Page last updated: 2024-09-04

2',4'-dichlorobenzamil amiloride and amiloride

2',4'-dichlorobenzamil amiloride has been researched along with amiloride in 16 studies

Compound Research Comparison

Studies
(2',4'-dichlorobenzamil amiloride)
Trials
(2',4'-dichlorobenzamil amiloride)
Recent Studies (post-2010)
(2',4'-dichlorobenzamil amiloride)
Studies
(amiloride)
Trials
(amiloride)
Recent Studies (post-2010) (amiloride)
18027,584339788

Protein Interaction Comparison

ProteinTaxonomy2',4'-dichlorobenzamil amiloride (IC50)amiloride (IC50)
Urokinase-type plasminogen activatorHomo sapiens (human)4.7
Urokinase-type plasminogen activatorMus musculus (house mouse)2.3
Amine oxidase [flavin-containing] AHomo sapiens (human)3.909
Sodium/hydrogen exchanger 1Rattus norvegicus (Norway rat)1
Amiloride-sensitive sodium channel subunit alphaHomo sapiens (human)0.776
Sodium/hydrogen exchanger 2Oryctolagus cuniculus (rabbit)1
Acid-sensing ion channel 3Homo sapiens (human)4.4

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (31.25)18.2507
2000's10 (62.50)29.6817
2010's1 (6.25)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Northover, BJ1
Feuvray, D; Lagadic-Gossmann, D1
Conner, JA; Hernández-Cruz, A; Santi, CM1
Hartung, K; Kappl, M1
Friis, UG; Johansen, T; Praetorius, HA; Praetorius, J1
Mayer, A; Pecht, I; Pilatus, U; Rumpel, E1
Eriksson, KS; Haas, HL; Stevens, DR1
Gupta, S; Patni, A; Reddy, PR; Sharma, A; Tiwary, AK1
Kato, M; Kitazono, T; Nakamura, U; Uchizono, Y; Wakisaka, M; Yoshinari, M; Yoshioka, M1
Garg, SK; Gupta, S; Patni, AK; Sharma, A; Tiwary, AK1
Hogg, DS; Kozlowski, RZ1
Au, AL; Chau, WH; Kwan, YW; Lau, WH; Lee, WH; Raymond, K1
Gupta, A; Gupta, S; Tiwary, AK1
Gupta, A; Gupta, S; Moudgil, P; Sharma, A; Tiwary, AK1
Choi, S; Kim, JA; Liang, GH; Park, S; Suh, SH1
Calafat, AM; Chiu, YH; Dadd, R; Hauser, R; Mínguez-Alarcón, L; Nassan, FL; Ospina, M; Segal, TR; Williams, PL1

Other Studies

16 other study(ies) available for 2',4'-dichlorobenzamil amiloride and amiloride

ArticleYear
Effects of 8-(N,N-diethylamino)octyl 3,4,5-trimethoxybenzoate (TMB8) on rat atrial muscle.
    Biochemical pharmacology, 1992, Aug-04, Volume: 44, Issue:3

    Topics: Amiloride; Animals; Carrier Proteins; Fluorescent Dyes; Gallic Acid; Heart; Heart Atria; Indoles; Myocardium; Rats; Sodium-Calcium Exchanger; Sodium-Potassium-Exchanging ATPase

1992
Decreased sensitivity of contraction to changes of intracellular pH in papillary muscle from diabetic rat hearts.
    The Journal of physiology, 1990, Volume: 422

    Topics: Amiloride; Ammonium Chloride; Animals; Caffeine; Diabetes Mellitus, Experimental; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Muscle Contraction; Papillary Muscles; Rats; Rats, Inbred Strains; Ryanodine

1990
A significant fraction of calcium transients in intact guinea pig ventricular myocytes is mediated by Na(+)-Ca2+ exchange.
    Cellular signalling, 1995, Volume: 7, Issue:8

    Topics: Amiloride; Animals; Biological Transport; Calcium; Calcium Channel Blockers; Calcium Channels; Carrier Proteins; Cells, Cultured; Guinea Pigs; Heart; Heart Ventricles; Membrane Potentials; Microscopy, Confocal; Microscopy, Fluorescence; Monensin; Muscle Proteins; Myocardium; Nickel; Ouabain; Potassium; Ryanodine; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Signal Transduction; Sodium-Calcium Exchanger; Verapamil

1995
Rapid charge translocation by the cardiac Na(+)-Ca2+ exchanger after a Ca2+ concentration jump.
    Biophysical journal, 1996, Volume: 71, Issue:5

    Topics: Amiloride; Animals; Calcium; Carrier Proteins; Cell-Free System; Cytoplasm; Electric Conductivity; Guinea Pigs; Heart; Kinetics; Myocardium; Nickel; Patch-Clamp Techniques; Rats; Sodium; Sodium-Calcium Exchanger; Temperature

1996
Evidence for a Na+/Ca2+ exchange mechanism in rat peritoneal mast cells.
    Pflugers Archiv : European journal of physiology, 1998, Volume: 437, Issue:1

    Topics: Amiloride; Animals; Calcium; Electric Conductivity; Histamine Release; Lanthanum; Male; Mast Cells; Membrane Potentials; Ouabain; Patch-Clamp Techniques; Peritoneal Cavity; Rats; Rats, Sprague-Dawley; Sodium; Sodium-Calcium Exchanger

1998
Na(+)-dependent Ca(2+) transport modulates the secretory response to the Fcepsilon receptor stimulus of mast cells.
    Biophysical journal, 2000, Volume: 79, Issue:6

