2--acetylacteoside and isoacteoside

Phytochemical investigation on the EtOH extract from the aerial part of Callicarpa kwangtungensis led to the isolation and characterization of 10 caffeoyl phenylethanoid glycosides, 2'-acetylacteoside (1), tubuloside E (2), acteoside (3), tubuloside B (4), isoacteoside (5), alyssonoside (6), 2'-acetylforsythoside B (7), brandioside (8), forsythoside B (9), and poliumoside (10). Compound 4 was isolated from the plants of Verbenaceae,and 6 was obtained from the Callicarpa genus, for the first time, while compounds 1, 2, 5 and 7 were firstly reported from the plant.

Topics: Caffeic Acids; Catechols; Chromatography, High Pressure Liquid; Ethanol; Glucosides; Glycosides; Phenols; Verbenaceae

Four phenylethanoids isolated from the stems of Cistanche deserticola, acteoside (1), 2'-acetylacteoside (2), isoacteoside (3) and tubuloside B (4), significantly suppressed NADPH/CCl4-induced lipid peroxidation in rat liver microsomes. Addition of them to primary cultured rat hepatocytes efficiently prevented cell damage induced by exposure to CCl4 or D-galactosamine (D-GalN). Acteoside (1) further showed pronounced anti-hepatotoxic activity against CCl4 in vivo.

Topics: Animals; Carbon Tetrachloride; Cell Survival; Cells, Cultured; Glucosides; Lipid Peroxidation; Liver; Male; Medicine, Chinese Traditional; Microsomes, Liver; Molecular Structure; Phenols; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar