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2',3'-dideoxycytidinene and zalcitabine

2',3'-dideoxycytidinene has been researched along with zalcitabine in 28 studies

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-199016 (57.14)18.7374
1990's10 (35.71)18.2507
2000's1 (3.57)29.6817
2010's1 (3.57)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barchi, JJ; Driscoll, JS; Kelley, JA; Marquez, VE; Mitsuya, H; Roth, JS; Shirasaka, T; Siddiqui, MA1
Horwitz, JP; Kessel, D; Meltsner, BR; Palomino, E1
Augustyns, K; Balzarini, J; Blaton, N; De Clercq, E; De Ranter, C; Everaert, D; Janssen, G; Jie, L; Peeters, O; Van Aerschot, A1
Baba, M; Balzarini, J; Broder, S; De Clercq, E; Herdewijn, P; Pauwels, R; Vanderhaeghe, H1
Chen, MS; Gao, YS; Ghazzouli, I; Lin, TS; McLaren, C; Prusoff, WH1
Antonenko, SV; Chentsova, NP; Kukhar, VP; Luik, AI; Poda, GI; Tetko, IV1
Töglhofer, W1
Chen, CH; Cheng, YC; Vazquez-Padua, M1
Darby, G; Larder, BA; Richman, DD1
Hill, DL; Hoover, EA; Mullins, JI; Perigo, NA; Strobel, JD; Zeidner, NS1
Bianchi, M; Cucchiarini, L; Magnani, M; Rossi, L; Stocchi, V1
Fukushima, S; Kawaguchi, T; Mishima, M; Nakano, M; Ohmura, M1
Broder, S; Lawley, TJ; McNeely, MC; Yarchoan, R1
Fukushima, S; Ishikawa, K; Juni, K; Kawaguchi, T; Nakano, M; Seki, T1
Broder, S; Dalakas, M; Dubinsky, RM; Yarchoan, R1
Chen, CH; Cheng, YC1
Agrawal, KC; Beckman, BS; Gogu, SR1
Plagemann, PG; Woffendin, C1
Hiraoka, W; Kuwabara, M; Matsuda, A; Sato, F; Tanabe, K; Ueda, T1
Balzarini, J; Broder, S; Cooney, DA; Dalal, M; De Clercq, E; Herdewijn, P; Johns, DG; Kang, GJ; Pauwels, R1
Chen, MS; Kinney-Thomas, E; Lin, TS; Prusoff, WH; Schinazi, RF1
Hamamoto, Y; Matsuda, A; Matsui, T; Nakashima, H; Ueda, T; Yamamoto, N1
Anderson, KP; Azad, RF; Brown-Driver, V; Buckheit, RW1
Cheng, YC; Dutschman, GE; Gullen, E; Lin, TS; Liu, MC; Luo, MZ; Zhu, YL1
Carr, A; Cooper, DA; Emery, S; Kelleher, A; Law, M1
Faraj, A; Gosselin, G; Imbach, JL; Martin, LT; Mathe, C; Schinazi, RF; Sommadossi, JP1
Back, N; Bakker, M; Berkhout, B; de Ronde, A; Jebbink, MF; Jurriaans, S; Parkin, N; Reiss, P; van der Hoek, L1
Hovorun, DM; Ponomareva, AG; van Mourik, T; Yurenko, YP; Zhurakivsky, RO1

Trials

1 trial(s) available for 2',3'-dideoxycytidinene and zalcitabine

ArticleYear
CD8+ lymphocyte responses to antiretroviral therapy of HIV infection.
    Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1996, Dec-01, Volume: 13, Issue:4

    Topics: Acetamides; Acetophenones; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Didanosine; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; HIV Reverse Transcriptase; Humans; Lamivudine; Lymphocyte Count; Pyridines; Reverse Transcriptase Inhibitors; Ritonavir; Viral Load; Zalcitabine; Zidovudine

1996

Other Studies

27 other study(ies) available for 2',3'-dideoxycytidinene and zalcitabine

ArticleYear
Chemistry and anti-HIV properties of 2'-fluoro-2',3'-dideoxyarabinofuranosylpyrimidines.
    Journal of medicinal chemistry, 1992, Jun-12, Volume: 35, Issue:12

