2--deoxyguanosine-5--phosphate and 2-4-diamino-5-adamantyl-6-methylpyrimidine

2--deoxyguanosine-5--phosphate has been researched along with 2-4-diamino-5-adamantyl-6-methylpyrimidine* in 2 studies

Other Studies

2 other study(ies) available for 2--deoxyguanosine-5--phosphate and 2-4-diamino-5-adamantyl-6-methylpyrimidine

Article	Year
Interaction of the aziridine moiety of RSU-1069 with nucleotides and inorganic phosphate. Implications for alkylation of DNA. Biochemical pharmacology, 1986, Apr-01, Volume: 35, Issue:7 The aziridine moiety of RSU-1069 (1-(2-nitro-1-imidazolyl)-3-(1-aziridino-2-propanol] alkylates inorganic phosphate and a range of nucleotides in aqueous solutions of pH 7.0. From the rate constants obtained and a study of the adducts formed it is demonstrated that phosphate is a major target on nucleotides at neutral pH, although additional sites may exist particularly on dGMP and dAMP. From the dependence of reactivity on pH and the influence of ionic strength, it is established that the protonated aziridine is the reactive species and that hydrolysis is insignificant when compared to the rate of phosphorylation. The reaction kinetics detailed in this study are discussed in terms of DNA alkylation and strand breakage effected by the aziridine moiety of RSU-1069. Topics: Adamantane; Alkylation; Animals; Chromatography, Liquid; Deoxyguanine Nucleotides; DNA; Hydrogen-Ion Concentration; Kinetics; Mathematics; Misonidazole; Nucleotides; Osmolar Concentration; Phosphates	1986
Nuclear magnetic resonance of protamines. A 1H-NMR study of the interaction of clupeine fractions with mononucleotides. Biochimica et biophysica acta, 1986, May-05, Volume: 866, Issue:4 The interaction of the three clupeine fractions, YI, YII, Z, and salmine fraction AI with mononucleotides has been examined by means of 1H nuclear magnetic resonance. The results obtained are interpreted in terms of electrostatic interactions between positive arginine guanidinyl groups and negative nucleotide phosphates. In addition, clupeine fraction YI and salmine fraction AI exhibit with guanine and adenine nucleotides a more specific interaction that leads to the formation of large aggregates in solution. The experimental data presented in this work demonstrate that the strength of interaction between clupeine YI and salmine AI with mononucleotides follows the order: 5'-dTMP approximately equal to 5'-dCMP much less than 5'-dAMP less than 5'-dGMP approximately equal to 5'-GMP. Topics: Adamantane; Amino Acid Sequence; Arginine; Clupeine; Deoxycytidine Monophosphate; Deoxyguanine Nucleotides; Magnetic Resonance Spectroscopy; Nucleotides; Protamines; Salmine; Thymidine Monophosphate	1986

Article

Year

Interaction of the aziridine moiety of RSU-1069 with nucleotides and inorganic phosphate. Implications for alkylation of DNA.

Biochemical pharmacology, 1986, Apr-01, Volume: 35, Issue:7

The aziridine moiety of RSU-1069 (1-(2-nitro-1-imidazolyl)-3-(1-aziridino-2-propanol] alkylates inorganic phosphate and a range of nucleotides in aqueous solutions of pH 7.0. From the rate constants obtained and a study of the adducts formed it is demonstrated that phosphate is a major target on nucleotides at neutral pH, although additional sites may exist particularly on dGMP and dAMP. From the dependence of reactivity on pH and the influence of ionic strength, it is established that the protonated aziridine is the reactive species and that hydrolysis is insignificant when compared to the rate of phosphorylation. The reaction kinetics detailed in this study are discussed in terms of DNA alkylation and strand breakage effected by the aziridine moiety of RSU-1069.

Topics: Adamantane; Alkylation; Animals; Chromatography, Liquid; Deoxyguanine Nucleotides; DNA; Hydrogen-Ion Concentration; Kinetics; Mathematics; Misonidazole; Nucleotides; Osmolar Concentration; Phosphates

1986

Nuclear magnetic resonance of protamines. A 1H-NMR study of the interaction of clupeine fractions with mononucleotides.

Biochimica et biophysica acta, 1986, May-05, Volume: 866, Issue:4

The interaction of the three clupeine fractions, YI, YII, Z, and salmine fraction AI with mononucleotides has been examined by means of 1H nuclear magnetic resonance. The results obtained are interpreted in terms of electrostatic interactions between positive arginine guanidinyl groups and negative nucleotide phosphates. In addition, clupeine fraction YI and salmine fraction AI exhibit with guanine and adenine nucleotides a more specific interaction that leads to the formation of large aggregates in solution. The experimental data presented in this work demonstrate that the strength of interaction between clupeine YI and salmine AI with mononucleotides follows the order: 5'-dTMP approximately equal to 5'-dCMP much less than 5'-dAMP less than 5'-dGMP approximately equal to 5'-GMP.

Topics: Adamantane; Amino Acid Sequence; Arginine; Clupeine; Deoxycytidine Monophosphate; Deoxyguanine Nucleotides; Magnetic Resonance Spectroscopy; Nucleotides; Protamines; Salmine; Thymidine Monophosphate

1986