Compounds > 2'-deoxy-2'-methylenecytidine
Page last updated: 2024-09-03

2'-deoxy-2'-methylenecytidine and cytarabine

2'-deoxy-2'-methylenecytidine has been researched along with cytarabine in 11 studies

Compound Research Comparison

Studies
(2'-deoxy-2'-methylenecytidine)		Trials
(2'-deoxy-2'-methylenecytidine)		Recent Studies (post-2010)
(2'-deoxy-2'-methylenecytidine)		Studies
(cytarabine)		Trials
(cytarabine)		Recent Studies (post-2010) (cytarabine)
302015,4872,4243,188

Protein Interaction Comparison

ProteinTaxonomy2'-deoxy-2'-methylenecytidine (IC50)cytarabine (IC50)
nuclear receptor coactivator 3 isoform aHomo sapiens (human)7.533
E3 ubiquitin-protein ligase Mdm2Homo sapiens (human)0.02

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19901 (9.09)18.7374
1990's6 (54.55)18.2507
2000's4 (36.36)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Birnbaum, GI; Cheng, YC; Clarke-Katzenburg, RH; Gabe, EJ; Giziewicz, J; Lin, TS; Liu, MC; Luo, MZ; Mancini, WR; Prusoff, WH1
Arita, M; Fujii, A; Matsuda, A; Okumoto, T; Sakata, S; Sasaki, T; Ueda, T; Yamagami, K1
Fujii, A; Matsuda, A; Sasaki, T; Takenuki, K; Ueda, T; Yamagami, K1
Tsukagoshi, S2
Fujii, A; Hosoya, M; Matsuda, A; Okumoto, T; Ono, T; Sakata, S; Sasaki, T; Yamagami, K1
Matsuda, A1
Honma, Y; Ishii, Y; Matsuda, A; Niitsu, N1
Kodama, T; Matsuda, A; Nomura, M; Shuto, S1
Endo, Y; Matsuda, A; Obata, T; Sasaki, T; Tanaka, M; Uchida, H1
Higashihara, M; Honma, Y; Niitsu, N1

Reviews

3 review(s) available for 2'-deoxy-2'-methylenecytidine and cytarabine

ArticleYear
[Development of antimetabolites, II].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1993, Volume: 20, Issue:1

    Topics: Aminopterin; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Cytarabine; Deoxycytidine; Humans; Leukemia L1210; Methotrexate; Mice; Trimetrexate

1993
[Recent development of antitumor antimetabolites in Japan--cytosine arabinoside analogues].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24, Issue:7

    Topics: Animals; Antimetabolites, Antineoplastic; Arabinonucleotides; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Cytarabine; Cytidine Monophosphate; Deoxycytidine; Gemcitabine; Humans; Lung Neoplasms; Mice; Neoplasm Transplantation

1997
[Nucleoside kinases and new types of antitumor nucleosides].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24, Issue:11

    Topics: Antimetabolites, Antineoplastic; Cytarabine; Deoxycytidine; Gemcitabine; Humans; Nucleic Acid Synthesis Inhibitors; Phosphotransferases

1997

Other Studies

8 other study(ies) available for 2'-deoxy-2'-methylenecytidine and cytarabine

ArticleYear
Synthesis and anticancer and antiviral activities of various 2'- and 3'-methylidene-substituted nucleoside analogues and crystal structure of 2'-deoxy-2'-methylidenecytidine hydrochloride.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:8

    Topics: Animals; Antineoplastic Agents; Antiviral Agents; Chemical Phenomena; Chemistry; Crystallization; Cytarabine; Deoxycytidine; Female; Humans; Leukemia L1210; Leukemia P388; Leukemia, Lymphoid; Mice; Molecular Structure; Nucleosides; Sarcoma 180; Simplexvirus; Tumor Cells, Cultured; X-Ray Diffraction

1991
Antitumor activity of 2'-deoxy-2'-methylidenecytidine, a new 2'-deoxycytidine derivative.
    Cancer research, 1991, May-01, Volume: 51, Issue:9

    Topics: Animals; Cytarabine; Deoxycytidine; Drug Administration Schedule; Drug Screening Assays, Antitumor; Female; Humans; Leukemia P388; Male; Melanoma; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasms; Tumor Cells, Cultured

1991
Design, synthesis, and antineoplastic activity of 2'-deoxy-2'-methylidenecytidine.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:6

    Topics: Antineoplastic Agents; Cytarabine; Deoxycytidine; Fluorouracil; Humans; Tumor Cells, Cultured

1988
Cell kill kinetics of an antineoplastic nucleoside, 1-(2-deoxy-2-methylene-beta-D-erythro-pentofuranosyl)cytosine.
    Biochemical pharmacology, 1996, Oct-25, Volume: 52, Issue:8

    Topics: Antineoplastic Agents; Cell Cycle; Cell Death; Cytarabine; Deoxycytidine; Deoxycytosine Nucleotides; Humans; Kinetics; Phosphorylation; S Phase; Tumor Cells, Cultured

1996
Induction of differentiation of acute promyelocytic leukemia cells by a cytidine deaminase-resistant analogue of 1-beta-D-arabinofuranosylcytosine, 1-(2-deoxy-2-methylene-beta-D-erythro-pentofuranosyl)cytidine.
    Cancer research, 2001, Jan-01, Volume: 61, Issue:1

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Differentiation; Cell Division; Cytarabine; Cytidine Deaminase; Deoxycytidine; Drug Resistance, Neoplasm; Drug Synergism; Female; Growth Inhibitors; HL-60 Cells; Humans; Leukemia, Promyelocytic, Acute; Male; Middle Aged; Tretinoin; Tumor Cells, Cultured; U937 Cells

2001
An efficient method for the preparation of 1'alpha-branched-chain sugar pyrimidine ribonucleosides from uridine: the first conversion of a natural nucleoside into 1'-substituted ribonucleosides.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2001, Jun-01, Volume: 7, Issue:11

    Topics: Cyclization; Cytarabine; Cytidine; Deoxycytidine; Glycosylation; Molecular Structure; Organoselenium Compounds; Pyrimidine Nucleosides; Ribonucleosides; Selenium; Silicon; Stereoisomerism; Structure-Activity Relationship; Uridine; Vinyl Compounds

2001
Deletion mutants of human deoxycytidine kinase mRNA in cells resistant to antitumor cytosine nucleosides.
    Japanese journal of cancer research : Gann, 2001, Volume: 92, Issue:7

    Topics: Antimetabolites, Antineoplastic; Cytarabine; Deoxycytidine; Deoxycytidine Kinase; Drug Resistance, Neoplasm; Fibrosarcoma; Gene Deletion; Gene Expression; Humans; Inhibitory Concentration 50; Melanoma; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured

2001
The catalytic DNA topoisomerase II inhibitor ICRF-193 and all-trans retinoic acid cooperatively induce granulocytic differentiation of acute promyelocytic leukemia cells: candidate drugs for chemo-differentiation therapy against acute promyelocytic leukem
    Experimental hematology, 2002, Volume: 30, Issue:11

    Topics: Antineoplastic Agents; Catalysis; Cell Cycle; Cell Differentiation; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cytarabine; Daunorubicin; Deoxycytidine; Diketopiperazines; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Granulocytes; HL-60 Cells; Humans; Leukemia, Promyelocytic, Acute; Neoplasm Proteins; Neoplastic Stem Cells; Piperazines; Razoxane; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; RNA, Messenger; RNA, Neoplasm; Topoisomerase II Inhibitors; Tretinoin; Tumor Cells, Cultured; U937 Cells

2002