2'-deoxy-2'-methylenecytidine and gemcitabine

2'-deoxy-2'-methylenecytidine has been researched along with gemcitabine in 5 studies

Compound Research Comparison

Studies (2'-deoxy-2'-methylenecytidine)	Trials (2'-deoxy-2'-methylenecytidine)	Recent Studies (post-2010) (2'-deoxy-2'-methylenecytidine)	Studies (gemcitabine)	Trials (gemcitabine)	Recent Studies (post-2010) (gemcitabine)
30	2	0	12,523	3,208	6,923

Protein Interaction Comparison

Protein	Taxonomy	2'-deoxy-2'-methylenecytidine (IC50)	gemcitabine (IC50)
Chain A, DEOXYNUCLEOSIDE KINASE	Drosophila melanogaster (fruit fly)		0.76
Equilibrative nucleoside transporter 1	Homo sapiens (human)		0.19

Research

Studies (5)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	5 (100.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Fukuoka, M; Matsui, K	1
Tsukagoshi, S	1
Matsuda, A	1
Eda, H; F-Ouchi, K; Ishitsuka, H; Miwa, M; Tanaka, Y; Ura, M	1
Eda, H; Foley, LH; Ishitsuka, H; Keith, DD; Miwa, M; Ouchi, KF; Ura, M	1

Reviews

3 review(s) available for 2'-deoxy-2'-methylenecytidine and gemcitabine

Article	Year
[New antitumor antimetabolites--gemcitabine and DMDC]. Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:13 Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Deoxycytidine; Drug Administration Schedule; Female; Gemcitabine; Humans; Lung Neoplasms; Male	1992
[Recent development of antitumor antimetabolites in Japan--cytosine arabinoside analogues]. Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24, Issue:7 Topics: Animals; Antimetabolites, Antineoplastic; Arabinonucleotides; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Cytarabine; Cytidine Monophosphate; Deoxycytidine; Gemcitabine; Humans; Lung Neoplasms; Mice; Neoplasm Transplantation	1997
[Nucleoside kinases and new types of antitumor nucleosides]. Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24, Issue:11 Topics: Antimetabolites, Antineoplastic; Cytarabine; Deoxycytidine; Gemcitabine; Humans; Nucleic Acid Synthesis Inhibitors; Phosphotransferases	1997

Other Studies

2 other study(ies) available for 2'-deoxy-2'-methylenecytidine and gemcitabine

Article	Year
The antiproliferative activity of DMDC is modulated by inhibition of cytidine deaminase. Cancer research, 1998, Mar-15, Volume: 58, Issue:6 Topics: Animals; Antimetabolites, Antineoplastic; Cytidine Deaminase; Deoxycytidine; Enzyme Inhibitors; Gemcitabine; Growth Inhibitors; Humans; Male; Mice; Mice, Nude; Substrate Specificity; Tumor Cells, Cultured	1998
High susceptibility of human cancer xenografts with higher levels of cytidine deaminase to a 2'-deoxycytidine antimetabolite, 2'-deoxy-2'-methylidenecytidine. Clinical cancer research : an official journal of the American Association for Cancer Research, 1998, Volume: 4, Issue:2 Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Cytidine Deaminase; Deoxycytidine; Disease Susceptibility; Enzyme Inhibitors; Female; Gemcitabine; Humans; Kinetics; Male; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neoplasms; Transplantation, Heterologous; Tumor Cells, Cultured	1998

Article

Year

The antiproliferative activity of DMDC is modulated by inhibition of cytidine deaminase.

Cancer research, 1998, Mar-15, Volume: 58, Issue:6

Topics: Animals; Antimetabolites, Antineoplastic; Cytidine Deaminase; Deoxycytidine; Enzyme Inhibitors; Gemcitabine; Growth Inhibitors; Humans; Male; Mice; Mice, Nude; Substrate Specificity; Tumor Cells, Cultured

1998

High susceptibility of human cancer xenografts with higher levels of cytidine deaminase to a 2'-deoxycytidine antimetabolite, 2'-deoxy-2'-methylidenecytidine.

Clinical cancer research : an official journal of the American Association for Cancer Research, 1998, Volume: 4, Issue:2

Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Cytidine Deaminase; Deoxycytidine; Disease Susceptibility; Enzyme Inhibitors; Female; Gemcitabine; Humans; Kinetics; Male; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neoplasms; Transplantation, Heterologous; Tumor Cells, Cultured

1998