Page last updated: 2024-09-03

2',6'-pipecoloxylidide and ropivacaine

2',6'-pipecoloxylidide has been researched along with ropivacaine in 9 studies

Compound Research Comparison

Studies (2',6'-pipecoloxylidide)	Trials (2',6'-pipecoloxylidide)	Recent Studies (post-2010) (2',6'-pipecoloxylidide)	Studies (ropivacaine)	Trials (ropivacaine)	Recent Studies (post-2010) (ropivacaine)
34	2	2	3,869	1,982	1,857

Research

Studies (9)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (33.33)	18.2507
2000's	4 (44.44)	29.6817
2010's	2 (22.22)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Arvidsson, T; Bruce, HF; Halldin, MM	1
Butterworth, J; Grimes, J; James, RL	1
Chevanne, F; Dollo, G; Le Corre, P; Le Verge, R; Reif, S	1
Haasio, J; Jokinen, M; Neuvonen, PJ; Pere, P; Rosenberg, PH; Salonen, M	1
Ahonen, J; Jokinen, MJ; Neuvonen, PJ; Olkkola, KT	1
Berggren, S; Ekelund, M; Hoogstraate, J; Lennernäs, H; Lennernäs, P; Weström, B	1
Honda, K; Inomata, S; Nakamura, T; Tanaka, E	1
Ekstrand, A; Henriksson, J; Honkanen, E; Pere, PJ; Rosenberg, PH; Salonen, M; Sjövall, J	1
Aarons, L; Henriksson, J; Molnár, V; Pitsiu, M; Sadler, B; Sjövall, J	1

Trials

1 trial(s) available for 2',6'-pipecoloxylidide and ropivacaine

Article	Year
Effect of ciprofloxacin on the pharmacokinetics of ropivacaine. European journal of clinical pharmacology, 2003, Volume: 58, Issue:10 Topics: Adult; Amides; Anesthetics, Local; Anti-Infective Agents; Area Under Curve; Bupivacaine; Ciprofloxacin; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Double-Blind Method; Drug Interactions; Female; Humans; Male; Ropivacaine; Stereoisomerism	2003

Article

Year

Effect of ciprofloxacin on the pharmacokinetics of ropivacaine.

European journal of clinical pharmacology, 2003, Volume: 58, Issue:10

Topics: Adult; Amides; Anesthetics, Local; Anti-Infective Agents; Area Under Curve; Bupivacaine; Ciprofloxacin; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Double-Blind Method; Drug Interactions; Female; Humans; Male; Ropivacaine; Stereoisomerism

2003

Other Studies

8 other study(ies) available for 2',6'-pipecoloxylidide and ropivacaine

Article	Year
Lack of metabolic racemisation of ropivacaine, determined by liquid chromatography using a chiral AGP column. Chirality, 1995, Volume: 7, Issue:4 Topics: Amides; Anesthetics, Local; Animals; Bupivacaine; Chromatography, Liquid; Dogs; Female; Male; Pregnancy; Rats; Ropivacaine; Sheep; Species Specificity; Spectrophotometry, Ultraviolet; Stereoisomerism	1995
Structure-affinity relationships and stereospecificity of several homologous series of local anesthetics for the beta2-adrenergic receptor. Anesthesia and analgesia, 1997, Volume: 85, Issue:2 Topics: Adrenergic beta-2 Receptor Antagonists; Adrenergic beta-Antagonists; Adult; Alkanes; Amides; Anesthetics, Local; Blood Vessels; Bupivacaine; Cyclic AMP; Dihydroalprenolol; Drug Overdose; Etidocaine; Female; Heart; Humans; Injections, Intravenous; Lidocaine; Ligands; Male; Mepivacaine; Molecular Conformation; Molecular Structure; Nerve Block; Pipecolic Acids; Prilocaine; Procaine; Receptors, Adrenergic, beta-2; Ropivacaine; Stereoisomerism; Structure-Activity Relationship; Tetracaine; Tritium	1997
High-performance liquid chromatographic determination of ropivacaine, 3-hydroxy-ropivacaine, 4-hydroxy-ropivacaine and 2',6'-pipecoloxylidide in plasma. Journal of chromatography. B, Biomedical sciences and applications, 1998, Nov-20, Volume: 719, Issue:1-2 Topics: Amides; Anesthetics, Local; Animals; Bupivacaine; Chromatography, High Pressure Liquid; Rabbits; Ropivacaine; Sensitivity and Specificity; Spectrophotometry, Ultraviolet	1998
Pharmacokinetics of ropivacaine in uremic and nonuremic patients after axillary brachial plexus block. Anesthesia and analgesia, 2003, Volume: 96, Issue:2 Topics: Aged; Amides; Anesthetics, Local; Area Under Curve; Biotransformation; Brachial Plexus; Bupivacaine; Female; Forearm; Hand; Hand Strength; Humans; Male; Middle Aged; Nerve Block; Orosomucoid; Pain Measurement; Protein Binding; Ropivacaine; Uremia	2003
Regional transport and metabolism of ropivacaine and its CYP3A4 metabolite PPX in human intestine. The Journal of pharmacy and pharmacology, 2003, Volume: 55, Issue:7 Topics: Amides; Anesthetics, Local; Biological Transport, Active; Bupivacaine; Colon; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Female; Humans; Ileum; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Jejunum; Male; Permeability; Ropivacaine	2003
Effects of premedication medicines on the formation of the CYP3A4-dependent metabolite of ropivacaine, 2', 6'-Pipecoloxylidide, on human liver microsomes in vitro. Basic & clinical pharmacology & toxicology, 2006, Volume: 98, Issue:2 Topics: Amides; Anesthetics, Local; Bupivacaine; Cells, Cultured; Cimetidine; Clonidine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diazepam; Drug Interactions; Humans; Lidocaine; Microsomes, Liver; Midazolam; Premedication; Ropivacaine; Thiamylal; Vecuronium Bromide	2006
Pharmacokinetics of ropivacaine in patients with chronic renal failure. British journal of anaesthesia, 2011, Volume: 106, Issue:4 Topics: Adult; Aged; Amides; Anesthetics, Local; Bupivacaine; Creatinine; Female; Follow-Up Studies; Humans; Kidney Failure, Chronic; Male; Middle Aged; Orosomucoid; Ropivacaine	2011
Population pharmacokinetic analysis of ropivacaine and its metabolite 2',6'-pipecoloxylidide from pooled data in neonates, infants, and children. British journal of anaesthesia, 2011, Volume: 107, Issue:3 Topics: Age Factors; Amides; Anesthetics, Local; Body Weight; Bupivacaine; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Male; Metabolic Clearance Rate; Models, Biological; Orosomucoid; Protein Binding; Ropivacaine	2011