecular Dynamics Simulation; Quantum Theory; Tetrahydrofolates; Thymidylate Synthase | 2018 |