    Topics: Animals; Antiviral Agents; CD4-Positive T-Lymphocytes; Cell Line; Chemical Phenomena; Chemistry, Physical; Cytarabine; Cytidine Deaminase; Cytopathogenic Effect, Viral; Dose-Response Relationship, Drug; Drug Stability; HIV-1; Hydrogen-Ion Concentration; Macaca mulatta; Molecular Structure; Structure-Activity Relationship; Zalcitabine

1992
Synthesis and in vitro evaluation of some modified 4-thiopyrimidine nucleosides for prevention or reversal of AIDS-associated neurological disorders.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:1

    Topics: AIDS Dementia Complex; Animals; Antiviral Agents; Cell Line; Chemical Phenomena; Chemistry; Chemistry, Physical; Cytopathogenic Effect, Viral; Dideoxynucleosides; HIV; Humans; Kinetics; Molecular Structure; Phosphorylation; Pyrimidine Nucleosides; Rabbits; Stavudine; T-Lymphocytes; Thymidine Kinase; Thymus Gland; Zidovudine

1990
Synthesis and anti-HIV evaluation of 2',3'-dideoxyribo-5-chloropyrimidine analogues: reduced toxicity of 5-chlorinated 2',3'-dideoxynucleosides.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:6

    Topics: Antiviral Agents; Cell Line; Dideoxynucleosides; HIV; Humans; Molecular Conformation; X-Ray Diffraction

1990
3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:8

    Topics: Antiviral Agents; Cell Line; Chemical Phenomena; Chemistry; Cytopathogenic Effect, Viral; Deoxyribonucleosides; HIV; Humans; Structure-Activity Relationship; T-Lymphocytes; Virus Replication

1987
Synthesis and antiviral activity of various 3'-azido, 3'-amino, 2',3'-unsaturated, and 2',3'-dideoxy analogues of pyrimidine deoxyribonucleosides against retroviruses.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:2

    Topics: Antiviral Agents; Cell Line; HIV; Indicators and Reagents; Magnetic Resonance Spectroscopy; Moloney murine leukemia virus; Pyrimidine Nucleosides; Spectrophotometry; Structure-Activity Relationship

1987
HIV-1 reverse transcriptase inhibitor design using artificial neural networks.
    Journal of medicinal chemistry, 1994, Aug-05, Volume: 37, Issue:16

    Topics: Algorithms; Cell Line; Drug Design; HIV Reverse Transcriptase; HIV-1; Humans; Molecular Structure; Neural Networks, Computer; Pyrimidines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; T-Lymphocytes; Zidovudine

1994
[New, in Austria registered specialty drugs. Hivid (2',3'-dideoxycytidine; ddC)].
    Wiener klinische Wochenschrift, 1992, Volume: 104, Issue:12

    Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Animals; Antiviral Agents; Austria; CD4-Positive T-Lymphocytes; Humans; Leukocyte Count; Zalcitabine; Zidovudine

1992
Effect of anti-human immunodeficiency virus nucleoside analogs on mitochondrial DNA and its implication for delayed toxicity.
    Molecular pharmacology, 1991, Volume: 39, Issue:5

    Topics: Antiviral Agents; Cell Line; Cytarabine; Didanosine; Dideoxynucleosides; DNA, Mitochondrial; HIV; Humans; Lymphocyte Activation; Nucleosides; Stavudine; T-Lymphocytes; Zalcitabine; Zidovudine

1991
HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy.
    Science (New York, N.Y.), 1989, Mar-31, Volume: 243, Issue:4899

    Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Dideoxynucleosides; Drug Resistance; Foscarnet; HeLa Cells; HIV; HIV Core Protein p24; Humans; Microbial Sensitivity Tests; Phosphonoacetic Acid; Retroviridae Proteins; Reverse Transcriptase Inhibitors; Viral Plaque Assay; Virus Replication; Zalcitabine; Zidovudine

1989
Treatment of FeLV-induced immunodeficiency syndrome (FeLV-FAIDS) with controlled release capsular implantation of 2',3'-dideoxycytidine.
    Antiviral research, 1989, Volume: 11, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Animals; Antibodies, Monoclonal; Capsules; Cats; Dideoxynucleosides; Disease Models, Animal; Drug Implants; Drug Therapy, Combination; Gene Products, gag; Immunologic Deficiency Syndromes; Infusions, Intravenous; Injections, Subcutaneous; Interferon Type I; Leukemia Virus, Feline; Retroviridae Proteins; Tetrahydrouridine; Tumor Necrosis Factor-alpha; Virus Replication; Zalcitabine

