2--amino-2--deoxyguanosine has been researched along with phosphoramidite* in 1 studies
1 other study(ies) available for 2--amino-2--deoxyguanosine and phosphoramidite
Article | Year |
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Improved synthesis of 2'-amino-2'-deoxyguanosine and its phosphoramidite.
2'-Amino-2'-deoxynucleosides and oligonucleotides containing them have proven highly effective for an array of biochemical applications. The guanosine analogue and its phosphoramidite derivatives have been accessed previously from 2'-amino-2'-deoxyuridine by transglycosylation, but with limited overall efficiency and convenience. Using simple modifications of known reaction types, we have developed useful protocols to obtain 2'-amino-2'-deoxyguanosine and two of its phosphoramidite derivatives with greater convenience, fewer steps, and higher yields than reported previously. These phosphoramidites provide effective synthons for the incorporation of 2'-amino-2'-deoxyguanosine into oligonucleotides. Topics: Deoxyguanosine; Methods; Oligonucleotides; Organophosphorus Compounds | 2006 |