Compounds > 2--amino-2--deoxyadenosine

2--amino-2--deoxyadenosine and phosphoramidic-acid

2--amino-2--deoxyadenosine has been researched along with phosphoramidic-acid* in 1 studies

Other Studies

1 other study(ies) available for 2--amino-2--deoxyadenosine and phosphoramidic-acid

ArticleYear
2-Amino-alpha-2'-deoxyadenosine increased duplex stability of methoxyethylphosphoramidate alpha-oligodeoxynucleotides with RNA target.
    Bioorganic & medicinal chemistry letters, 2002, Jun-03, Volume: 12, Issue:11

    A new efficient synthesis of 2-amino-alpha-2'-deoxyadenosine and its incorporation into methoxyethylphosphoramidate alpha-oligodeoxynucleotides (ODNs) via H-phosphonate chemistry were reported. Thermal denaturation experiments demonstrated a significant stabilization of the complexes formed between these analogues and their RNA target (+2 degrees C/NH2A) relative to adenosine-containing phosphoramidate alpha-oligonucleotides. Concerning the binding specificity of these modified ODNs, unlike natural ODNs, discrimination against G pairing is higher and against C pairing is lower.

    Topics: Amides; Base Sequence; Cytosine; Deoxyadenosines; DNA, Complementary; Guanosine; Hot Temperature; Nucleic Acid Denaturation; Nucleic Acid Heteroduplexes; Nucleic Acid Hybridization; Oligodeoxyribonucleotides; Phosphoric Acids; RNA

2002