2'-deoxy-2'-methylenecytidine has been researched along with deoxycytidine in 28 studies
| Studies (2'-deoxy-2'-methylenecytidine) | Trials (2'-deoxy-2'-methylenecytidine) | Recent Studies (post-2010) (2'-deoxy-2'-methylenecytidine) | Studies (deoxycytidine) | Trials (deoxycytidine) | Recent Studies (post-2010) (deoxycytidine) |
|---|---|---|---|---|---|
| 30 | 2 | 0 | 18,160 | 4,652 | 8,898 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.57) | 18.7374 |
| 1990's | 16 (57.14) | 18.2507 |
| 2000's | 11 (39.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hassan, AA; Matsuda, A | 1 |
| Fukuoka, M; Matsui, K | 1 |
| Celewicz, L; Shetlar, MD | 1 |
| Balzarini, J; Borchardt, RT; De Clercq, E; Lee, Y; Robins, MJ; Samano, V; Yuan, CS; Zhang, W | 1 |
| Birnbaum, GI; Cheng, YC; Clarke-Katzenburg, RH; Gabe, EJ; Giziewicz, J; Lin, TS; Liu, MC; Luo, MZ; Mancini, WR; Prusoff, WH | 1 |
| Matsuda, A; Sasaki, T; Takenuki, K; Tanaka, M; Ueda, T | 1 |
| Arita, M; Fujii, A; Matsuda, A; Okumoto, T; Sakata, S; Sasaki, T; Ueda, T; Yamagami, K | 1 |
| Baker, CH; Banzon, J; Bollinger, JM; Jarvi, E; Lippert, B; Resvick, R; Robins, MJ; Samano, V; Stubbe, J | 1 |
| Fujii, A; Matsuda, A; Sasaki, T; Takenuki, K; Ueda, T; Yamagami, K | 1 |
| Tsukagoshi, S | 2 |
| Machida, H; Matsuda, A; Miura, S; Sakata, S; Sasaki, T; Satoh, H; Tanaka, M; Yoshimura, Y | 1 |
| Fujii, A; Hosoya, M; Matsuda, A; Okumoto, T; Ono, T; Sakata, S; Sasaki, T; Yamagami, K | 1 |
| Ariyoshi, Y; Fukuoka, M; Fukuyama, E; Furue, H; Furuse, K; Gemma, A; Harada, M; Hasegawa, K; Horikoshi, N; Kanamaru, R; Kudoh, S; Kurihara, M; Kurita, Y; Mori, K; Niitani, H; Ota, K; Taguchi, T; Tsukagoshi, S; Wakui, A; Yoneda, S | 1 |
| Matsuda, A | 1 |
| Eda, H; F-Ouchi, K; Ishitsuka, H; Miwa, M; Tanaka, Y; Ura, M | 1 |
| Eda, H; Foley, LH; Ishitsuka, H; Keith, DD; Miwa, M; Ouchi, KF; Ura, M | 1 |
| Fukuoka, M; Kudoh, S; Masuda, N; Matsui, K; Myobudani, H; Nakagawa, K; Negoro, S; Nemoto, S; Nihira, S; Nogami, T; Ogawa, K; Okuda, T; Takeda, K; Takifuji, N; Yamada, M; Yamamoto, N | 1 |
| Brindley, CJ; Devlin, AJ; Funaki, T; Gordon, RJ; Morrison, R; van der Gaast, A; Verweij, L | 1 |
| Brindley, CJ; Devlin, AJ; Friberg, LE; Karlsson, MO | 1 |
| Honma, Y; Ishii, Y; Matsuda, A; Niitsu, N | 1 |
| Kodama, T; Matsuda, A; Nomura, M; Shuto, S | 1 |
| Endo, Y; Matsuda, A; Obata, T; Sasaki, T; Tanaka, M; Uchida, H | 1 |
| Higashihara, M; Honma, Y; Niitsu, N | 1 |
| Friberg, LE; Henningsson, A; Karlsson, MO; Maas, H; Nguyen, L | 1 |
| Aso, K; Hattori, K; Inagaki, Y; Ishitsuka, H; Isshiki, Y; Kohchi, Y; Miwa, M; Mizuguchi, E; Ogawa, K; Oikawa, N; Okabe, H; Shimma, N; Shirai, H; Ura, M; Yoshinari, K | 1 |
| Horii, I; Kawashima, A; Kobayashi, K; Nakano, K; Shindoh, H; Shishido, N | 1 |
| Basaran, P; Basaran-Akgul, N; Churey, JJ; Worobo, RW | 1 |
5 review(s) available for 2'-deoxy-2'-methylenecytidine and deoxycytidine
| Article | Year |
|---|---|
[New antitumor antimetabolites--gemcitabine and DMDC].
