2',6'-pipecoloxylidide has been researched along with bupivacaine in 34 studies
| Studies (2',6'-pipecoloxylidide) | Trials (2',6'-pipecoloxylidide) | Recent Studies (post-2010) (2',6'-pipecoloxylidide) | Studies (bupivacaine) | Trials (bupivacaine) | Recent Studies (post-2010) (bupivacaine) |
|---|---|---|---|---|---|
| 34 | 2 | 2 | 12,968 | 4,843 | 3,530 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (11.76) | 18.7374 |
| 1990's | 21 (61.76) | 18.2507 |
| 2000's | 7 (20.59) | 29.6817 |
| 2010's | 2 (5.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hung, MF; Kastrissios, H; Triggs, EJ | 1 |
| Heavner, JE; Rosenberg, PH | 1 |
| Pere, P; Rosenberg, PH; Tuominen, M | 1 |
| Hekali, R; Pere, P; Rosenberg, PH; Tuominen, M | 1 |
| Kanto, J; Karanko, M; Kiilholma, P; Lindberg, R; Pihlajamäki, K | 1 |
| Bovill, JG; Dokter, PW; Odoom, JA; Oosting, J; Sturk, A; ten Cate, JW | 1 |
| Kanto, JH; Lindberg, RL; Pihlajamäki, KK | 1 |
| Gross, TL; Kuhnert, BR; Kuhnert, PM; Stitts, JM | 1 |
| Ericson, J; Lesko, LJ; Marion, A; Ostheimer, G | 1 |
| Bruguerolle, B; Coquet, M; Giaufré, E; Lorec, AM; Rastello, C | 1 |
| Attolini, L; Bruguerolle, B; Gantenbein, M; Lorec, AM | 1 |
| Arvidsson, T; Bruce, HF; Halldin, MM | 1 |
| Attolini, L; Bruguerolle, B; Gantenbein, M | 3 |
| Attolini, L; Bruguerolle, B; Lorec, AM; Roucoules, X | 3 |
| Dauphin, A; Gupta, RN | 1 |
| Bruguerolle, B; Lorec, AM | 1 |
| Butterworth, J; Grimes, J; James, RL | 1 |
| Chevanne, F; Dollo, G; Le Corre, P; Le Verge, R; Reif, S | 1 |
| Faibushevich, AA; Lunte, CE; McLaughlin, KJ; Schieferecke, MA | 1 |
| Bruguerolle, B; Gamerre, M; Lorec, AM; Martin, C; Ortega, D; Viviand, X | 1 |
| Armstrong, KP; Bennett, J; Chess, DG; Ganapathy, S; MacDonald, C; Stockall, CA; Wasserman, RA; Watson, JT | 1 |
| Attolini, L; Bruguerolle, B; Durand, A; Gantenbein, M; Hardwigsen, J; Lacarelle, B; Le-Treut, YP; Puyoou, F; Villard, PH | 1 |
| Haasio, J; Jokinen, M; Neuvonen, PJ; Pere, P; Rosenberg, PH; Salonen, M | 1 |
| Ahonen, J; Jokinen, MJ; Neuvonen, PJ; Olkkola, KT | 1 |
| Krisko, RM; Lunte, CE; Schieferecke, MA; Williams, TD | 1 |
| Berggren, S; Ekelund, M; Hoogstraate, J; Lennernäs, H; Lennernäs, P; Weström, B | 1 |
| Ledger, R | 1 |
| Honda, K; Inomata, S; Nakamura, T; Tanaka, E | 1 |
| Ekstrand, A; Henriksson, J; Honkanen, E; Pere, PJ; Rosenberg, PH; Salonen, M; Sjövall, J | 1 |
| Aarons, L; Henriksson, J; Molnár, V; Pitsiu, M; Sadler, B; Sjövall, J | 1 |
2 trial(s) available for 2',6'-pipecoloxylidide and bupivacaine
| Article | Year |
|---|---|
Modified continuous femoral three-in-one block for postoperative pain after total knee arthroplasty.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia, Spinal; Anesthetics, Local; Arthroplasty, Replacement, Knee; Bupivacaine; Female; Fentanyl; Humans; Male; Morphine; Nerve Block; Pain Measurement; Pain, Postoperative | 1999 |
Effect of ciprofloxacin on the pharmacokinetics of ropivacaine.