    Topics: Amiloride; Animals; beta-N-Acetylhexosaminidases; Biological Transport; Calcium; Cell Line; Cell Membrane; Fluorescent Dyes; Indoles; Kinetics; Magnetic Resonance Spectroscopy; Mast Cells; Models, Chemical; Rats; Receptors, IgE; Sodium; Strontium

2000
Serotonin excites tuberomammillary neurons by activation of Na(+)/Ca(2+)-exchange.
    Neuropharmacology, 2001, Volume: 40, Issue:3

    Topics: Amiloride; Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypothalamic Area, Lateral; In Vitro Techniques; Ion Transport; Lithium; Male; Meglumine; Membrane Potentials; Neurons; Nickel; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Serotonin; Sodium; Sodium-Calcium Exchanger; Temperature; Tetrodotoxin

2001
Effect of 2',4'-dichlorobenzamil hydrochloride, a Na(+)-Ca(2+) exchange inhibitor, on human spermatozoa.
    European journal of pharmacology, 2001, Apr-20, Volume: 418, Issue:1-2

    Topics: Amiloride; Calcium; Cell Survival; Dose-Response Relationship, Drug; Glucose; Humans; Male; Sodium-Calcium Exchanger; Sperm Count; Sperm Motility; Spermatocidal Agents; Spermatozoa; Time Factors

2001
Sodium-coupled glucose transporter as a functional glucose sensor of retinal microvascular circulation.
    Circulation research, 2001, Jun-08, Volume: 88, Issue:11

    Topics: Amiloride; Angiotensin II; Animals; Calcium; Calcium Channel Blockers; Cattle; Cell Size; Deoxyglucose; Dose-Response Relationship, Drug; Extracellular Space; Glucose; Methylglucosides; Microcirculation; Monosaccharide Transport Proteins; Pericytes; Phlorhizin; Retinal Vessels; Sodium; Sodium-Calcium Exchanger; Vasoconstrictor Agents

2001
Role of intracellular calcium in the spermicidal action of 2',4'-dichlorobenzamil, a novel contact spermicide.
    The Journal of pharmacy and pharmacology, 2001, Volume: 53, Issue:10

    Topics: Adrenergic beta-Antagonists; Adult; Amiloride; Calcium; Humans; In Vitro Techniques; Male; Propranolol; Semen; Sperm Motility; Spermatocidal Agents; Spermatozoa

2001
Hypoxia activates a background conductance in freshly isolated pulmonary arterial endothelial cells of the rat.
    FEBS letters, 2002, Jul-03, Volume: 522, Issue:1-3

    Topics: Amiloride; Animals; Cell Hypoxia; Cells, Cultured; Electrophysiology; Endothelium, Vascular; Gadolinium; Lanthanum; Male; Oxygen; Potassium Channels; Pulmonary Artery; Rats; Rats, Wistar; Sodium-Calcium Exchanger

2002
Role of Na+/H+ exchanger in acetylcholine-mediated pulmonary artery contraction of spontaneously hypertensive rats.
    European journal of pharmacology, 2003, Mar-19, Volume: 464, Issue:2-3

    Topics: Acetylcholine; Amiloride; Animals; Calcium; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Female; Hypertension; Imidazoles; In Vitro Techniques; Indoles; Male; Maleimides; Muscarinic Agonists; Muscarinic Antagonists; Neostigmine; Protein Kinase C; Pulmonary Artery; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Muscarinic; Sodium; Sodium-Calcium Exchanger; Sodium-Hydrogen Exchangers; Sodium-Potassium-Exchanging ATPase; Species Specificity; Thiourea; Vasoconstriction; Vasodilator Agents

2003
Spermicidal efficacy of H2-receptor antagonists and potentiation with 2', 4'-dichlorobenzamil hydrochloride: role of intrasperm Ca2+.
    Contraception, 2003, Volume: 68, Issue:1

    Topics: Adult; Amiloride; Calcium; Cimetidine; Famotidine; Histamine H2 Antagonists; Humans; In Vitro Techniques; Male; Ranitidine; Receptors, Cytoplasmic and Nuclear; Sodium-Calcium Exchanger; Sperm Motility; Spermatocidal Agents; Spermatozoa; Time Factors

2003
Potentiation of spermicidal activity of 2',4'-dichlorobenzamil by lidocaine.
    Indian journal of experimental biology, 2002, Volume: 40, Issue:12

    Topics: Amiloride; Animals; Humans; Lidocaine; Male; Rabbits; Spermatocidal Agents; Spermatozoa

2002
Stimulation of large-conductance Ca2+-activated K+ channels by the Na+/Ca2+ exchanger inhibitor dichlorobenzamil in cultured human umbilical vein endothelial cells and mouse aortic smooth muscle cells.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2009, Volume: 60, Issue:1

    Topics: Amiloride; Animals; Aorta; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Large-Conductance Calcium-Activated Potassium Channels; Male; Membrane Potentials; Mice; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Sodium-Calcium Exchanger; Umbilical Veins

2009
Urinary concentrations of 3-(diethylcarbamoyl)benzoic acid (DCBA), a major metabolite of N,N-diethyl-m-toluamide (DEET) and semen parameters among men attending a fertility center.
    Human reproduction (Oxford, England), 2017, Dec-01, Volume: 32, Issue:12

    Topics: Adult; Amiloride; Body Mass Index; DEET; Fertility; Humans; Infertility, Male; Insect Repellents; Male; Massachusetts; Middle Aged; Prospective Studies; Semen; Semen Analysis; Sperm Count; Sperm Motility; Young Adult

2017