2--deoxy-2-fluoroadenosine and 2-aminoadenosine

2--deoxy-2-fluoroadenosine has been researched along with 2-aminoadenosine* in 1 studies

Other Studies

1 other study(ies) available for 2--deoxy-2-fluoroadenosine and 2-aminoadenosine

Article	Year
A convenient synthesis of 2'-deoxy-2-fluoroadenosine; a potential prodrug for suicide gene therapy. Nucleosides, nucleotides & nucleic acids, 2000, Volume: 19, Issue:3 A convenient synthesis of 2'-deoxy-2-fluoro-adenosine (1) is described. Deaminative fluorination of 2-aminoadenosine (2) followed by silylation of the 3', 5'-hydroxyl groups gave the corresponding 2-fluoroadenosine derivative 4 in good yield. Thiocarbonylation of 4 to thiocarbonylimidazolyl derivative 5a followed by treatment with an excess of tris(trimethylsilyl)silane (TTMSS) and tert-butyl peroxide in toluene at 80 degrees C was found to affect an efficient deoxygenation to the corresponding 2'-deoxy derivative 6. Desilylation of 6 by Et4NF in CH3CN afforded 1 in high yield. Topics: Adenosine; Deoxyadenosines; Genetic Therapy; Prodrugs	2000

Article

Year

A convenient synthesis of 2'-deoxy-2-fluoroadenosine; a potential prodrug for suicide gene therapy.

Nucleosides, nucleotides & nucleic acids, 2000, Volume: 19, Issue:3

A convenient synthesis of 2'-deoxy-2-fluoro-adenosine (1) is described. Deaminative fluorination of 2-aminoadenosine (2) followed by silylation of the 3', 5'-hydroxyl groups gave the corresponding 2-fluoroadenosine derivative 4 in good yield. Thiocarbonylation of 4 to thiocarbonylimidazolyl derivative 5a followed by treatment with an excess of tris(trimethylsilyl)silane (TTMSS) and tert-butyl peroxide in toluene at 80 degrees C was found to affect an efficient deoxygenation to the corresponding 2'-deoxy derivative 6. Desilylation of 6 by Et4NF in CH3CN afforded 1 in high yield.

Topics: Adenosine; Deoxyadenosines; Genetic Therapy; Prodrugs

2000