Topics: Adult; Amides; Anesthetics, Local; Anti-Infective Agents; Area Under Curve; Bupivacaine; Ciprofloxacin; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Double-Blind Method; Drug Interactions; Female; Humans; Male; Ropivacaine; Stereoisomerism | 2003 |
32 other study(ies) available for 2',6'-pipecoloxylidide and bupivacaine
| Article | Year |
|---|---|
High-performance liquid chromatographic method for the quantitation of bupivacaine, 2,6-pipecoloxylidide and 4'-hydroxybupivacaine in plasma and urine.
Topics: Bupivacaine; Chromatography, High Pressure Liquid; Humans; Infusions, Intravenous; Reproducibility of Results; Spectrophotometry, Ultraviolet | 1992 |
Acute cardiovascular and central nervous system toxicity of bupivacaine and desbutylbupivacaine in the rat.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Bupivacaine; Depression, Chemical; Electroencephalography; Male; Rats; Rats, Inbred Strains; Seizures | 1992 |
Cumulation of bupivacaine, desbutylbupivacaine and 4-hydroxybupivacaine during and after continuous interscalene brachial plexus block.
Topics: Adult; Brachial Plexus; Bupivacaine; Female; Humans; Male; Middle Aged; Nerve Block | 1991 |
Plasma concentrations of bupivacaine and two of its metabolites during continuous interscalene brachial plexus block.
Topics: Adult; Aged; Biotransformation; Brachial Plexus; Bupivacaine; Female; Humans; Male; Middle Aged; Nerve Block; Orosomucoid; Pain, Postoperative; Time Factors | 1991 |
Extradural administration of bupivacaine: pharmacokinetics and metabolism in pregnant and non-pregnant women.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Epidural; Anesthesia, Obstetrical; Bupivacaine; Cesarean Section; Female; Humans; Middle Aged; Pregnancy | 1990 |
The effects of bupivacaine and pipecoloxylidide on platelet function in vitro.
Topics: Adult; beta-Thromboglobulin; Blood Platelets; Bupivacaine; Female; Humans; In Vitro Techniques; Male; Platelet Aggregation; Platelet Aggregation Inhibitors | 1989 |
Simultaneous determination of bupivacaine and its two metabolites, desbutyl- and 4'-hydroxybupivacaine, in human serum and urine.
Topics: Aged; Anesthesia, Epidural; Bupivacaine; Chromatography, High Pressure Liquid; Female; Humans; Indicators and Reagents | 1986 |
The use of a selected ion monitoring technique to study the disposition of bupivacaine in mother, fetus, and neonate following epidural anesthesia for cesarean section.
Topics: Anesthesia, Epidural; Anesthesia, Obstetrical; Bupivacaine; Cesarean Section; Chromatography, Gas; Female; Fetus; Humans; Infant, Newborn; Mass Spectrometry; Maternal-Fetal Exchange; Pregnancy; Umbilical Cord | 1981 |
Simultaneous determination of bupivacaine and 2,6-pipecoloxylidide in serum by gas-liquid chromatography.
Topics: Bupivacaine; Chromatography, Gas; Female; Fetal Blood; Humans; Infant, Newborn; Labor, Obstetric; Lidocaine; Maternal-Fetal Exchange; Pregnancy | 1980 |
New regimen for interpleural block in children.
