Page last updated: 2024-09-02

2'-5'-oligoadenylate trimer and adenosine

2'-5'-oligoadenylate trimer has been researched along with adenosine in 23 studies

Compound Research Comparison

Studies (2'-5'-oligoadenylate trimer)	Trials (2'-5'-oligoadenylate trimer)	Recent Studies (post-2010) (2'-5'-oligoadenylate trimer)	Studies (adenosine)	Trials (adenosine)	Recent Studies (post-2010) (adenosine)
590	4	88	32,536	1,075	8,930

Protein Interaction Comparison

Protein	Taxonomy	adenosine (IC50)
high affinity choline transporter 1 isoform a	Homo sapiens (human)	0.3851
Sodium/nucleoside cotransporter 1	Homo sapiens (human)	5.5
Sodium/nucleoside cotransporter 2	Homo sapiens (human)	5.5
Adenosine receptor A3	Homo sapiens (human)	0.0011
Adenosine receptor A1	Homo sapiens (human)	0.0023
Equilibrative nucleoside transporter 1	Homo sapiens (human)	63
Solute carrier family 28 member 3	Homo sapiens (human)	3.3

Research

Studies (23)

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (39.13)	18.7374
1990's	8 (34.78)	18.2507
2000's	5 (21.74)	29.6817
2010's	1 (4.35)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Hirota, K; Kitade, Y; Maki, Y; Nakata, Y; Pabuccuoglu, A; Torrence, PF	1
Kawai, G; Nagai, K; Shuhadlnik, RJ; Takaku, H; Yokoyama, S	1
Hirano, A; Mori, H; Sawai, H	1
Kanou, M; Kawai, G; Ohomori, H; Sobol, R; Suhadolnik, RJ; Takaku, H; Yokoyama, S	1
Bayard, B; Lesiak, K; Nolan-Sorden, NL; Silverman, RH; Torrence, PF	1
Johnston, MI; White, JC; Williams, RW	1
Hirota, K; Kitade, Y; Maki, Y; Nakata, Y; Pabuccoglu, A; Torrence, PF	1
Imai, J; Lesiak, K; Sawai, H; Torrence, PF	1
Lesiak, K; Torrence, PF	1
Hubbell, HR; Lee, C; Pequignot, EC; Suhadolnik, RJ; Willis, DH	1
Hayakawa, Y; Nobori, T; Noyori, R	1
Takaku, H; Yoshida, S	1
Black, PL; Charubala, R; Henderson, EE; Pfleiderer, W; Suhadolnik, RJ	1
Crea, R; den Hartog, JA; van Boom, JH; Wijnands, RA	1
Muñoz, M; Ríos, M; Spencer, E; Torrence, PF	1
Ito, T; Kokaji, K; Sawai, H; Shimazu, M; Shinozuka, K	1
Kalinichenko, EN; Mikhailopulo, IA; Player, MR; Podkopaeva, TL; Seela, F; Torrence, PF	1
Kitade, Y; Nakanishi, M; Yatome, C; Yoshimura, A	1
Kitade, Y; Nakanishi, M; Tanida, Y; Tuboi, T; Yatome, C; Yoshimura, A	1
Imanishi, T; Kaneko, M; Kitade, Y; Koizumi, M; Morita, K; Obika, S	1
Ito, Y; Kitade, Y; Mochizuki, M; Nakamura, T; Ueno, Y	1
Kitade, Y; Kitamura, Y; Kito, S; Nagaoka, K; Ueno, Y	1
Kitade, Y; Kitamura, Y; Nagaoka, K; Ueno, Y	1