1989
Reversed-phase liquid chromatographic determination of 2',3'-dideoxycytidine in human blood samples.
    Journal of chromatography, 1989, Jun-30, Volume: 491, Issue:1

    Topics: Chromatography, High Pressure Liquid; Erythrocytes; Kinetics; Spectrophotometry, Ultraviolet; Zalcitabine

1989
Enzymatic and chemical stability of 2',3'-dideoxy-2',3'-didehydropyrimidine nucleosides: potential anti-acquired immunodeficiency syndrome agents.
    Chemical & pharmaceutical bulletin, 1989, Volume: 37, Issue:7

    Topics: Acquired Immunodeficiency Syndrome; Animals; Antiviral Agents; Chemical Phenomena; Chemistry; Cytarabine; Dideoxynucleosides; Drug Stability; Humans; Mice; Stavudine; Zalcitabine

1989
Dermatologic complications associated with administration of 2',3'-dideoxycytidine in patients with human immunodeficiency virus infection.
    Journal of the American Academy of Dermatology, 1989, Volume: 21, Issue:6

    Topics: Acquired Immunodeficiency Syndrome; Adult; Drug Administration Schedule; Drug Eruptions; Drug Evaluation; HIV Antigens; Humans; Male; Middle Aged; Mouth Diseases; T-Lymphocytes, Helper-Inducer; Ulcer; Zalcitabine

1989
Studies on 2',3'-dideoxy-2',3'-didehydropyrimidine nucleosides. II. N4-benzoyl-2',3'-dideoxy-2',3'-didehydrocytidine as a prodrug of 2',3'-dideoxy-2',3'-didehydrocytidine (DDCN).
    Chemical & pharmaceutical bulletin, 1989, Volume: 37, Issue:9

    Topics: Animals; Chemical Phenomena; Chemistry; Male; Mice; Mice, Inbred Strains; Prodrugs; Zalcitabine

1989
Reversible axonal neuropathy from the treatment of AIDS and related disorders with 2',3'-dideoxycytidine (ddC).
    Muscle & nerve, 1989, Volume: 12, Issue:10

    Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Axons; Dose-Response Relationship, Drug; Electromyography; Humans; Pain; Peripheral Nervous System Diseases; Zalcitabine

1989
Delayed cytotoxicity and selective loss of mitochondrial DNA in cells treated with the anti-human immunodeficiency virus compound 2',3'-dideoxycytidine.
    The Journal of biological chemistry, 1989, Jul-15, Volume: 264, Issue:20

    Topics: Antiviral Agents; Cell Line; Cell Survival; Deoxyribonuclease BamHI; Dideoxynucleosides; DNA, Mitochondrial; Electrophoresis, Agar Gel; HIV; Lactates; Lactic Acid; Zalcitabine

1989
Anti-HIV drugs: comparative toxicities in murine fetal liver and bone marrow erythroid progenitor cells.
    Life sciences, 1989, Volume: 45, Issue:4

    Topics: Animals; Antiviral Agents; Bone Marrow Cells; Cells, Cultured; Colony-Forming Units Assay; Dideoxynucleosides; Fetus; Hematopoietic Stem Cells; HIV; Liver; Mice; Ribavirin; Zalcitabine; Zidovudine

1989
Permeation and salvage of dideoxyadenosine in mammalian cells.
    Molecular pharmacology, 1989, Volume: 36, Issue:1

    Topics: Animals; Carrier Proteins; Coformycin; Deamination; Dideoxyadenosine; Dideoxynucleosides; Erythrocytes; Humans; Leukemia, Experimental; Membrane Proteins; Mice; Nucleoside Transport Proteins; Pentostatin; Permeability; Zalcitabine

1989
Sensitization of X-irradiated Chinese hamster V79 cells by derivatives of pyrimidine nucleosides.
    Journal of radiation research, 1988, Volume: 29, Issue:4

    Topics: Animals; Antiviral Agents; Cell Count; Cell Line; Cell Survival; Dideoxynucleosides; Pyrimidine Nucleosides; Radiation-Sensitizing Agents; Stavudine; Zalcitabine; Zidovudine

