2--amino-2--deoxyguanosine and phosphoramidite

2--amino-2--deoxyguanosine has been researched along with phosphoramidite* in 1 studies

Other Studies

1 other study(ies) available for 2--amino-2--deoxyguanosine and phosphoramidite

ArticleYear
Improved synthesis of 2'-amino-2'-deoxyguanosine and its phosphoramidite.
    Bioorganic & medicinal chemistry, 2006, Feb-01, Volume: 14, Issue:3

    2'-Amino-2'-deoxynucleosides and oligonucleotides containing them have proven highly effective for an array of biochemical applications. The guanosine analogue and its phosphoramidite derivatives have been accessed previously from 2'-amino-2'-deoxyuridine by transglycosylation, but with limited overall efficiency and convenience. Using simple modifications of known reaction types, we have developed useful protocols to obtain 2'-amino-2'-deoxyguanosine and two of its phosphoramidite derivatives with greater convenience, fewer steps, and higher yields than reported previously. These phosphoramidites provide effective synthons for the incorporation of 2'-amino-2'-deoxyguanosine into oligonucleotides.

    Topics: Deoxyguanosine; Methods; Oligonucleotides; Organophosphorus Compounds

2006