2--deoxyguanosine-5--phosphate and phthalocyanine

2--deoxyguanosine-5--phosphate has been researched along with phthalocyanine* in 1 studies

Other Studies

1 other study(ies) available for 2--deoxyguanosine-5--phosphate and phthalocyanine

Article	Year
Fe(II) phthalocyanine catalyzed oxidation of dGMP by molecular oxygen. Bioorganic & medicinal chemistry letters, 2009, Aug-01, Volume: 19, Issue:15 We show that iron(II)-phthalocyanines are able to catalyze guanosine oxidation by molecular oxygen in the presence of reducing agents such as ascorbic acid and 2-mercaptoethanol. The products of 5'-monophosphate-2'-deoxyguanosine (dGMP) oxidation were directly analyzed using the HPLC-ESI/MS method. The main oxidation products were 5'-phospho-2'-deoxy-8-oxo-7,8-dihydroguanine and the 1,N2-glyoxal adduct of the 5'-monophosphate-2'-deoxyguanosine. Topics: Antineoplastic Agents; Antiviral Agents; Ascorbic Acid; Catalysis; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Deoxyguanine Nucleotides; Drug Design; Humans; Hydroxyl Radical; Indoles; Iron; Isoindoles; Mercaptoethanol; Models, Chemical; Oxygen; Spectrometry, Mass, Electrospray Ionization	2009

Article

Year

Fe(II) phthalocyanine catalyzed oxidation of dGMP by molecular oxygen.

Bioorganic & medicinal chemistry letters, 2009, Aug-01, Volume: 19, Issue:15

We show that iron(II)-phthalocyanines are able to catalyze guanosine oxidation by molecular oxygen in the presence of reducing agents such as ascorbic acid and 2-mercaptoethanol. The products of 5'-monophosphate-2'-deoxyguanosine (dGMP) oxidation were directly analyzed using the HPLC-ESI/MS method. The main oxidation products were 5'-phospho-2'-deoxy-8-oxo-7,8-dihydroguanine and the 1,N2-glyoxal adduct of the 5'-monophosphate-2'-deoxyguanosine.

Topics: Antineoplastic Agents; Antiviral Agents; Ascorbic Acid; Catalysis; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Deoxyguanine Nucleotides; Drug Design; Humans; Hydroxyl Radical; Indoles; Iron; Isoindoles; Mercaptoethanol; Models, Chemical; Oxygen; Spectrometry, Mass, Electrospray Ionization

2009