Topics: Analgesia; Anesthesia, Epidural; Anesthetics, Local; Bupivacaine; Child; Child, Preschool; Humans; Infant; Nerve Block; Orosomucoid; Pain Measurement; Pain, Postoperative; Pleura; Pleural Effusion; Pneumonectomy; Safety | 1995 |
Kinetics of bupivacaine after clonidine pretreatment in mice.
Topics: Animals; Biological Availability; Bupivacaine; Clonidine; Half-Life; Liver; Male; Metabolic Clearance Rate; Mice; Mice, Inbred Strains | 1995 |
Lack of metabolic racemisation of ropivacaine, determined by liquid chromatography using a chiral AGP column.
Topics: Amides; Anesthetics, Local; Animals; Bupivacaine; Chromatography, Liquid; Dogs; Female; Male; Pregnancy; Rats; Ropivacaine; Sheep; Species Specificity; Spectrophotometry, Ultraviolet; Stereoisomerism | 1995 |
Acute toxicity of bupivacaine metabolites in mice.
Topics: Animals; Biotransformation; Bupivacaine; Convulsants; Injections, Intraperitoneal; Male; Mice; Pipecolic Acids | 1994 |
Rapid simultaneous determination of lidocaine, bupivacaine, and their two main metabolites using capillary gas-liquid chromatography with nitrogen phosphorus detector.
Topics: Bupivacaine; Chromatography, Gas; Humans; Lidocaine; Nitrogen; Phosphorus; Reproducibility of Results | 1994 |
Cigarette smoke increases bupivacaine metabolism in rats.
Topics: Animals; Bupivacaine; Half-Life; Male; Metabolic Clearance Rate; Rats; Rats, Wistar; Smoke; Smoking; Time Factors; Tissue Distribution | 1994 |
Column liquid chromatographic determination of bupivacaine in human serum using solid-phase extraction.
Topics: Acetonitriles; Bupivacaine; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Methanol; Perchlorates; Sensitivity and Specificity | 1994 |
Bupivacaine kinetics during hyperthermia in rats.
Topics: Animals; Body Temperature; Bupivacaine; Fever; Half-Life; Hyperthermia, Induced; Male; Metabolic Clearance Rate; Rats; Rats, Wistar | 1994 |
Bupivacaine kinetic changes induced by diltiazem in mice.
Topics: Animals; Bupivacaine; Diltiazem; Male; Metabolic Clearance Rate; Mice; Mice, Inbred Strains | 1994 |
Effects of tobacco smoke exposure on the kinetics of bupivacaine in mice.
Topics: Anesthetics, Local; Animals; Blood Proteins; Bupivacaine; Erythrocytes; Male; Mice; Mice, Inbred Strains; Nicotiana; Plants, Toxic; Protein Binding; Smoke; Time Factors | 1997 |
Kinetics of bupivacaine after levcromakalim treatment in mice.
Topics: Anesthetics, Local; Animals; Benzopyrans; Bupivacaine; Cromakalim; Drug Synergism; Male; Mice; Pyrroles; Vasodilator Agents | 1997 |
Structure-affinity relationships and stereospecificity of several homologous series of local anesthetics for the beta2-adrenergic receptor.
Topics: Adrenergic beta-2 Receptor Antagonists; Adrenergic beta-Antagonists; Adult; Alkanes; Amides; Anesthetics, Local; Blood Vessels; Bupivacaine; Cyclic AMP; Dihydroalprenolol; Drug Overdose; Etidocaine; Female; Heart; Humans; Injections, Intravenous; Lidocaine; Ligands; Male; Mepivacaine; Molecular Conformation; Molecular Structure; Nerve Block; Pipecolic Acids; Prilocaine; Procaine; Receptors, Adrenergic, beta-2; Ropivacaine; Stereoisomerism; Structure-Activity Relationship; Tetracaine; Tritium | 1997 |
High-performance liquid chromatographic determination of ropivacaine, 3-hydroxy-ropivacaine, 4-hydroxy-ropivacaine and 2',6'-pipecoloxylidide in plasma.