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Deoxycytidine; Drug Administration Schedule; Female; Gemcitabine; Humans; Lung Neoplasms; Male | 1992 |
[Development of antimetabolites, II].
Topics: Aminopterin; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Cytarabine; Deoxycytidine; Humans; Leukemia L1210; Methotrexate; Mice; Trimetrexate | 1993 |
[Recent development of antitumor antimetabolites in Japan--cytosine arabinoside analogues].
Topics: Animals; Antimetabolites, Antineoplastic; Arabinonucleotides; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Cytarabine; Cytidine Monophosphate; Deoxycytidine; Gemcitabine; Humans; Lung Neoplasms; Mice; Neoplasm Transplantation | 1997 |
[Nucleoside kinases and new types of antitumor nucleosides].
Topics: Antimetabolites, Antineoplastic; Cytarabine; Deoxycytidine; Gemcitabine; Humans; Nucleic Acid Synthesis Inhibitors; Phosphotransferases | 1997 |
Clinical pharmacokinetics of 2'-deoxy-2'-methylidenecytidine (DMDC), a deoxycytidine analogue antineoplastic agent.
Topics: Animals; Antineoplastic Agents; Deoxycytidine; Humans | 2000 |
2 trial(s) available for 2'-deoxy-2'-methylenecytidine and deoxycytidine
| Article | Year |
|---|---|
[Phase I study on DMDC].
Topics: Aged; Antineoplastic Agents; Colonic Neoplasms; Deoxycytidine; Drug Administration Schedule; Esophageal Neoplasms; Female; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Middle Aged; Stomach Neoplasms | 1996 |
Phase I trial of oral 2'-deoxy-2'-methylidenecytidine: on a daily x 14-day schedule.
Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Deoxycytidine; Deoxyuridine; Dose-Response Relationship, Drug; Female; Humans; Lung Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Time Factors | 2000 |
21 other study(ies) available for 2'-deoxy-2'-methylenecytidine and deoxycytidine
| Article | Year |
|---|---|
Synthesis of 3'-substituted-2',3'-deoxy-2'-methylidenepyrimidine nucleosides.
Topics: Deoxycytidine; Pyrimidine Nucleosides | 1992 |
The photochemistry of 5-methylcytosine and 5-methyl-2'-deoxycytidine in aqueous solution.
Topics: 5-Methylcytosine; Antineoplastic Agents; Cytosine; Deoxycytidine; Photochemistry; Ultraviolet Rays | 1992 |
Nucleic acid related compounds. 74. Synthesis and biological activity of 2'(and 3')-deoxy-2'(and 3')-methylenenucleoside analogues that function as mechanism-based inhibitors of S-adenosyl-L-homocysteine hydrolase and/or ribonucleotide reductase.