1988
Potent and selective anti-HTLV-III/LAV activity of 2',3'-dideoxycytidinene, the 2',3'-unsaturated derivative of 2',3'-dideoxycytidine.
    Biochemical and biophysical research communications, 1986, Oct-30, Volume: 140, Issue:2

    Topics: Animals; Antigens, Viral; Antineoplastic Agents; Antiviral Agents; Cell Line; Cell Survival; Cytopathogenic Effect, Viral; Deoxycytidine; Deoxycytidine Kinase; HIV; Humans; Mice; Zalcitabine

1986
Antiviral activity of 2',3'-dideoxycytidin-2'-ene (2',3'-dideoxy-2',3'-didehydrocytidine) against human immunodeficiency virus in vitro.
    Biochemical pharmacology, 1987, Feb-01, Volume: 36, Issue:3

    Topics: Antiviral Agents; Deoxycytidine; Fluorescence; HIV; Humans; In Vitro Techniques; Monocytes; Thymidine; Zalcitabine; Zidovudine

1987
Inhibitory effect of 2',3'-didehydro-2',3'-dideoxynucleosides on infectivity, cytopathic effects, and replication of human immunodeficiency virus.
    Antimicrobial agents and chemotherapy, 1987, Volume: 31, Issue:6

    Topics: Antigens, Viral; Antiviral Agents; Cells, Cultured; Cytopathogenic Effect, Viral; Dideoxynucleosides; HIV; Humans; Stavudine; Thymidine; Viral Plaque Assay; Virus Replication; Zalcitabine; Zidovudine

1987
Antiviral activity of a phosphorothioate oligonucleotide complementary to human cytomegalovirus RNA when used in combination with antiviral nucleoside analogs.
    Antiviral research, 1995, Volume: 28, Issue:2

    Topics: Antiviral Agents; Base Sequence; Cell Line; Cytomegalovirus; Drug Interactions; Foscarnet; Ganciclovir; HIV-1; Humans; Molecular Sequence Data; Nucleic Acid Synthesis Inhibitors; RNA, Viral; Thionucleotides; Virus Replication; Zalcitabine; Zidovudine

1995
Design and synthesis of 2',3'-dideoxy-2',3'-didehydro-beta-L-cytidine (beta-L-d4C) and 2',3'-dideoxy 2',3'-didehydro-beta-L-5-fluorocytidine (beta-L-Fd4C), two exceptionally potent inhibitors of human hepatitis B virus (HBV) and potent inhibitors of human
    Journal of medicinal chemistry, 1996, Apr-26, Volume: 39, Issue:9

    Topics: Antiviral Agents; Drug Design; Hepatitis B virus; HIV; Humans; Zalcitabine

1996
Effect of stereoisomerism on the cellular pharmacology of beta-enantiomers of cytidine analogs in Hep-G2 cells.
    Biochemical pharmacology, 1997, Jan-10, Volume: 53, Issue:1

    Topics: Antiviral Agents; Cells, Cultured; Chromatography, High Pressure Liquid; Humans; Liver; Liver Neoplasms; Phosphorylation; Stereoisomerism; Tumor Cells, Cultured; Zalcitabine

1997
Increased multinucleoside drug resistance and decreased replicative capacity of a human immunodeficiency virus type 1 variant with an 8-amino-Acid insert in the reverse transcriptase.
    Journal of virology, 2005, Volume: 79, Issue:6

    Topics: Adult; Amino Acid Substitution; Anti-HIV Agents; Drug Resistance, Multiple, Viral; Evolution, Molecular; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Male; Molecular Sequence Data; Mutation; Recombination, Genetic; Reverse Transcriptase Inhibitors; Sequence Analysis, DNA; Virus Replication; Zalcitabine; Zidovudine

2005
Complete conformational space of the potential HIV-1 reverse transcriptase inhibitors d4U and d4C. A quantum chemical study.
    Physical chemistry chemical physics : PCCP, 2012, May-21, Volume: 14, Issue:19

    Topics: Crystallography, X-Ray; Dideoxynucleosides; HIV-1; Hydrogen Bonding; Models, Molecular; Molecular Conformation; Quantum Theory; Reverse Transcriptase Inhibitors; Zalcitabine

2012