Topics: Amides; Anesthetics, Local; Animals; Bupivacaine; Chromatography, High Pressure Liquid; Rabbits; Ropivacaine; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 1998 |
Determination of bupivacaine and three of its metabolites in rat urine by capillary electrophoresis.
Topics: Anesthetics, Local; Animals; Bupivacaine; Electrophoresis, Capillary; Female; Rats; Rats, Sprague-Dawley | 1998 |
Excretion of lidocaine and bupivacaine in breast milk following epidural anesthesia for cesarean delivery.
Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthetics, Local; Apgar Score; Area Under Curve; Bupivacaine; Cesarean Section; Chromatography, Gas; Female; Follow-Up Studies; Humans; Infant, Newborn; Lidocaine; Milk, Human; Pregnancy; Safety | 1999 |
Oxidative metabolism of bupivacaine into pipecolylxylidine in humans is mainly catalyzed by CYP3A.
Topics: Anesthetics, Local; Animals; Antibodies, Blocking; Aryl Hydrocarbon Hydroxylases; Bupivacaine; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA; Enzyme Inhibitors; Humans; In Vitro Techniques; Insecta; Isoenzymes; Oxidation-Reduction; Oxidoreductases, N-Demethylating | 2000 |
Pharmacokinetics of ropivacaine in uremic and nonuremic patients after axillary brachial plexus block.
Topics: Aged; Amides; Anesthetics, Local; Area Under Curve; Biotransformation; Brachial Plexus; Bupivacaine; Female; Forearm; Hand; Hand Strength; Humans; Male; Middle Aged; Nerve Block; Orosomucoid; Pain Measurement; Protein Binding; Ropivacaine; Uremia | 2003 |
Determination of bupivacaine and metabolites in rat urine using capillary electrophoresis with mass spectrometric detection.
Topics: Animals; Bupivacaine; Electrophoresis, Capillary; Molecular Structure; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization | 2003 |
Regional transport and metabolism of ropivacaine and its CYP3A4 metabolite PPX in human intestine.
Topics: Amides; Anesthetics, Local; Biological Transport, Active; Bupivacaine; Colon; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Female; Humans; Ileum; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Jejunum; Male; Permeability; Ropivacaine | 2003 |
Nonaromatic hydroxylation of bupivacaine during continuous epidural infusion in man.
Topics: Analgesia, Epidural; Anesthetics, Local; Bupivacaine; Chromatography, Liquid; Humans; Hydrocarbons, Aromatic; Hydroxylation; Infusions, Parenteral; Injections, Epidural; Male; Mass Spectrometry; Metabolic Clearance Rate; Stereoisomerism; Urinalysis | 2003 |
Effects of premedication medicines on the formation of the CYP3A4-dependent metabolite of ropivacaine, 2', 6'-Pipecoloxylidide, on human liver microsomes in vitro.
Topics: Amides; Anesthetics, Local; Bupivacaine; Cells, Cultured; Cimetidine; Clonidine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diazepam; Drug Interactions; Humans; Lidocaine; Microsomes, Liver; Midazolam; Premedication; Ropivacaine; Thiamylal; Vecuronium Bromide | 2006 |
Pharmacokinetics of ropivacaine in patients with chronic renal failure.
Topics: Adult; Aged; Amides; Anesthetics, Local; Bupivacaine; Creatinine; Female; Follow-Up Studies; Humans; Kidney Failure, Chronic; Male; Middle Aged; Orosomucoid; Ropivacaine | 2011 |
Population pharmacokinetic analysis of ropivacaine and its metabolite 2',6'-pipecoloxylidide from pooled data in neonates, infants, and children.
Topics: Age Factors; Amides; Anesthetics, Local; Body Weight; Bupivacaine; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Male; Metabolic Clearance Rate; Models, Biological; Orosomucoid; Protein Binding; Ropivacaine | 2011 |