Topics: Adenosylhomocysteinase; Animals; Antineoplastic Agents; Antiviral Agents; Cell Division; Deoxyadenosines; Deoxycytidine; Deoxyguanosine; Humans; Hydrolases; Mice; Molecular Structure; Nucleosides; Ribonucleotide Reductases; Structure-Activity Relationship; Tumor Cells, Cultured; Virus Replication | 1992 |
Synthesis and anticancer and antiviral activities of various 2'- and 3'-methylidene-substituted nucleoside analogues and crystal structure of 2'-deoxy-2'-methylidenecytidine hydrochloride.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Chemical Phenomena; Chemistry; Crystallization; Cytarabine; Deoxycytidine; Female; Humans; Leukemia L1210; Leukemia P388; Leukemia, Lymphoid; Mice; Molecular Structure; Nucleosides; Sarcoma 180; Simplexvirus; Tumor Cells, Cultured; X-Ray Diffraction | 1991 |
Nucleosides and nucleotides. 97. Synthesis of new broad spectrum antineoplastic nucleosides, 2'-deoxy-2'-methylidenecytidine (DMDC) and its derivatives.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chemical Phenomena; Chemistry; Deoxycytidine; Female; Humans; Leukemia L1210; Mice; Structure-Activity Relationship | 1991 |
Antitumor activity of 2'-deoxy-2'-methylidenecytidine, a new 2'-deoxycytidine derivative.
Topics: Animals; Cytarabine; Deoxycytidine; Drug Administration Schedule; Drug Screening Assays, Antitumor; Female; Humans; Leukemia P388; Male; Melanoma; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasms; Tumor Cells, Cultured | 1991 |
2'-Deoxy-2'-methylenecytidine and 2'-deoxy-2',2'-difluorocytidine 5'-diphosphates: potent mechanism-based inhibitors of ribonucleotide reductase.
Topics: Cytosine; Deoxycytidine; Deoxycytosine Nucleotides; Dithiothreitol; Escherichia coli; Ribonucleotide Reductases; Spectrophotometry, Ultraviolet | 1991 |
Design, synthesis, and antineoplastic activity of 2'-deoxy-2'-methylidenecytidine.
Topics: Antineoplastic Agents; Cytarabine; Deoxycytidine; Fluorouracil; Humans; Tumor Cells, Cultured | 1988 |
In vitro and in vivo antitumor activity of a novel nucleoside, 4'-thio-2'-deoxy-2'-methylidenecytidine.
Topics: Animals; Antineoplastic Agents; Cytidine Deaminase; Deoxycytidine; DNA Replication; Female; Humans; Mice; Phosphorylation; Protein Biosynthesis; RNA; Thionucleosides; Tumor Cells, Cultured | 1996 |
Cell kill kinetics of an antineoplastic nucleoside, 1-(2-deoxy-2-methylene-beta-D-erythro-pentofuranosyl)cytosine.
Topics: Antineoplastic Agents; Cell Cycle; Cell Death; Cytarabine; Deoxycytidine; Deoxycytosine Nucleotides; Humans; Kinetics; Phosphorylation; S Phase; Tumor Cells, Cultured | 1996 |
The antiproliferative activity of DMDC is modulated by inhibition of cytidine deaminase.
Topics: Animals; Antimetabolites, Antineoplastic; Cytidine Deaminase; Deoxycytidine; Enzyme Inhibitors; Gemcitabine; Growth Inhibitors; Humans; Male; Mice; Mice, Nude; Substrate Specificity; Tumor Cells, Cultured | 1998 |
High susceptibility of human cancer xenografts with higher levels of cytidine deaminase to a 2'-deoxycytidine antimetabolite, 2'-deoxy-2'-methylidenecytidine.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Cytidine Deaminase; Deoxycytidine; Disease Susceptibility; Enzyme Inhibitors; Female; Gemcitabine; Humans; Kinetics; Male; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neoplasms; Transplantation, Heterologous; Tumor Cells, Cultured | 1998 |
Models of schedule dependent haematological toxicity of 2'-deoxy-2'-methylidenecytidine (DMDC).