Other Studies

23 other study(ies) available for 2'-5'-oligoadenylate trimer and adenosine

Article	Year
8-Methyladenosine-substituted analogues of 2-5A: synthesis and their biological activities. Nucleic acids research, 1991, Aug-11, Volume: 19, Issue:15 Topics: Adenine Nucleotides; Adenosine; Animals; Endoribonucleases; Kinetics; Liver Extracts; Magnetic Resonance Spectroscopy; Methylation; Oligoribonucleotides; Phosphodiesterase I; Phosphoric Diester Hydrolases; Protein Biosynthesis; Rats; RNA	1991
Synthesis and biological activities of 8-substituted 2-5A analogues. Nucleic acids symposium series, 1990, Issue:22 Topics: Adenine Nucleotides; Adenosine; Animals; Endoribonucleases; Enzyme Activation; L Cells; Mice; Oligoribonucleotides; RNA, Ribosomal	1990
Uranyl ion-catalyzed synthesis of several 8-substituted 2'-5'-oligoadenylates, and their properties. Nucleic acids symposium series, 1990, Issue:22 Topics: Adenine Nucleotides; Adenosine; Oligonucleotides; Oligoribonucleotides; Polymers; Uranium	1990
Chemical synthesis and biological activities of analogues of 2',5'-oligoadenylates containing 8-substituted adenosine derivatives. Nucleic acids research, 1990, Aug-11, Volume: 18, Issue:15 Topics: Adenine Nucleotides; Adenosine; Chemical Phenomena; Chemistry; Circular Dichroism; Endoribonucleases; Magnetic Resonance Spectroscopy; Molecular Structure; Oligoribonucleotides; Phosphodiesterase I; Phosphoric Diester Hydrolases; RNA, Ribosomal; Uranium	1990
Photochemical crosslinking in oligonucleotide-protein complexes between a bromine-substituted 2-5A analog and 2-5A-dependent RNase by ultraviolet lamp or laser. Analytical biochemistry, 1990, Feb-01, Volume: 184, Issue:2 Topics: Adenine Nucleotides; Adenosine; Affinity Labels; Endoribonucleases; Enzyme Activation; Lasers; Oligoribonucleotides; Photochemistry; Protein Binding; Ultraviolet Rays	1990
Raman spectroscopy of interferon-induced 2',5'-linked oligoadenylates. Biochemistry, 1987, Dec-01, Volume: 26, Issue:24 Topics: Adenine Nucleotides; Adenosine; Adenosine Monophosphate; Adenosine Triphosphate; Deuterium; Deuterium Oxide; Interferons; Nucleic Acid Conformation; Oligoribonucleotides; Spectrum Analysis, Raman; Structure-Activity Relationship; Thermodynamics; Water	1987
8-Methyladenosine-substituted analogs of 2-5A: synthesis and properties. Nucleic acids symposium series, 1989, Issue:21 Topics: Adenine Nucleotides; Adenosine; Oligoribonucleotides; Phosphodiesterase I; Phosphoric Diester Hydrolases	1989
Replacement of the ribofuranose oxygen of 2-5A derivatives by methylene: synthesis of an aristeromycin analogue of 2-5A core 5'-monophosphate (5'-O-phosphoryladenylyl)(2'----5')adenyl(2'----5')adenosine. Journal of medicinal chemistry, 1985, Volume: 28, Issue:9 Topics: Adenine Nucleotides; Adenosine; Animals; Cell Line; Chemical Phenomena; Chemistry; Endonucleases; Endoribonucleases; Enzyme Activation; Half-Life; Humans; L Cells; Lymphocytes; Mice; Oligoribonucleotides; Rabbits; Reticulocytes	1985
Purine 8-bromination modulates the ribonuclease L binding and activation abilities of 2',5'-oligoadenylates. Possible influence of glycosyl torsion angle. The Journal of biological chemistry, 1987, Feb-15, Volume: 262, Issue:5 Topics: Adenine Nucleotides; Adenosine; Chemical Phenomena; Chemistry, Physical; Electrophoresis, Agar Gel; Endoribonucleases; Enzyme Activation; Mathematics; Oligoribonucleotides; Structure-Activity Relationship	1987
Differential antiproliferative actions of 2',5' oligo A trimer core and its cordycepin analogue on human tumor cells. International journal of cancer, 1985, Sep-15, Volume: 36, Issue:3 Topics: Adenine Nucleotides; Adenosine; Cell Division; Cell Line; Coformycin; Culture Techniques; Dose-Response Relationship, Drug; Drug Resistance; Humans; Neoplasms; Oligodeoxyribonucleotides; Oligonucleotides; Oligoribonucleotides; Pentostatin	1985
Synthesis of 2'-end-modified 2'-5'-oligoadenylates. Nucleic acids symposium series, 1985, Issue:16 Topics: Adenine Nucleotides; Adenosine; Indicators and Reagents; Oligoribonucleotides; Structure-Activity Relationship	1985
