2'-cyano-2'-deoxyarabinofuranosylcytosine has been researched along with gemcitabine in 5 studies
| Studies (2'-cyano-2'-deoxyarabinofuranosylcytosine) | Trials (2'-cyano-2'-deoxyarabinofuranosylcytosine) | Recent Studies (post-2010) (2'-cyano-2'-deoxyarabinofuranosylcytosine) | Studies (gemcitabine) | Trials (gemcitabine) | Recent Studies (post-2010) (gemcitabine) |
|---|---|---|---|---|---|
| 31 | 0 | 6 | 12,523 | 3,208 | 6,923 |
| Protein | Taxonomy | 2'-cyano-2'-deoxyarabinofuranosylcytosine (IC50) | gemcitabine (IC50) |
|---|---|---|---|
| Chain A, DEOXYNUCLEOSIDE KINASE | Drosophila melanogaster (fruit fly) | 0.76 | |
| Equilibrative nucleoside transporter 1 | Homo sapiens (human) | 0.19 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Matsuda, A | 1 |
| Azuma, A; Huang, P; Matsuda, A; Plunkett, W | 1 |
| Benhadji, K; Calvo, F; Chiao, J; Cvitkovic, E; Faivre, S; Galmarini, CM; Ghoul, A; Green, SR; Le Tourneau, C; Raymond, E; Serova, M | 1 |
| Liu, XJ; Nowak, B; Plunkett, W; Wang, YQ | 1 |
| Eshima, K; Fukushima, M; Iizuka, K; Jin, C; Zhang, C | 1 |
1 review(s) available for 2'-cyano-2'-deoxyarabinofuranosylcytosine and gemcitabine
| Article | Year |
|---|---|
[Nucleoside kinases and new types of antitumor nucleosides].
Topics: Antimetabolites, Antineoplastic; Cytarabine; Deoxycytidine; Gemcitabine; Humans; Nucleic Acid Synthesis Inhibitors; Phosphotransferases | 1997 |
4 other study(ies) available for 2'-cyano-2'-deoxyarabinofuranosylcytosine and gemcitabine
| Article | Year |
|---|---|
2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine: a novel anticancer nucleoside analog that causes both DNA strand breaks and G(2) arrest.
Topics: Antineoplastic Agents; CDC2 Protein Kinase; Chromosome Breakage; Cyclin B; Cyclin B1; Cytarabine; Deoxycytidine; DNA, Neoplasm; G2 Phase; Gemcitabine; Humans; Leukemia, Myeloid, Acute; Lymphocytes; Phosphorylation; RNA; Tumor Cells, Cultured | 2001 |
Antiproliferative effects of sapacitabine (CYC682), a novel 2'-deoxycytidine-derivative, in human cancer cells.
Topics: 5'-Nucleotidase; Antineoplastic Agents; Apoptosis; Arabinonucleosides; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Cytarabine; Cytosine; Deoxycytidine; Docetaxel; Drug Resistance, Neoplasm; Drug Synergism; Equilibrative Nucleoside Transporter 1; Gemcitabine; Gene Expression Regulation, Neoplastic; HCT116 Cells; HT29 Cells; Humans; Inhibitory Concentration 50; Molecular Structure; Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; Taxoids | 2007 |
Sapacitabine, the prodrug of CNDAC, is a nucleoside analog with a unique action mechanism of inducing DNA strand breaks.
Topics: Animals; Antimetabolites, Antineoplastic; Arabinonucleosides; CHO Cells; Cricetinae; Cricetulus; Cytarabine; Cytosine; Deoxycytidine; DNA Breaks, Double-Stranded; DNA Repair; DNA-Binding Proteins; Gemcitabine; Homologous Recombination; Inhibitory Concentration 50; Prodrugs | 2012 |
Analysis of the prolonged infusion of DFP-10917, a deoxycytidine analog, as a therapeutic strategy for the treatment of human tumor xenografts in vivo.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cytarabine; Deoxycytidine; DNA Breaks, Double-Stranded; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; G2 Phase Cell Cycle Checkpoints; Gemcitabine; Humans; Infusions, Intravenous; Isoflurophate; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mice, SCID; Neoplasms; Paclitaxel; Xenograft Model Antitumor Assays | 2018 |