Topics: Antineoplastic Agents; Blood Platelets; Body Fluid Compartments; Carcinoma, Non-Small-Cell Lung; Cell Survival; Colorectal Neoplasms; Deoxycytidine; Drug Administration Schedule; Hematologic Diseases; Humans; Leukocyte Count; Leukocytes; Lung Neoplasms; Models, Biological; Neutropenia; Neutrophils; Platelet Count | 2000 |
Induction of differentiation of acute promyelocytic leukemia cells by a cytidine deaminase-resistant analogue of 1-beta-D-arabinofuranosylcytosine, 1-(2-deoxy-2-methylene-beta-D-erythro-pentofuranosyl)cytidine.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Differentiation; Cell Division; Cytarabine; Cytidine Deaminase; Deoxycytidine; Drug Resistance, Neoplasm; Drug Synergism; Female; Growth Inhibitors; HL-60 Cells; Humans; Leukemia, Promyelocytic, Acute; Male; Middle Aged; Tretinoin; Tumor Cells, Cultured; U937 Cells | 2001 |
An efficient method for the preparation of 1'alpha-branched-chain sugar pyrimidine ribonucleosides from uridine: the first conversion of a natural nucleoside into 1'-substituted ribonucleosides.
Topics: Cyclization; Cytarabine; Cytidine; Deoxycytidine; Glycosylation; Molecular Structure; Organoselenium Compounds; Pyrimidine Nucleosides; Ribonucleosides; Selenium; Silicon; Stereoisomerism; Structure-Activity Relationship; Uridine; Vinyl Compounds | 2001 |
Deletion mutants of human deoxycytidine kinase mRNA in cells resistant to antitumor cytosine nucleosides.
Topics: Antimetabolites, Antineoplastic; Cytarabine; Deoxycytidine; Deoxycytidine Kinase; Drug Resistance, Neoplasm; Fibrosarcoma; Gene Deletion; Gene Expression; Humans; Inhibitory Concentration 50; Melanoma; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2001 |
The catalytic DNA topoisomerase II inhibitor ICRF-193 and all-trans retinoic acid cooperatively induce granulocytic differentiation of acute promyelocytic leukemia cells: candidate drugs for chemo-differentiation therapy against acute promyelocytic leukem
Topics: Antineoplastic Agents; Catalysis; Cell Cycle; Cell Differentiation; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cytarabine; Daunorubicin; Deoxycytidine; Diketopiperazines; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Granulocytes; HL-60 Cells; Humans; Leukemia, Promyelocytic, Acute; Neoplasm Proteins; Neoplastic Stem Cells; Piperazines; Razoxane; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; RNA, Messenger; RNA, Neoplasm; Topoisomerase II Inhibitors; Tretinoin; Tumor Cells, Cultured; U937 Cells | 2002 |
Model of chemotherapy-induced myelosuppression with parameter consistency across drugs.
Topics: Antineoplastic Agents; Bone Marrow; Camptothecin; Deoxycytidine; Docetaxel; Etoposide; Humans; Irinotecan; Leukocytes; Models, Biological; Neutrophils; Paclitaxel; Taxoids; Vinblastine | 2002 |
Design and synthesis of novel prodrugs of 2'-deoxy-2'-methylidenecytidine activated by membrane dipeptidase overexpressed in tumor tissues.
Topics: Antineoplastic Agents; Deoxycytidine; Dipeptidases; Drug Design; Gene Expression Regulation, Neoplastic; Humans; Hydrolysis; Membrane Proteins; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Prodrugs; Structure-Activity Relationship; Tumor Cells, Cultured | 2007 |
Effect of dose regimen on the toxicity of 2'-deoxy-2'-methylidenecytidine (DMDC) in monkeys.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Deoxycytidine; Drug Administration Schedule; Drug Evaluation, Preclinical; Female; Humans; Macaca fascicularis; Male; No-Observed-Adverse-Effect Level; Toxicity Tests | 2007 |
Inactivation of different strains of Escherichia coli O157:H7 in various apple ciders treated with dimethyl dicarbonate (DMDC) and sulfur dioxide (SO2) as an alternative method.
Topics: Beverages; Colony Count, Microbial; Consumer Product Safety; Deoxycytidine; Dose-Response Relationship, Drug; Escherichia coli O157; Food Handling; Food Microbiology; Food Preservation; Food Preservatives; Humans; Hydrogen-Ion Concentration; Malus; Sulfur Dioxide; Temperature; Time Factors | 2009 |