Synthesis and properties of a modified 2'-5'-adenylate trimer containing 2'-terminal 8-bromoadenosine. Nucleic acids symposium series, 1985, Issue:16 Topics: Adenine Nucleotides; Adenosine; Circular Dichroism; Indicators and Reagents; Nucleic Acid Conformation; Oligoribonucleotides; Structure-Activity Relationship	1985
2',5'-Oligoadenylate trimer core and the cordycepin analog augment the tumoricidal activity of human natural killer cells. Journal of immunology (Baltimore, Md. : 1950), 1984, Volume: 133, Issue:5 Topics: Adenine Nucleotides; Adenosine; Adjuvants, Immunologic; Adult; Cell Line; Cytotoxicity, Immunologic; Deoxyadenosines; Humans; Killer Cells, Natural; Kinetics; Leukemia, Myeloid; Macromolecular Substances; Oligodeoxyribonucleotides; Oligonucleotides; Oligoribonucleotides	1984
Chemical synthesis of an effective inhibitor of protein synthesis in eukaryotic cells: pppA2'-5'A2'-5'A and some analogues. Nucleic acids symposium series, 1980, Issue:7 Topics: Adenine Nucleotides; Adenosine; Indicators and Reagents; Methods; Oligonucleotides; Oligoribonucleotides; Protein Biosynthesis; Structure-Activity Relationship	1980
Effect of interferon and 2',5'-oligoadenylates on rotavirus RNA synthesis. Antiviral research, 1995, Volume: 26, Issue:2 Topics: Adenine Nucleotides; Adenosine; Antiviral Agents; Cell Line; DNA-Directed RNA Polymerases; Humans; Interferon alpha-2; Interferon-alpha; Oligoribonucleotides; Phosphates; Recombinant Proteins; RNA, Messenger; RNA, Viral; Rotavirus	1995
Synthesis and properties of 2',5'-oligoadenylates containing alpha-adenosine. Nucleic acids symposium series, 1995, Issue:34 Topics: Adenine Nucleotides; Adenosine; Chromatography, High Pressure Liquid; Circular Dichroism; Molecular Structure; Oligoribonucleotides	1995
Dissection of the roles of adenine ring nitrogen (N-1) and exocyclic amino (N-6) moieties in the interaction of 2-5A with RNase L. Biochemical and biophysical research communications, 1998, Apr-17, Volume: 245, Issue:2 Topics: Adenine Nucleotides; Adenosine; Endoribonucleases; Enzyme Activation; Humans; Molecular Structure; Oligoribonucleotides; Recombinant Proteins; RNA-Binding Proteins; Tubercidin	1998
Comparative study on the biological properties of 2',5'-oligoadenylate derivatives with purified human RNase L expressed in E. coli. Journal of biochemistry, 2002, Volume: 132, Issue:4 Topics: Adenine Nucleotides; Adenosine; Dimerization; Electrophoresis, Polyacrylamide Gel; Endoribonucleases; Enzyme Activation; Escherichia coli; Gene Expression; Humans; Oligoribonucleotides; Plasmids; Recombinant Proteins; RNA, Ribosomal; Saccharomyces cerevisiae; Stereoisomerism	2002
Synthesis of 2-5As possessing base-modified adenosines and their activities to human recombinant RNase L. Nucleic acids symposium series, 2000, Issue:44 Topics: Adenine Nucleotides; Adenosine; Endoribonucleases; Humans; In Vitro Techniques; Kinetics; Molecular Structure; Oligoribonucleotides; Recombinant Proteins; Substrate Specificity	2000
Biologically stable 2-5A analogues containing 3'-O,4'-C-bridged adenosine as potent RNase L agonists. ChemMedChem, 2007, Volume: 2, Issue:12 Topics: Adenine Nucleotides; Adenosine; Endoribonucleases; Enzyme Activation; Oligoribonucleotides	2007
Synthesis of 2',5'-oligoadenylate analogs possessing a linker moiety in the place of the second adenosine and their ability to activate human RNase L. Nucleic acids symposium series (2004), 2007, Issue:51 Topics: Adenine Nucleotides; Adenosine; Endoribonucleases; Enzyme Activation; Ethylenes; Humans; Oligoribonucleotides	2007
Introduction of 8-methyladenosine into 2', 5'-oligoadenylate (2-5A) 2'-terminus induces dramatic shift in binding site of RNase L. Nucleic acids symposium series (2004), 2009, Issue:53 Topics: Adenine Nucleotides; Adenosine; Binding Sites; Endoribonucleases; Humans; Models, Molecular; Oligoribonucleotides	2009
5'-O-dephosphorylated 2',5'-oligoadenylate (2-5A) with 8-methyladenosine at the 2'-terminus activates human RNase L. Bioorganic & medicinal chemistry letters, 2010, Feb-01, Volume: 20, Issue:3 Topics: Adenine Nucleotides; Adenosine; Animals; Crystallography, X-Ray; Endoribonucleases; Enzyme Activation; Humans; Oligoribonucleotides; Phosphorylation; Recombinant Proteins; Snake Venoms	2010