Compounds > 2--3--didehydro-3--deoxy-4--ethynylthymidine

2--3--didehydro-3--deoxy-4--ethynylthymidine and dimethyldioxirane

2--3--didehydro-3--deoxy-4--ethynylthymidine has been researched along with dimethyldioxirane* in 1 studies

Other Studies

1 other study(ies) available for 2--3--didehydro-3--deoxy-4--ethynylthymidine and dimethyldioxirane

Article	Year
An alternative synthetic method for 4'-C-ethynylstavudine by means of nucleophilic substitution of 4'-benzoyloxythymine nucleoside. Nucleosides, nucleotides & nucleic acids, 2007, Volume: 26, Issue:6-7 For the synthesis of 2',3' -didehydro-3' -deoxy-4' -C-ethynylthymidine (8: 4' -Ed4T), a recently reported promising anti-HIV agent, a new approach was developed. Since treatment of 1-(2,5-dideoxy-beta-l-glycero-pent-4-enofuranosyl)thymine with Pb(OBz)4 allowed the introduction of a 4'-benzoyloxy leaving group, nucleophilic substitution at the 4' -position became feasible for the first time. Thus, reaction between the 4'-benzoyloxy derivative (11) and Me3SiC identical with CAl(Et)Cl as a nucleophile led to the isolation of the desired 4'-"down"-ethynyl derivative (15) stereoselectively in 62% yield. Topics: Chemistry, Organic; Epoxy Compounds; Methylation; Nucleosides; Stavudine; Thymine	2007

Article

Year

An alternative synthetic method for 4'-C-ethynylstavudine by means of nucleophilic substitution of 4'-benzoyloxythymine nucleoside.

Nucleosides, nucleotides & nucleic acids, 2007, Volume: 26, Issue:6-7

For the synthesis of 2',3' -didehydro-3' -deoxy-4' -C-ethynylthymidine (8: 4' -Ed4T), a recently reported promising anti-HIV agent, a new approach was developed. Since treatment of 1-(2,5-dideoxy-beta-l-glycero-pent-4-enofuranosyl)thymine with Pb(OBz)4 allowed the introduction of a 4'-benzoyloxy leaving group, nucleophilic substitution at the 4' -position became feasible for the first time. Thus, reaction between the 4'-benzoyloxy derivative (11) and Me3SiC identical with CAl(Et)Cl as a nucleophile led to the isolation of the desired 4'-"down"-ethynyl derivative (15) stereoselectively in 62% yield.

Topics: Chemistry, Organic; Epoxy Compounds; Methylation; Nucleosides; Stavudine; Thymine

2007